Detailed information for compound 446829

Basic information

Technical information
  • TDR Targets ID: 446829
  • Name: 2-naphthalen-1-yl-1-phenothiazin-10-ylethanon e
  • MW: 367.463 | Formula: C24H17NOS
  • H donors: 0 H acceptors: 1 LogP: 5.83 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1c2ccccc2Sc2c1cccc2)Cc1cccc2c1cccc2
  • InChi: 1S/C24H17NOS/c26-24(16-18-10-7-9-17-8-1-2-11-19(17)18)25-20-12-3-5-14-22(20)27-23-15-6-4-13-21(23)25/h1-15H,16H2
  • InChiKey: WKQIWZWIIXDMRT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1-naphthyl)-1-phenothiazin-10-yl-ethanone
  • 2-(1-naphthalenyl)-1-(10-phenothiazinyl)ethanone
  • 2-naphthalen-1-yl-1-phenothiazin-10-yl-ethanone
  • 2-(1-naphthyl)-1-(10-phenothiazinyl)ethanone
  • AG-690/11837044
  • STK093653
  • ZINC02262109
  • BAS 00721883
  • Oprea1_018845

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens butyrylcholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein butyrylcholinesterase 602 aa 546 aa 30.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.0019 0.0015 0.0461
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0038 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0022 0.3005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0015 0.0008
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0015 0.0008
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0017 0.0011
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0015 0.0008
Echinococcus granulosus importin subunit beta 1 0.003 0.0059 0.0053
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0451 0.1644 1
Echinococcus granulosus BC026374 protein S09 family 0.0451 0.1644 0.1638
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0109 0.0358 0.0351
Echinococcus multilocularis importin subunit beta 1 0.003 0.0059 0.0053
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0143 0.0137
Schistosoma mansoni acetylcholinesterase 0.0451 0.1644 0.1638
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0451 0.1644 0.1638
Loa Loa (eye worm) carboxylesterase 0.0451 0.1644 0.1638
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0025 0.0019
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0038 0.0095
Echinococcus multilocularis acetylcholinesterase 0.2666 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0038 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0007 0.0001
Loa Loa (eye worm) glutaminase 0.0284 0.1014 0.1008
Entamoeba histolytica hypothetical protein 0.0025 0.0038 0.9993
Loa Loa (eye worm) hypothetical protein 0.0451 0.1644 0.1638
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0025 0.0019
Schistosoma mansoni ran 0.0022 0.0029 0.0023
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0015 0.0008
Trichomonas vaginalis glutaminase, putative 0.0284 0.1014 0.6116
Schistosoma mansoni sodium/chloride dependent transporter 0.0109 0.0358 0.0351
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 0.0023
Loa Loa (eye worm) carboxylesterase 0.2666 1 1
Brugia malayi hypothetical protein 0.0019 0.0015 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.4204
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 0.4275
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0025 0.1716
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0007 0.0001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0451 0.1644 0.1638
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0011
Plasmodium falciparum importin beta, putative 0.003 0.0059 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0025 0.0019
Brugia malayi Importin beta-1 subunit 0.003 0.0059 0.0053
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.0442 0.0435
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0451 0.1644 0.1638
Loa Loa (eye worm) hypothetical protein 0.0451 0.1644 0.1638
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0038 0.0457
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0451 0.1644 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0017 0.0011
Trichomonas vaginalis spcc417.12 protein, putative 0.0451 0.1644 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.0015 0.0008
Brugia malayi Carboxylesterase family protein 0.0451 0.1644 0.1638
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0186 0.018
Loa Loa (eye worm) solute carrier family 6 member 4 0.0109 0.0358 0.0351
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0038 0.1737
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.4204
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0029 0.7247
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0038 0.1737
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.008 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0124 0.0117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0124 0.0117
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0038 0.1737
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0019 0.0015 0.0008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0025 0.0113
Echinococcus granulosus para nitrobenzyl esterase 0.0451 0.1644 0.1638
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0022 0.0016
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0022 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.4204
Brugia malayi RNA, U transporter 1 0.0086 0.0271 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.4204
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0022 0.376
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0275 0.0269
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0017 0.0011
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0025 0.0016
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 1
Echinococcus multilocularis GPCR, family 2 0.0017 0.0007 0.0001
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0019 0.0015 0.0008
Brugia malayi Carboxylesterase family protein 0.0451 0.1644 0.1638
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0186 0.1011
Leishmania major GTP-binding protein, putative 0.0022 0.0029 0.1258
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0019 0.0015 0.0008
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0025 0.0019
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0015 0.0008
Echinococcus granulosus carboxylesterase 5A 0.2666 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0025 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0025 0.5936
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0124 0.0117
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0019
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0358 0.0351
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0001
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0017 0.0014
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0015 0.0008
