Detailed information for compound 447021

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 658.636 | Formula: C31H39N4O10P
  • H donors: 3 H acceptors: 6 LogP: 2.5 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)CNC(=O)c1ccc(cc1)OP(=O)(C1CCCN1C(=O)C1CCCN1)Oc1ccc(cc1)C(=O)NCC(=O)OCC
  • InChi: 1S/C31H39N4O10P/c1-3-42-27(36)19-33-29(38)21-9-13-23(14-10-21)44-46(41,26-8-6-18-35(26)31(40)25-7-5-17-32-25)45-24-15-11-22(12-16-24)30(39)34-20-28(37)43-4-2/h9-16,25-26,32H,3-8,17-20H2,1-2H3,(H,33,38)(H,34,39)
  • InChiKey: JFLWTONGCRBODS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References
Homo sapiens dipeptidyl-peptidase 8 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) Get druggable targets OG5_129743 All targets in OG5_129743
Leishmania infantum dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase Get druggable targets OG5_129743 All targets in OG5_129743
Echinococcus multilocularis Dipeptidyl peptidase 9 Get druggable targets OG5_129743 All targets in OG5_129743
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative Get druggable targets OG5_129743 All targets in OG5_129743
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Trypanosoma brucei gambiense dipeptidyl-peptidase 8-like serine protease Get druggable targets OG5_129743 All targets in OG5_129743
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Leishmania donovani serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Echinococcus granulosus Dipeptidyl peptidase 9 Get druggable targets OG5_129743 All targets in OG5_129743
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129743 All targets in OG5_129743
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Leishmania mexicana dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Trypanosoma brucei serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Leishmania braziliensis dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K08656 dipeptidyl-peptidase 9, putative Get druggable targets OG5_129743 All targets in OG5_129743
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_129743 All targets in OG5_129743
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0208 0.2542 0.6511
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0399 0.0384
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0048 0.039 0.0375
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0577 0.1386
Brugia malayi TAR-binding protein 0.0068 0.0664 0.0901
Echinococcus granulosus dual specificity 0.0096 0.104 0.1025
Brugia malayi MH2 domain containing protein 0.0129 0.1477 0.2005
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0664 0.0901
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0208 0.2542 0.6511
Onchocerca volvulus 0.004 0.028 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0091 0.0967 0.1275
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0086 0.0896 0.0882
Brugia malayi conserved hypotetical protein 0.0043 0.0321 0.0436
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.027 0.225
Loa Loa (eye worm) hypothetical protein 0.003 0.0154 0.0168
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0321 0.0436
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0033 0.0191 0.0198
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.104 0.2591
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.014 0.0244
Mycobacterium ulcerans glutaminase 0.0567 0.7368 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0043 0.0321 0.0396
Onchocerca volvulus 0.0091 0.0967 0.2469
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0091 0.0967 0.1312
Echinococcus multilocularis nuclear receptor nhr 48 0.0043 0.0321 0.0306
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.028 0.0264
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0577 0.0562
Brugia malayi glutathione reductase 0.0038 0.0263 0.0357
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0091 0.0967 0.0952
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0096 0.104 0.2591
Schistosoma mansoni metabotropic glutamate receptor 0.0022 0.0042 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.028 0.061
Schistosoma mansoni d-amino acid oxidase 0.018 0.2172 0.2159
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.027 0.0305
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0134 0.0119
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0191 0.146
Plasmodium falciparum importin beta, putative 0.003 0.0154 0.4834
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.027 1
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0165 0.197 0.5984
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0664 0.0649
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0033 0.0191 0.0378
Loa Loa (eye worm) hypothetical protein 0.004 0.028 0.034
Brugia malayi nuclear receptor RXR 0.0043 0.0321 0.0436
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.065 0.1575
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.027 0.0366
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0077 0.0042
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0789 0.1014
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0191 0.0198
Echinococcus granulosus FTZ F1 alpha 0.0091 0.0967 0.0952
Echinococcus granulosus neutral alpha glucosidase AB 0.0078 0.0789 0.0774
Entamoeba histolytica hypothetical protein 0.0076 0.0772 0.7308
Brugia malayi nuclear hormone receptor 0.0091 0.0967 0.1312
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.039 0.053
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0572 0.0557
