Detailed information for compound 445976

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 546.186 | Formula: C34H44ClN3O
  • H donors: 2 H acceptors: 1 LogP: 7.31 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC1CCC(CC1)CC1CCC(CC1)N(C(=O)CCCc1c[nH]c2c1cccc2)C/C(=C/c1ccccc1)/Cl
  • InChi: 1S/C34H44ClN3O/c35-29(22-25-7-2-1-3-8-25)24-38(31-19-15-27(16-20-31)21-26-13-17-30(36)18-14-26)34(39)12-6-9-28-23-37-33-11-5-4-10-32(28)33/h1-5,7-8,10-11,22-23,26-27,30-31,37H,6,9,12-21,24,36H2/b29-22-
  • InChiKey: CRXBLMIVMQUQBT-IADYIPOJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 4 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 3 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 5 receptor Starlite/ChEMBL References
Mus musculus melanocortin 1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein melanocortin 5 receptor 325 aa 311 aa 20.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3672 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0077 0.0071
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0094 0.0195
Echinococcus granulosus serine protein kinase ATM 0.0009 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.001 0.0077 0.0159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0836 0.0831
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0045 0.0039
Schistosoma mansoni DNA helicase recq1 0.001 0.0071 0.0065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0077 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0163 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0094 0.0088
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0094 0.0088
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0077 0.0071
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0023 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0146 0.0313
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Brugia malayi AKH receptor 0.0011 0.0094 0.0195
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0009 0.005 0.0044
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0146 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0094 0.0088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.0042
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1669 0.3706
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0033 0.0027
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0094 0.0088
Brugia malayi G-protein coupled receptor 0.0011 0.0094 0.0195
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0077 0.0159
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0313 0.4493 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0654 0.1444
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0094 0.0088
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0004
Echinococcus granulosus dnaJ subfamily B 0.0419 0.6036 0.6034
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0009 0.005 0.0044
Brugia malayi hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0094 0.0195
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0071 0.0065
Schistosoma mansoni patched 1 0.0129 0.1806 0.1802
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0094 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2384 0.6485
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0009 0.005 0.0099
Echinococcus granulosus GPCR family 2 0.0016 0.0157 0.0151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0077 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0102 0.0257
Schistosoma mansoni nuclear hormone receptor 0.001 0.0077 0.0071
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0077 0.0071
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0113 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0077 0.0159
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0146 0.0377
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0147 0.2069 0.5625
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0094 0.0071
Echinococcus granulosus Protein patched homolog 1 0.0129 0.1806 0.1802
Schistosoma mansoni hypothetical protein 0.0016 0.0157 0.0151
Schistosoma mansoni hypothetical protein 0.0011 0.0094 0.0088
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0077 0.0159
Brugia malayi hypothetical protein 0.0011 0.0094 0.0195
Schistosoma mansoni amine GPCR 0.0011 0.0094 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0414 0.1109
Loa Loa (eye worm) hypothetical protein 0.001 0.0077 0.0159
Echinococcus multilocularis somatostatin receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2384 0.6485
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0023 0.0042
Onchocerca volvulus 0.0011 0.0094 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Echinococcus granulosus allatostatin A receptor 0.0011 0.0094 0.0088
Onchocerca volvulus 0.0011 0.0094 0.0071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0157 0.0335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Schistosoma mansoni neuropeptide receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.0042
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0094 0.0088
Echinococcus granulosus hypothetical protein 0.0011 0.0094 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0077 0.0159
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0366 0.0978
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0448 0.1201
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0094 0.0088
Echinococcus multilocularis GPCR, family 2 0.0016 0.0157 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0094 0.0088
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0451 0.0446
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0094 0.0088
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0094 0.0195
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0147 0.2069 1
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2384 0.6485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.028 0.0744
Schistosoma mansoni cpg binding protein 0.0031 0.038 0.0374
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0094 0.0088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0094 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2384 0.6485
Brugia malayi hypothetical protein 0.0011 0.0094 0.0195
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0277 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0314 0.0836
Brugia malayi FAT domain containing protein 0.0007 0.0022 0.0036
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0094 0.0088
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0146 0.014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0582 0.0577
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0094 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.028 0.0744
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0071 0.096
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0077 0.0071
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0077 0.0071
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0094 0.0195
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0094 0.0088
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0077 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0077 0.0159
