Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, PLK | 0.0094 | 0.0792 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.155 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0094 | 0.0792 | 0.2089 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0792 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0792 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0151 | 0.0752 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0094 | 0.0792 | 0.5109 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0213 | 0.2349 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.0304 | 0.0304 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0792 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0151 | 0.0971 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.3577 | 0.9438 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0094 | 0.0792 | 0.7023 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0151 | 0.0397 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0151 | 0.0752 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1127 | 0.3152 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0792 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0094 | 0.0792 | 0.2213 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0792 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0186 | 0.2001 | 0.2001 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.155 | 0.155 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0792 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.0304 | 0.1959 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0151 | 0.0421 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0094 | 0.0792 | 0.0792 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0151 | 0.0752 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.0304 | 0.0801 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.1127 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.3552 | 0.9929 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.1127 | 1 |
Schistosoma mansoni | kinase | 0.0048 | 0.018 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1127 | 0.3152 |
Schistosoma mansoni | thyroid hormone receptor | 0.0186 | 0.2001 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0057 | 0.0304 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0151 | 0.0971 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0054 | 0.0253 | 0.0706 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0151 | 0.0151 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.155 | 0.7744 |
Leishmania major | hypothetical protein, conserved | 0.0213 | 0.2349 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0094 | 0.0792 | 0.2387 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0057 | 0.0304 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0094 | 0.0792 | 0.5 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0057 | 0.0304 | 0.1517 |
Schistosoma mansoni | thyroid hormone receptor | 0.0186 | 0.2001 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0792 | 0.3956 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0792 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0306 | 0.3577 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0057 | 0.0304 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0213 | 0.2349 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0322 | 0.379 | 1 |
Brugia malayi | hypothetical protein | 0.012 | 0.1127 | 0.2975 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.3577 | 0.9438 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0213 | 0.2349 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.53 | Inhibition of thyroid hormone receptor alpha (unknown origin) | ChEMBL. | 17467994 |
IC50 (binding) | = 7.96 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
IC50 (binding) | = 7.96 | Inhibition of thyroid hormone receptor beta (unknown origin) | ChEMBL. | 17467994 |
Log IC50 (binding) | = 6.53 | Inhibition of thyroid hormone receptor alpha (unknown origin) | ChEMBL. | 17467994 |
Log IC50 (binding) | = 7.96 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
Log IC50 (binding) | = 7.96 | Inhibition of thyroid hormone receptor beta (unknown origin) | ChEMBL. | 17467994 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.