Detailed information for compound 446047

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 316.398 | Formula: C17H24N4O2
  • H donors: 2 H acceptors: 2 LogP: 2.31 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCC1(CC1)Nc1cc(OCC)nc2c1nc(OC)cc2
  • InChi: 1S/C17H24N4O2/c1-3-23-15-11-13(21-17(8-9-17)7-4-10-18)16-12(19-15)5-6-14(20-16)22-2/h5-6,11H,3-4,7-10,18H2,1-2H3,(H,19,21)
  • InChiKey: VZSOLFYPPVAKIO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Onchocerca volvulus Matrilysin homolog 0.0170916 0.224921 0.224921
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011583 0.138701 0.138701
Echinococcus granulosus hypothetical protein 0.066611 1 1
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus neuropeptides capa receptor 0.011583 0.138701 0.138701
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0280181 0.395943 0.395943
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004887 0.033895 0.033895
Entamoeba histolytica oligo-1,6-glucosidase, putative 0.0113963 0.135778 0.0884312
Onchocerca volvulus 0.011583 0.138701 0.138701
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0058123 0.0483777 0.0483777
Echinococcus multilocularis fmrfamide receptor 0.011583 0.138701 0.138701
Schistosoma mansoni carbonic anhydrase-related 0.0138554 0.174269 0.174269
Loa Loa (eye worm) hypothetical protein 0.004887 0.033895 0.033895
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.00604426 0.0520084 0.0520084
Echinococcus multilocularis carbonic anhydrase 0.0138554 0.174269 0.174269
Onchocerca volvulus 0.011583 0.138701 0.138701
Schistosoma mansoni lipoxygenase 0.00760707 0.0764694 0.0764694
Brugia malayi Integrin alpha cytoplasmic region family protein 0.00950329 0.106149 0.106149
Brugia malayi G protein-coupled receptor F59B2.13 0.011583 0.138701 0.138701
Brugia malayi hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus aldo keto reductase family 1 member B4 0.066611 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.011583 0.138701 0.138701
Brugia malayi Matrixin family protein 0.00770604 0.0780185 0.0780185
Mycobacterium ulcerans oxidoreductase 0.066611 1 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.00272147 0.00000000292051 0.00000000292051
Echinococcus multilocularis apoptotic protease activating factor 1 0.00343496 0.0111675 0.0111675
Trichomonas vaginalis aldo/keto reductase, putative 0.066611 1 1
Schistosoma mansoni hypothetical protein 0.011583 0.138701 0.138701
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.011583 0.138701 0.138701
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011583 0.138701 0.138701
Echinococcus multilocularis integrin alpha ps 0.00563234 0.0455609 0.0455609
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.066611 1 1
Echinococcus granulosus neuropeptide receptor A26 0.011583 0.138701 0.138701
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Brugia malayi Uncoordinated protein 44 0.00272147 0.00000000292051 0.00000000292051
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.00272147 0.00000000292051 0.00000000292051
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0138554 0.174269 0.174269
Echinococcus multilocularis biogenic amine (5HT) receptor 0.011583 0.138701 0.138701
Schistosoma mansoni neuropeptide receptor 0.011583 0.138701 0.138701
Echinococcus granulosus aldo keto reductase family 1 member B4 0.066611 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.011583 0.138701 0.138701
Echinococcus granulosus biogenic amine 5HT receptor 0.011583 0.138701 0.138701
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0138554 0.174269 0.174269
Echinococcus granulosus neuropeptides capa receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis neuropeptide FF receptor 2 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011583 0.138701 0.138701
Schistosoma mansoni integrin alpha 0.0137317 0.172333 0.172333
Loa Loa (eye worm) hypothetical protein 0.00293254 0.00330364 0.00330364
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.066611 1 1
Echinococcus granulosus microsomal glutathione S transferase 3 0.0058123 0.0483777 0.0483777
Echinococcus multilocularis fibrillin 1 0.00363367 0.0142777 0.0142777
Brugia malayi Kelch motif family protein 0.00604426 0.0520084 0.0520084
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.066611 1 1
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.00603987 0.0519397 0.0519397
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.011583 0.138701 0.138701
Echinococcus granulosus neuropeptide FF receptor 2 0.011583 0.138701 0.138701
Trypanosoma brucei aldo/keto reductase, putative 0.0210423 0.286758 0.019736
Echinococcus multilocularis voltage gated potassium channel subunit 0.0210423 0.286758 0.286758
Loa Loa (eye worm) hypothetical protein 0.00809939 0.0841753 0.0841753
Schistosoma mansoni microsomal glutathione s-transferase 0.0058123 0.0483777 0.0483777