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0146 0.014
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0009 0.005 0.0094
Schistosoma mansoni opsin-like receptor 0.0011 0.0094 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0077 0.0159
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0582 0.1567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0077 0.0159
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0009 0.005 0.0044
Echinococcus granulosus orexin receptor type 2 0.0011 0.0094 0.0088
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0077 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0023 0.0042
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0094 0.0088
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3672 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.005 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0077 0.0159
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0277 0.0271
Loa Loa (eye worm) Smad1 0.0008 0.0045 0.0087
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0094 0.0088
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0094 0.0088
Schistosoma mansoni coup transcription factor 0.001 0.0077 0.0071
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0071 0.0145
Echinococcus multilocularis cpg binding protein 0.0031 0.038 0.0374
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0077 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.028 0.0744
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3672 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Echinococcus multilocularis smad 0.0008 0.0045 0.0039
Schistosoma mansoni amine GPCR 0.0011 0.0094 0.0088
Schistosoma mansoni thyroid hormone receptor 0.001 0.0077 0.0071
Schistosoma mansoni myosin xvIII 0.0011 0.0094 0.0088
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0033 0.0027
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.005 0.0654 0.1444
Brugia malayi hypothetical protein 0.0011 0.0094 0.0195
Brugia malayi MH1 domain containing protein 0.0008 0.0045 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0077 0.0159
Schistosoma mansoni hypothetical protein 0.0016 0.0157 0.0151
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0094 0.0088
Brugia malayi larval opioid receptor 0.0011 0.0094 0.0195
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Onchocerca volvulus 0.0011 0.0094 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2516 0.6846
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0071 0.0145
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0094 0.0088
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0094 0.0088
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0094 0.0088
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0157 0.0335
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0094 0.0195
Schistosoma mansoni opsin-like receptor 0.0011 0.0094 0.0088
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0313 0.4493 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0094 0.0088
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0237 0.0419
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0077 0.0159
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0077 0.0071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0414 0.1109
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0023 0.0042
Brugia malayi hypothetical protein 0.0011 0.0094 0.0195
Echinococcus granulosus FTZ F1 alpha 0.001 0.0077 0.0071
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0129 0.1806 0.4012
Brugia malayi sulfakinin receptor protein 0.0011 0.0094 0.0195
Onchocerca volvulus 0.0011 0.0094 0.0071
Onchocerca volvulus 0.0011 0.0094 0.0071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0424 0.0931
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0582 0.1197
Onchocerca volvulus 0.0011 0.0094 0.0071
Echinococcus multilocularis protein dispatched 1 0.0129 0.1806 0.1802
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0094 0.0088
Echinococcus granulosus sterol regulatory element binding protein 0.0129 0.1806 0.1802
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0094 0.0088
Brugia malayi nuclear hormone receptor 0.001 0.0077 0.0159
Schistosoma mansoni biogenic amine receptor 0.0011 0.0094 0.0088
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0077 0.0071
Entamoeba histolytica hypothetical protein 0.0036 0.0451 0.7753
Entamoeba histolytica hypothetical protein 0.0009 0.005 0.0865
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0313 0.4493 0.449
Schistosoma mansoni amine GPCR 0.0011 0.0094 0.0088
Schistosoma mansoni hypothetical protein 0.0016 0.0157 0.0151
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0157 0.0151
Schistosoma mansoni histamine h1 receptor 0.0011 0.0094 0.0088
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0157 0.0151
Schistosoma mansoni amine GPCR 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Brugia malayi hypothetical protein 0.0011 0.0094 0.0195
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0199 0.0334
Echinococcus granulosus sex peptide receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0414 0.1109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.0042
Brugia malayi hypothetical protein 0.0011 0.0094 0.0195
Schistosoma mansoni neuropeptide receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0094 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0094 0.0088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0654 0.1444
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.005 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0077 0.0159
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0077 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0414 0.1109
Brugia malayi G protein-coupled receptor 0.0011 0.0094 0.0195
Brugia malayi MH1 domain containing protein 0.0008 0.0045 0.0087
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2516 0.6846
Echinococcus granulosus g protein coupled receptor 0.0011 0.0094 0.0088
Brugia malayi Dopamine receptor protein 1 0.0011 0.0094 0.0195
Echinococcus multilocularis serine protein kinase ATM 0.0009 0.005 0.0044
Brugia malayi MH2 domain containing protein 0.0008 0.0045 0.0087
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1669 0.3706
Loa Loa (eye worm) hypothetical protein 0.0016 0.0157 0.0335
Brugia malayi ecdysteroid receptor 0.001 0.0077 0.0159
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0146 0.0075
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Schistosoma mansoni opsin-like receptor 0.0011 0.0094 0.0088
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.2384 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Schistosoma mansoni neuropeptide receptor 0.0011 0.0094 0.0088
Schistosoma mansoni Smad4 0.0008 0.0045 0.0039
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0094 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.6036 0.6034
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0146 0.0308
Loa Loa (eye worm) hypothetical protein 0.0129 0.1806 0.4012
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0094 0.0088
