Detailed information for compound 445410

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 637.678 | Formula: C35H33F2N7O3
  • H donors: 3 H acceptors: 4 LogP: 4.47 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: C#CCNC(=O)c1cn(Cc2c(F)cccc2F)c2n(c1=O)c(CN(Cc1ccccc1)C)c(n2)c1ccc(cc1)NC(=O)NCC
  • InChi: 1S/C35H33F2N7O3/c1-4-18-39-32(45)27-21-43(20-26-28(36)12-9-13-29(26)37)35-41-31(24-14-16-25(17-15-24)40-34(47)38-5-2)30(44(35)33(27)46)22-42(3)19-23-10-7-6-8-11-23/h1,6-17,21H,5,18-20,22H2,2-3H3,(H,39,45)(H2,38,40,47)
  • InChiKey: WIIMOPLUSIGAGH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens gonadotropin-releasing hormone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GnHR receptor homolog Get druggable targets OG5_131719 All targets in OG5_131719
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Brugia malayi hypothetical protein 0.0032 0.0236 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0236 0.1984
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0621 0.7272 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0094 0.0071
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0283 0.0288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.7272 1
Echinococcus granulosus phd:f box containing protein 0.0016 0.0038 0.0041
Echinococcus granulosus lamin 0.0027 0.0174 0.0216
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0183 0.2041 0.578
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0041 0.0336 0.0385
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0028 0.0182 0.035
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0028 0.0182 0.035
Loa Loa (eye worm) hypothetical protein 0.0041 0.0336 0.0336
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.7272 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0041 0.0336 0.0362
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0032 0.0236 0.0213
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Onchocerca volvulus 0.0032 0.0236 0.0535
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0182 0.1443
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0094 0.0071
Trypanosoma brucei polo-like protein kinase 0.0099 0.1035 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0818 0.9624 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0032 0.0236 0.0213
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0183 0.2041 0.5824
Echinococcus granulosus GPCR family 2 0.0032 0.0236 0.0296
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0032 0.0236 0.0213
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.004 0.0018
Schistosoma mansoni twik family of potassium channels-related 0.0032 0.0236 0.0255
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.1035 0.1035
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Plasmodium falciparum thioredoxin reductase 0.008 0.081 1
Plasmodium falciparum glutathione reductase 0.008 0.081 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.0076 0.0106
Toxoplasma gondii hypothetical protein 0.0019 0.0076 0.049
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Mycobacterium tuberculosis Probable oxidoreductase 0.0204 0.2285 0.6536
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0182 0.1443
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0267 0.3041 0.3156
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0032 0.0236 0.1984
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0032 0.0236 0.0142
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0032 0.0236 0.1984
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0032 0.0236 0.0213
Leishmania major calcium/potassium channel (CAKC), putative 0.0032 0.0236 0.1984
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.004 0.0018
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0041 0.0336 0.2991
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.004 0.0014
Brugia malayi jmjC domain containing protein 0.0016 0.0038 0.0015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.004 0.0014
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0283 0.0288
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0336 0.2991
Schistosoma mansoni calcium-activated potassium channel 0.0664 0.7785 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0303 0.3475 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0563 0.0677
Onchocerca volvulus 0.0027 0.0174 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0336 0.0362
Toxoplasma gondii hypothetical protein 0.0019 0.0076 0.049
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0041 0.0336 0.0314
Onchocerca volvulus 0.0032 0.0236 0.0535
Echinococcus multilocularis geminin 0.0348 0.401 0.4163
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0076 0.049
Leishmania major hypothetical protein, conserved 0.0041 0.0336 0.2991
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0563 0.5265
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0236 0.024
Loa Loa (eye worm) TWK-28 protein 0.0032 0.0236 0.0236
Leishmania major cAMP-specific phosphodiesterase, putative 0.0041 0.0336 0.2991
Mycobacterium ulcerans transmembrane cation transporter 0.0032 0.0236 0.0508
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0558 0.0558
Echinococcus granulosus potassium channel subfamily K 8 0.0032 0.0236 0.0296
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0028 0.0182 0.1443
Giardia lamblia Hypothetical protein 0.0041 0.0336 0.0218
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.1035 0.107
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0135 0.0212
Loa Loa (eye worm) hypothetical protein 0.0849 1 1
Schistosoma mansoni twik family of potassium channels-related 0.0032 0.0236 0.0255
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0183 0.2041 0.5824
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0032 0.0236 0.0213
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0032 0.0236 0.0236
Plasmodium falciparum phosphodiesterase gamma, putative 0.0041 0.0336 0.3864
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0063
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0041 0.0336 0.2991
Loa Loa (eye worm) hypothetical protein 0.0226 0.2554 0.2554
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0041 0.0336 0.0362
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0563 0.0677
Plasmodium vivax potassium channel, putative 0.0032 0.0236 0.2564
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0236 0.0296
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0563 0.5265
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0233 0.263 0.3346
Loa Loa (eye worm) hypothetical protein 0.006 0.0563 0.0563
Brugia malayi glutathione reductase 0.008 0.081 0.0788
Schistosoma mansoni calcium-activated potassium channel 0.0632 0.7398 0.9501