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0321 0.0306
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.065 0.0635
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.388 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0163 0.0734
Brugia malayi nuclear receptor NHR-67 0.0043 0.0321 0.0436
Mycobacterium leprae Probable lipase LipE 0.004 0.028 0.0448
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0043 0.0321 0.0436
Trichomonas vaginalis set domain proteins, putative 0.0247 0.3063 0.412
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0033 0.0191 0.0378
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Echinococcus multilocularis lysosomal alpha glucosidase 0.035 0.4448 0.4439
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0091 0.0967 0.0952
Schistosoma mansoni ap endonuclease 0.0039 0.027 0.0254
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0191 0.146
Leishmania major oligopeptidase b 0.0033 0.0191 0.0378
Schistosoma mansoni hypothetical protein 0.0021 0.0031 0.0015
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0321 0.0556
Loa Loa (eye worm) hypothetical protein 0.0091 0.0967 0.1275
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.104 0.1025
Onchocerca volvulus 0.0067 0.0649 0.1528
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0326 0.0731
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Schistosoma mansoni RAR-like nuclear receptor 0.0091 0.0967 0.0952
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0038 0.0255 0.024
Schistosoma mansoni nuclear hormone receptor 0.0091 0.0967 0.0952
Brugia malayi nuclear receptor NHR-88 0.0043 0.0321 0.0436
Mycobacterium ulcerans beta-lactamase 0.004 0.028 0.0246
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.065 0.0635
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.028 0.0264
Loa Loa (eye worm) hypothetical protein 0.0048 0.039 0.049
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0102 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0321 0.0306
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0091 0.0967 0.0952
Brugia malayi RNA binding protein 0.0068 0.0664 0.0901
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0091 0.0967 0.0952
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.027 0.956
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0091 0.0967 0.1275
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0208 0.2542 0.6511
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0664 0.0649
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.028 0.034
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0134 0.0228
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0057 0.0041
Loa Loa (eye worm) hypothetical protein 0.0073 0.0724 0.0945
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.018 0.2172 1
Echinococcus multilocularis FTZ F1 alpha 0.0091 0.0967 0.0952
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0091 0.0967 0.1275
Mycobacterium tuberculosis Probable hydrolase 0.004 0.028 0.0299
Leishmania major cytochrome p450-like protein 0.0026 0.0102 0.0144
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.388 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0078 0.0789 0.1014
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0263 0.0565
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.028 0.3507 0.3496
Schistosoma mansoni alpha glucosidase 0.0078 0.0789 0.0774
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0078 0.0789 0.1033
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0091 0.0967 0.2469
Trypanosoma cruzi oligopeptidase b 0.0033 0.0191 0.0378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0399 0.0384
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0321 0.0306
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0033 0.0191 0.0911
Schistosoma mansoni retinoic acid receptor RXR 0.0091 0.0967 0.0952
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.1923 0.5827
Loa Loa (eye worm) hypothetical protein 0.0049 0.0399 0.0502
Onchocerca volvulus 0.0043 0.0321 0.0556
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0077 0.0042
Mycobacterium leprae conserved hypothetical protein 0.004 0.028 0.0448
Schistosoma mansoni jun-related protein 0.007 0.0681 0.0666
Loa Loa (eye worm) glutaminase 0.0567 0.7368 1
Brugia malayi Pre-SET motif family protein 0.0217 0.266 0.361
Leishmania major alpha glucosidase II subunit, putative 0.0078 0.0789 0.1936
Brugia malayi ecdysteroid receptor 0.0091 0.0967 0.1312
Echinococcus granulosus importin subunit beta 1 0.003 0.0154 0.0138
Brugia malayi ecdysone receptor 0.0043 0.0321 0.0436
Mycobacterium ulcerans D-amino acid oxidase Aao 0.018 0.2172 0.2849
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.028 0.0299
Loa Loa (eye worm) hypothetical protein 0.0048 0.039 0.049
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.014 0.0244
Leishmania major importin beta-1 subunit, putative 0.0025 0.0077 0.008
Loa Loa (eye worm) hypothetical protein 0.0048 0.039 0.049
Brugia malayi glutaminase DH11.1 0.0567 0.7368 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0134 0.0119
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.028 0.0264
Brugia malayi Importin beta-1 subunit 0.003 0.0154 0.0209
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.014 0.4192
Loa Loa (eye worm) glutamate receptor 0.0045 0.0354 0.0441
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0033 0.0191 0.0378
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0208 0.2542 0.253
