Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.048 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.048 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.048 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.048 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.048 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.048 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.048 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.048 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.048 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.048 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.048 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.048 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.048 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.048 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.048 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.048 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.048 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.048 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.048 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.048 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.048 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.048 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.048 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.048 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.048 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.048 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.048 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.048 | 0.5 | 0.5 |
Onchocerca volvulus | 0.048 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.048 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.048 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.048 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.048 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.048 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.048 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.048 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.048 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.048 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.048 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.048 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.048 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 9.7 % | Cell cycle arrest in SW48 cells by accumulation at S phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 9.7 % | Cell cycle arrest in SW48 cells by accumulation at S phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 14.7 % | Cell cycle arrest in SW480 cells by accumulation at G2/M phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 14.7 % | Cell cycle arrest in SW480 cells by accumulation at G2/M phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 17.4 % | Cell cycle arrest in HCT116 cells by accumulation at S phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 17.4 % | Cell cycle arrest in HCT116 cells by accumulation at S phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 29.3 % | Cell cycle arrest in HCT116 cells by accumulation at G2/M phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 29.3 % | Cell cycle arrest in HCT116 cells by accumulation at G2/M phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 32.4 % | Cell cycle arrest in SW48 cells by accumulation at G2/M phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 32.4 % | Cell cycle arrest in SW48 cells by accumulation at G2/M phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 33 % | Cell cycle arrest in SW480 cells by accumulation at S phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 33 % | Cell cycle arrest in SW480 cells by accumulation at S phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 52.3 % | Cell cycle arrest in SW480 cells by accumulation at G1 phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 52.3 % | Cell cycle arrest in SW480 cells by accumulation at G1 phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 53.3 % | Cell cycle arrest in HCT116 cells by accumulation at G1 phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 53.3 % | Cell cycle arrest in HCT116 cells by accumulation at G1 phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 57.4 % | Cell cycle arrest in SW48 cells by accumulation at G1 phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
Activity (functional) | = 57.4 % | Cell cycle arrest in SW48 cells by accumulation at G1 phase at 100 uM after 72 hrs | ChEMBL. | 17548198 |
IC50 (functional) | = 21.1 uM | Antiproliferative activity against human SW48 cells after 72 hrs | ChEMBL. | 17548198 |
IC50 (functional) | = 21.1 uM | Antiproliferative activity against human SW48 cells after 72 hrs | ChEMBL. | 17548198 |
IC50 (functional) | = 36.6 uM | Antiproliferative activity against human HCT116 cells after 72 hrs | ChEMBL. | 17548198 |
IC50 (functional) | = 36.6 uM | Antiproliferative activity against human HCT116 cells after 72 hrs | ChEMBL. | 17548198 |
IC50 (functional) | = 58 uM | Antiproliferative activity against human MCF7 cells after 72 hrs | ChEMBL. | 17548198 |
IC50 (functional) | = 58 uM | Antiproliferative activity against human MCF7 cells after 72 hrs | ChEMBL. | 17548198 |
IC50 (functional) | = 63.1 uM | Antiproliferative activity against human SW480 cells after 72 hrs | ChEMBL. | 17548198 |
IC50 (functional) | = 63.1 uM | Antiproliferative activity against human SW480 cells after 72 hrs | ChEMBL. | 17548198 |
IC50 (functional) | = 65 uM | Antiproliferative activity against human Mes-sa cells after 72 hrs | ChEMBL. | 17548198 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.