TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.307 | Formula: C16H14N4O3
H donors: 3 H acceptors: 3 LogP: 1.5 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CC1=NNC(=O)C1)N/N=C/c1c(O)ccc2c1cccc2
InChi: 1S/C16H14N4O3/c21-14-6-5-10-3-1-2-4-12(10)13(14)9-17-19-15(22)7-11-8-16(23)20-18-11/h1-6,9,21H,7-8H2,(H,19,22)(H,20,23)/b17-9+
InChiKey: VBTFPTJIZCLIGC-RQZCQDPDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	neuropeptide receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Schistosoma mansoni	biogenic amine receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus multilocularis	fmrfamide receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	G-protein coupled receptor	0.0033	0.3182	0.2953
Echinococcus granulosus	neuropeptide receptor A26	0.0033	0.3182	0.3105
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.3182	0.3105
Loa Loa (eye worm)	neuropeptide F receptor	0.0033	0.3182	0.2953
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0033	0.3182	0.2953
Echinococcus multilocularis	serotonin receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.3182	0.3105
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.3182	0.3105
Echinococcus multilocularis	dro:myosuppressin receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Onchocerca volvulus		0.0033	0.3182	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0033	0.3182	0.3105
Brugia malayi	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.3182	0.3105
Echinococcus granulosus	7TM GPCR rhodopsin	0.0033	0.3182	0.3105
Echinococcus granulosus	g protein coupled receptor	0.0033	0.3182	0.3105
Onchocerca volvulus		0.0033	0.3182	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0033	0.3182	0.3105
Chlamydia trachomatis	glutamine binding protein	0.0018	0	0.5
Onchocerca volvulus		0.0033	0.3182	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Echinococcus granulosus	sex peptide receptor	0.0033	0.3182	0.3105
Echinococcus granulosus	g-protein coupled receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.3182	0.3105
Loa Loa (eye worm)	CYP4Cod1	0.003	0.2547	0.2296
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.002	0.0326	1
Trypanosoma cruzi	cytochrome P450, putative	0.003	0.2547	1
Brugia malayi	AKH receptor	0.0033	0.3182	0.2953
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.002	0.0326	0.128
Echinococcus granulosus	hypothetical protein	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0033	0.3182	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0033	0.3182	0.3105
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.002	0.0326	0.128
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0033	0.3182	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0033	0.3182	0.2953
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Brugia malayi	hypothetical protein	0.0033	0.3182	0.2953
Schistosoma mansoni	neuropeptide receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	Cytochrome P450 family protein	0.003	0.2547	0.2296
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0039	0.4576	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0033	0.3182	0.3105
Brugia malayi	ORL1-like opioid receptor	0.0033	0.3182	0.2953
Echinococcus multilocularis	somatostatin receptor	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.002	0.0326	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.002	0.0326	0.128
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.002	0.0326	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0061	0.9526	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	follicle stimulating hormone receptor	0.0033	0.3182	0.2953
Brugia malayi	hypothetical protein	0.0033	0.3182	0.2953
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.3182	0.3105
Schistosoma mansoni	hypothetical protein	0.0033	0.3182	0.3105
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	neuropeptide receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Brugia malayi	hypothetical protein	0.0033	0.3182	0.2953
Onchocerca volvulus		0.0033	0.3182	0.5
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0061	0.9526	1
Onchocerca volvulus		0.0033	0.3182	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.003	0.2547	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0033	0.3182	0.3105
Brugia malayi	GnHR receptor homolog	0.0033	0.3182	0.2953
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0039	0.4576	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0033	0.3182	0.2953
Brugia malayi	larval opioid receptor	0.0033	0.3182	0.2953
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0033	0.3182	0.3105
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0033	0.3182	0.2953
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.002	0.0326	0.128
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Onchocerca volvulus		0.0033	0.3182	0.5
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0041	0.5191	0.5029
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	g-protein coupled receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	G protein-coupled receptor	0.0033	0.3182	0.2953
Echinococcus multilocularis	neuropeptide receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	allatostatin A receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	glutamate receptor NMDA	0.0061	0.9526	1
Onchocerca volvulus		0.0033	0.3182	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0033	0.3182	0.3105
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.3182	0.3105
Onchocerca volvulus		0.0033	0.3182	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	Dopamine receptor protein 1	0.0033	0.3182	0.2953
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.002	0.0326	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.3182	0.3105
Schistosoma mansoni	opsin-like receptor	0.0033	0.3182	0.3105
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.002	0.0326	0.128
Brugia malayi	G protein-coupled receptor F59B2.13	0.0033	0.3182	0.2953
