Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0031 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0031 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 76 nM | Displacement of TAMRA labeled dexamethasone at human glucocorticoid receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | = 76 nM | Displacement of TAMRA labeled dexamethasone at human glucocorticoid receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | = 900 nM | Displacement of TAMRA labeled mifepristone at human mineralocorticoid receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | = 900 nM | Displacement of TAMRA labeled mifepristone at human mineralocorticoid receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | = 1300 nM | Displacement of TAMRA labeled dexamethasone at human progesterone receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | = 1300 nM | Displacement of TAMRA labeled dexamethasone at human progesterone receptor in insect cell | ChEMBL. | 17692519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.