Loa Loa (eye worm) hypothetical protein 0.0103339 0.11915 0.11915
Onchocerca volvulus 0.011583 0.138701 0.138701
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.011583 0.138701 0.138701
Loa Loa (eye worm) oxidoreductase 0.066611 1 1
Schistosoma mansoni caspase-7 (C14 family) 0.00491023 0.0342585 0.0342585
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0210423 0.286758 0.261468
Brugia malayi hypothetical protein 0.00604426 0.0520084 0.0520084
Brugia malayi Dopamine receptor 0.011583 0.138701 0.138701
Brugia malayi Hemopexin family protein 0.0109265 0.128425 0.128425
Brugia malayi AKH receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Loa Loa (eye worm) oxidoreductase 0.066611 1 1
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011583 0.138701 0.138701
Onchocerca volvulus 0.011583 0.138701 0.138701
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0111576 0.132042 0.132042
Loa Loa (eye worm) hypothetical protein 0.0110319 0.130075 0.130075
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus Ankyrin 0.00273059 0.000142736 0.000142736
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.011583 0.138701 0.138701
Onchocerca volvulus 0.00420616 0.0232384 0.0232384
Echinococcus multilocularis rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Onchocerca volvulus 0.066611 1 1
Onchocerca volvulus 0.004887 0.033895 0.033895
Echinococcus granulosus tm gpcr rhodopsin 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.00950329 0.106149 0.106149
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Toxoplasma gondii hypothetical protein 0.0138554 0.174269 0.14499
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.00938556 0.104306 0.104306
Loa Loa (eye worm) alpha amylase 0.0113963 0.135778 0.135778
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase 0.066611 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011583 0.138701 0.138701
Toxoplasma gondii aldo-keto reductase 0.0210423 0.286758 0.261468
Echinococcus granulosus aldo keto reductase family 1 member B4 0.066611 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.066611 1 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0210423 0.286758 0.247683
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0210423 0.286758 0.286758
Brugia malayi ORL1-like opioid receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.066611 1 1
Echinococcus granulosus somatostatin receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis neuropeptides capa receptor 0.011583 0.138701 0.138701
Echinococcus granulosus orexin receptor type 2 0.011583 0.138701 0.138701
Echinococcus multilocularis neuropeptide receptor 0.011583 0.138701 0.138701
Echinococcus granulosus dro:myosuppressin receptor 0.011583 0.138701 0.138701
Echinococcus granulosus aldo keto reductase family 1 member B4 0.066611 1 1
Brugia malayi hypothetical protein 0.011583 0.138701 0.138701
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0210423 0.286758 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0210423 0.286758 0.286758
Plasmodium falciparum aldo-keto reductase, putative 0.0210423 0.286758 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0355618 0.514017 0.514017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.011583 0.138701 0.138701
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.00938556 0.104306 0.104306
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0113963 0.135778 0.135778
Echinococcus multilocularis fmrfamide receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.0138554 0.174269 0.174269
Onchocerca volvulus 0.011583 0.138701 0.138701
Brugia malayi hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) TYRA-2 protein 0.011583 0.138701 0.138701
Echinococcus granulosus aldo keto reductase family 1 member B4 0.066611 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.011583 0.138701 0.138701
Brugia malayi G protein-coupled receptor 0.011583 0.138701 0.138701
Schistosoma mansoni amine GPCR 0.011583 0.138701 0.138701
Loa Loa (eye worm) G-protein coupled receptor 0.011583 0.138701 0.138701
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0172851 0.22795 0.22795
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Brugia malayi Dopamine receptor protein 2 0.011583 0.138701 0.138701
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.00603987 0.0519397 0.0183233
Onchocerca volvulus 0.00343496 0.0111675 0.0111675
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.066611 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.011583 0.138701 0.138701
Schistosoma mansoni histamine h1 receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0186289 0.248983 0.248983
Echinococcus granulosus rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Echinococcus granulosus integrin beta 2 0.0299394 0.426015 0.426015
Onchocerca volvulus 0.011583 0.138701 0.138701