Brugia malayi nuclear receptor NHR-88 0.001 0.0077 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0023 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0077 0.0159
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0277 0.0733
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0654 0.1444
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0007 0.0022 0.0016
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0094 0.0088
Toxoplasma gondii FATC domain-containing protein 0.0009 0.005 0.0681
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0045 0.0039
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0023 0.0042
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0094 0.0088
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0739 1
Schistosoma mansoni hypothetical protein 0.0011 0.0094 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0414 0.1109
Onchocerca volvulus 0.0011 0.0094 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Brugia malayi neuropeptide F receptor 0.0011 0.0094 0.0195
Schistosoma mansoni neuropeptide receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0022 0.0039
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0094 0.0088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0094 0.0088
Onchocerca volvulus 0.0011 0.0094 0.0071
Brugia malayi putative neuropeptide receptor 0.0011 0.0094 0.0195
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0234 1
Echinococcus granulosus bloom syndrome protein 0.0024 0.0277 0.0271
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0077 0.0071
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0033 0.0027
Schistosoma mansoni hypothetical protein 0.0007 0.0022 0.0016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0094 0.0088
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0146 0.0216
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0094 0.0195
Entamoeba histolytica protein kinase rad3, putative 0.0009 0.005 0.0865
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0094 0.0088
Onchocerca volvulus 0.0029 0.0355 0.1205
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0129 0.1806 0.1802
Onchocerca volvulus 0.0011 0.0094 0.0071
Onchocerca volvulus 0.0011 0.0094 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.028 0.0742
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0313 0.4493 1
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0094 0.0195
Echinococcus multilocularis protein patched 0.0129 0.1806 0.1802
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0157 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0146 0.0377
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0094 0.0195
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0094 0.0088
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0414 0.5605
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0077 0.0159
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0313 0.4493 0.449
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0203 0.0197
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0077 0.0071
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0094 0.0088
Entamoeba histolytica hypothetical protein 0.0036 0.0451 0.7753
Echinococcus granulosus somatostatin receptor 0.0011 0.0094 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Brugia malayi steroid hormone receptor 0.001 0.0077 0.0159
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2384 0.6485
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Echinococcus multilocularis Niemann Pick C1 protein 0.0129 0.1806 0.1802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0314 0.0836
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0077 0.0071
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0094 0.0088
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0033 0.0027
Schistosoma mansoni smad1 5 8 and 0.0008 0.0045 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0146 0.0377
Entamoeba histolytica hypothetical protein 0.0036 0.0451 0.7753
Schistosoma mansoni adenoreceptor 0.0011 0.0094 0.0088
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Schistosoma mansoni fkbp-rapamycin associated protein 0.0009 0.005 0.0044
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0582 0.107
Loa Loa (eye worm) hypothetical protein 0.0007 0.0022 0.0036
Echinococcus granulosus g protein coupled receptor 0.0011 0.0094 0.0088
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0094 0.0088
Schistosoma mansoni hypothetical protein 0.0034 0.0424 0.0418
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Echinococcus granulosus Niemann Pick C1 protein 0.0129 0.1806 0.1802
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0094 0.0088
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0582 0.0577
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Entamoeba histolytica hypothetical protein 0.0036 0.0451 0.7753
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0094 0.0088
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0449 0.0896
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0094 0.0088
Echinococcus granulosus neuropeptide receptor 0.0011 0.0094 0.0088
Brugia malayi RE15519p 0.0011 0.0094 0.0195
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0094 0.0088
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0094 0.0195
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0094 0.0088
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.028 0.0744
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0009 0.005 0.0865
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0071 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0045 0.0039
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0094 0.0088
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0582 0.1197
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0094 0.0088
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0582 0.1284
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0071 0.0065
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0077 0.0071
Schistosoma mansoni hypothetical protein 0.0036 0.0451 0.0446
Loa Loa (eye worm) hypothetical protein 0.001 0.0077 0.0159
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0094 0.0088
Onchocerca volvulus 0.0011 0.0094 0.0071
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0094 0.0088
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0157 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0448 0.1201
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0146 0.014
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0582 0.107
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0071 0.096
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0313 0.4493 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0146 0.0313
Schistosoma mansoni thyroid hormone receptor 0.001 0.0077 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3672 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0077 0.0159
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0313 0.4493 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0582 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0094 0.0195
