Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0648 | 0.0648 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.1441 | 0.8652 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.3647 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0118 | 0.0044 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0066 | 0.1403 | 0.1403 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0445 | 1 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0068 | 0.1441 | 0.1377 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.1242 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1657 | 1 |
Echinococcus multilocularis | protein patched | 0.0068 | 0.1441 | 0.1377 |
Schistosoma mansoni | patched 1 | 0.0068 | 0.1441 | 0.1441 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.1441 | 0.1377 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.1441 | 0.1377 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0118 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.3647 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1657 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0648 | 0.0578 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0068 | 0.1441 | 0.1377 |
Echinococcus multilocularis | protein dispatched 1 | 0.0068 | 0.1441 | 0.1377 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.3647 | 0.3599 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1657 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1441 | 0.3751 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.1657 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0648 | 0.0648 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.3647 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0608 | 0.0608 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.0608 | 0.1388 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.3647 | 0.3599 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0068 | 0.1441 | 0.1441 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.1441 | 0.3751 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.3647 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.0608 | 0.5 | |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.3647 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0445 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.3647 | 0.3647 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.1441 | 0.3756 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.3647 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0648 | 0.0578 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0068 | 0.1441 | 0.1377 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.3647 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.0608 | 0.1395 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.17 nM | Inhibition of cholesterol synthesis in rat liver hepatocytes after 4 hrs | ChEMBL. | 17560788 |
IC50 (binding) | = 2.4 nM | Inhibition of rat microsomal HMG-CoA reductase assessed as inhibition of cholesterol synthesis after 30 mins | ChEMBL. | 17560788 |
IC50 (binding) | = 2.4 nM | Inhibition of rat microsomal HMG-CoA reductase assessed as inhibition of cholesterol synthesis after 30 mins | ChEMBL. | 17560788 |
IC50 (functional) | = 28 nM | Inhibition of cholesterol synthesis in rat L6 cells after 3 hrs | ChEMBL. | 17560788 |
Inhibition (functional) | Inhibition of cholesterol synthesis in C57/BL6 mouse at 30 mg/kg, po by MAICS assay | ChEMBL. | 17560788 | |
Inhibition (functional) | 0 | Inhibition of cholesterol synthesis in C57/BL6 mouse at 30 mg/kg, po by MAICS assay | ChEMBL. | 17560788 |
Ratio IC50 (functional) | = 165 | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for rat hepatocytes | ChEMBL. | 17560788 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.