Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0077 | 0.4479 | 0.4641 | |
Schistosoma mansoni | nuclear receptor | 0.0048 | 0.1269 | 0.1763 |
Onchocerca volvulus | Peroxidase homolog | 0.0077 | 0.4479 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Brugia malayi | Animal haem peroxidase family protein | 0.0077 | 0.4479 | 0.4479 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0077 | 0.4479 | 0.4479 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Schistosoma mansoni | peroxidasin | 0.0077 | 0.4479 | 0.6222 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0077 | 0.4479 | 0.4641 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0048 | 0.1269 | 0.1269 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0048 | 0.1269 | 0.1315 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0077 | 0.4479 | 0.4479 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0054 | 0.1904 | 0.1973 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0048 | 0.1269 | 0.1269 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0101 | 0.7198 | 0.746 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0101 | 0.7198 | 0.746 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0048 | 0.1269 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.7198 | 0.7198 |
Schistosoma mansoni | nuclear hormone receptor | 0.0101 | 0.7198 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0101 | 0.7198 | 0.746 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0101 | 0.7198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Onchocerca volvulus | 0.0077 | 0.4479 | 0.4641 | |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0048 | 0.1269 | 0.1269 |
Brugia malayi | steroid hormone receptor | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | DR-78 | 0.0048 | 0.1269 | 0.1269 |
Brugia malayi | Animal haem peroxidase family protein | 0.0077 | 0.4479 | 0.4479 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0048 | 0.1269 | 0.1269 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0048 | 0.1269 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0054 | 0.1904 | 0.2645 |
Schistosoma mansoni | zinc finger protein | 0.0048 | 0.1269 | 0.1763 |
Brugia malayi | Animal haem peroxidase family protein | 0.0077 | 0.4479 | 0.4479 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.7198 | 0.7198 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0101 | 0.7198 | 0.746 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0048 | 0.1269 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0048 | 0.1269 | 0.1315 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0048 | 0.1269 | 0.1763 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0101 | 0.7198 | 0.746 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0048 | 0.1269 | 0.1763 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0054 | 0.1904 | 0.2645 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0101 | 0.7198 | 0.746 |
Onchocerca volvulus | 0.0048 | 0.1269 | 0.1315 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0101 | 0.7198 | 0.7198 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0048 | 0.1269 | 0.1315 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0101 | 0.7198 | 0.7198 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0036 | 0 | 0.5 |
Brugia malayi | conserved hypotetical protein | 0.0048 | 0.1269 | 0.1269 |
Brugia malayi | nuclear hormone receptor | 0.0048 | 0.1269 | 0.1269 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0101 | 0.7198 | 0.746 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0048 | 0.1269 | 0.1269 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0101 | 0.7198 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0048 | 0.1269 | 0.1269 |
Brugia malayi | ecdysteroid receptor | 0.0101 | 0.7198 | 0.7198 |
Echinococcus granulosus | peroxidasin | 0.0077 | 0.4479 | 0.4641 |
Brugia malayi | nuclear receptor RXR | 0.0054 | 0.1904 | 0.1904 |
Onchocerca volvulus | 0.0048 | 0.1269 | 0.1315 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1904 | 0.1904 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0101 | 0.7198 | 0.746 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0101 | 0.7198 | 0.7198 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0077 | 0.4479 | 0.4479 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0101 | 0.7198 | 0.7198 |
Echinococcus multilocularis | peroxidasin | 0.0077 | 0.4479 | 0.4641 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0077 | 0.4479 | 0.4479 |
Echinococcus granulosus | FTZ F1 alpha | 0.0101 | 0.7198 | 0.746 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0101 | 0.7198 | 0.746 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.01 | 0.7039 | 0.7039 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0048 | 0.1269 | 0.1269 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0101 | 0.7198 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0054 | 0.1904 | 0.1904 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0101 | 0.7198 | 0.746 |
Brugia malayi | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0048 | 0.1269 | 0.1269 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0048 | 0.1269 | 0.1315 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0101 | 0.7198 | 0.746 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0101 | 0.7198 | 0.746 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0077 | 0.4479 | 0.4479 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Entamoeba histolytica | aminopeptidase, putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0077 | 0.4479 | 0.4641 |
Schistosoma mansoni | nuclear hormone receptor | 0.0048 | 0.1269 | 0.1763 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Brugia malayi | Animal haem peroxidase family protein | 0.0077 | 0.4479 | 0.4479 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.7198 | 0.7198 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0048 | 0.1269 | 0.1315 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0048 | 0.1269 | 0.1315 |
Schistosoma mansoni | nuclear hormone receptor | 0.0048 | 0.1269 | 0.1763 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0101 | 0.7198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.7198 | 0.7198 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0054 | 0.1904 | 0.1904 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0101 | 0.7198 | 0.7198 |
