Detailed information for compound 44813

Basic information

Technical information
  • TDR Targets ID: 44813
  • Name: 4-methoxy-2-methyl-2-(4-methylcyclohex-3-en-1 -yl)-3H-1-benzofuran-7-carboxylic acid
  • MW: 302.365 | Formula: C18H22O4
  • H donors: 1 H acceptors: 2 LogP: 3.36 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c2c1CC(O2)(C)C1CCC(=CC1)C)C(=O)O
  • InChi: 1S/C18H22O4/c1-11-4-6-12(7-5-11)18(2)10-14-15(21-3)9-8-13(17(19)20)16(14)22-18/h4,8-9,12H,5-7,10H2,1-3H3,(H,19,20)
  • InChiKey: KOQXWCDWJCHVBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methoxy-2-methyl-2-(4-methylcyclohex-3-en-1-yl)-3H-benzofuran-7-carboxylic acid
  • 4-methoxy-2-methyl-2-(4-methyl-1-cyclohex-3-enyl)-3H-benzofuran-7-carboxylic acid
  • 4-methoxy-2-methyl-2-(4-methylcyclohex-3-en-1-yl)coumaran-7-carboxylic acid
  • 4-methoxy-2-methyl-2-(4-methyl-1-cyclohex-3-enyl)-3H-1-benzofuran-7-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0122 0.0271 0.0322
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.007 0.0087 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0017 0.0106
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0761 0.253 0.253
Echinococcus granulosus zinc finger protein 0.0064 0.0065 0.0083
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.2256 0.7814 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0007 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0007 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0264 0.0772 0.3007
Brugia malayi MH2 domain containing protein 0.0101 0.0195 0.0245
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.007 0.0087 0.0318
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0777 0.2587 0.3311
Schistosoma mansoni glutamate synthase 0.007 0.0087 0.0103
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.007 0.0087 0.0111
Brugia malayi glutaminase DH11.1 0.0269 0.0792 0.1009
Entamoeba histolytica disulphide oxidoreductase, putative 0.007 0.0087 0.0275
Loa Loa (eye worm) hypothetical protein 0.0133 0.0309 0.0391
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0264 0.0772 0.3007
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.007 0.0087 0.0087
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0264 0.0772 0.3032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0007 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Echinococcus granulosus cathepsin l cysteine peptidase 0.005 0.0017 0.0022
Echinococcus granulosus thioredoxin glutathione reductase 0.0762 0.2532 0.324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0017 0.0106
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.193 0.6662 0.8525
Schistosoma mansoni hypothetical protein 0.005 0.0016 0.0019
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.007 0.0087 0.0283
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0007 0.0004
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.007 0.0087 0.0283
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0271 0.0347
Schistosoma mansoni cellular tumor antigen P53 0.0311 0.094 0.1117
Schistosoma mansoni microtubule-associated protein tau 0.1406 0.4811 0.5712
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.007 0.0087 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.1475 0.5055 0.6467
Echinococcus multilocularis zinc finger protein 0.0064 0.0065 0.0083
Toxoplasma gondii selenide, water dikinase 0.007 0.0087 0.009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.045 0.143 0.1826
Brugia malayi Cathepsin L-like precursor 0.005 0.0017 0.0017
Echinococcus granulosus methyl CpG binding domain protein 2 0.0056 0.0036 0.0046
Echinococcus granulosus histone lysine methyltransferase setb 0.0119 0.0259 0.0331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0017 0.0106
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0264 0.0772 0.0988
Trichomonas vaginalis glutaminase, putative 0.0269 0.0792 0.4926
Schistosoma mansoni zinc finger protein 0.005 0.0016 0.0019
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0264 0.0772 0.0988
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0017 0.0017
Brugia malayi glutamate synthase 0.007 0.0087 0.0107
Loa Loa (eye worm) hypothetical protein 0.0119 0.0259 0.0327
Onchocerca volvulus Cathepsin F homolog 0.005 0.0017 0.0065
Echinococcus multilocularis cysteine protease 0.005 0.0017 0.0022
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0264 0.0772 0.3032
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.007 0.0087 0.0087
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.1479 0.5067 0.6484
