Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.3592 | 0.3592 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.9157 | 0.9157 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0071 | 0.3592 | 0.3923 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.3592 | 0.3592 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0071 | 0.3592 | 0.5 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0071 | 0.3592 | 0.3592 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.3592 | 0.3592 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0071 | 0.3592 | 0.3923 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.9157 | 1 |
Schistosoma mansoni | apoptosis regulator bax | 0.0071 | 0.3592 | 0.3592 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3592 | 0.5 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0071 | 0.3592 | 0.3592 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0071 | 0.3592 | 0.5 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0071 | 0.3592 | 0.3592 |
Giardia lamblia | Rrm3p helicase | 0.0019 | 0 | 0.5 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.2655 | 0.2655 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0058 | 0.2655 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.9157 | 0.9157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.