Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.1 nM | Inhibition of cholesterol synthesis in rat liver hepatocytes after 4 hrs | ChEMBL. | 17560788 |
IC50 (binding) | = 4.8 nM | Inhibition of rat microsomal HMG-CoA reductase assessed as inhibition of cholesterol synthesis after 30 mins | ChEMBL. | 17560788 |
IC50 (binding) | = 4.8 nM | Inhibition of rat microsomal HMG-CoA reductase assessed as inhibition of cholesterol synthesis after 30 mins | ChEMBL. | 17560788 |
IC50 (functional) | = 1730 nM | Inhibition of cholesterol synthesis in rat L6 cells after 3 hrs | ChEMBL. | 17560788 |
Inhibition (functional) | = -72 % | Inhibition of cholesterol synthesis in C57/BL6 mouse at 30 mg/kg, po by MAICS assay | ChEMBL. | 17560788 |
Inhibition (functional) | = -72 % | Inhibition of cholesterol synthesis in C57/BL6 mouse at 30 mg/kg, po by MAICS assay | ChEMBL. | 17560788 |
Ratio IC50 (functional) | = 824 | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for rat hepatocytes | ChEMBL. | 17560788 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.