Mycobacterium tuberculosis Conserved protein 0.004 0.028 0.0299
Brugia malayi prolyl oligopeptidase family protein 0.028 0.3507 0.476
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0191 0.026
Trypanosoma brucei oligopeptidase b 0.0033 0.0191 0.0378
Mycobacterium tuberculosis Probable reductase 0.0088 0.0927 0.2474
Onchocerca volvulus Bile acid receptor homolog 0.0091 0.0967 0.2469
Brugia malayi beta-lactamase 0.004 0.028 0.038
Loa Loa (eye worm) prolyl oligopeptidase 0.0033 0.0191 0.0219
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0572 0.0557
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0091 0.0967 0.0952
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0163 0.0147
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0927 0.2474
Plasmodium falciparum thioredoxin reductase 0.0038 0.0263 0.9695
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0577 0.1299
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0191 0.0175
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.027 0.0254
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Brugia malayi Pre-SET motif family protein 0.0031 0.0163 0.0221
Loa Loa (eye worm) steroid hormone receptor 0.0091 0.0967 0.1275
Brugia malayi follicle stimulating hormone receptor 0.0275 0.3448 0.468
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0577 0.0655
Loa Loa (eye worm) hypothetical protein 0.0091 0.0967 0.1275
Echinococcus multilocularis thyroid hormone receptor alpha 0.0219 0.2692 0.2681
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.028 0.0246
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0043 0.0321 0.0306
Echinococcus multilocularis snurportin 1 0.0325 0.4114 0.4105
Echinococcus granulosus acylamino acid releasing enzyme 0.0033 0.0191 0.0175
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0134 0.0119
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.028 0.038
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0057 0.0041
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0191 0.146
Loa Loa (eye worm) hypothetical protein 0.018 0.2172 0.2918
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0148 0.0132
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0191 0.6489
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.014 0.0589
Brugia malayi hypothetical protein 0.0029 0.014 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.028 0.0319
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0091 0.0967 0.1312
Brugia malayi bZIP transcription factor family protein 0.0086 0.0896 0.1216
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0091 0.0967 0.1312
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.065 0.6077
Brugia malayi beta-lactamase family protein 0.004 0.028 0.038
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Echinococcus granulosus Dipeptidyl peptidase 9 0.0208 0.2542 0.253
Loa Loa (eye worm) hypothetical protein 0.004 0.028 0.034
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0048 0.039 0.049
Onchocerca volvulus 0.004 0.028 0.0434
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0134 0.0119
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0134 0.0119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0091 0.0967 0.0952
Echinococcus granulosus geminin 0.0353 0.4497 0.4488
Mycobacterium ulcerans hypothetical protein 0.0162 0.1923 0.2507
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.027 0.0583
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.027 0.0254
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0191 0.6203
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0577 0.0562
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0191 0.0378
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0789 0.1014
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Echinococcus multilocularis importin subunit beta 1 0.003 0.0154 0.0138
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0321 0.0556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.1676 0.1663
Schistosoma mansoni importin beta-1 0.003 0.0154 0.0138
Leishmania major hypothetical protein, conserved 0.0029 0.014 0.0244
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0243 0.0227
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0927 0.2474
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.014 0.0244
Brugia malayi nuclear hormone receptor family member nhr-6 0.0043 0.0321 0.0436
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0238 0.0283
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0577 0.0562
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0048 0.039 0.0375
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0772 0.0757
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.028 0.0299
Plasmodium falciparum peptidase, putative 0.0033 0.0191 0.6489
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0191 0.026
Brugia malayi Bromodomain containing protein 0.0039 0.0275 0.0374
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.4114 0.5565
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0789 0.1014
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0102 0.0097
Loa Loa (eye worm) hypothetical protein 0.0033 0.0191 0.0219
Schistosoma mansoni ran 0.0022 0.0046 0.003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0091 0.0967 0.0952
Echinococcus granulosus snurportin 1 0.0325 0.4114 0.4105
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0577 0.0655
