Detailed information for compound 449375

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 588.604 | Formula: C32H40BrN6-
  • H donors: 0 H acceptors: 0 LogP: 7.81 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: N=c1ncc(cn1CCCCCCCCCCCCn1cc(cnc1=N)c1ccccc1)c1ccccc1.[Br-]
  • InChi: 1S/C32H40N6.BrH/c33-31-35-23-29(27-17-11-9-12-18-27)25-37(31)21-15-7-5-3-1-2-4-6-8-16-22-38-26-30(24-36-32(38)34)28-19-13-10-14-20-28;/h9-14,17-20,23-26,33-34H,1-8,15-16,21-22H2;1H/p-1
  • InChiKey: HOAIAXHOKZKSMI-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0051 0.0172 0.0456
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0713 0.2089
Trypanosoma brucei beta tubulin 0.0574 0.333 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0038 0.009 0.0106
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0242 0.1322 0.393
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Trypanosoma cruzi epsilon tubulin, putative 0.0302 0.1686 0.5032
Trypanosoma cruzi tubulin delta chain 0.0131 0.0654 0.1912
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0252 0.0756
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0142 0.0363
Echinococcus granulosus heat shock protein 90 0.0065 0.0252 0.0696
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0671 0.065
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Echinococcus granulosus beta tubulin 0.0574 0.333 1
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0252 0.0696
Echinococcus multilocularis tubulin alpha chain 0.0413 0.2354 0.2338
Schistosoma mansoni tubulin subunit delta 0.0131 0.0654 0.1912
Mycobacterium leprae cell division protein FtsZ 0.0131 0.0654 1
Onchocerca volvulus 0.0171 0.0894 1
Echinococcus multilocularis chromobox protein 1 0.008 0.0344 0.0323
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0038 0.009 0.0207
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Brugia malayi Tubulin alpha-2 chain 0.0413 0.2354 0.277
Echinococcus granulosus tubulin alpha chain 0.0413 0.2354 0.7051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Leishmania major beta tubulin 0.0574 0.333 1
Toxoplasma gondii beta-1 tubulin, putative 0.0574 0.333 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0038 0.009 0.0207
Loa Loa (eye worm) endoplasmin 0.0065 0.0252 0.0296
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.0252 0.0499
Trichomonas vaginalis tubulin epsilon chain, putative 0.0574 0.333 1
Loa Loa (eye worm) alpha-tubulin 0.0413 0.2354 0.277
Giardia lamblia Heat shock protein HSP 90-alpha 0.0051 0.0172 0.0254
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0671 0.1962
Loa Loa (eye worm) tubulin beta-1 chain 0.0574 0.333 0.3918
Giardia lamblia Delta tubulin 0.0131 0.0654 0.174
Brugia malayi TAR-binding protein 0.0134 0.0671 0.0789
Giardia lamblia Epsilon tubulin 0.0131 0.0654 0.174
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0571 0.8737
Trichomonas vaginalis tubulin epsilon chain, putative 0.0574 0.333 1
Loa Loa (eye worm) BEN-1 protein 0.0574 0.333 0.3918
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Brugia malayi tubulin alpha-2 chain 0.0413 0.2354 0.277
Brugia malayi heat shock protein 90 0.0065 0.0252 0.0296
Schistosoma mansoni tubulin subunit alpha 0.0413 0.2354 0.7051
Trypanosoma brucei alpha tubulin 0.0413 0.2354 0.7051
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.009 0.0207
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Schistosoma mansoni endoplasmin 0.0065 0.0252 0.0696
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0252 0.0696
Trypanosoma brucei tubulin gamma chain 0.0302 0.1686 0.5032
Echinococcus multilocularis tubulin alpha chain 0.0413 0.2354 0.2338
Toxoplasma gondii thioredoxin reductase 0.0046 0.0142 0.0363
Echinococcus granulosus Tubulin alpha 1 chain 0.0413 0.2354 0.7051
Loa Loa (eye worm) tubulin alpha-2 chain 0.0413 0.2354 0.277
Schistosoma mansoni heat shock protein 0.0065 0.0252 0.0696
Leishmania major hypothetical protein, conserved 0.0038 0.009 0.0271