Loa Loa (eye worm) alpha amylase 0.0113963 0.135778 0.135778
Schistosoma mansoni biogenic amine (5HT) receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis carbonic anhydrase II 0.0355618 0.514017 0.514017
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.011583 0.138701 0.138701
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.066611 1 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0138554 0.174269 0.174269
Echinococcus multilocularis carbonic anhydrase 0.0138554 0.174269 0.174269
Echinococcus granulosus peptide allatostatin:somatostatin 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.00343496 0.0111675 0.0111675
Echinococcus granulosus tm gpcr rhodopsin 0.011583 0.138701 0.138701
Brugia malayi Matrixin family protein 0.00770604 0.0780185 0.0780185
Loa Loa (eye worm) follicle stimulating hormone receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis serotonin receptor 0.011583 0.138701 0.138701
Brugia malayi hypothetical protein 0.011583 0.138701 0.138701
Onchocerca volvulus Matrix metalloproteinase homolog 0.0170916 0.224921 0.224921
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0355618 0.514017 0.514017
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.066611 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.011583 0.138701 0.138701
Giardia lamblia Aldose reductase 0.066611 1 1
Schistosoma mansoni neuropeptide receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis tachykinin peptides receptor 99D 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Onchocerca volvulus 0.011583 0.138701 0.138701
Echinococcus multilocularis g protein coupled receptor 0.011583 0.138701 0.138701
Entamoeba histolytica aldose reductase, putative 0.066611 1 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.00603987 0.0519397 0.0519397
Echinococcus multilocularis integrin alpha 3 0.0107992 0.126433 0.126433
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.011583 0.138701 0.138701
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0210423 0.286758 0.261468
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Loa Loa (eye worm) hypothetical protein 0.0201249 0.272399 0.272399
Echinococcus granulosus rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Brugia malayi Matrixin family protein 0.00770604 0.0780185 0.0780185
Echinococcus granulosus aldo keto reductase 0.066611 1 1
Echinococcus granulosus neuropeptide receptor 0.011583 0.138701 0.138701
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.011583 0.138701 0.138701
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.011583 0.138701 0.138701
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.011583 0.138701 0.138701
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Echinococcus multilocularis caspase 2 0.00491023 0.0342585 0.0342585
Schistosoma mansoni carbonic anhydrase 0.0138554 0.174269 0.174269
Onchocerca volvulus 0.011583 0.138701 0.138701
Brugia malayi larval opioid receptor 0.011583 0.138701 0.138701
Echinococcus granulosus neuropeptide receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.011583 0.138701 0.138701
Brugia malayi putative neuropeptide receptor NPR1 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Loa Loa (eye worm) matrixin family protein 0.0170916 0.224921 0.224921
Echinococcus granulosus integrin alpha ps 0.00563234 0.0455609 0.0455609
Brugia malayi G-protein coupled receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Onchocerca volvulus 0.00770604 0.0780185 0.0780185
Schistosoma mansoni amine GPCR 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.066611 1 1
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus aldo keto reductase 0.066611 1 1
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus hypothetical protein 0.011583 0.138701 0.138701
Mycobacterium tuberculosis Conserved protein 0.0210423 0.286758 0.203699
Trichomonas vaginalis aldo-keto reductase, putative 0.0210423 0.286758 0.261468
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus g protein coupled receptor 0.011583 0.138701 0.138701
Schistosoma mansoni carbonic anhydrase-related 0.0138554 0.174269 0.174269
Onchocerca volvulus 0.011583 0.138701 0.138701
Echinococcus granulosus fmrfamide receptor 0.011583 0.138701 0.138701
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011583 0.138701 0.138701
Schistosoma mansoni amine GPCR 0.011583 0.138701 0.138701
Onchocerca volvulus Neuropeptide F receptor homolog 0.011583 0.138701 0.138701
Loa Loa (eye worm) matrixin family protein 0.0186325 0.24904 0.24904
Echinococcus multilocularis alpha glucosidase 0.0113963 0.135778 0.135778
Loa Loa (eye worm) integrin alpha pat-2 0.0205352 0.278821 0.278821
Echinococcus granulosus rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Echinococcus multilocularis integrin beta 2 0.0299394 0.426015 0.426015
Brugia malayi G-protein coupled receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011583 0.138701 0.138701