Brugia malayi metabotropic glutamate receptor type 2 0.0022 0.0042 0.0057
Mycobacterium ulcerans lipase LipD 0.004 0.028 0.0246
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0191 0.6489
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0033 0.0191 0.0378
Brugia malayi Steroid receptor seven-up type 2 0.0091 0.0967 0.1312
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0091 0.0967 0.0952
Onchocerca volvulus Prolyl endopeptidase homolog 0.0033 0.0191 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0664 0.0649
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0091 0.0967 0.0952
Trypanosoma brucei glucosidase, putative 0.0078 0.0789 0.1936
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.028 0.0299
Schistosoma mansoni nuclear receptor nhr-48 0.0043 0.0321 0.0306
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0789 0.1014
Loa Loa (eye worm) prolyl oligopeptidase 0.028 0.3507 0.4738
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0664 0.0863
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.027 0.0583
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.028 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0091 0.0967 0.1312
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0051 0.0438 0.0422
Trypanosoma cruzi prolyl endopeptidase 0.0033 0.0191 0.0378
Leishmania major trypanothione reductase 0.0038 0.0263 0.0565
Brugia malayi Metabotropic glutamate receptor precursor. 0.0045 0.0354 0.0481
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0096 0.104 0.2591
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0091 0.0967 0.1312
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Echinococcus granulosus nuclear receptor nhr 48 0.0043 0.0321 0.0306
Brugia malayi nuclear hormone receptor 0.0043 0.0321 0.0436
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.028 0.3507 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0091 0.0967 0.0952
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0091 0.0967 0.0952
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.039 0.053
Brugia malayi nuclear hormone receptor family member odr-7 0.0043 0.0321 0.0436
Brugia malayi hypothetical protein 0.0108 0.1192 0.1618
Loa Loa (eye worm) hypothetical protein 0.0048 0.039 0.049
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0321 0.0306
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.3163 1
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.028 0.3507 0.3496
Schistosoma mansoni coup transcription factor 0.0091 0.0967 0.0952
Loa Loa (eye worm) hypothetical protein 0.0091 0.0967 0.1275
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.065 0.0635
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.1676 0.1663
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0927 0.2474
Loa Loa (eye worm) hypothetical protein 0.004 0.028 0.034
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0091 0.0967 0.0952
Echinococcus multilocularis prolyl endopeptidase 0.0033 0.0191 0.0175
Brugia malayi Thioredoxin reductase 0.0038 0.0263 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0091 0.0967 0.1312
Echinococcus multilocularis jun protein 0.0086 0.0896 0.0882
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0789 0.1936
Brugia malayi PHD-finger family protein 0.0026 0.009 0.0122
Schistosoma mansoni hypothetical protein 0.0353 0.4497 0.4488
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.027 0.5
Plasmodium vivax hypothetical protein, conserved 0.004 0.028 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0046 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.1676 0.1663
Loa Loa (eye worm) beta-lactamase 0.004 0.028 0.034
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0048 0.039 0.0375
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0789 0.1936
Toxoplasma gondii thioredoxin reductase 0.0038 0.0263 0.1362
Echinococcus granulosus thyroid hormone receptor alpha 0.0043 0.0321 0.0306
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0789 0.1014
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0191 0.026
Brugia malayi hypothetical protein 0.0048 0.039 0.053
Plasmodium vivax glutathione reductase, putative 0.0038 0.0263 0.9268
Brugia malayi Protein kinase domain containing protein 0.0096 0.104 0.1411
Loa Loa (eye worm) hypothetical protein 0.0091 0.0967 0.1275
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0664 0.0649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0091 0.0967 0.1275
Brugia malayi hypothetical protein 0.0076 0.0772 0.1048
Schistosoma mansoni ran 0.0022 0.0046 0.003
Loa Loa (eye worm) hypothetical protein 0.0091 0.0967 0.1275
Onchocerca volvulus 0.0202 0.2465 0.6912
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0927 0.3712
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0091 0.0967 0.0952
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.014
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.1471 0.1457
Schistosoma mansoni nuclear receptor 0.0043 0.0321 0.0306
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0154 0.0679
Plasmodium falciparum glutathione reductase 0.0038 0.0263 0.9695
Echinococcus multilocularis dual specificity 0.0096 0.104 0.1025
Brugia malayi Bromodomain containing protein 0.0077 0.0784 0.1064
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0191 0.146
Echinococcus multilocularis microtubule associated protein 2 0.0762 1 1
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0269 0.0253
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0263 0.9268