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0194 0.0244
Leishmania major cathepsin L-like protease 0.005 0.0017 0.0041
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0777 0.2587 0.3311
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0007 0.0009
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0017 0.0017
Schistosoma mansoni peptidase Clp (S14 family) 0.2256 0.7814 0.9279
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0007 0.0009
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.007 0.0087 0.0107
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0264 0.0772 0.0988
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.0772 0.3007
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0264 0.0772 0.0984
Onchocerca volvulus 0.005 0.0017 0.0065
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0029 0.0052
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0264 0.0772 0.0988
Plasmodium falciparum glutathione reductase 0.0761 0.253 0.3223
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.0087 0.0283
Echinococcus granulosus beta LACTamase domain containing family member 0.045 0.143 0.183
Brugia malayi MH2 domain containing protein 0.1475 0.5055 0.6467
Mycobacterium leprae Probable lipase LipE 0.045 0.143 0.183
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.1479 0.5067 0.5067
Mycobacterium tuberculosis Conserved protein 0.045 0.143 0.143
Loa Loa (eye worm) hypothetical protein 0.0139 0.0331 0.042
Loa Loa (eye worm) RNA binding protein 0.0456 0.1452 0.1855
Plasmodium falciparum ferrodoxin reductase-like protein 0.007 0.0087 0.009
Schistosoma mansoni smad1 5 8 and 0.0101 0.0195 0.0231
Leishmania major hypothetical protein, conserved 0.007 0.0087 0.0318
Echinococcus multilocularis mothers against decapentaplegic 5 0.0101 0.0195 0.0249
Leishmania major NADH dehydrogenase, putative 0.007 0.0087 0.0318
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1736 0.5977 0.7649
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.0087 0.0541
Loa Loa (eye worm) hypothetical protein 0.045 0.143 0.1826
Loa Loa (eye worm) hypothetical protein 0.045 0.143 0.1826
Trichomonas vaginalis penicillin-binding protein, putative 0.045 0.143 0.8897
Mycobacterium tuberculosis Probable conserved lipoprotein 0.045 0.143 0.143
Loa Loa (eye worm) hypothetical protein 0.007 0.0087 0.0107
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0017 0.0022
Schistosoma mansoni hypothetical protein 0.01 0.0194 0.023
Schistosoma mansoni methyl-cpg binding protein mbd 0.0056 0.0036 0.0043
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0264 0.0772 0.0988
Schistosoma mansoni Smad4 0.0101 0.0195 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0516 0.199
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0062 0.0074
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.0087 0.0283
Echinococcus multilocularis lamin dm0 0.025 0.0724 0.0926
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1736 0.5977 0.5977
Loa Loa (eye worm) programmed cell death 8 0.007 0.0087 0.0107
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.007 0.0087 0.0111
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.007 0.0087 0.0111
Leishmania major cathepsin L-like protease 0.0191 0.0516 0.2019
Loa Loa (eye worm) hypothetical protein 0.0311 0.094 0.12
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.025 0.0724 0.0922
Mycobacterium tuberculosis Conserved protein 0.045 0.143 0.143
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0017 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.045 0.143 0.8897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Onchocerca volvulus 0.005 0.0017 0.0065
Loa Loa (eye worm) hypothetical protein 0.0121 0.0266 0.0336
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.007 0.0087 0.0275
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.193 0.6662 0.6662
Echinococcus multilocularis GPCR, family 2 0.0046 0.0003 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Mycobacterium leprae conserved hypothetical protein 0.045 0.143 0.183
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0017 0.0022
Onchocerca volvulus 0.005 0.0017 0.0065
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0072 0.0093
Trypanosoma cruzi NADH dehydrogenase, putative 0.007 0.0087 0.0283
Mycobacterium tuberculosis Probable oxidoreductase 0.193 0.6662 0.6662
Schistosoma mansoni intermediate filament proteins 0.025 0.0724 0.0859
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0516 0.199