Schistosoma mansoni	neuropeptide receptor	0.0033	0.3182	0.3105
Echinococcus granulosus	orexin receptor type 2	0.0033	0.3182	0.3105
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.002	0.0326	0.128
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0018	0	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0033	0.3182	0.3105
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.002	0.0326	0.128
Echinococcus granulosus	g protein coupled receptor	0.0033	0.3182	0.3105
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Trypanosoma brucei	cytochrome P450, putative	0.003	0.2547	1
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.605	0.6222
Schistosoma mansoni	hypothetical protein	0.0033	0.3182	0.3105
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0033	0.3182	0.3105
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0033	0.3182	0.3105
Brugia malayi	Dopamine receptor protein 2	0.0033	0.3182	0.2953
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0041	0.5191	0.5288
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.002	0.0326	0.128
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Schistosoma mansoni	amine GPCR	0.0033	0.3182	0.3105
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	hypothetical protein	0.0033	0.3182	0.2953
Loa Loa (eye worm)	G-protein coupled receptor	0.0033	0.3182	0.2953
Echinococcus multilocularis	g protein coupled receptor	0.0033	0.3182	0.3105
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0033	0.3182	0.2953
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0033	0.3182	0.2953
Brugia malayi	G-protein coupled receptor	0.0033	0.3182	0.2953
Onchocerca volvulus		0.0033	0.3182	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	Serotonin receptor	0.0033	0.3182	0.2953
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.002	0.0326	1
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.002	0.0326	0.128
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0018	0	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Onchocerca volvulus		0.0033	0.3182	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.002	0.0326	0.128
Echinococcus granulosus	neuropeptide FF receptor 2	0.0033	0.3182	0.3105
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0033	0.3182	0.3105
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0041	0.5191	0.5288
Echinococcus granulosus	dro:myosuppressin receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus granulosus	allatostatin A receptor	0.0033	0.3182	0.3105
Echinococcus granulosus	nmda type glutamate receptor	0.0026	0.1623	0.141
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0018	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	orexin receptor type 2	0.0033	0.3182	0.3105
Schistosoma mansoni	amine GPCR	0.0033	0.3182	0.3105
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.2547	0.2296
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.002	0.0326	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.002	0.0326	0.128
Brugia malayi	neuropeptide F receptor	0.0033	0.3182	0.2953
Echinococcus multilocularis	serotonin receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.002	0.0326	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0033	0.3182	0.2953
Schistosoma mansoni	adenoreceptor	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.002	0.0326	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0033	0.3182	0.3105
Echinococcus granulosus	serotonin receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	amine GPCR	0.0033	0.3182	0.3105
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.605	0.6222
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0033	0.3182	0.3105
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0033	0.3182	0.2953
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0033	0.3182	0.3105
Echinococcus granulosus	neuropeptide Y receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	neuropeptide Y receptor	0.0033	0.3182	0.3105
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.002	0.0326	0.128
Echinococcus granulosus	7tm_1 domain containing protein	0.0033	0.3182	0.3105
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	amine GPCR	0.0033	0.3182	0.3105
Onchocerca volvulus		0.0033	0.3182	0.5
Brugia malayi	RE15519p	0.0033	0.3182	0.2953
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.2547	0.2296
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0033	0.3182	0.3105
Onchocerca volvulus		0.0033	0.3182	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus granulosus	neuropeptides capa receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0033	0.3182	0.3105
Echinococcus multilocularis	neuropeptides capa receptor	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.002	0.0326	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus multilocularis	neuropeptide Y receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	neuropeptide F-like receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	biogenic amine receptor	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Mycobacterium leprae	putative cytochrome p450	0.002	0.0326	0.5
Echinococcus granulosus	neuropeptide receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0026	0.1623	0.141
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0033	0.3182	0.3105
Onchocerca volvulus		0.0033	0.3182	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.002	0.0326	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.3182	0.3105
Schistosoma mansoni	histamine h1 receptor	0.0033	0.3182	0.3105
Mycobacterium leprae	Conserved hypothetical protein	0.002	0.0326	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	putative neuropeptide receptor	0.0033	0.3182	0.2953
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0033	0.3182	0.2953
Loa Loa (eye worm)	TYRA-2 protein	0.0033	0.3182	0.2953
Schistosoma mansoni	myosin xvIII	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus granulosus	neuropeptides capa receptor	0.0033	0.3182	0.3105