Giardia lamblia Fructose-bisphosphate aldolase 0.0621 0.7272 1
Trypanosoma brucei trypanothione reductase 0.008 0.081 0.7739
Echinococcus multilocularis musashi 0.0027 0.0174 0.0175
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0467 0.0467
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1035 0.1333
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.1035 0.1323
Loa Loa (eye worm) hypothetical protein 0.0207 0.2327 0.2327
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0041 0.0336 0.0362
Leishmania major hypothetical protein, conserved 0.0041 0.0336 0.2991
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.1035 0.4763
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0467 0.0554
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0135 0.0278
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0032 0.0236 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0336 0.2991
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0467 0.0402
Brugia malayi jmjC domain containing protein 0.0016 0.0038 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0336 0.2991
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.0563 0.0716
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0038 0.0041
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0563 0.0677
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0563 0.5265
Toxoplasma gondii thioredoxin reductase 0.008 0.081 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0467 0.0544
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.0563 0.0677
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0041 0.0336 0.0385
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0467 0.556
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0041 0.0336 0.3864
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0336 0.2991
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0336 0.2991
Plasmodium vivax thioredoxin reductase, putative 0.008 0.081 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0204 0.2285 0.6536
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0032 0.0236 0.0236
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0041 0.0336 0.0425
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0032 0.0236 0.0213
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0563 0.0677
Loa Loa (eye worm) TWK-7 protein 0.0032 0.0236 0.0236
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0041 0.0336 0.0344
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0041 0.0336 0.0362
Trichomonas vaginalis glutathione reductase, putative 0.0028 0.0182 0.0147
Loa Loa (eye worm) glutathione reductase 0.008 0.081 0.081
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0558 0.0671
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Schistosoma mansoni calcium-activated potassium channel 0.0032 0.0236 0.0255
Treponema pallidum fructose-bisphosphate aldolase 0.0621 0.7272 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1035 0.1333
Toxoplasma gondii ion channel protein 0.0032 0.0236 0.2564
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1035 0.1333
Schistosoma mansoni hypothetical protein 0.0348 0.401 0.5127
Plasmodium vivax glutathione reductase, putative 0.008 0.081 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0467 0.4302
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.0043
Onchocerca volvulus 0.0032 0.0236 0.0535
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0028 0.0182 0.035
Brugia malayi hypothetical protein 0.0032 0.0236 0.0213
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0467 0.0593
Echinococcus granulosus twik family of potassium channels 0.0032 0.0236 0.0296
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0038 0.0033
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0038 0.0038
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0038 0.0033
Trypanosoma brucei protein kinase, putative 0.0052 0.0467 0.4302
Schistosoma mansoni lamin 0.0027 0.0174 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1035 0.1333
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0558 0.0671
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1073 0.1052
Brugia malayi Isocitrate dehydrogenase 0.0016 0.004 0.0016
Brugia malayi isocitrate dehydrogenase 0.0016 0.004 0.0016
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.004 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.7272 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0558 0.0574
Loa Loa (eye worm) hypothetical protein 0.0041 0.0336 0.0336
Schistosoma mansoni hypothetical protein 0.0032 0.0236 0.0255
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0028 0.0182 0.1864
Schistosoma mansoni hypothetical protein 0.0032 0.0236 0.0256
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0041 0.0336 0.2991
Echinococcus granulosus small conductance calcium activated potassium 0.0664 0.7785 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0028 0.0182 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0081 0.0823 0.0849
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0038 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0135 0.0212
Schistosoma mansoni hypothetical protein 0.0032 0.0236 0.0256
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0032 0.0236 0.0213
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Plasmodium falciparum glutathione reductase 0.0028 0.0182 0.1864
Brugia malayi jmjC domain containing protein 0.0016 0.0038 0.0015
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0032 0.0236 0.0239
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Loa Loa (eye worm) hypothetical protein 0.0102 0.1073 0.1073
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0032 0.0236 0.0213
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0063
Echinococcus granulosus calcium activated potassium channel variant 0.0032 0.0236 0.0296
Schistosoma mansoni hypothetical protein 0.0348 0.401 0.5127
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0439 0.0505
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.006 0.0563 0.0678
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Brugia malayi GnHR receptor homolog 0.0558 0.6524 0.6516
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.1035 0.1262
Schistosoma mansoni lamin 0.0027 0.0174 0.0176
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0028 0.0182 0.1443
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0063
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0267 0.3041 0.3025
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0028 0.0182 0.1864
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0182 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0032 0.0236 0.0213