Loa Loa (eye worm) MH2 domain-containing protein 0.0101 0.0195 0.0245
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0259 0.0307
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0029 0.0015
Onchocerca volvulus 0.005 0.0017 0.0065
Brugia malayi Cathepsin L-like precursor 0.005 0.0017 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.0772 0.3007
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.007 0.0087 0.0111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0017 0.0106
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0007 0.0009
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.007 0.0087 0.0111
Plasmodium vivax thioredoxin reductase, putative 0.0761 0.253 0.3223
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0017 0.0035
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.007 0.0087 0.0111
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0017 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0264 0.0772 0.3007
Onchocerca volvulus Cathepsin L homolog 0.005 0.0017 0.0065
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.005 0.0017 0.0017
Trichomonas vaginalis apoptosis inducing factor, putative 0.007 0.0087 0.0541
Toxoplasma gondii ABC1 family protein 0.045 0.143 0.1812
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.2256 0.7814 1
Onchocerca volvulus 0.0063 0.0062 0.0347
Echinococcus multilocularis geminin 0.0392 0.1225 0.1567
Leishmania major cathepsin L-like protease 0.005 0.0017 0.0041
Echinococcus multilocularis microtubule associated protein 2 0.1406 0.4811 0.6156
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.007 0.0087 0.0111
Onchocerca volvulus 0.007 0.0087 0.0501
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.007 0.0087 0.0111
Entamoeba histolytica thioredoxin reductase, putative 0.007 0.0087 0.0275
Trypanosoma cruzi major cysteine proteinase, putative 0.015 0.0371 0.1414
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1736 0.5977 0.5977
Brugia malayi Cathepsin L-like precursor 0.005 0.0017 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0259 0.0307
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0264 0.0772 0.0988
Schistosoma mansoni smad1 5 8 and 0.0101 0.0195 0.0231
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.007 0.0087 0.0318
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0194 0.0524 0.0667
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0072 0.0093
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0264 0.0772 0.0968
Loa Loa (eye worm) glutaminase 0.0269 0.0792 0.1009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Onchocerca volvulus 0.025 0.0724 0.4481
Brugia malayi cytoplasmic intermediate filament protein 0.0134 0.0313 0.0397
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.007 0.0087 0.0111
Onchocerca volvulus 0.005 0.0017 0.0065
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.007 0.0087 0.0087
Brugia malayi glutathione reductase 0.0761 0.253 0.3235
Trypanosoma cruzi cruzipain precursor, putative 0.0191 0.0516 0.199
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0062 0.0074
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0007 0.0009
Loa Loa (eye worm) cysteine protease 0.005 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0017 0.0106
Toxoplasma gondii thioredoxin reductase 0.0761 0.253 0.3223
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0054 0.0069
Entamoeba histolytica glutamate synthase beta subunit, putative 0.007 0.0087 0.0275
Schistosoma mansoni hypothetical protein 0.0392 0.1225 0.1454
Mycobacterium ulcerans ferredoxin reductase 0.007 0.0087 0.0111
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.045 0.143 0.143
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0121 0.0266 0.0341
Loa Loa (eye worm) bromodomain containing protein 0.0058 0.0043 0.0051
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.007 0.0087 0.009
Mycobacterium tuberculosis Probable lipase LipD 0.045 0.143 0.143
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0007 0.0009
Trypanosoma brucei NADH dehydrogenase 0.007 0.0087 0.0283
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.2256 0.7814 1
Plasmodium falciparum thioredoxin reductase 0.0264 0.0772 0.0968
Plasmodium falciparum glutathione reductase 0.0264 0.0772 0.0968
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.007 0.0087 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.007 0.0087 0.0111
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0017 0.0005
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0264 0.0772 0.0772
