Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FTZ F1 alpha | 0.0304 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0304 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0304 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0304 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0304 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0304 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0304 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0304 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0304 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0304 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0304 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0304 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0304 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0304 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0304 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0304 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0304 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.6527 | 0.9749 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0304 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0304 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.6384 | 0.9524 | 0.977 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0304 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0304 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.6527 | 0.9749 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0304 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0304 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0304 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0304 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0304 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0304 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0304 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0304 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0304 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0304 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log activity (ADMET) | = 0.3 | Negative log transformed activity | ChEMBL. | 2296013 |
EC50 (functional) | = 0.5 uM | In vitro macrofilaricidal activity against D. viteae was determined using the leakage of incorporated radiolabeled adenine method. | ChEMBL. | 2296013 |
Worm reduction (functional) | = 42 % | In vivo percent reduction of Brugia pahangi worm in gerbils | ChEMBL. | 2296013 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.