Echinococcus multilocularis neuropeptide Y receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis dro:myosuppressin receptor 0.011583 0.138701 0.138701
Onchocerca volvulus 0.066611 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis g protein coupled receptor 0.011583 0.138701 0.138701
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0138554 0.174269 0.174269
Toxoplasma gondii aldose reductase, putative 0.066611 1 1
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus apoptotic protease activating factor 1 0.00343496 0.0111675 0.0111675
Echinococcus multilocularis neuropeptide s receptor 0.011583 0.138701 0.138701
Schistosoma mansoni biogenic amine (5HT) receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Onchocerca volvulus 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.066611 1 1
Echinococcus multilocularis integrin alpha ps 0.00563234 0.0455609 0.0455609
Mycobacterium leprae Possible oxidoreductase 0.0210423 0.286758 0.203699
Echinococcus granulosus neuropeptide Y receptor 0.011583 0.138701 0.138701
Brugia malayi Matrixin family protein 0.00770604 0.0780185 0.0780185
Brugia malayi Integrin alpha pat-2 precursor 0.0137317 0.172333 0.172333
Onchocerca volvulus 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.011583 0.138701 0.138701
Echinococcus granulosus aldo keto reductase family 1 member B4 0.066611 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.066611 1 1
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Mycobacterium leprae Putative uncharacterized protein ML2045 0.0113963 0.135778 0.0351363
Plasmodium vivax aldehyde reductase, putative 0.0210423 0.286758 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011583 0.138701 0.138701
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0138554 0.174269 0.174269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase 0.066611 1 1
Echinococcus granulosus carbonic anhydrase II 0.0355618 0.514017 0.514017
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011583 0.138701 0.138701
Brugia malayi Cell death protein 3 precursor 0.00491023 0.0342585 0.0342585
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004887 0.033895 0.033895
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus carbonic anhydrase 0.0138554 0.174269 0.174269
Mycobacterium leprae Conserved hypothetical protein 0.0455687 0.670645 0.632291
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Schistosoma mansoni opsin-like receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.066611 1 1
Echinococcus multilocularis somatostatin receptor 0.011583 0.138701 0.138701
Schistosoma mansoni alpha-1 adrenergic receptor 0.011583 0.138701 0.138701
Trypanosoma brucei aldo-keto reductase, putative 0.066611 1 1
Brugia malayi Trypsin family protein 0.004887 0.033895 0.033895
Echinococcus granulosus neuropeptide s receptor 0.011583 0.138701 0.138701
Schistosoma mansoni neuropeptide receptor 0.011583 0.138701 0.138701
Mycobacterium ulcerans hypothetical protein 0.0210423 0.286758 0.203699
Schistosoma mansoni neuropeptide F-like receptor 0.011583 0.138701 0.138701
Echinococcus granulosus rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.00273059 0.000142736 0.000142736
Schistosoma mansoni alpha-amylase 0.0113963 0.135778 0.135778
Onchocerca volvulus 0.011583 0.138701 0.138701
Brugia malayi hypothetical protein 0.011583 0.138701 0.138701
Echinococcus multilocularis aldehyde reductase 0.0455687 0.670645 0.670645
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0355618 0.514017 0.514017
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.011583 0.138701 0.138701
Schistosoma mansoni biogenic amine receptor 0.011583 0.138701 0.138701
Schistosoma mansoni pol-related 0.066611 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.066611 1 1
Echinococcus granulosus g protein coupled receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus multilocularis neuropeptide receptor 0.011583 0.138701 0.138701
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0355618 0.514017 0.332075
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus aldehyde reductase 0.0455687 0.670645 0.670645
Echinococcus granulosus rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.0138554 0.174269 0.174269
Schistosoma mansoni amine GPCR 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.066611 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.011583 0.138701 0.138701
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.011583 0.138701 0.138701
Onchocerca volvulus 0.011583 0.138701 0.138701
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0210423 0.286758 0.261468
Entamoeba histolytica aldose reductase, putative 0.066611 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.00770604 0.0780185 0.0780185
Echinococcus granulosus g-protein coupled receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.00603987 0.0519397 0.0519397
