Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0322 | 0.1523 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0548 | 0.9282 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0322 | 0.1523 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0322 | 0.1523 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0277 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 90.8 uM | Antioxidant activity assessed as superoxide radical scavenging activity by xanthine oxidase method | ChEMBL. | 17980585 |
Ratio IC50 (functional) | = 0.58 | Ratio of IC50 for drug to trolox for ABTS radical scavenging activity | ChEMBL. | 17980585 |
Ratio IC50 (functional) | = 1.42 | Ratio of IC50 for drug to trolox for DPPH radical scavenging activity | ChEMBL. | 17980585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.