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.007 0.0087 0.0541
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0062 0.0058
Mycobacterium ulcerans glutaminase 0.0269 0.0792 0.1013
Brugia malayi beta-lactamase 0.045 0.143 0.1826
Schistosoma mansoni tar DNA-binding protein 0.0456 0.1452 0.1724
Entamoeba histolytica hypothetical protein 0.0871 0.292 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0516 0.199
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.007 0.0087 0.009
Loa Loa (eye worm) hypothetical protein 0.0125 0.0282 0.0356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0516 0.199
Brugia malayi MH2 domain containing protein 0.0101 0.0195 0.0245
Schistosoma mansoni smad 0.0101 0.0195 0.0231
Brugia malayi hypothetical protein 0.0871 0.292 0.3734
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0007 0.0004
Loa Loa (eye worm) Smad1 0.0101 0.0195 0.0245
Echinococcus multilocularis smad 0.0101 0.0195 0.0249
Schistosoma mansoni sulfide quinone reductase 0.007 0.0087 0.0103
Echinococcus multilocularis thioredoxin glutathione reductase 0.0762 0.2532 0.324
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.0087 0.0541
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.2256 0.7814 1
Schistosoma mansoni lamin 0.025 0.0724 0.0859
Treponema pallidum NADH oxidase 0.0264 0.0772 0.0988
Schistosoma mansoni transcription factor LCR-F1 0.0871 0.292 0.3467
Brugia malayi Cathepsin L-like precursor 0.005 0.0017 0.0017
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.007 0.0087 0.0111
Treponema pallidum thioredoxin reductase (trxB) 0.007 0.0087 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0516 0.199
Brugia malayi Thioredoxin reductase 0.0761 0.253 0.3235
Echinococcus granulosus mothers against decapentaplegic 5 0.0101 0.0195 0.0249
Echinococcus granulosus cathepsin l1 0.005 0.0017 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.045 0.143 0.1698
Echinococcus granulosus glutamate synthase 0.007 0.0087 0.0111
Leishmania major cathepsin L-like protease 0.005 0.0017 0.0041
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0264 0.0772 0.3007
Echinococcus granulosus smad 0.0101 0.0195 0.0249
Echinococcus granulosus intermediate filament protein 0.025 0.0724 0.0926
Onchocerca volvulus 0.025 0.0724 0.4481
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.1479 0.5067 0.5067
Mycobacterium tuberculosis Probable reductase 0.1736 0.5977 0.5977
Echinococcus multilocularis lamin 0.025 0.0724 0.0926
Loa Loa (eye worm) nuclear factor I 0.0056 0.0036 0.0042
Mycobacterium ulcerans hypothetical protein 0.045 0.143 0.183
Schistosoma mansoni glutamate synthase 0.007 0.0087 0.0103
Trichomonas vaginalis mercuric reductase, putative 0.0264 0.0772 0.4803
Plasmodium vivax ferrodoxin reductase, putative 0.007 0.0087 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0516 0.199
Schistosoma mansoni hypothetical protein 0.0046 0.0003 0.0004
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0777 0.2587 0.3296
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0871 0.292 0.3737
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0516 0.199
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.045 0.143 0.1826
Leishmania major hypothetical protein, conserved 0.045 0.143 0.564
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0175 0.0457 0.1756
Mycobacterium ulcerans NADH dehydrogenase 0.007 0.0087 0.0111
Trichomonas vaginalis glutathione reductase, putative 0.0264 0.0772 0.4803
Brugia malayi MH1 domain containing protein 0.0101 0.0195 0.0245
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0003 0.0004
Trichomonas vaginalis glutamate synthase, putative 0.007 0.0087 0.0541
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.007 0.0087 0.009
Entamoeba histolytica glutamate synthase beta subunit, putative 0.007 0.0087 0.0275
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.0358 0.0453
Echinococcus granulosus geminin 0.0392 0.1225 0.1567
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0029 0.0015
Brugia malayi Pre-SET motif family protein 0.0439 0.1393 0.1778
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.007 0.0087 0.0111
Mycobacterium ulcerans beta-lactamase 0.045 0.143 0.183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.0358 0.0453
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0074 0.0099 0.0127
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.007 0.0087 0.0111
Echinococcus granulosus tar DNA binding protein 0.0456 0.1452 0.1858