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Echinococcus multilocularis potassium channel subfamily K 0.0032 0.0236 0.0239
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1073 0.1073
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0135 0.0212
Schistosoma mansoni intermediate filament proteins 0.0027 0.0174 0.0176
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Loa Loa (eye worm) hypothetical protein 0.0664 0.7785 0.7785
Echinococcus multilocularis small conductance calcium activated potassium 0.0664 0.7785 0.8088
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0558 0.071
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Schistosoma mansoni hypothetical protein 0.0032 0.0236 0.0256
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0041 0.0336 0.0362
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.0076 0.0106
Leishmania major hypothetical protein, conserved 0.0032 0.0236 0.1984
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0467 0.0593
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0041 0.0336 0.0362
Leishmania major trypanothione reductase 0.008 0.081 0.7739
Trichomonas vaginalis mercuric reductase, putative 0.0028 0.0182 0.0147
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0135 0.0212
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0236 0.0214
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0183 0.2041 0.5824
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0303 0.3475 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0336 0.2991
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0028 0.0182 0.0226
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0135 0.0112
Onchocerca volvulus 0.0032 0.0236 0.0535
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0333 0.3828 0.3828
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1035 0.1287
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0051 0.0033
Schistosoma mansoni twik family of potassium channels-related 0.0032 0.0236 0.0255
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0038
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0467 0.048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.7272 1
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0038 0.0041
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.004 0.0035
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0041 0.0336 0.0385
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0063 0.0067
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Brugia malayi jmjC domain containing protein 0.0016 0.0038 0.0015
Plasmodium falciparum thioredoxin reductase 0.0028 0.0182 0.1864
Giardia lamblia Kinase, PLK 0.0099 0.1035 0.1204
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0467 0.4302
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0076 0.049
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0563 0.0677
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.2025 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1073 0.1052
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0041 0.0336 0.2991
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0032 0.0236 0.0213
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.0563 0.0541
Echinococcus multilocularis GPCR, family 2 0.0032 0.0236 0.024
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0076 0.0039
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0023 0.0023
Onchocerca volvulus 0.0032 0.0236 0.0535
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0032 0.0236 0.0213
Schistosoma mansoni hypothetical protein 0.0664 0.7785 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0028 0.0182 0.1443
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0041 0.0336 0.2991
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.008 0.081 0.2242
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.004 0.0002
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0439 0.0505
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1035 0.1333
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0041 0.0336 0.0385
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0041 0.0336 0.0362
Trypanosoma brucei calcium-activated potassium channel, putative 0.0032 0.0236 0.1984
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.007 0.0686 0.0836
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0041 0.0336 0.0385
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0028 0.0182 0.1864
Mycobacterium ulcerans hypothetical protein 0.0024 0.0135 0.0212
Onchocerca volvulus 0.0027 0.0174 0.0208
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0032 0.0236 0.1984
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0135 0.0212
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0558 0.0671
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0076 0.0039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.0035
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1035 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0182 0.1443
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.7272 1
Loa Loa (eye worm) PDE1B protein 0.0233 0.263 0.263
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0236 0.024
Mycobacterium tuberculosis Probable reductase 0.0183 0.2041 0.5824
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Echinococcus multilocularis calcium activated potassium channel variant 0.0032 0.0236 0.0239
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0041 0.0336 0.0336
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0041 0.0336 0.0385
Loa Loa (eye worm) hypothetical protein 0.0809 0.9513 0.9513
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0267 0.3041 0.3902
Loa Loa (eye worm) uncoordinated protein 58 0.0032 0.0236 0.0236
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1035 0.1333
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0038 0.0041
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.0182 0.1443
Loa Loa (eye worm) hypothetical protein 0.007 0.0686 0.0686
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0135 0.0212
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0135 0.0112
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0051 0.0033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0032 0.0236 0.0213
Trypanosoma cruzi trypanothione reductase, putative 0.008 0.081 0.7739
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0182 0.1443
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Echinococcus multilocularis lamin 0.0027 0.0174 0.0175
Brugia malayi Thioredoxin reductase 0.008 0.081 0.0788
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0038
Toxoplasma gondii ion channel protein 0.0032 0.0236 0.2564
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0204 0.2285 0.6499
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0063 0.0317