Brugia malayi	hypothetical protein	0.0033	0.3182	0.2953
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.002	0.0326	0.128
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0041	0.5191	0.5029
Schistosoma mansoni	growth hormone secretagogue receptor	0.0033	0.3182	0.3105
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.002	0.0326	0.128
Onchocerca volvulus		0.0033	0.3182	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	putative neuropeptide receptor NPR1	0.0033	0.3182	0.2953
Echinococcus granulosus	biogenic amine 5HT receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0033	0.3182	0.3105
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0033	0.3182	0.2953
Echinococcus multilocularis	neuropeptide receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	sex peptide receptor	0.0033	0.3182	0.3105
Brugia malayi	Cytochrome P450 family protein	0.003	0.2547	0.2296
Brugia malayi	Dopamine receptor	0.0033	0.3182	0.2953
Onchocerca volvulus		0.0033	0.3182	0.5
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.002	0.0326	0.128
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.3182	0.3105
Brugia malayi	neuropeptide F receptor	0.0033	0.3182	0.2953
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.002	0.0326	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Schistosoma mansoni	neuropeptide F-like receptor	0.0033	0.3182	0.3105
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0033	0.3182	0.3105
Echinococcus granulosus	neuropeptide s receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0033	0.3182	0.3105
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.002	0.0326	0.128
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	neuropeptides capa receptor	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.002	0.0326	1
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.002	0.0326	0.128
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0033	0.3182	0.2953
Brugia malayi	hypothetical protein	0.0033	0.3182	0.2953
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus multilocularis	nmda type glutamate receptor	0.0026	0.1623	0.141
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.002	0.0326	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Brugia malayi	Serotonin receptor	0.0033	0.3182	0.2953
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Schistosoma mansoni	amine GPCR	0.0033	0.3182	0.3105
Brugia malayi	G-protein coupled receptor	0.0033	0.3182	0.2953
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.002	0.0326	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0033	0.3182	0.3105
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.002	0.0326	0.128
Echinococcus granulosus	g protein coupled receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0033	0.3182	0.3105
Echinococcus granulosus	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.002	0.0326	0.128
Schistosoma mansoni	hypothetical protein	0.0033	0.3182	0.3105
Leishmania major	cytochrome p450-like protein	0.003	0.2547	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0063	1	1
Brugia malayi	hypothetical protein	0.0033	0.3182	0.2953
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.002	0.0326	1
Toxoplasma gondii	cytochrome p450 superfamily protein	0.002	0.0326	0.5
Echinococcus granulosus	fmrfamide receptor	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.002	0.0326	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.002	0.0326	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus multilocularis	G protein coupled receptor 139	0.0033	0.3182	0.3105
Echinococcus multilocularis	neuropeptide receptor A26	0.0033	0.3182	0.3105
Schistosoma mansoni	hypothetical protein	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0036	0.3956	0.3753
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0033	0.3182	0.3105
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0033	0.3182	0.3105
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0033	0.3182	0.3105
Echinococcus granulosus	biogenic amine 5HT receptor	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.002	0.0326	1
Echinococcus granulosus	somatostatin receptor	0.0033	0.3182	0.3105
Schistosoma mansoni	opsin-like receptor	0.0033	0.3182	0.3105
Echinococcus granulosus	neuropeptide receptor	0.0033	0.3182	0.3105
Trypanosoma cruzi	cytochrome P450, putative	0.003	0.2547	1
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.002	0.0326	0.128
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.002	0.0326	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Onchocerca volvulus		0.0033	0.3182	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0033	0.3182	0.2953
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Echinococcus granulosus	G protein coupled receptor 139	0.0033	0.3182	0.3105
Schistosoma mansoni	opsin-like receptor	0.0033	0.3182	0.3105
Onchocerca volvulus		0.0033	0.3182	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0033	0.3182	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0033	0.3182	0.2953
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0033	0.3182	0.2953
Brugia malayi	Melatonin receptor type 1A	0.0033	0.3182	0.2953
Echinococcus multilocularis	neuropeptide s receptor	0.0033	0.3182	0.3105
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.002	0.0326	1
Brugia malayi	sulfakinin receptor protein	0.0033	0.3182	0.2953

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 23 %	Inhibition of ovine AANAT at 100 uM by alphaKD-coupled spectrophotometric assay	ChEMBL.	17924613
Inhibition (binding)	= 23 %	Inhibition of ovine AANAT at 100 uM by alphaKD-coupled spectrophotometric assay	ChEMBL.	17924613
Inhibition (binding)	= 50 %	Inhibition of ovine AANAT at 100 uM by spectrophotometric assay	ChEMBL.	17924613
Inhibition (binding)	= 50 %	Inhibition of ovine AANAT at 100 uM by spectrophotometric assay	ChEMBL.	17924613

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL396665

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 448572