Trypanosoma brucei prolyl endopeptidase 0.0033 0.0191 0.0378
Loa Loa (eye worm) hypothetical protein 0.004 0.028 0.034
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0134 0.0182
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.028 0.0319
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0134 0.0228
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.028 0.0246
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.1471 0.1457
Loa Loa (eye worm) hypothetical protein 0.004 0.028 0.034
Brugia malayi Glycosyl hydrolases family 31 protein 0.035 0.4448 0.6037
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0208 0.2542 0.6511
Leishmania major hypothetical protein, conserved 0.004 0.028 0.061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.1676 0.1663
Brugia malayi orphan nuclear receptor NR2E1 0.0043 0.0321 0.0436
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.027 0.0583
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0664 0.0649
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0134 0.0881
Loa Loa (eye worm) hypothetical protein 0.0039 0.0276 0.0335
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.028 0.0299
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.028 0.0299
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0046 0.0063
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0149
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0077 0.0042
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.027 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0043 0.0321 0.0306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.1676 0.1663
Echinococcus multilocularis neutral alpha glucosidase AB 0.0078 0.0789 0.0774
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.388 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0967 0.1275
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0134 0.0119
Brugia malayi tailless protein 0.0043 0.0321 0.0436
Trichomonas vaginalis esterase, putative 0.004 0.028 0.0319
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0033 0.0191 0.0378
Plasmodium vivax importin-beta 2, putative 0.003 0.0154 0.4621
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0321 0.0306
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.1676 0.2243
Trypanosoma brucei glycosyl hydrolase-like protein 0.0029 0.0134 0.0228
Loa Loa (eye worm) hypothetical protein 0.0096 0.1033 0.1366
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0772 0.0757
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1702 0.4319
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0102 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.028 0.061
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.065 0.1575
Echinococcus multilocularis acylamino acid releasing enzyme 0.0033 0.0191 0.0175
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0789 0.1014
Brugia malayi Nuclear hormone receptor-like 1 0.0091 0.0967 0.1312
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0091 0.0967 0.1312
Leishmania major glycosyl hydrolase-like protein 0.0029 0.0134 0.0228
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0191 0.146
Onchocerca volvulus 0.0031 0.0163 0.0087
Schistosoma mansoni zinc finger protein 0.0043 0.0321 0.0306
Loa Loa (eye worm) RNA binding protein 0.0068 0.0664 0.0863
Schistosoma mansoni thyroid hormone receptor 0.0219 0.2692 0.2681
Echinococcus granulosus jun protein 0.0086 0.0896 0.0882
Loa Loa (eye worm) hypothetical protein 0.0042 0.0309 0.0379
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0163 0.0147
Mycobacterium tuberculosis Conserved protein 0.004 0.028 0.0299
Onchocerca volvulus 0.0247 0.3063 0.8684
Brugia malayi hypothetical protein 0.0043 0.0321 0.0436
Onchocerca volvulus 0.0043 0.0321 0.0556
Brugia malayi beta-lactamase family protein 0.004 0.028 0.038
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0057 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0091 0.0967 0.1312
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0577 0.0562
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.027 0.0254
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.1058 0.2917
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0041 0.0297 0.0403
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.065 0.1575
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0326 0.0731
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0046 0.003
Onchocerca volvulus 0.004 0.028 0.0434
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0134 0.0119
Toxoplasma gondii hypothetical protein 0.005 0.0412 0.2298
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0077 0.008
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0577 0.3337
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0243 0.0227
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0091 0.0967 0.0952
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0043 0.0321 0.0306
Echinococcus granulosus metabotropic glutamate receptor 2 0.0038 0.0255 0.024
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0102 0.0097
Schistosoma mansoni hypothetical protein 0.0325 0.4114 0.4105
Echinococcus multilocularis geminin 0.0353 0.4497 0.4488
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0789 0.7473
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0091 0.0967 0.0952
Brugia malayi hypothetical protein 0.0067 0.0649 0.0881
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.1676 0.2275
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0154 0.0282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0091 0.0967 0.1275