Echinococcus granulosus sulfide:quinone oxidoreductase 0.007 0.0087 0.0111
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0264 0.0772 0.0968
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.0087 0.0283
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0194 0.0524 0.0667
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0003 0.0004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0264 0.0772 0.3032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0007 0.0004
Brugia malayi RNA recognition motif domain containing protein 0.0456 0.1452 0.1855
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.007 0.0087 0.0283
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1736 0.5977 0.5977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0516 0.199
Loa Loa (eye worm) hypothetical protein 0.0116 0.025 0.0316
Entamoeba histolytica hypothetical protein 0.0871 0.292 1
Loa Loa (eye worm) hypothetical protein 0.045 0.143 0.1826
Schistosoma mansoni bromodomain containing protein 0.0206 0.0569 0.0676
Leishmania major hypothetical protein, conserved 0.005 0.0016 0.0036
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.007 0.0087 0.0111
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0017 0.002
Leishmania major cathepsin L-like protease 0.005 0.0017 0.0041
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.045 0.143 0.183
Brugia malayi Probable ClpP-like protease 0.2256 0.7814 1
Schistosoma mansoni hypothetical protein 0.0392 0.1225 0.1454
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0195 0.0528 0.0675
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0072 0.0071
Plasmodium vivax hypothetical protein, conserved 0.045 0.143 0.1812
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0101 0.0195 0.0231
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0029 0.0015
Brugia malayi Smad1 0.0101 0.0195 0.0245
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.2256 0.7814 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.0231 0.0655 0.0834
Entamoeba histolytica hypothetical protein 0.0871 0.292 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0264 0.0772 0.0886
Giardia lamblia NADH oxidase lateral transfer candidate 0.0264 0.0772 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0194 0.0244
Trichomonas vaginalis D-aminoacylase, putative 0.045 0.143 0.8897
Mycobacterium ulcerans glutamate synthase subunit beta 0.007 0.0087 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0516 0.199
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0072 0.026
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0264 0.0772 0.0917
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.045 0.143 0.1826
Loa Loa (eye worm) intermediate filament protein 0.025 0.0724 0.0922
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.007 0.0087 0.0111
Schistosoma mansoni hypothetical protein 0.0046 0.0003 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0456 0.1452 0.1724
Schistosoma mansoni smad1 5 8 and 0.0101 0.0195 0.0231
Mycobacterium ulcerans dehydrogenase 0.007 0.0087 0.0111
Trypanosoma brucei trypanothione reductase 0.0761 0.253 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0017 0.0106
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.007 0.0087 0.009
Echinococcus multilocularis glutamate synthase 0.007 0.0087 0.0111
Echinococcus multilocularis beta LACTamase domain containing family member 0.045 0.143 0.183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0072 0.0093
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.0087 0.0541
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0017 0.0035
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0029 0.0052
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0117 0.0254 0.0325
Loa Loa (eye worm) hypothetical protein 0.0116 0.025 0.0316
Loa Loa (eye worm) TAR-binding protein 0.0456 0.1452 0.1855
Trichomonas vaginalis D-aminoacylase, putative 0.045 0.143 0.8897
Echinococcus granulosus Smad4 0.0101 0.0195 0.0249
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0871 0.292 0.3737
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.007 0.0087 0.0275
Leishmania major trypanothione reductase 0.0761 0.253 1
Plasmodium vivax SET domain protein, putative 0.0063 0.0062 0.0058
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0072 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0516 0.199
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.0358 0.0453
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.007 0.0087 0.0107