Schistosoma mansoni | thyroid hormone receptor | 0.0101 | 0.7198 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0101 | 0.7198 | 0.7198 |
Onchocerca volvulus | 0.0101 | 0.7198 | 0.746 | |
Schistosoma mansoni | peroxidasin | 0.0077 | 0.4479 | 0.6222 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Brugia malayi | ecdysone receptor | 0.0048 | 0.1269 | 0.1269 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.7198 | 0.7198 |
Onchocerca volvulus | Dual oxidase homolog | 0.0077 | 0.4479 | 0.4641 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0101 | 0.7198 | 0.7198 |
Brugia malayi | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0048 | 0.1269 | 0.1269 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0101 | 0.7198 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0077 | 0.4479 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5624 | 0.5624 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0101 | 0.7198 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0124 | 0.9649 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0124 | 0.9649 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.8234 | 0.8234 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0036 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0036 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0077 | 0.4479 | 0.4479 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0054 | 0.1904 | 0.1973 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1904 | 0.1904 |
Brugia malayi | Peroxidasin | 0.0077 | 0.4479 | 0.4479 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.7198 | 0.7198 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0101 | 0.7198 | 0.746 |
Schistosoma mansoni | nuclear receptor | 0.0048 | 0.1269 | 0.1763 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0048 | 0.1269 | 0.1315 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0048 | 0.1269 | 0.1315 |
Brugia malayi | nuclear receptor NHR-88 | 0.0048 | 0.1269 | 0.1269 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0101 | 0.7198 | 0.746 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0048 | 0.1269 | 0.1763 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0101 | 0.7198 | 0.7198 |
Brugia malayi | hypothetical protein | 0.0054 | 0.1904 | 0.1904 |
Schistosoma mansoni | thyroid hormone receptor | 0.0101 | 0.7198 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0048 | 0.1269 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0101 | 0.7198 | 0.7198 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0048 | 0.1269 | 0.1315 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0101 | 0.7198 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0101 | 0.7198 | 0.746 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0048 | 0.1269 | 0.1269 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0101 | 0.7198 | 0.746 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0101 | 0.7198 | 0.7198 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0101 | 0.7198 | 0.7198 |
Brugia malayi | Blistered cuticle protein 3 | 0.0077 | 0.4479 | 0.4479 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.7198 | 0.7198 |
Brugia malayi | tailless protein | 0.0048 | 0.1269 | 0.1269 |
Onchocerca volvulus | 0.0077 | 0.4479 | 0.4641 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0101 | 0.7198 | 0.746 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0101 | 0.7198 | 0.746 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0101 | 0.7198 | 0.7198 |
Brugia malayi | nuclear receptor NHR-67 | 0.0048 | 0.1269 | 0.1269 |
Onchocerca volvulus | 0.0124 | 0.9649 | 1 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0101 | 0.7198 | 0.7198 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0101 | 0.7198 | 0.7198 |
Onchocerca volvulus | Peroxidase homolog | 0.0077 | 0.4479 | 0.4641 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0048 | 0.1269 | 0.1315 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0101 | 0.7198 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0101 | 0.7198 | 0.746 |
Brugia malayi | hypothetical protein | 0.0054 | 0.1904 | 0.1904 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0101 | 0.7198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0054 | 0.1904 | 0.1904 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0101 | 0.7198 | 0.746 |
Brugia malayi | nuclear hormone receptor | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0101 | 0.7198 | 0.7198 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1269 | 0.1269 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0101 | 0.7198 | 0.7198 |
Brugia malayi | Peptidase family M1 containing protein | 0.0124 | 0.9649 | 0.9649 |
Schistosoma mansoni | coup transcription factor | 0.0101 | 0.7198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4479 | 0.4479 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0101 | 0.7198 | 0.7198 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 23.1 uM | Displacement of labeled SRC2-2 from human TRbeta expressed in BL21 (DE3) cells FP assay | ChEMBL. | 17918822 |
IC50 (binding) | = 23.1 uM | Displacement of labeled SRC2-2 from human TRbeta expressed in BL21 (DE3) cells FP assay | ChEMBL. | 17918822 |
IC50 (binding) | = 47.7 uM | Displacement of labeled SRC2-2 from human TRalpha by FP assay | ChEMBL. | 17918822 |
IC50 (binding) | = 47.7 uM | Displacement of labeled SRC2-2 from human TRalpha by FP assay | ChEMBL. | 17918822 |
LD50 (functional) | = 8.3 uM | Cytotoxicity against human U2OS cells after 48 hrs by MTS assay | ChEMBL. | 17918822 |
LD50 (functional) | = 8.3 uM | Cytotoxicity against human U2OS cells after 48 hrs by MTS assay | ChEMBL. | 17918822 |
LD50 (functional) | = 12.2 uM | Cytotoxicity against human ARO cells after 48 hrs by MTS assay | ChEMBL. | 17918822 |
LD50 (functional) | = 12.2 uM | Cytotoxicity against human ARO cells after 48 hrs by MTS assay | ChEMBL. | 17918822 |
permeability (ADMET) | = 1029 10^-6 cm/s | Permeability across artificial membrane at pH 7.4 by PAMPA assay | ChEMBL. | 17918822 |
Ratio IC50 (binding) | = 2.1 | Selectivity ratio of IC50 for TRBeta to IC50 for TRalpha | ChEMBL. | 17918822 |
Solubility | = 103 uM | Solubility in PBS | ChEMBL. | 17918822 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.