Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0632 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0632 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0632 | 1 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0632 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0632 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0632 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0632 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.94 uM | Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassay | ChEMBL. | 17915854 |
IC50 (binding) | = 0.94 uM | Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassay | ChEMBL. | 17915854 |
IC50 (binding) | > 100 uM | Inhibition of COX1 in mouse J774 cells assessed as arachidonic acid-induced PGE2 levels by radio immunoassay | ChEMBL. | 17915854 |
IC50 (binding) | > 100 uM | Inhibition of COX1 in mouse J774 cells assessed as arachidonic acid-induced PGE2 levels by radio immunoassay | ChEMBL. | 17915854 |
Inhibition (binding) | = 59 % | Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels at 1 uM by radioimmunoassay | ChEMBL. | 17915854 |
Inhibition (binding) | = 59 % | Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels at 1 uM by radioimmunoassay | ChEMBL. | 17915854 |
Inhibition (binding) | = 70 % | Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels at 10 uM by radioimmunoassay | ChEMBL. | 17915854 |
Inhibition (binding) | = 70 % | Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels at 10 uM by radioimmunoassay | ChEMBL. | 17915854 |
Ratio IC50 (binding) | > 100 | Selectivity ratio of IC50 for mouse COX1 to IC50 for mouse COX2 | ChEMBL. | 17915854 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.