Loa Loa (eye worm) hypothetical protein 0.0121 0.169 0.3753
Loa Loa (eye worm) hypothetical protein 0.0313 0.4493 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0094 0.0195
Echinococcus granulosus g protein coupled receptor 0.0011 0.0094 0.0088
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0424 0.0931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0146 0.0377
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0077 0.0071
Echinococcus granulosus smad 0.0008 0.0045 0.0039
Echinococcus multilocularis sex peptide receptor 0.0011 0.0094 0.0088
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.028 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0582 0.1567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0451 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0448 0.1201
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0118
Brugia malayi ORL1-like opioid receptor 0.0011 0.0094 0.0195
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0077 0.0071
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0146 0.0308
Schistosoma mansoni DNA helicase recq5 0.001 0.0071 0.0065
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0077 0.0071
Schistosoma mansoni hypothetical protein 0.0011 0.0094 0.0088
Schistosoma mansoni hypothetical protein 0.0419 0.6036 0.6034
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0113 0.0235
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0094 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0448 0.1201
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0094 0.0071
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0077 0.0071
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2384 0.6485
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0094 0.0088
Onchocerca volvulus 0.0011 0.0094 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) hypothetical protein 0.001 0.0077 0.0159
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0147 0.2069 0.5625
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0113 0.1949
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0355 0.0778
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0045 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0077 0.0159
Schistosoma mansoni cpg binding protein 0.0031 0.038 0.0374
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.0042
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0094 0.0088
Brugia malayi G-protein coupled receptor 0.0011 0.0094 0.0195
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0582 0.128
Loa Loa (eye worm) RecQ helicase 0.0024 0.0277 0.0603
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0318 0.0847
Echinococcus granulosus cpg binding protein 0.0031 0.038 0.0374
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2384 0.6485
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0077 0.0159
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0094 0.0088
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0094 0.0088
Schistosoma mansoni hypothetical protein 0.0016 0.0157 0.0151
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0094 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0007 0.0022 0.0016
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0094 0.0195
Onchocerca volvulus 0.0011 0.0094 0.0071
Echinococcus granulosus Smad4 0.0008 0.0045 0.0039
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0094 0.0088
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0094 0.0088
Brugia malayi CXXC zinc finger family protein 0.0029 0.0355 0.0778
Schistosoma mansoni microtubule-associated protein tau 0.0691 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0094 0.0088
Brugia malayi hypothetical protein 0.0011 0.0094 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Echinococcus granulosus fmrfamide receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.001 0.0077 0.0159
Schistosoma mansoni biogenic amine receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.005 0.0116
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.0009 0.006 0.012
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0094 0.0088
Brugia malayi hypothetical protein 0.0036 0.0451 0.0993
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0077 0.0159
Echinococcus multilocularis microtubule associated protein 2 0.0691 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0023 0.0042
Brugia malayi CHE-14 protein 0.0129 0.1806 0.4012
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0582 0.0577
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0094 0.0088
Brugia malayi hypothetical protein 0.0011 0.0094 0.0195
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0449 0.0765
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3672 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0094 0.0088
Brugia malayi Melatonin receptor type 1A 0.0011 0.0094 0.0195
Brugia malayi neuropeptide F receptor 0.0011 0.0094 0.0195
Schistosoma mansoni smad 0.0008 0.0045 0.0039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0009 0.005 0.0099
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0045 0.0039
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0023 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0094 0.0088
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0094 0.0088
Onchocerca volvulus 0.0011 0.0094 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0065 0.013
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0094 0.0195
Echinococcus multilocularis serotonin receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.3672 0.8169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0318 0.0847
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0065 0.0154
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0094 0.0088
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0094 0.0195
Giardia lamblia GTOR 0.0045 0.0582 0.2559
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0094 0.0088
Echinococcus multilocularis Smad4 0.0008 0.0045 0.0039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0582 0.1284
Brugia malayi Dopamine receptor protein 2 0.0011 0.0094 0.0195
Brugia malayi Smad1 0.0008 0.0045 0.0087
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0313 0.4493 0.5
Echinococcus granulosus neuropeptide receptor 0.0011 0.0094 0.0088
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.001 0.0077 0.0159
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0094 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0077 0.0071
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0094 0.0195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.028 0.0742
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0094 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0414 0.1109
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0033 0.0027
Echinococcus multilocularis serotonin receptor 0.0011 0.0094 0.0088
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0094 0.0088
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0449 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0352 0.0939
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0277 0.0733
