Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0287 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5511 | 0.5511 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0048 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0287 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0287 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0048 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0287 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0048 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0186 | 0.5768 | 0.5768 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.5768 | 0.5768 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0048 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0287 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 1 nM | Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor | ChEMBL. | 17944454 |
IC50 (binding) | = 6.54 nM | Inhibition of human Acetylcholinesterase | ChEMBL. | 17944454 |
IC50 (binding) | = 26.5 nM | Inhibition of human butyrylcholinesterase | ChEMBL. | 17944454 |
IC50 (binding) | = 90 nM | Inhibition of Electrophorus electricus Acetylcholinesterase | ChEMBL. | 17944454 |
IC50 (binding) | = 334 nM | Inhibition of Torpedo californica Acetylcholinesterase | ChEMBL. | 17944454 |
Log EC50 (binding) | = 8.99 | Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor | ChEMBL. | 17944454 |
Ratio IC50 (binding) | = 0.3 | Selectivity for human butyrylcholinesterase over human butyrylcholinesterase | ChEMBL. | 17944454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.