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.027 0.0264
Echinococcus multilocularis lysosomal alpha glucosidase 0.035 0.4448 0.4439
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0091 0.0967 0.0952
Schistosoma mansoni ap endonuclease 0.0039 0.027 0.0254
Schistosoma mansoni thyroid hormone receptor 0.0219 0.2692 0.2681
Entamoeba histolytica hypothetical protein 0.0076 0.0772 0.7308
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.065 0.0882
Loa Loa (eye worm) nuclear receptor NHR-67 0.0043 0.0321 0.0396
Loa Loa (eye worm) hypothetical protein 0.0096 0.1033 0.1366
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.027 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.027 0.0583
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.104 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0399 0.0384
Trypanosoma brucei hypothetical protein, conserved 0.004 0.028 0.061
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.266 0.3584
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.1676 0.1663
Echinococcus granulosus metabotropic glutamate receptor 5 0.0056 0.0495 0.048
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.1058 0.2917
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.014 0.4008
Trypanosoma brucei trypanothione reductase 0.0038 0.0263 0.0565
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0056 0.0495 0.048
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.027 0.0254
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Mycobacterium ulcerans hypothetical protein 0.004 0.028 0.0246
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Loa Loa (eye worm) hypothetical protein 0.0091 0.0967 0.1275
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0321 0.0436
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1702 0.4319
Plasmodium vivax SET domain protein, putative 0.0031 0.0163 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.039 0.049
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.028 0.0264
Brugia malayi Cytochrome P450 family protein 0.0026 0.0102 0.0138
Schistosoma mansoni hypothetical protein 0.0128 0.1471 0.1457
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0078 0.0789 0.4664
Brugia malayi photoreceptor-specific nuclear receptor 0.0091 0.0967 0.1312
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.1058 0.2917
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0163 0.0147
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0043 0.0321 0.0306
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0096 0.104 0.2591
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0154 0.0282
Toxoplasma gondii exonuclease III APE 0.0039 0.027 0.1404
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0664 0.0863
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0208 0.2542 0.6511
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0091 0.0967 0.1312
Echinococcus multilocularis ecdysone induced protein 78C 0.0091 0.0967 0.0952
Loa Loa (eye worm) hypothetical protein 0.0044 0.0336 0.0415
Entamoeba histolytica hypothetical protein 0.0076 0.0772 0.7308
Schistosoma mansoni metabotropic glutamate receptor 0.0038 0.0255 0.024
Loa Loa (eye worm) glutaminase 2 0.0567 0.7368 1
Brugia malayi hypothetical protein 0.0048 0.039 0.053
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.027 0.0232
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0096 0.104 0.1375
Loa Loa (eye worm) glutathione reductase 0.0038 0.0263 0.0316
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0048 0.039 0.0375
Entamoeba histolytica hypothetical protein 0.0076 0.0772 0.7308
Trypanosoma cruzi oligopeptidase b 0.0033 0.0191 0.0378
Echinococcus granulosus lysosomal alpha glucosidase 0.035 0.4448 0.4439
Entamoeba histolytica protein kinase, putative 0.0096 0.104 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0091 0.0967 0.1275
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.028 0.0319
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0191 0.0175
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0454 0.1063
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0208 0.2542 0.253
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0091 0.0967 0.1312
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0772 0.0757
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0191 0.0378
Schistosoma mansoni hypothetical protein 0.007 0.0681 0.0666
Schistosoma mansoni alpha-glucosidase 0.0301 0.3793 0.3783
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0043 0.0321 0.0306
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0102 0.0144
Loa Loa (eye worm) hypothetical protein 0.0083 0.0865 0.1137
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0134 0.0119
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.1477 0.1971
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.028 0.0319
Schistosoma mansoni hypothetical protein 0.0076 0.0772 0.0757
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0046 0.0021
Brugia malayi nuclear receptor NHR-88 0.0091 0.0967 0.1312
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.1058 0.4377
Loa Loa (eye worm) nuclear hormone receptor 0.0043 0.0321 0.0396
Loa Loa (eye worm) hypothetical protein 0.0033 0.0191 0.0219
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0275 0.3448 0.4657
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0927 0.2474
Brugia malayi steroid hormone receptor 0.0091 0.0967 0.1312