Onchocerca volvulus 0.0451 0.1644 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0124 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.4204
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0059 0.2943
Schistosoma mansoni ran 0.0022 0.0029 0.0023
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0025 0.4204
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0015 0.0008
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0025 0.0113
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0006 0.108
Echinococcus multilocularis carboxylesterase 5A 0.2666 1 1
Brugia malayi Serotonin receptor 0.0569 0.2091 0.2086
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0025 0.5936
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.4204
Mycobacterium ulcerans glutaminase 0.0284 0.1014 0.6116
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0029 0.0023
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0015 0.0461
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0001
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.039 0.1414 0.8591
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0029 0.1258
Brugia malayi DIX domain containing protein 0.0019 0.0017 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0124 0.0117
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0124 0.0117
Brugia malayi Carboxylesterase family protein 0.2666 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0143 0.0137
Loa Loa (eye worm) hypothetical protein 0.0088 0.0275 0.0269
Loa Loa (eye worm) hypothetical protein 0.0451 0.1644 0.1638
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0017 0.0011
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0025 0.0016
Echinococcus granulosus dna polymerase eta 0.0021 0.0025 0.0019
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0038 0.0094
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0038 1
Plasmodium falciparum amino acid transporter, putative 0.0019 0.0015 0.1568
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0025 0.4204
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0186 0.1011
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0038 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0022 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0025 0.5936
Echinococcus granulosus dna polymerase kappa 0.0021 0.0025 0.0019
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0025 0.0019
Echinococcus granulosus acetylcholinesterase 0.2666 1 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0451 0.1644 0.1638
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0275 0.0269
Echinococcus granulosus hypothetical protein 0.0847 0.3138 0.3134
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2666 1 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0017 0.0011
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0059 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.1169 0.1163
Loa Loa (eye worm) hypothetical protein 0.039 0.1414 0.1409
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0007 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0124 0.0117
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0186 0.018
Echinococcus multilocularis dna polymerase eta 0.0021 0.0025 0.0019
Schistosoma mansoni importin beta-1 0.003 0.0059 0.0053
Loa Loa (eye worm) hypothetical protein 0.2666 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.008 0.0074
Schistosoma mansoni ap endonuclease 0.0021 0.0022 0.0016
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0186 0.1098
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0038 0.0191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0124 0.0117
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0451 0.1644 0.1638
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0015 0.0008
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0025 0.0019
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.1014 0.3767 0.3763
Entamoeba histolytica hypothetical protein 0.0025 0.0038 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.4204
Mycobacterium ulcerans carboxylesterase, LipT 0.0451 0.1644 1
Loa Loa (eye worm) glutaminase 2 0.0284 0.1014 0.1008
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0029 0.0023
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0015 0.0008
Loa Loa (eye worm) serotonin transporter b 0.0109 0.0358 0.0351
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0275 0.0269
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0017 0.0011
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0022 0.0884
Schistosoma mansoni dep domain containing protein 0.0019 0.0017 0.0011
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.0015 0.0008
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0186 1
Echinococcus granulosus snurportin 1 0.0325 0.1169 0.1163
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.4204
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0186 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0015 0.0461
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0186 0.1011
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0029 0.4275
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0015 0.0008
Schistosoma mansoni gliotactin 0.0451 0.1644 0.1638
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.0015 0.0008
Onchocerca volvulus 0.0451 0.1644 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0017 0.0011
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0109 0.0358 0.0351
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0029 0.4894
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0025 0.1031
Echinococcus multilocularis acetylcholinesterase 0.2666 1 1
Brugia malayi MH2 domain containing protein 0.0132 0.0442 0.0435
Schistosoma mansoni DNA polymerase eta 0.0021 0.0025 0.0019
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0006 0.108
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0451 0.1644 0.1638
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.0442 0.0435
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0025 0.0016
Brugia malayi Carboxylesterase family protein 0.0451 0.1644 0.1638
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.4204
Loa Loa (eye worm) hypothetical protein 0.0451 0.1644 0.1638
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0017 0.0011
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0275 0.0269
Loa Loa (eye worm) acetylcholinesterase 1 0.2666 1 1
Echinococcus multilocularis snurportin 1 0.0325 0.1169 0.1163
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0143 0.0137
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0017 0.0011
Giardia lamblia DINP protein human, muc B family 0.0021 0.0025 0.3911
Echinococcus granulosus neuroligin 0.0451 0.1644 0.1638
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0017 0.0011
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0015 0.0008
