Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | p450 reductase, putative | 0.0689 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0689 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0689 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0689 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0689 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0689 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0342 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0689 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0689 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0689 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0611 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0689 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0689 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0611 | 0.7743 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0426 | 0.2407 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0342 | 0 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0689 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0689 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0689 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0347 | 0.0151 | 0.0151 |
Brugia malayi | FAD binding domain containing protein | 0.0689 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0689 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0689 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0689 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0426 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0689 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0689 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0689 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0689 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Induction of neurite outgrowth in Long-Evans rat E18/19 cortical neurons after 72 hrs | ChEMBL. | 18038971 |
Kd (binding) | = 1285 uM | Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry | ChEMBL. | 18038971 |
Kd (binding) | = 1285 uM | Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry | ChEMBL. | 18038971 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.