Loa Loa (eye worm) oxidoreductase 0.066611 1 1
Onchocerca volvulus Matrilysin homolog 0.00770604 0.0780185 0.0780185
Loa Loa (eye worm) carbonic anhydrase 3 0.0355618 0.514017 0.514017
Brugia malayi Matrixin family protein 0.0186325 0.24904 0.24904
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Leishmania major carbonic anhydrase-like protein 0.0355618 0.514017 0.332075
Echinococcus granulosus alpha 1A adrenergic receptor 0.011583 0.138701 0.138701
Brugia malayi neuropeptide F receptor 0.011583 0.138701 0.138701
Mycobacterium tuberculosis Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas 0.0113963 0.135778 0.0351363
Echinococcus multilocularis rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0113963 0.135778 0.135778
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Schistosoma mansoni aldo-keto reductase 0.066611 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0138554 0.174269 0.174269
Echinococcus multilocularis carbonic anhydrase 0.0138554 0.174269 0.174269
Brugia malayi RE15519p 0.011583 0.138701 0.138701
Echinococcus granulosus serotonin receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.011583 0.138701 0.138701
Echinococcus granulosus nuclear factor of activated T cells 5 0.0186289 0.248983 0.248983
Echinococcus multilocularis neuropeptides capa receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis sex peptide receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Schistosoma mansoni neuropeptide f receptor 76f 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Trichomonas vaginalis aldo-keto reductase, putative 0.0210423 0.286758 0.261468
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.066611 1 1
Brugia malayi Serotonin receptor 0.011583 0.138701 0.138701
Schistosoma mansoni hypothetical protein 0.011583 0.138701 0.138701
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.011583 0.138701 0.138701
Plasmodium falciparum aldehyde reductase, putative 0.0210423 0.286758 1
Onchocerca volvulus 0.0210423 0.286758 0.286758
Echinococcus granulosus aldo keto reductase family 1 member B4 0.066611 1 1
Loa Loa (eye worm) kelch domain-containing protein family protein 0.00604426 0.0520084 0.0520084
Mycobacterium tuberculosis Trehalose synthase TreS 0.0113963 0.135778 0.0351363
Echinococcus multilocularis serotonin receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis neuropeptide receptor A26 0.011583 0.138701 0.138701
Echinococcus granulosus allatostatin A receptor 0.011583 0.138701 0.138701
Echinococcus granulosus voltage gated potassium channel subunit 0.0210423 0.286758 0.286758
Schistosoma mansoni lipoxygenase 0.0111576 0.132042 0.132042
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0201249 0.272399 0.272399
Echinococcus granulosus sex peptide receptor 0.011583 0.138701 0.138701
Brugia malayi Melatonin receptor type 1A 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.066611 1 1
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Onchocerca volvulus 0.011583 0.138701 0.138701
Echinococcus multilocularis allatostatin A receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.00603987 0.0519397 0.0519397
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.00603987 0.0519397 0.0183233
Onchocerca volvulus 0.011583 0.138701 0.138701
Echinococcus granulosus aldo keto reductase family 1 member B4 0.066611 1 1
Schistosoma mansoni hypothetical protein 0.011583 0.138701 0.138701
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0210423 0.286758 0.019736
Loa Loa (eye worm) hypothetical protein 0.00770604 0.0780185 0.0780185
Schistosoma mansoni aldo-keto reductase 0.066611 1 1
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Brugia malayi hypothetical protein 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Brugia malayi GnHR receptor homolog 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0355618 0.514017 0.514017
Toxoplasma gondii MAPEG family protein 0.0058123 0.0483777 0.014635
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.00572819 0.0470611 0.0470611
Schistosoma mansoni integrin alpha-ps 0.00563234 0.0455609 0.0455609
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.011583 0.138701 0.138701
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Brugia malayi follicle stimulating hormone receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Brugia malayi neuropeptide F receptor 0.011583 0.138701 0.138701
Entamoeba histolytica alcohol dehydrogenase, putative 0.0210423 0.286758 0.247683
Leishmania major prostaglandin f synthase, putative 0.066611 1 1
Echinococcus multilocularis g-protein coupled receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.066611 1 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.066611 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0355618 0.514017 0.514017
Schistosoma mansoni alpha-amylase 0.0113963 0.135778 0.135778