Mycobacterium ulcerans lipase LipD 0.045 0.143 0.183
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0074 0.0099 0.0118
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0264 0.0772 0.3007
Mycobacterium ulcerans hypothetical protein 0.0047 0.0007 0.0009
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.007 0.0087 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0087 0.0283
Loa Loa (eye worm) hypothetical protein 0.045 0.143 0.1826
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0017 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Trypanosoma cruzi trypanothione reductase, putative 0.0264 0.0772 0.3007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0017 0.0106
Schistosoma mansoni disulfide oxidoreductase 0.007 0.0087 0.0103
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.2256 0.7814 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.0772 0.3007
Echinococcus granulosus GPCR family 2 0.0046 0.0003 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0516 0.199
Schistosoma mansoni zinc finger protein 0.0064 0.0065 0.0077
Trichomonas vaginalis penicillin-binding protein, putative 0.045 0.143 0.8897
Plasmodium vivax glutathione reductase, putative 0.0761 0.253 0.3223
Brugia malayi MH1 domain containing protein 0.0101 0.0195 0.0245
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0456 0.1452 0.1855
Echinococcus multilocularis tar DNA binding protein 0.0456 0.1452 0.1858
Mycobacterium tuberculosis Probable esterase LipL 0.045 0.143 0.143
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0056 0.0036 0.0046
Onchocerca volvulus Cathepsin L homolog 0.005 0.0017 0.0065
Toxoplasma gondii NADPH-glutathione reductase 0.0264 0.0772 0.0968
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0017 0.002
Mycobacterium tuberculosis Probable dehydrogenase 0.1736 0.5977 0.5977
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0264 0.0772 0.0988
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0264 0.0772 0.0968
Brugia malayi RNA binding protein 0.0456 0.1452 0.1855
Brugia malayi Cathepsin L-like precursor 0.005 0.0017 0.0017
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.2256 0.7814 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.2256 0.7814 1
Schistosoma mansoni lamin 0.025 0.0724 0.0859
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.2256 0.7814 1
Brugia malayi TAR-binding protein 0.0456 0.1452 0.1855
Brugia malayi Intermediate filament tail domain containing protein 0.025 0.0724 0.0922
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0777 0.2587 0.3296
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.007 0.0087 0.0111
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.0772 0.3007
Echinococcus granulosus fetal alzheimer antigen falz 0.0074 0.0099 0.0127
Onchocerca volvulus 0.0311 0.094 0.5834
Mycobacterium ulcerans monoxygenase 0.007 0.0087 0.0111
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0271 0.0347
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.007 0.0087 0.0107
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0306 0.0363
Trypanosoma cruzi hypothetical protein, conserved 0.045 0.143 0.5624
Echinococcus granulosus lamin 0.025 0.0724 0.0926
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.2256 0.7814 1
Loa Loa (eye worm) PHD-finger family protein 0.0067 0.0077 0.0095
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.007 0.0087 0.0111
Brugia malayi Bromodomain containing protein 0.0125 0.0281 0.0355
Trypanosoma cruzi hypothetical protein, conserved 0.045 0.143 0.5624
Mycobacterium tuberculosis Probable lipase LipE 0.045 0.143 0.143
Echinococcus granulosus peptidase Clp S14 family 0.1479 0.5067 0.6484
Schistosoma mansoni methyl-cpg binding protein mbd 0.0056 0.0036 0.0043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0017 0.0106
Trichomonas vaginalis glutamate synthase, putative 0.007 0.0087 0.0541
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0134 0.0313 0.0397
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.007 0.0087 0.0111
Brugia malayi beta-lactamase family protein 0.045 0.143 0.1826
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0029 0.0052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0439 0.1393 0.1778
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.007 0.0087 0.0275
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.007 0.0087 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0456 0.1452 0.1724
Leishmania major cathepsin L-like protease 0.0191 0.0516 0.2019