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.0563 0.0579
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Schistosoma mansoni twik family of potassium channels-related 0.0032 0.0236 0.0255
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0076 0.049
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0038 0.0041
Echinococcus multilocularis potassium channel subfamily K 8 0.0032 0.0236 0.0239
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.0563 0.0678
Echinococcus multilocularis twik family of potassium channels 0.0032 0.0236 0.0239
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0041 0.0336 0.0425
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0041 0.0336 0.2991
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.004 0.0014
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0041 0.0336 0.0425
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0041 0.0336 0.0385
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0076 0.0039
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0563 0.0677
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0041 0.0336 0.3864
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0038 0.0033
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0563 0.0677
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0236 0.0296
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0563 0.0677
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0041 0.0336 0.2991
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0467 0.4302
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Mycobacterium tuberculosis Probable dehydrogenase 0.0183 0.2041 0.5824
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0041 0.0336 0.2991
Schistosoma mansoni twik family of potassium channels-related 0.0032 0.0236 0.0255
Onchocerca volvulus 0.0032 0.0236 0.0535
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0041 0.0336 0.0425
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0041 0.0336 0.0362
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0028 0.0182 0.1443
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0032 0.0236 0.0213
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0236 0.0222
Brugia malayi intermediate filament protein 0.0027 0.0174 0.0151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0051 0.0033
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0621 0.7272 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.0035
Plasmodium falciparum phosphodiesterase delta, putative 0.0041 0.0336 0.3864
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0563 0.5265
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0041 0.0336 0.0362
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.0174
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0063 0.0317
Schistosoma mansoni calcium-activated potassium channel 0.0032 0.0236 0.0255
Giardia lamblia Hypothetical protein 0.0032 0.0236 0.0076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0135 0.097
Brugia malayi jmjC domain containing protein 0.0059 0.0558 0.0536
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.1035 1
Toxoplasma gondii NADPH-glutathione reductase 0.0028 0.0182 0.1864
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0041 0.0336 0.0362
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0135
Schistosoma mansoni kinase 0.0051 0.0455 0.0538
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0032 0.0236 0.0213
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.7272 1
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0686 0.0664
Plasmodium vivax phosphodiesterase gamma, putative 0.0041 0.0336 0.3864
Plasmodium vivax potassium channel, putative 0.0032 0.0236 0.2564
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0041 0.0336 0.2991
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0041 0.0336 0.0362
Giardia lamblia hypothetical protein 0.0041 0.0336 0.0218
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0038 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0038 0.0038
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0135 0.0212
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0041 0.0336 0.0314
Toxoplasma gondii hypothetical protein 0.0019 0.0076 0.049
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0135 0.0173
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0182 0.1443
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0182 0.1443
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Echinococcus granulosus twik family of potassium channels 0.0032 0.0236 0.0296
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0135 0.097
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0028 0.0182 0.0183
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0041 0.0336 0.0344
Echinococcus granulosus lamin dm0 0.0027 0.0174 0.0216
Schistosoma mansoni twik family of potassium channels-related 0.0032 0.0236 0.0255
Loa Loa (eye worm) hypothetical protein 0.0027 0.0168 0.0168
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0041 0.0336 0.0344
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0032 0.0236 0.0239
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0182 0.1443
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0336 0.0362
Brugia malayi MAP kinase sur-1 0.0052 0.0467 0.0445
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0051 0.0033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0032 0.0236 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0336 0.2991
Onchocerca volvulus 0.0032 0.0236 0.0535
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Loa Loa (eye worm) thioredoxin reductase 0.008 0.081 0.081
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0135 0.0173
Plasmodium falciparum potassium channel 0.0032 0.0236 0.2564
Echinococcus granulosus potassium channel subfamily K 0.0032 0.0236 0.0296
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0183 0.2041 0.5824
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0135 0.0112
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0041 0.0336 0.3864
Leishmania major hypothetical protein, conserved 0.0032 0.0236 0.1984
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0233 0.263 0.2613
Loa Loa (eye worm) hypothetical protein 0.0182 0.2025 0.2025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0135 0.0278
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1035 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0563 0.0677
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0563 0.0677
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0233 0.263 0.3373
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0182 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0236 0.1984
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0028 0.0182 0.0415
