TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 299.227 | Formula: C14H21BrNO-
H donors: 2 H acceptors: 1 LogP: 4.08 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCCNC1CCc2c(C1)ccc(c2)O.[Br-]
InChi: 1S/C14H21NO.BrH/c1-2-3-8-15-13-6-4-12-10-14(16)7-5-11(12)9-13;/h5,7,10,13,15-16H,2-4,6,8-9H2,1H3;1H/p-1
InChiKey: OMNZXJYUHBOIIY-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0126	0.0152
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0842	0.0842
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0142	0.1435	0.1435
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0842	0.1013
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0301	0.3308	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0142	0.1435	0.4113
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0301	0.3308	0.398
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0306	0.0843
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0301	0.3308	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0373	0.1129
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0301	0.3308	0.3308
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0489	0.1478
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1635	0.4944
Plasmodium falciparum	LCCL domain-containing protein	0.026	0.2815	1
Brugia malayi	TAR-binding protein	0.0062	0.0489	0.1478
Brugia malayi	hypothetical protein	0.026	0.2815	0.8511
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0301	0.3308	0.398
Trichomonas vaginalis	set domain proteins, putative	0.0246	0.265	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0301	0.3308	0.398
Brugia malayi	nuclear hormone receptor family member odr-7	0.0142	0.1435	0.4338
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0301	0.3308	1
Onchocerca volvulus		0.0246	0.265	0.7933
Brugia malayi	nuclear hormone receptor	0.0142	0.1435	0.4338
Leishmania major	hypothetical protein, conserved	0.0069	0.0572	0.1578
Schistosoma mansoni	nuclear receptor nhr-48	0.0142	0.1435	0.1727
Onchocerca volvulus		0.0301	0.3308	1
Brugia malayi	ecdysone receptor	0.0142	0.1435	0.4338
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0159	0.1635	0.1968
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0301	0.3308	1
Loa Loa (eye worm)	doublecortin family protein	0.026	0.2815	0.8511
Onchocerca volvulus	Protein ultraspiracle homolog	0.0301	0.3308	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0126	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0301	0.3308	1
Onchocerca volvulus	Bile acid receptor homolog	0.0301	0.3308	1
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0069	0.0572	0.1578
Toxoplasma gondii	Erv1 / Alr family protein	0.0069	0.0572	1
Schistosoma mansoni	loxhd1	0.026	0.2815	0.3388
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0489	0.1478
Schistosoma mansoni	lipoxygenase	0.026	0.2815	0.3388
Echinococcus granulosus	lipoxygenase domain containing protein	0.026	0.2815	0.3388
Brugia malayi	nuclear hormone receptor	0.0301	0.3308	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0301	0.3308	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0159	0.1635	0.1968
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0301	0.3308	0.3308
Schistosoma mansoni	RAR-like nuclear receptor	0.0301	0.3308	0.398
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1635	0.4944
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0842	0.1013
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0142	0.1435	0.4338
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0142	0.1435	0.1435
Schistosoma mansoni	hypothetical protein	0.0036	0.018	0.0217
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0301	0.3308	0.398
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Brugia malayi	hypothetical protein	0.0142	0.1435	0.4338
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0489	0.0588
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0301	0.3308	1
Schistosoma mansoni	zinc finger protein	0.0142	0.1435	0.1727
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0301	0.3308	0.398
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0301	0.3308	0.398
Brugia malayi	RNA binding protein	0.0062	0.0489	0.1478
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Loa Loa (eye worm)	DR-78	0.0142	0.1435	0.4338
Brugia malayi	hypothetical protein	0.0159	0.1635	0.4944
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1635	0.4944
Echinococcus multilocularis	RUN	0.026	0.2815	0.2815
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0159	0.1635	0.4944
Brugia malayi	Doublecortin family protein	0.026	0.2815	0.8511
Loa Loa (eye worm)	hypothetical protein	0.0036	0.018	0.0545
Echinococcus granulosus	Polycystic kidney disease protein	0.026	0.2815	0.3388
Brugia malayi	Steroid receptor seven-up type 2	0.0301	0.3308	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0489	0.0588
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0301	0.3308	0.398
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0727	0.831	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0301	0.3308	0.398
Brugia malayi	nuclear receptor NHR-88	0.0301	0.3308	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0373	0.1129
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0126	0.0126
Brugia malayi	Nuclear hormone receptor-like 1	0.0159	0.1635	0.4944
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0173	0.1798	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0142	0.1435	0.1727
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0306	0.0843
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0842	0.1013