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0101 0.0195 0.0249
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0264 0.0772 0.0968
Echinococcus granulosus cathepsin L cysteine proteinase 0.005 0.0017 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0117 0.0254 0.0325
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1736 0.5977 0.5977
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.007 0.0087 0.0107
Schistosoma mansoni hypothetical protein 0.0046 0.0003 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.045 0.143 0.1698
Onchocerca volvulus 0.005 0.0017 0.0065
Echinococcus multilocularis peptidase Clp (S14 family) 0.1479 0.5067 0.6484
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.0772 0.3007
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.193 0.6662 0.6662
Onchocerca volvulus 0.045 0.143 0.8892
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0007 0.0009
Brugia malayi intermediate filament protein 0.025 0.0724 0.0922
Trichomonas vaginalis set domain proteins, putative 0.05 0.1607 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0072 0.0093
Mycobacterium ulcerans hypothetical protein 0.007 0.0087 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0087 0.0283
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.007 0.0087 0.0283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0007 0.0007
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0072 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0516 0.199
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0007 0.0009
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.007 0.0087 0.0087
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.007 0.0087 0.0541
Schistosoma mansoni hypothetical protein 0.0871 0.292 0.3467
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.007 0.0087 0.0111
Trypanosoma cruzi trypanothione reductase, putative 0.0761 0.253 1
Echinococcus multilocularis tumor protein p63 0.2128 0.7361 0.942
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.007 0.0087 0.0283
Leishmania major hypothetical protein, conserved 0.007 0.0087 0.0318
Schistosoma mansoni tar DNA-binding protein 0.0456 0.1452 0.1724
Leishmania major cathepsin L-like protease 0.005 0.0017 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0087 0.0283
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0007 0.0009
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.007 0.0087 0.0283
Loa Loa (eye worm) hypothetical protein 0.0047 0.0007 0.0004
Brugia malayi Pre-SET motif family protein 0.0063 0.0062 0.0075
Brugia malayi MH1 domain containing protein 0.0056 0.0036 0.0042
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.2256 0.7814 1
Onchocerca volvulus 0.045 0.143 0.8892
Brugia malayi Bromodomain containing protein 0.0245 0.0704 0.0897
Loa Loa (eye worm) hypothetical protein 0.005 0.0017 0.0017
Onchocerca volvulus 0.045 0.143 0.8892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Brugia malayi PHD-finger family protein 0.0081 0.0127 0.0158
Loa Loa (eye worm) ctsf protein 0.005 0.0017 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0456 0.1452 0.1724
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0029 0.0015
Toxoplasma gondii hypothetical protein 0.0777 0.2587 0.3296
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0264 0.0772 0.3032
Loa Loa (eye worm) beta-lactamase 0.045 0.143 0.1826
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0516 0.199
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.045 0.143 0.143
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0516 0.199
Trichomonas vaginalis esterase, putative 0.045 0.143 0.8897
Brugia malayi MH1 domain containing protein 0.0056 0.0036 0.0042
Loa Loa (eye worm) MH1 domain-containing protein 0.0101 0.0195 0.0245
Mycobacterium ulcerans esterase/lipase LipP 0.045 0.143 0.183
Echinococcus multilocularis musashi 0.025 0.0724 0.0926
Brugia malayi Cathepsin L-like precursor 0.005 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0054 0.0029 0.0033
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.007 0.0087 0.0111
Echinococcus granulosus lamin dm0 0.025 0.0724 0.0926
Echinococcus multilocularis Smad4 0.0101 0.0195 0.0249
Loa Loa (eye worm) thioredoxin reductase 0.0761 0.253 0.3235
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.007 0.0087 0.009
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.0087 0.0541
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0072 0.0086
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.2256 0.7814 1
