Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.5 | 0.5 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0018 | 0.5 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0018 | 0.5 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0018 | 0.5 | 0.5 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0018 | 0.5 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0018 | 0.5 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | cytochrome P450 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0018 | 0.5 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0018 | 0.5 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.5 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | 0.0018 | 0.5 | 0.5 | |
Loa Loa (eye worm) | CYP4Cod1 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0018 | 0.5 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.5 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0018 | 0.5 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0018 | 0.5 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0018 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0018 | 0.5 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0018 | 0.5 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0018 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Effect on p38 activation in SMS-KCNR cells after 1 hr by Western blotting | ChEMBL. | 17855093 | |
Activity (binding) | Inhibition of AKT in SMS-KCNR cells after 36 hrs by western blotting | ChEMBL. | 17855093 | |
Activity (functional) | 0 | Cytotoxicity against SMS-KCNR cells after 48 hrs by MTS assay | ChEMBL. | 17855093 |
Activity (functional) | 0 | Cytotoxicity against IMR32 cells after 48 hrs by MTS assay | ChEMBL. | 17855093 |
Activity (functional) | 0 | Cytotoxicity against SH-SY5Y cells after 48 hrs by MTS assay | ChEMBL. | 17855093 |
Activity (ADMET) | 0 | Cytotoxicity against lung fibroblast cells after 48 hrs by MTS assay | ChEMBL. | 17855093 |
Activity (binding) | 0 | Effect on p38 activation in SMS-KCNR cells after 1 hr by Western blotting | ChEMBL. | 17855093 |
Activity (binding) | 0 | Effect on JNK activation in SMS-KCNR cells after 1 hr by Western blotting | ChEMBL. | 17855093 |
Activity (binding) | 0 | Inhibition of AKT in SMS-KCNR cells after 36 hrs by western blotting | ChEMBL. | 17855093 |
Activity (functional) | 0 | Induction of apoptosis in SMS-KCNR cells assessed as increase in caspase 3 activation by Western blotting | ChEMBL. | 17855093 |
Activity (functional) | 0 | Induction of apoptosis in SMS-KCNR cells assessed as increase in caspase 8 activation by Western blotting | ChEMBL. | 17855093 |
Activity (functional) | 0 | Induction of apoptosis in SMS-KCNR cells assessed as increase in caspase 9 activation by Western blotting | ChEMBL. | 17855093 |
Activity (functional) | 0 | Induction of apoptosis in SMS-KCNR cells assessed as increase in PARP1 activation by Western blotting | ChEMBL. | 17855093 |
Activity (functional) | 0 | Inhibition of cell proliferation of SMS-KCNR cells at 600 nm after 48 hrs by BrdU assay | ChEMBL. | 17855093 |
Activity (functional) | 0 | Cytotoxicity against SMS-KCNR cells at 2.5 uM to 5.0 uM after 48 hrs by MTS assay | ChEMBL. | 17855093 |
Activity (functional) | 0 | Reduction of SMS-KCNR cell viability at 5 uM after 48 hrs in presence of Z-VAD-FM | ChEMBL. | 17855093 |
Activity (functional) | 0 | Reduction of SMS-KCNR cell viability at 5 uM after 48 hrs in presence of Z-DEVD-FMK | ChEMBL. | 17855093 |
Activity (functional) | 0 | Reduction of SMS-KCNR cell viability at 5 uM after 48 hrs in presence of Z-IETD-FMK | ChEMBL. | 17855093 |
Activity (functional) | 0 | Reduction of SMS-KCNR cell viability at 5 uM after 48 hrs in presence of Z-LEHD-FMK | ChEMBL. | 17855093 |
Activity (functional) | = 6.5 % | Cell cycle arrest in SMS-KCNR cells by accumulation at S phase at 3 uM after 24 hrs by flow cytometry | ChEMBL. | 17855093 |
Activity (functional) | = 7.3 % | Cell cycle arrest in SMS-KCNR cells by accumulation at S phase at 3 uM after 12 hrs by flow cytometry | ChEMBL. | 17855093 |
Activity (functional) | = 18.8 % | Induction of apoptosis in SMS-KCNR cells at 3 uM after 24 hrs by flow cytometry | ChEMBL. | 17855093 |
Activity (functional) | = 19.7 % | Induction of apoptosis in SMS-KCNR cells at 3 uM after 12 hrs by flow cytometry | ChEMBL. | 17855093 |
Activity (functional) | = 24.5 % | Cell cycle arrest in SMS-KCNR cells by accumulation at G2/M phase at 3 uM after 24 hrs by flow cytometry | ChEMBL. | 17855093 |
Activity (functional) | = 26.3 % | Cell cycle arrest in SMS-KCNR cells by accumulation at G2/M phase at 3 uM after 12 hrs by flow cytometry | ChEMBL. | 17855093 |
Activity (functional) | = 66.4 % | Cell cycle arrest in SMS-KCNR cells by accumulation at G0/G1 phase at 3 uM after 12 hrs by flow cytometry | ChEMBL. | 17855093 |
Activity (functional) | = 68.9 % | Cell cycle arrest in SMS-KCNR cells by accumulation at G0/G1 phase at 3 uM after 24 hrs by flow cytometry | ChEMBL. | 17855093 |
IC50 (functional) | < 2.5 uM | Cytotoxicity against human SK-N-SH cells after 48 hrs | ChEMBL. | 17855093 |
IC50 (functional) | < 2.5 uM | Cytotoxicity against human SK-N-SH cells after 48 hrs | ChEMBL. | 17855093 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17855093 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.