Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0356 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.022 | 0.2407 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0177 | 0 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0356 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0315 | 0.7743 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0356 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0356 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0315 | 0.7743 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0356 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0177 | 0 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0356 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0356 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0356 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0356 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0356 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0356 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0356 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0356 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.022 | 0.2407 | 0.2407 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0356 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0356 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0356 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0356 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0356 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0356 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0356 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0179 | 0.0151 | 0.0151 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0356 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Induction of neurite outgrowth in Long-Evans rat E18/19 cortical neurons after 72 hrs | ChEMBL. | 18038971 |
Kd (binding) | = 426 uM | Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry | ChEMBL. | 18038971 |
Kd (binding) | = 426 uM | Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry | ChEMBL. | 18038971 |
t1/2 (ADMET) | > 60 min | Metabolic stability in human liver microsomes | ChEMBL. | 18038971 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.