Treponema pallidum oxidoreductase 0.007 0.0087 0.0111
Entamoeba histolytica hypothetical protein 0.0871 0.292 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.2256 0.7814 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0264 0.0772 0.3007
Leishmania major cysteine peptidase A (CPA) 0.005 0.0017 0.0041
Mycobacterium tuberculosis Conserved protein 0.045 0.143 0.143
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0062 0.008
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0264 0.0772 0.0968
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.0306 0.0391
Loa Loa (eye worm) glutathione reductase 0.0761 0.253 0.3235
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0003 0.0004
Echinococcus granulosus tumor protein p63 0.2128 0.7361 0.942
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.2256 0.7814 1
Loa Loa (eye worm) hypothetical protein 0.0246 0.0708 0.0902
Schistosoma mansoni glutamate synthase 0.007 0.0087 0.0103
Leishmania major hypothetical protein, conserved 0.0054 0.0029 0.0088
Brugia malayi hypothetical protein 0.0054 0.0029 0.0033
Schistosoma mansoni glutaminase 0.0269 0.0792 0.094
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0119 0.0259 0.0331
Echinococcus granulosus TGF beta signal transducer SmadC 0.0101 0.0195 0.0249
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.007 0.0087 0.009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0147 0.0358 0.0453
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.0087 0.0541
Schistosoma mansoni hypothetical protein 0.007 0.0087 0.0103
Trichomonas vaginalis disulfide oxidoreductase, putative 0.007 0.0087 0.0541
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0121 0.0266 0.0341
Mycobacterium tuberculosis Probable hydrolase 0.045 0.143 0.143
Schistosoma mansoni hypothetical protein 0.0067 0.0077 0.0092
Loa Loa (eye worm) hypothetical protein 0.045 0.143 0.1826
Schistosoma mansoni sulfide quinone reductase 0.007 0.0087 0.0103
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.007 0.0087 0.0087
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.007 0.0087 0.0541
Loa Loa (eye worm) fibroinase 0.005 0.0017 0.0017
Trypanosoma cruzi NADH dehydrogenase, putative 0.007 0.0087 0.0283
Leishmania major hypothetical protein, conserved 0.007 0.0087 0.0318
Loa Loa (eye worm) transcription factor SMAD2 0.1475 0.5055 0.6467
Leishmania major cathepsin L-like protease 0.0191 0.0516 0.2019
Echinococcus granulosus microtubule associated protein 2 0.1406 0.4811 0.6156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0264 0.0772 0.3007
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.007 0.0087 0.0541
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0017 0.0106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0017 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Loa Loa (eye worm) hypothetical protein 0.025 0.0724 0.0922
Brugia malayi beta-lactamase family protein 0.045 0.143 0.1826
Loa Loa (eye worm) glutaminase 2 0.0269 0.0792 0.1009
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0306 0.0363
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.007 0.0087 0.009
Echinococcus multilocularis cysteine protease 0.005 0.0017 0.0022
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0195 0.0528 0.0675
Schistosoma mansoni hypothetical protein 0.0046 0.0003 0.0004
Plasmodium falciparum thioredoxin reductase 0.0761 0.253 0.3223
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.007 0.0087 0.0111
Onchocerca volvulus 0.05 0.1607 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0017 0.0106
Trypanosoma brucei hypothetical protein, conserved 0.045 0.143 0.5624
Entamoeba histolytica cysteine protease, putative 0.005 0.0017 0.0035
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.007 0.0087 0.0111
Onchocerca volvulus 0.005 0.0017 0.0065
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.007 0.0087 0.009

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) < 2.8 mM Inhibitory activity of the compound against mitogen-stimulated PBL proliferation; Range 1.7-2.8 mM ChEMBL. 7739002
IC50 (functional) < 2.8 mM Inhibitory activity of the compound against mitogen-stimulated PBL proliferation; Range 1.7-2.8 mM ChEMBL. 7739002
IC50 (functional) = 6 mM Compound was tested to inhibit the production of C5a relative to C3a ChEMBL. 7739002
IC50 (functional) = 8 mM Compound was tested to inhibit the production of C5a relative to C3a ChEMBL. 7739002

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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