Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.3628 | 0.944 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.1573 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0306 | 0.3628 | 0.944 |
Schistosoma mansoni | kinase | 0.0047 | 0.0168 | 0.0827 |
Schistosoma mansoni | thyroid hormone receptor | 0.0186 | 0.2029 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0207 | 0.2308 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0138 | 0.0879 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0138 | 0.0682 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0138 | 0.0682 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0771 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0771 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.0239 | 0.0659 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 0.0771 | 0.2126 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0207 | 0.2308 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0771 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0186 | 0.2029 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0092 | 0.0771 | 0.6865 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0056 | 0.0289 | 0.1426 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 0.0771 | 0.0771 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1124 | 0.3097 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.0771 | 0.3802 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0207 | 0.2308 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0138 | 0.0138 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0771 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.1573 | 0.7752 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0138 | 0.0879 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0138 | 0.0381 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0771 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0138 | 0.036 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 0.0771 | 0.2387 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.0289 | 0.184 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0186 | 0.2029 | 0.2029 |
Brugia malayi | hypothetical protein | 0.0118 | 0.1124 | 0.2924 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0092 | 0.0771 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.3602 | 0.9929 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0056 | 0.0289 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.0092 | 0.0771 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0092 | 0.0771 | 0.2007 |
Onchocerca volvulus | Huntingtin homolog | 0.0118 | 0.1124 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0771 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0322 | 0.3843 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.0289 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0118 | 0.1124 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0138 | 0.0682 |
Leishmania major | hypothetical protein, conserved | 0.0207 | 0.2308 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0306 | 0.3628 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.0289 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0138 | 0.0138 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0771 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.0289 | 0.0289 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.0289 | 0.0753 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.1573 | 0.1573 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1124 | 0.3097 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 0.0771 | 0.4904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.09 | Inhibition of thyroid hormone receptor alpha (unknown origin) | ChEMBL. | 17467994 |
IC50 (binding) | = 7.39 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
IC50 (binding) | = 7.39 | Inhibition of thyroid hormone receptor beta (unknown origin) | ChEMBL. | 17467994 |
Log IC50 (binding) | = 6.09 | Inhibition of thyroid hormone receptor alpha (unknown origin) | ChEMBL. | 17467994 |
Log IC50 (binding) | = 7.39 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
Log IC50 (binding) | = 7.39 | Inhibition of thyroid hormone receptor beta (unknown origin) | ChEMBL. | 17467994 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.