Schistosoma mansoni hypothetical protein 0.0109265 0.128425 0.128425
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0138554 0.174269 0.174269
Echinococcus granulosus carbonic anhydrase 0.0138554 0.174269 0.174269
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.066611 1 1
Loa Loa (eye worm) hypothetical protein 0.00491023 0.0342585 0.0342585
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.00603987 0.0519397 0.0183233
Echinococcus granulosus carbonic anhydrase 0.0138554 0.174269 0.174269
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.066611 1 1
Onchocerca volvulus 0.0109265 0.128425 0.128425
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.066611 1 1
Onchocerca volvulus 0.066611 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.011583 0.138701 0.138701
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Leishmania major aldo-keto reductase-like protein 0.066611 1 1
Brugia malayi sulfakinin receptor protein 0.011583 0.138701 0.138701
Onchocerca volvulus 0.066611 1 1
Echinococcus multilocularis Ankyrin 0.00273059 0.000142736 0.000142736
Trypanosoma cruzi aldo/keto reductase, putative 0.0210423 0.286758 0.019736
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.011583 0.138701 0.138701
Brugia malayi hypothetical protein 0.00343496 0.0111675 0.0111675
Trypanosoma cruzi aldo-keto reductase 0.066611 1 1
Schistosoma mansoni alpha-amylase 0.0113963 0.135778 0.135778
Onchocerca volvulus 0.066611 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0210423 0.286758 0.286758
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0280181 0.395943 0.395943
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Schistosoma mansoni potassium channel beta 0.0210423 0.286758 0.286758
Schistosoma mansoni alpha-amylase 0.0113963 0.135778 0.135778
Brugia malayi putative neuropeptide receptor 0.011583 0.138701 0.138701
Brugia malayi Integrin beta pat-3 precursor 0.0402502 0.5874 0.5874
Echinococcus granulosus 7tm_1 domain containing protein 0.011583 0.138701 0.138701
Echinococcus granulosus integrin alpha 3 0.0107992 0.126433 0.126433
Mycobacterium ulcerans trehalose synthase TreS 0.0113963 0.135778 0.0351363
Echinococcus multilocularis g protein coupled receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) G-protein coupled receptor 0.011583 0.138701 0.138701
Echinococcus multilocularis alpha 1A adrenergic receptor 0.011583 0.138701 0.138701
Onchocerca volvulus 0.066611 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.011583 0.138701 0.138701
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.011583 0.138701 0.138701
Echinococcus granulosus G protein coupled receptor 139 0.011583 0.138701 0.138701
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0210423 0.286758 0.261468
Schistosoma mansoni ankyrin 23/unc44 0.00272147 0.00000000292051 0.00000000292051
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.066611 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.011583 0.138701 0.138701
Echinococcus granulosus thyrotropin releasing hormone receptor 0.011583 0.138701 0.138701
Schistosoma mansoni opsin-like receptor 0.011583 0.138701 0.138701
Brugia malayi Dopamine receptor protein 1 0.011583 0.138701 0.138701
Brugia malayi Protein kinase domain containing protein 0.00272147 0.00000000292051 0.00000000292051
Schistosoma mansoni growth hormone secretagogue receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Schistosoma mansoni opsin-like receptor 0.011583 0.138701 0.138701
Brugia malayi hypothetical protein 0.011583 0.138701 0.138701
Entamoeba histolytica aldose reductase, putative 0.066611 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.066611 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011583 0.138701 0.138701
Schistosoma mansoni neuropeptide F-like receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.066611 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.011583 0.138701 0.138701
Trypanosoma cruzi aldo/keto reductase, putative 0.066611 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) matrix metalloproteinase 0.00770604 0.0780185 0.0780185
Brugia malayi hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Schistosoma mansoni alpha-amylase 0.0113963 0.135778 0.135778
Trichomonas vaginalis aldo-keto reductase, putative 0.066611 1 1
Trypanosoma brucei carbonic anhydrase-like protein 0.0355618 0.514017 0.332075
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.00603987 0.0519397 0.0519397
Brugia malayi NADH-dependent xylose reductase 0.0210423 0.286758 0.286758
Schistosoma mansoni neuropeptide receptor 0.011583 0.138701 0.138701
Schistosoma mansoni adenoreceptor 0.011583 0.138701 0.138701
Echinococcus multilocularis rhodopsin orphan GPCR 0.011583 0.138701 0.138701
Onchocerca volvulus Cell death protein 3 homolog 0.00491023 0.0342585 0.0342585
Echinococcus granulosus g protein coupled receptor 0.011583 0.138701 0.138701
