Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0215 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0215 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0215 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0215 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0215 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0215 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0215 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0215 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0215 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0215 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
RBA (binding) | = 3.8 | Relative binding affinity for the calf uterine estrogen receptor measured as the ratio of molar concentration of 17-beta-estradiol (E2) and inhibitor required to decrease the amount of bound [3H]-E2 by 50% | ChEMBL. | 6492074 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.