Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Mus musculus | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0202 | 0.956 | 0.9452 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0118 | 0.4784 | 0.5004 |
Schistosoma mansoni | thyroid hormone receptor | 0.0119 | 0.4806 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.9507 | 0.9945 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0069 | 0.1972 | 0.3566 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.102 | 0.1067 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0202 | 0.956 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0952 | 0.0996 |
Onchocerca volvulus | 0.0041 | 0.0401 | 1 | |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0041 | 0.0401 | 1 |
Onchocerca volvulus | 0.0041 | 0.0401 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.3873 | 0.8045 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0952 | 0.0996 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0118 | 0.4784 | 0.3503 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0069 | 0.1972 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0069 | 0.1972 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0069 | 0.1972 | 0.4059 |
Onchocerca volvulus | 0.0041 | 0.0401 | 1 | |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0102 | 0.3873 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.102 | 0.1067 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0119 | 0.4806 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1972 | 0.2063 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0952 | 0.0996 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0051 | 0.0952 | 0.0996 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.102 | 0.1067 |
Toxoplasma gondii | peptidase family M13 protein | 0.0069 | 0.1972 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.102 | 0.1067 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0069 | 0.1972 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0102 | 0.3873 | 0.7882 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1972 | 0.2063 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0041 | 0.0401 | 0.0766 |
Onchocerca volvulus | 0.0041 | 0.0401 | 1 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0119 | 0.4806 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0202 | 0.956 | 0.9452 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.102 | 0.1067 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0952 | 0.0996 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0069 | 0.1972 | 0.4524 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0051 | 0.0952 | 0.0996 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.102 | 0.1067 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1972 | 0.2063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.33 nM | Displacement of [3H]CP 55940 from human CB2 receptor expressed in CHO cells after 90 mins by liquid scintillation counting | ChEMBL. | 23466226 |
Ki (binding) | = 9.23 nM | Displacement of [3H]CP 55940 from CB1 receptor in mouse whole brain membrane homogenates after 90 mins by liquid scintillation counting | ChEMBL. | 23466226 |
Survival (functional) | = 0.71 | Growth inhibition of HT29 cells assessed as relative survival at 150 uM after 2 hrs relative to control | ChEMBL. | 17980582 |
Survival (functional) | > 70 % | Cell survival of human HT29 cells at 150 uM after 2 hrs | ChEMBL. | 17980582 |
Survival (functional) | > 70 % | Cell survival of human HT29 cells at 150 uM after 2 hrs | ChEMBL. | 17980582 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.