Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0116 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0116 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0116 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0116 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0116 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0116 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0116 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0116 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0116 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0116 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0116 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0116 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0116 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0116 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0116 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0116 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0116 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0116 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0116 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0116 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0116 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0116 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0116 | 1 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0116 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.0116 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0116 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0116 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0116 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0116 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0116 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0116 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0116 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0116 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0116 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0116 | 1 | 0.5 |
Leishmania major | prostaglandin f synthase, putative | 0.0116 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0116 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0116 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0116 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0116 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0116 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0116 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0116 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0116 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0116 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0116 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0116 | 1 | 1 |
Onchocerca volvulus | 0.0116 | 1 | 0.5 | |
Onchocerca volvulus | 0.0116 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0116 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0116 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0116 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0116 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0116 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0116 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0116 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0116 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0116 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0116 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0116 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0116 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0116 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0116 | 1 | 1 |
Onchocerca volvulus | 0.0116 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25.2 uM | Inhibition of ovine AANAT by spectrophotometric assay | ChEMBL. | 17924613 |
IC50 (binding) | = 25.2 uM | Inhibition of ovine AANAT by spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 54 % | Inhibition of ovine AANAT at 100 uM in presence of Triton X-100 by spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 54 % | Inhibition of ovine AANAT at 100 uM in presence of Triton X-100 by spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 84 % | Inhibition of ovine AANAT at 100 uM by spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 84 % | Inhibition of ovine AANAT at 100 uM by spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 98 % | Inhibition of ovine AANAT at 100 uM by alphaKD-coupled spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 98 % | Inhibition of ovine AANAT at 100 uM by alphaKD-coupled spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 99 % | Inhibition of ovine AANAT at 100 uM by TLC-based radioactive assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 99 % | Inhibition of ovine AANAT at 100 uM by TLC-based radioactive assay | ChEMBL. | 17924613 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.