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0126	0.0152
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0301	0.3308	0.3308
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0155	0.1591	0.4388
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0155	0.1591	0.4388
Brugia malayi	Nuclear hormone receptor E75	0.0142	0.1435	0.4338
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0301	0.3308	0.398
Onchocerca volvulus		0.026	0.2815	0.8452
Brugia malayi	nuclear receptor RXR	0.0142	0.1435	0.4338
Schistosoma mansoni	hypothetical protein	0.026	0.2815	0.3388
Echinococcus multilocularis	nuclear receptor nhr 48	0.0142	0.1435	0.1435
Echinococcus granulosus	neuropeptide receptor	0.0116	0.1121	0.1349
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0373	0.1129
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0306	0.0843
Schistosoma mansoni	nuclear receptor	0.0142	0.1435	0.1727
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0373	0.1129
Brugia malayi	orphan nuclear receptor NR2E1	0.0142	0.1435	0.4338
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.0842	0.2546
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0126	0.0152
Schistosoma mansoni	neuropeptide receptor	0.0116	0.1121	0.1349
Brugia malayi	Pre-SET motif family protein	0.0031	0.0126	0.0382
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0069	0.0572	0.2032
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0056	0.0425	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0126	0.0382
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0329	0.3627	1
Brugia malayi	hypothetical protein	0.026	0.2815	0.8511
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0301	0.3308	0.398
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0842	0.1013
Brugia malayi	photoreceptor-specific nuclear receptor	0.0301	0.3308	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0159	0.1635	0.1968
Brugia malayi	tailless protein	0.0142	0.1435	0.4338
Brugia malayi	Nuclear hormone receptor-like 1	0.0159	0.1635	0.4944
Echinococcus multilocularis	lipoxygenase domain containing protein	0.026	0.2815	0.2815
Loa Loa (eye worm)	hypothetical protein	0.026	0.2815	0.8511
Echinococcus granulosus	FTZ F1 alpha	0.0301	0.3308	0.398
Loa Loa (eye worm)	hypothetical protein	0.0301	0.3308	1
Brugia malayi	steroid hormone receptor	0.0301	0.3308	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0301	0.3308	0.398
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0155	0.1591	0.4388
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.018	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0301	0.3308	0.3308
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0301	0.3308	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0159	0.1635	0.1635
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0301	0.3308	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0301	0.3308	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0301	0.3308	1
Schistosoma mansoni	nuclear hormone receptor	0.0142	0.1435	0.1727
Schistosoma mansoni	lipoxygenase	0.0727	0.831	1
Loa Loa (eye worm)	hypothetical protein	0.0301	0.3308	1
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0069	0.0572	0.1578
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0301	0.3308	0.398
Brugia malayi	nuclear receptor NHR-88	0.0142	0.1435	0.4338
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0069	0.0572	0.0572
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0126	0.0152
Toxoplasma gondii	hypothetical protein	0.0053	0.0386	0.6743
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Brugia malayi	Augmenter of liver regeneration	0.0069	0.0572	0.173
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0301	0.3308	1
Loa Loa (eye worm)	hypothetical protein	0.0301	0.3308	1
Brugia malayi	nuclear receptor NHR-67	0.0142	0.1435	0.4338
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0301	0.3308	1
Schistosoma mansoni	rab6-interacting	0.026	0.2815	0.3388
Mycobacterium ulcerans	hypothetical protein	0.0173	0.1798	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0301	0.3308	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.0842	0.2546
Onchocerca volvulus		0.026	0.2815	0.8452
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0301	0.3308	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0142	0.1435	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Loa Loa (eye worm)	hypothetical protein	0.026	0.2815	0.8511
Loa Loa (eye worm)	hypothetical protein	0.0301	0.3308	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0142	0.1435	0.1727
Schistosoma mansoni	polycystin 1-related	0.026	0.2815	0.3388
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0301	0.3308	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0142	0.1435	0.1435
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0142	0.1435	0.1727
Loa Loa (eye worm)	nuclear hormone receptor	0.0142	0.1435	0.4338
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0301	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Loa Loa (eye worm)	steroid hormone receptor	0.0301	0.3308	1
Schistosoma mansoni	nuclear hormone receptor	0.0301	0.3308	0.398
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0329	0.3627	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.026	0.2815	0.3388
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0301	0.3308	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0727	0.831	0.831
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0489	0.1478
Echinococcus granulosus	nuclear receptor nhr 48	0.0142	0.1435	0.1727
Brugia malayi	hypothetical protein	0.0159	0.1635	0.4944
