Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | mannose-6-phosphate isomerase, putative | 0.01 | 0.3531 | 0.8914 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0409 | 0.0987 |
Plasmodium falciparum | mannose-6-phosphate isomerase, putative | 0.01 | 0.3531 | 0.8914 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.01 | 0.3531 | 0.4073 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0358 | 0.0864 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0097 | 0.3402 | 0.869 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.003 | 0.0376 | 0.0909 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0376 | 0.0434 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.004 | 0.0853 | 0.2059 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0539 | 0.0622 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0376 | 0.0434 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0108 | 0.3915 | 1 |
Schistosoma mansoni | lipoxygenase | 0.004 | 0.0853 | 0.2059 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0409 | 0.0471 |
Toxoplasma gondii | phosphomannose isomerase type I protein | 0.01 | 0.3531 | 0.8914 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.01 | 0.3531 | 0.4073 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0097 | 0.3402 | 0.9473 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Giardia lamblia | Kinase, PLK | 0.0097 | 0.3402 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0853 | 0.0984 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0097 | 0.3402 | 0.8215 |
Schistosoma mansoni | rab6-interacting | 0.004 | 0.0853 | 0.2059 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.1839 | 0.4133 |
Loa Loa (eye worm) | PHD-finger family protein | 0.003 | 0.0376 | 0.0434 |
Entamoeba histolytica | phosphomannose isomerase, putative | 0.01 | 0.3531 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.124 | 0.143 |
Plasmodium falciparum | LCCL domain-containing protein | 0.004 | 0.0853 | 0.1346 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0409 | 0.0987 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0097 | 0.3402 | 0.869 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.1862 | 0.4497 |
Brugia malayi | Pre-SET motif family protein | 0.0213 | 0.8668 | 1 |
Schistosoma mansoni | rab6-interacting | 0.004 | 0.0853 | 0.2059 |
Brugia malayi | Doublecortin family protein | 0.004 | 0.0853 | 0.0984 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.124 | 0.143 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0063 | 0.1862 | 0.2149 |
Onchocerca volvulus | 0.004 | 0.0853 | 0.0495 | |
Echinococcus multilocularis | RUN | 0.004 | 0.0853 | 0.2059 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.066 | 0.0762 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.004 | 0.0853 | 0.2059 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.066 | 0.1595 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.004 | 0.0853 | 0.1346 |
Brugia malayi | hypothetical protein | 0.004 | 0.0853 | 0.0984 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.0107 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0853 | 0.2059 |
Echinococcus granulosus | mannose 6 phosphate isomerase | 0.01 | 0.3531 | 0.8526 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.003 | 0.0376 | 0.0909 |
Trichomonas vaginalis | set domain proteins, putative | 0.0243 | 1 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0409 | 0.0987 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1839 | 0.444 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.124 | 0.143 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0108 | 0.3915 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.1839 | 0.4697 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0108 | 0.3915 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0063 | 0.1862 | 0.4497 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.0107 | 0.0124 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0097 | 0.3402 | 0.8215 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.0853 | 0.2059 |
Schistosoma mansoni | loxhd1 | 0.004 | 0.0853 | 0.2059 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.066 | 0.1595 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.003 | 0.0376 | 0.0909 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0853 | 0.0984 |
Leishmania major | phosphomannose isomerase | 0.01 | 0.3531 | 0.9018 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.0853 | 0.2059 |
Echinococcus multilocularis | peregrin | 0.003 | 0.0376 | 0.0909 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0097 | 0.3402 | 0.869 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0539 | 0.1302 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0108 | 0.3915 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0409 | 0.0471 |
Schistosoma mansoni | mannose-6-phosphate isomerase | 0.01 | 0.3531 | 0.8526 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0097 | 0.3402 | 0.3925 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0108 | 0.3915 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.004 | 0.0853 | 0.0984 |
Trypanosoma brucei | polo-like protein kinase | 0.0097 | 0.3402 | 0.869 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0409 | 0.0987 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1839 | 0.444 |
Trichomonas vaginalis | mannose-6-phosphate isomerase, putative | 0.01 | 0.3531 | 0.2655 |
Brugia malayi | jmjC domain containing protein | 0.0098 | 0.3449 | 0.398 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.1862 | 0.4497 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.1839 | 0.1516 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.0905 | 0.2186 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.1839 | 0.444 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.066 | 0.1595 |
Echinococcus granulosus | leucine aminopeptidase protein | 0.0108 | 0.3915 | 0.9454 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1341 | 0.1547 |
Mycobacterium ulcerans | mannose-6-phosphate isomerase ManA | 0.01 | 0.3531 | 0.8149 |
Schistosoma mansoni | jumonji domain containing protein | 0.0078 | 0.254 | 0.6134 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.01 | 0.3531 | 0.4073 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.0905 | 0.2186 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.01 | 0.3531 | 0.4073 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.0853 | 0.2059 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0213 | 0.8668 | 1 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0108 | 0.3915 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0539 | 0.0622 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0409 | 0.0091 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0108 | 0.3915 | 1 |
Echinococcus multilocularis | leucine aminopeptidase protein | 0.0108 | 0.3915 | 0.9454 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0108 | 0.3915 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0063 | 0.1862 | 0.0113 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0409 | 0.0987 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0097 | 0.3402 | 0.3144 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0098 | 0.3449 | 0.833 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0097 | 0.3402 | 0.8215 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0097 | 0.3402 | 0.3925 |
Onchocerca volvulus | 0.0031 | 0.0409 | 0.0034 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0113 | 0.4141 | 1 |
Echinococcus granulosus | RUN | 0.004 | 0.0853 | 0.2059 |
Schistosoma mansoni | kinase | 0.0049 | 0.125 | 0.3018 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.01 | 0.3531 | 0.9018 |
Brugia malayi | Bromodomain containing protein | 0.003 | 0.0376 | 0.0434 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.01 | 0.3531 | 0.9018 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0063 | 0.1862 | 0.4757 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0409 | 0.0987 |
Trypanosoma brucei | phosphomannose isomerase | 0.01 | 0.3531 | 0.9018 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0098 | 0.3449 | 0.833 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0409 | 0.0091 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.066 | 0.1595 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0063 | 0.1862 | 0.1612 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0376 | 0.0909 |
Echinococcus multilocularis | mannose 6 phosphate isomerase | 0.01 | 0.3531 | 0.8526 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0063 | 0.1862 | 0.0113 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0108 | 0.3915 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.1839 | 0.444 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0055 | 0.1504 | 0.1736 |
Schistosoma mansoni | polycystin 1-related | 0.004 | 0.0853 | 0.2059 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.124 | 0.143 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0853 | 0.0984 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0108 | 0.3915 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0108 | 0.3915 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0113 | 0.4141 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0113 | 0.4141 | 1 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0108 | 0.3915 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.0853 | 0.2059 |
Echinococcus granulosus | peregrin | 0.003 | 0.0376 | 0.0909 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0409 | 0.0987 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.1815 | 0.2093 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.066 | 0.0762 |
Onchocerca volvulus | 0.004 | 0.0853 | 0.0495 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.