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0057 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0486 0.1306
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0071 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0077 0.0159
Brugia malayi MH2 domain containing protein 0.012 0.1669 0.3706
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0113 0.0142
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0094 0.0088
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0451 0.0446
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0094 0.0088
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0094 0.0195
Schistosoma mansoni hypothetical protein 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Schistosoma mansoni smad1 5 8 and 0.0008 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Brugia malayi MH2 domain containing protein 0.0008 0.0045 0.0087
Brugia malayi Dopamine receptor 0.0011 0.0094 0.0195
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0099
Brugia malayi Serotonin receptor 0.0011 0.0094 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0077 0.0159
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0009 0.0065 0.0873
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.3672 0.8169
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0313 0.4493 0.449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0094 0.0088
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0077 0.0071
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.016 0.2171
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.3672 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0146 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0023 0.0042
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0094 0.0088
Echinococcus multilocularis sterol regulatory element binding protein 0.0129 0.1806 0.1802
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0146 0.0216
Onchocerca volvulus 0.0011 0.0094 0.0071
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0582 0.128
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0414 0.1109
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0094 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0077 0.0159
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0094 0.0088
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0009 0.005 0.0094
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0582 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0448 0.1201
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) hypothetical protein 0.001 0.0077 0.0159
Brugia malayi hypothetical protein 0.0011 0.0094 0.0195
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0094 0.0088
Schistosoma mansoni cpg binding protein 0.0029 0.0355 0.0349
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0157 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0077 0.0159
Trichomonas vaginalis helicase, putative 0.0007 0.0023 0.0042
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0094 0.0088
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0045 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0582 0.1567
Onchocerca volvulus 0.0011 0.0094 0.0071
Brugia malayi GnHR receptor homolog 0.0011 0.0094 0.0195
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0071 0.0065
Onchocerca volvulus 0.0011 0.0094 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0094 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.1806 0.4909
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0077 0.0071
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0077 0.0071
Schistosoma mansoni amine GPCR 0.0011 0.0094 0.0088
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0094 0.0195
Echinococcus granulosus serotonin receptor 0.0011 0.0094 0.0088
Schistosoma mansoni smad1 5 8 and 0.0008 0.0045 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0318 0.0847
Schistosoma mansoni biogenic amine receptor 0.0011 0.0094 0.0088
Brugia malayi Serotonin receptor 0.0011 0.0094 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0077 0.0159
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0147 0.2069 0.5625
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0094 0.0088

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.51 uM Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells ChEMBL. 17618123
Ki (binding) = 0.51 uM Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells ChEMBL. 17618123
Ki (binding) = 0.61 uM Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells ChEMBL. 17618123
Ki (binding) = 0.61 uM Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells ChEMBL. 17618123
Ki (binding) = 0.96 uM Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells ChEMBL. 17618123
Ki (binding) = 0.96 uM Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells ChEMBL. 17618123
Ki (binding) = 1.4 uM Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells ChEMBL. 17618123
Ki (binding) = 1.4 uM Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells ChEMBL. 17618123
Ki (binding) = 2 uM Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 2 uM Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 2.3 uM Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells ChEMBL. 17618123
Ki (binding) = 2.3 uM Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells ChEMBL. 17618123
Ki (binding) = 3.2 uM Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 3.2 uM Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 4.1 uM Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 4.1 uM Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 4.9 uM Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 4.9 uM Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 5.2 uM Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 5.2 uM Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 5.4 uM Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 5.4 uM Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 5.6 uM Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 5.6 uM Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 6 uM Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 6 uM Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 7.1 uM Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 7.1 uM Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 8.7 uM Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 8.7 uM Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 17 uM Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 17 uM Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 21 uM Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 21 uM Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 31 uM Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 31 uM Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 33 uM Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 33 uM Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 47 uM Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells ChEMBL. 17618123
Ki (binding) = 47 uM Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells ChEMBL. 17618123

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.