Echinococcus multilocularis	neuropeptide receptor	0.0116	0.1121	0.1121
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0142	0.1435	0.1435
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0301	0.3308	0.398
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0142	0.1435	0.1727
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0489	0.0588
Plasmodium vivax	SET domain protein, putative	0.0031	0.0126	0.0449
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0301	0.3308	0.3308
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0126	0.221
Echinococcus granulosus	RUN	0.026	0.2815	0.3388
Loa Loa (eye worm)	hypothetical protein	0.0301	0.3308	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0306	0.0843
Brugia malayi	conserved hypotetical protein	0.0142	0.1435	0.4338
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0069	0.0572	0.2032
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1635	0.4944
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0301	0.3308	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0842	0.1013
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0142	0.1435	0.4338
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0489	0.0489
Schistosoma mansoni	coup transcription factor	0.0301	0.3308	0.398
Onchocerca volvulus		0.0142	0.1435	0.4113
Brugia malayi	nuclear receptor RXR	0.0159	0.1635	0.4944
Echinococcus multilocularis	lipoxygenase domain containing protein	0.026	0.2815	0.2815
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0069	0.0572	0.1578
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0301	0.3308	0.398
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0301	0.3308	0.3308
Leishmania major	mitochondrial DNA polymerase beta	0.0329	0.3627	1
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0069	0.0572	0.1578
Onchocerca volvulus		0.0142	0.1435	0.4113
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0489	0.0588
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0142	0.1435	0.4113
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0329	0.3627	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0301	0.3308	0.398
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0113	0.0136
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0142	0.1435	0.1727
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0489	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0301	0.3308	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0301	0.3308	0.3308
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0142	0.1435	0.1727
Schistosoma mansoni	rab6-interacting	0.026	0.2815	0.3388
Schistosoma mansoni	nuclear receptor	0.0142	0.1435	0.1727
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0301	0.3308	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0301	0.3308	0.398
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0301	0.3308	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0142	0.1435	0.1727
Brugia malayi	Nuclear hormone receptor-like 1	0.0301	0.3308	1
Brugia malayi	ecdysteroid receptor	0.0301	0.3308	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0216	0.23	0.6952
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0842	0.0842
Schistosoma mansoni	nuclear hormone receptor	0.0142	0.1435	0.1727
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0301	0.3308	1
Brugia malayi	hypothetical protein	0.0142	0.1435	0.4338
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0142	0.1435	0.1435
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1635	0.4944
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1435	0.4338
Schistosoma mansoni	thyroid hormone receptor	0.0301	0.3308	0.398
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0126	0.0152
Brugia malayi	Pre-SET motif family protein	0.0216	0.23	0.6952
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0489	0.0588
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0	0.5
Plasmodium vivax	multidomain scavenger receptor, putative	0.026	0.2815	1
Loa Loa (eye worm)	hepatopoietin HPO2	0.0069	0.0572	0.173
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0301	0.3308	1
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0069	0.0572	0.0688
Echinococcus multilocularis	Polycystic kidney disease protein	0.026	0.2815	0.2815
Loa Loa (eye worm)	hypothetical protein	0.0301	0.3308	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0489	0.1478
Toxoplasma gondii	Erv1 / Alr family protein	0.0069	0.0572	1
Brugia malayi	Nuclear hormone receptor E75	0.0142	0.1435	0.4338
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0142	0.1435	0.4338
Echinococcus multilocularis	G protein coupled receptor 139	0.0116	0.1121	0.1121
Echinococcus multilocularis	FTZ F1 alpha	0.0301	0.3308	0.3308
Schistosoma mansoni	thyroid hormone receptor	0.0301	0.3308	0.398

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	> 64 umol/L	Antifungal activity against Candida albicans after 24 hrs	ChEMBL.	17900179
MIC (functional)	> 64 umol/L	Antifungal activity against Candida parapsilosis after 24 hrs	ChEMBL.	17900179
MIC (functional)	> 64 umol/L	Antifungal activity against Cryptococcus neoformans after 72 hrs	ChEMBL.	17900179
MIC (functional)	= 64 umol/L	Antifungal activity against Trichophyton rubrum	ChEMBL.	17900179
MIC (functional)	> 64 umol/L	Antifungal activity against Fonsecaea compacta	ChEMBL.	17900179
MIC (functional)	> 64 umol/L	Antifungal activity against Aspergillus fumigatus	ChEMBL.	17900179
MIC (functional)	> 64 umol/L	Antifungal activity against Microsporum gypseum	ChEMBL.	17900179

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 504174

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 449266