Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0031 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.5 | 0.5 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0031 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0031 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0031 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0031 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0031 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0031 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 53 % | Antiinflammatory activity assesed as upregulation of aromatase in HFF cells by transactivation assay relative to dextomethasone | ChEMBL. | 17692519 |
Activity (functional) | = 53 % | Antiinflammatory activity assesed as upregulation of aromatase in HFF cells by transactivation assay relative to dextomethasone | ChEMBL. | 17692519 |
EC50 (functional) | > 2000 nM | Antiinflammatory activity assesed as inhibition of IL1 stimulated IL6 production in HFF cells by transrepression assay | ChEMBL. | 17692519 |
EC50 (functional) | > 2000 nM | Antiinflammatory activity assesed as inhibition of IL1 stimulated IL6 production in HFF cells by transrepression assay | ChEMBL. | 17692519 |
EC50 (functional) | = 4750 nM | Antiinflammatory activity assesed as upregulation of aromatase in HFF cells by transactivation assay | ChEMBL. | 17692519 |
EC50 (functional) | = 4750 nM | Antiinflammatory activity assesed as upregulation of aromatase in HFF cells by transactivation assay | ChEMBL. | 17692519 |
Efficacy (functional) | = 46 % | Antiinflammatory activity assesed as inhibition of IL6 production in HFF cells by transrepression assay relative to dextomethasone | ChEMBL. | 17692519 |
Efficacy (functional) | = 46 % | Antiinflammatory activity assesed as inhibition of IL6 production in HFF cells by transrepression assay relative to dextomethasone | ChEMBL. | 17692519 |
IC50 (binding) | = 27 nM | Displacement of TAMRA labeled dexamethasone at human glucocorticoid receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | = 27 nM | Displacement of TAMRA labeled dexamethasone at human glucocorticoid receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | = 730 nM | Displacement of TAMRA labeled mifepristone at human mineralocorticoid receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | = 730 nM | Displacement of TAMRA labeled mifepristone at human mineralocorticoid receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | > 2000 nM | Displacement of TAMRA labeled dexamethasone at human progesterone receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | > 2000 nM | Displacement of TAMRA labeled dexamethasone at human progesterone receptor in insect cell | ChEMBL. | 17692519 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17692519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.