Echinococcus granulosus GPCR family 2 0.0017 0.0007 0.0001
Plasmodium vivax amine transporter, putative 0.0019 0.0015 0.1568
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0109 0.0358 0.0351
Schistosoma mansoni BC026374 protein (S09 family) 0.0451 0.1644 0.1638
Echinococcus multilocularis conserved hypothetical protein 0.0833 0.3087 0.3083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Onchocerca volvulus 0.0451 0.1644 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0038 0.0095
Onchocerca volvulus 0.0088 0.0275 0.16
Plasmodium vivax importin-beta 2, putative 0.003 0.0059 1
Onchocerca volvulus 0.0451 0.1644 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0007 0.0001
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0025 0.4204
Echinococcus granulosus acetylcholinesterase 0.2666 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0025 0.5936
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0038 0.5901
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0015 0.0008
Schistosoma mansoni dishevelled 0.0019 0.0017 0.0011
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0019 0.0015 0.0008
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0017 0.0011
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0017 0.0011
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0017 0.0011
Trichomonas vaginalis ran, putative 0.0022 0.0029 0.0041
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0015 0.0461
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0038 0.0094
Treponema pallidum sodium- and chloride- dependent transporter 0.0109 0.0358 1
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0025 0.0019
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0015 0.0008
Schistosoma mansoni neuroligin 3 (S09 family) 0.0451 0.1644 0.1638
Brugia malayi N-terminal motif family protein 0.039 0.1414 0.1409
Trypanosoma brucei unspecified product 0.0021 0.0025 0.4204
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0017 0.0011
Schistosoma mansoni dishevelled 0.0019 0.0017 0.0011
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0015 0.0008
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.0015 0.0008
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0015 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1014 0.3767 0.3763
Echinococcus multilocularis BC026374 protein (S09 family) 0.0451 0.1644 0.1638
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0059 1
Schistosoma mansoni ap endonuclease 0.0021 0.0022 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0124 0.0117
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0186 0.018
Schistosoma mansoni glutaminase 0.0284 0.1014 0.1008
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0451 0.1644 0.1638
Brugia malayi glutaminase DH11.1 0.0284 0.1014 0.1008
Mycobacterium tuberculosis Carboxylesterase LipT 0.0451 0.1644 1
Brugia malayi hypothetical protein 0.0019 0.0017 0.0011
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0011
Leishmania major importin beta-1 subunit, putative 0.0025 0.0038 0.1736
Loa Loa (eye worm) norepinephrine transporter 0.0109 0.0358 0.0351
Brugia malayi Carboxylesterase family protein 0.0451 0.1644 0.1638
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0025 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0025 0.5936
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Onchocerca volvulus 0.0109 0.0358 0.2105
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0019 0.0015 0.0008
Echinococcus granulosus serotonin transporter 0.0109 0.0358 0.0351
Schistosoma mansoni hypothetical protein 0.0325 0.1169 0.1163
Leishmania major DNA polymerase kappa, putative 0.0021 0.0025 0.1031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0038 0.5901
Echinococcus multilocularis serotonin transporter 0.0109 0.0358 0.0351
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0019 0.0015 0.0008
Loa Loa (eye worm) carboxylesterase 0.0451 0.1644 0.1638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0186 0.018
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0025 0.4204
Onchocerca volvulus 0.0019 0.0017 0.0014
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 0.0023
Toxoplasma gondii hypothetical protein 0.0019 0.0017 0.0586
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0022 0.0016
Echinococcus multilocularis neuroligin 0.0451 0.1644 0.1638
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0022 0.3005
Loa Loa (eye worm) hypothetical protein 0.0451 0.1644 0.1638
Entamoeba histolytica Ran family GTPase 0.0022 0.0029 0.4387
Leishmania major DNA polymerase eta, putative 0.0021 0.0025 0.1031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0022 0.5094
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0053 0.0143 0.0137
Loa Loa (eye worm) hypothetical protein 0.0451 0.1644 0.1638
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Onchocerca volvulus 0.0451 0.1644 1
Toxoplasma gondii hypothetical protein 0.0019 0.0015 0.0461
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0015 0.1568
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0025 0.4204
Plasmodium falciparum transporter, putative 0.0019 0.0015 0.1568
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0029 0.7247
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0109 0.0358 0.0351
Toxoplasma gondii exonuclease III APE 0.0021 0.0022 0.0884
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0022 0.5094
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0038 0.6344
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0015 0.0008
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0017 0.0011
Brugia malayi hypothetical protein 0.0451 0.1644 0.1638
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0007 0.0001
Schistosoma mansoni sodium-dependent amino acid transporter 0.0019 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0074
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0015 0.0008
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.2666 1 1
Brugia malayi hypothetical protein 0.0019 0.0017 0.0011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0038 0.0094
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0011
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0451 0.1644 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0007 0.0001

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of recombinant human AChE activity ChEMBL. 17681768
Activity (binding) 0 Inhibition of recombinant human AChE activity ChEMBL. 17681768
Ki (binding) = 0.09 uM Inhibition of human plasma BuChE activity ChEMBL. 17681768
Ki (binding) = 0.09 uM Inhibition of human plasma BuChE activity ChEMBL. 17681768

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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