Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 7 | Starlite/ChEMBL | References |
Rattus norvegicus | P2X purinoceptor 7 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = -7.2 | Antagonist activity at rat P2X7 receptor transfected in HEK cells assessed as inhibition of benzylATP-induced changes in plasma membrane pore formation | ChEMBL. | 17963373 |
Kd (functional) | = 7.8 | Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzylATP-induced changes in plasma membrane pore formation | ChEMBL. | 17963373 |
Log IC50 (functional) | = 7.2 | Antagonist activity at rat P2X7 receptor transfected in HEK cells assessed as inhibition of benzylATP-induced changes in plasma membrane pore formation | ChEMBL. | 17963373 |
pA2 (functional) | = 7.8 | Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzylATP-induced changes in plasma membrane pore formation | ChEMBL. | 17963373 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.