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0563 0.5265
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0041 0.0336 0.0425
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0303 0.3475 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0467 0.4302
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0028 0.0182 0.0186
Mycobacterium ulcerans ion transport protein 0.0032 0.0236 0.0508
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0467 0.4302
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0236 0.0214
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Echinococcus granulosus potassium channel subfamily K 8 0.0032 0.0236 0.0296
Plasmodium falciparum potassium channel 0.0032 0.0236 0.2564
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0032 0.0236 0.0296
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0182 0.1443
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0041 0.0336 0.0344
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0041 0.0336 0.0362
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0182 0.1443
Onchocerca volvulus 0.0032 0.0236 0.0535
Echinococcus multilocularis potassium channel subfamily K 8 0.0032 0.0236 0.0239
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0467 0.0544
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0467 0.0544
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0135 0.097
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0028 0.0182 0.1864
Loa Loa (eye worm) hypothetical protein 0.0299 0.342 0.342
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0032 0.0236 0.1984
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0041 0.0336 0.0218
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0283 0.0288
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0182 0.1443
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0032 0.0236 0.1984
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0041 0.0336 0.3864
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0032 0.0236 0.0296
Leishmania major potassium channel subunit-like protein 0.0032 0.0236 0.1984
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0041 0.0336 0.0344
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0467 0.048
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0032 0.0236 0.0236
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0233 0.263 0.2728
Schistosoma mansoni twik family of potassium channels-related 0.0032 0.0236 0.0255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.7272 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0041 0.0336 0.3864
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0558 0.071
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0041 0.0336 0.3864
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0135
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0041 0.0336 0.2991
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0563 0.0677
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0038
Echinococcus multilocularis twik family of potassium channels 0.0032 0.0236 0.0239
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0467 0.4302
Echinococcus multilocularis lamin dm0 0.0027 0.0174 0.0175
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0563 0.0677
Schistosoma mansoni twik family of potassium channels-related 0.0032 0.0236 0.0255
Trypanosoma cruzi ion transport protein, putative 0.0032 0.0236 0.1984
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.7272 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0028 0.0182 0.0159
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.004 0.0018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0182 0.1443
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0182 0.1443
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.004 0.0018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Leishmania major ion transport protein-like protein 0.0032 0.0236 0.1984
Trypanosoma cruzi ion transport protein, putative 0.0032 0.0236 0.1984
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Loa Loa (eye worm) hypothetical protein 0.0032 0.0236 0.0236
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0032 0.0236 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1035 0.1333
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0336 0.3864
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0028 0.0182 0.1864
Brugia malayi jmjC domain containing protein 0.0059 0.0558 0.0536
Brugia malayi N-terminal motif family protein 0.0182 0.2025 0.2007
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0467 0.0544
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0283 0.0288
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0558 0.0574
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0038 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0174 0.0174
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0204 0.2285 0.6536
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0032 0.0236 0.0256
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0174 0.0174
Echinococcus granulosus geminin 0.0348 0.401 0.5147
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0041 0.0336 0.0385
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0032 0.0236 0.0572
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0174 0.0151
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0563 0.0677
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.1035 0.1014
Echinococcus granulosus intermediate filament protein 0.0027 0.0174 0.0216
Echinococcus granulosus thioredoxin glutathione reductase 0.0081 0.0823 0.105
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0063
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0467 0.4302
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0041 0.0336 0.3864

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 85 % Displacement of [125I]triptorelin from human GnRHR expressed in CHO cells at 1 uM ChEMBL. 17517510
Activity (binding) = 85 % Displacement of [125I]triptorelin from human GnRHR expressed in CHO cells at 1 uM ChEMBL. 17517510
IC50 (functional) = -5.15 Antagonist activity at human GnRHR expressed in CHO cells after 30 mins by luciferase reporter gene assay ChEMBL. 17517510
Ki (binding) = -6.79 Displacement of [125I]triptorelin from human GnRHR expressed in CHO cells ChEMBL. 17517510
Log IC50 (functional) = 5.15 Antagonist activity at human GnRHR expressed in CHO cells after 30 mins by luciferase reporter gene assay ChEMBL. 17517510
Log Ki (binding) = 6.79 Displacement of [125I]triptorelin from human GnRHR expressed in CHO cells ChEMBL. 17517510

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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