Schistosoma mansoni biogenic amine receptor 0.011583 0.138701 0.138701
Echinococcus granulosus aldo keto reductase 0.066611 1 1
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Brugia malayi Serotonin/octopamine receptor family protein 7 0.011583 0.138701 0.138701
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.066611 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.011583 0.138701 0.138701
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.00603987 0.0519397 0.0519397
Echinococcus granulosus caspase 2 0.00491023 0.0342585 0.0342585
Schistosoma mansoni integrin alpha-ps 0.00293254 0.00330364 0.00330364
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Trichomonas vaginalis aldo-keto reductase, putative 0.0210423 0.286758 0.261468
Loa Loa (eye worm) hypothetical protein 0.0138554 0.174269 0.174269
Echinococcus multilocularis neuropeptide Y receptor 0.011583 0.138701 0.138701
Schistosoma mansoni biogenic amine receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.00770604 0.0780185 0.0780185
Loa Loa (eye worm) hypothetical protein 0.011583 0.138701 0.138701
Trypanosoma brucei prostaglandin f synthase 0.066611 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase 0.066611 1 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.00273059 0.000142733 0.000142733
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0355618 0.514017 0.332075
Schistosoma mansoni hypothetical protein 0.00343496 0.0111675 0.0111675
Echinococcus multilocularis G-protein coupled receptor, putative 0.011583 0.138701 0.138701
Schistosoma mansoni hypothetical protein 0.011583 0.138701 0.138701
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.00770604 0.0780185 0.0780185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011583 0.138701 0.138701
Giardia lamblia Aldose reductase 0.066611 1 1
Loa Loa (eye worm) oxidoreductase 0.066611 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) hypothetical protein 0.004887 0.033895 0.033895
Schistosoma mansoni integrin beta subunit 0.0238952 0.33141 0.33141
Echinococcus granulosus neuropeptide Y receptor 0.011583 0.138701 0.138701
Plasmodium falciparum carbonic anhydrase 0.0138554 0.174269 0.520953
Echinococcus multilocularis orexin receptor type 2 0.011583 0.138701 0.138701
Echinococcus multilocularis aldo keto reductase 0.066611 1 1
Loa Loa (eye worm) oxidoreductase 0.066611 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.066611 1 1
Brugia malayi hypothetical protein 0.011583 0.138701 0.138701
Echinococcus granulosus tm gpcr rhodopsin 0.011583 0.138701 0.138701
Echinococcus granulosus alpha glucosidase 0.0113963 0.135778 0.135778
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0111576 0.132042 0.132042
Schistosoma mansoni hypothetical protein 0.0138554 0.174269 0.174269
Onchocerca volvulus 0.011583 0.138701 0.138701
Onchocerca volvulus 0.011583 0.138701 0.138701
Schistosoma mansoni amine GPCR 0.011583 0.138701 0.138701
Brugia malayi Death domain containing protein 0.00272147 0.00000000292051 0.00000000292051
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.011583 0.138701 0.138701
Echinococcus granulosus 7TM GPCR rhodopsin 0.011583 0.138701 0.138701
Schistosoma mansoni myosin xvIII 0.011583 0.138701 0.138701
Echinococcus multilocularis G protein coupled receptor 139 0.011583 0.138701 0.138701
Brugia malayi hypothetical protein 0.011583 0.138701 0.138701
Brugia malayi Serotonin receptor 0.011583 0.138701 0.138701
Loa Loa (eye worm) integrin beta-2 0.0402502 0.5874 0.5874

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = -0.1 % Toxicity against Mastomys coucha assessed as methemoglobin levels at 15 mg/kg after 3 days ChEMBL. 17900897
ED50 (functional) = 0.65 mg Kg-1 Antimalarial activity against Plasmodium yoelii nigeriensis in ip dosed Swiss mouse ChEMBL. 17900897
ED50 (functional) = 0.65 mg Kg-1 Antimalarial activity against Plasmodium yoelii nigeriensis in ip dosed Swiss mouse ChEMBL. 17900897
ED50 (functional) = 0.72 mg Kg-1 Antimalarial activity against Plasmodium berghei in ip dosed Swiss mouse ChEMBL. 17900897
ED50 (functional) = 0.72 mg Kg-1 Antimalarial activity against Plasmodium berghei in ip dosed Swiss mouse ChEMBL. 17900897
IC50 (functional) = 0.045 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 17900897
IC50 (functional) = 0.045 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 17900897
LD50 (ADMET) > 200 mg Kg-1 Toxicity in Swiss mouse after 10 days ChEMBL. 17900897
LD50 (ADMET) > 200 mg Kg-1 Toxicity in Swiss mouse after 10 days ChEMBL. 17900897
Ratio LD50/ED50 (functional) > 278 Therapeutic index, ratio of LD50 for Swiss mouse to IC50 for Plasmodium berghei infected Swiss mouse ChEMBL. 17900897

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 17900897

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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