Brugia malayi Cytochrome P450 family protein 0.0026 0.0102 0.0138
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0086 0.0896 0.0882
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0191 0.146
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0033 0.0191 0.0175
Toxoplasma gondii ABC1 family protein 0.004 0.028 0.1469
Schistosoma mansoni alpha-glucosidase 0.0301 0.3793 0.3783
Loa Loa (eye worm) hypothetical protein 0.0056 0.0495 0.0633
Echinococcus granulosus tar DNA binding protein 0.0068 0.0664 0.0649
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0399 0.0384
Loa Loa (eye worm) hypothetical protein 0.004 0.028 0.034
Mycobacterium tuberculosis Conserved protein 0.004 0.028 0.0299
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.1676 0.1663
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0091 0.0967 0.0952
Brugia malayi Cytochrome P450 family protein 0.0037 0.0238 0.0323
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0091 0.0967 0.0952
Schistosoma mansoni nuclear receptor 0.0043 0.0321 0.0306
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.065 0.1575
Loa Loa (eye worm) DR-78 0.0043 0.0321 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0091 0.0967 0.1312
Loa Loa (eye worm) hypothetical protein 0.0091 0.0967 0.1275
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.028 0.3507 0.3496
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0263 0.0316
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0033 0.0191 0.0378
Schistosoma mansoni bromodomain containing protein 0.0065 0.0621 0.0606
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0321 0.0306
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.065 0.0844
Entamoeba histolytica hypothetical protein 0.0025 0.0077 0.0309
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0321 0.0306
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0789 0.7473
Schistosoma mansoni microtubule-associated protein tau 0.0762 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0091 0.0967 0.1275
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0269 0.0253
Echinococcus granulosus ecdysone induced protein 78C 0.0091 0.0967 0.0952
Brugia malayi hypothetical protein 0.0043 0.0321 0.0436
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0577 0.0655
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0396
Trichomonas vaginalis sucrase-isomaltase, putative 0.0078 0.0789 0.1014
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0321 0.0306
Trichomonas vaginalis glutaminase, putative 0.0567 0.7368 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0141 0.1638 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0078 0.0789 0.107
Brugia malayi prolyl oligopeptidase family protein 0.0208 0.2542 0.3451
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.035 0.4448 0.6021
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0789 0.1014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0091 0.0967 0.1312
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.1477 0.1971
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0033 0.0191 0.0123
Schistosoma mansoni hypothetical protein 0.0353 0.4497 0.4488
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0033 0.0191 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0091 0.0967 0.1312
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.388 1
Echinococcus granulosus prolyl endopeptidase 0.0033 0.0191 0.0175
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0091 0.0967 0.0952
Trypanosoma brucei prolyl oligopeptidase, putative 0.0033 0.0191 0.0378
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0263 0.0241
Entamoeba histolytica protein kinase, putative 0.0096 0.104 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0091 0.0967 0.0952
Brugia malayi nuclear receptor RXR 0.0048 0.039 0.053
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1702 0.4319
Loa Loa (eye worm) hypothetical protein 0.0108 0.1192 0.1582
Loa Loa (eye worm) hypothetical protein 0.01 0.1096 0.1451
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0102 0.0144
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0664 0.0649
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.027 0.0326
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0191 0.0175
Toxoplasma gondii hypothetical protein 0.0033 0.0191 0.0911
Onchocerca volvulus Protein ultraspiracle homolog 0.0091 0.0967 0.2469
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0326 0.0731
Toxoplasma gondii prolyl endopeptidase 0.0033 0.0191 0.0911
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0927 0.2474
Schistosoma mansoni glutaminase 0.0567 0.7368 0.7364
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.027 0.0305
Entamoeba histolytica hypothetical protein 0.0096 0.104 1
Brugia malayi RNA, U transporter 1 0.0086 0.0909 0.1234
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0326 0.0731
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.014 0.4192
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.028 0.0299

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.014 uM Inhibition of human DPP4 ChEMBL. 17958345
IC50 (binding) = 0.014 uM Inhibition of human DPP4 ChEMBL. 17958345
IC50 (binding) = 0.53 uM Inhibition of human DPP8 ChEMBL. 17958345
IC50 (binding) = 0.53 uM Inhibition of human DPP8 ChEMBL. 17958345
IC50 (binding) > 100 uM Inhibition of human DPP2 ChEMBL. 17958345
IC50 (binding) > 100 uM Inhibition of human DPP2 ChEMBL. 17958345

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.