Treponema pallidum cell division protein FtsZ 0.0131 0.0654 1
Echinococcus granulosus heat shock protein 90 0.0051 0.0172 0.0456
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0038 0.009 0.0069
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0038 0.009 0.0207
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0038 0.009 0.0207
Leishmania major hypothetical protein, conserved 0.0038 0.009 0.0271
Echinococcus multilocularis Tubulin beta 2C chain 0.0574 0.333 0.3316
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major beta tubulin 0.0574 0.333 1
Loa Loa (eye worm) tubulin alpha 2 0.0282 0.1562 0.1838
Plasmodium vivax tubulin alpha chain, putative 0.0413 0.2354 0.7051
Brugia malayi Hsp90 protein 0.0026 0.0022 0.0025
Mycobacterium ulcerans heat shock protein 90 0.0051 0.0172 0.2636
Trypanosoma brucei alpha tubulin 0.0413 0.2354 0.7051
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0172 0.0456
Echinococcus granulosus Tubulin beta 2C chain 0.0574 0.333 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0713 0.2089
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Schistosoma mansoni tubulin subunit gamma 0.0302 0.1686 0.5032
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Schistosoma mansoni tubulin subunit beta 0.0131 0.0654 0.1912
Plasmodium falciparum tubulin epsilon chain, putative 0.0302 0.1686 0.5032
Trypanosoma cruzi epsilon tubulin, putative 0.0302 0.1686 0.5032
Loa Loa (eye worm) BEN-1 protein 0.0574 0.333 0.3918
Trypanosoma brucei alpha tubulin 0.0413 0.2354 0.7051
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0282 0.1562 0.4656
Echinococcus multilocularis beta tubulin 0.0574 0.333 0.3316
Echinococcus granulosus Tubulin beta 2C chain 0.0574 0.333 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0026 0.0022 0.0065
Echinococcus granulosus heat shock protein 0.0065 0.0252 0.0696
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0713 0.0838
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0142 0.2165
Brugia malayi Tubulin beta chain 0.0131 0.0654 0.077
Trichomonas vaginalis tubulin, putative 0.0574 0.333 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.05 0.7647
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.009 0.0207
Mycobacterium tuberculosis Probable reductase 0.0106 0.05 0.7647
Loa Loa (eye worm) heat shock protein 75 0.0026 0.0022 0.0025
Giardia lamblia Beta tubulin 0.0574 0.333 1
Giardia lamblia Grp94/Hsp90 0.0051 0.0172 0.0254
Echinococcus multilocularis chromobox protein 1 0.008 0.0344 0.0323
Toxoplasma gondii heat shock protein HSP90 0.0065 0.0252 0.0696
Echinococcus granulosus tar DNA binding protein 0.0134 0.0671 0.1962
Trichomonas vaginalis tubulin epsilon chain, putative 0.0413 0.2354 0.7051
Schistosoma mansoni chromobox protein 0.008 0.0344 0.0975
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Trypanosoma brucei heat shock protein, putative 0.0065 0.0252 0.0696
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0671 0.0789
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0142 0.0363
Echinococcus multilocularis heat shock protein 90 0.0051 0.0172 0.0151
Echinococcus granulosus Tubulin alpha 1 chain 0.0413 0.2354 0.7051
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0038 0.009 0.0069
Echinococcus granulosus tubulin alpha 1C chain 0.0413 0.2354 0.7051
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0252 0.0696
Echinococcus multilocularis Tubulin alpha 1 chain 0.0413 0.2354 0.2338
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0131 0.0654 0.1912
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0671 0.0789
Schistosoma mansoni tubulin subunit beta 0.0574 0.333 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Loa Loa (eye worm) tubulin alpha chain 0.0413 0.2354 0.277
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0671 0.0789
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0038 0.009 0.0207
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Trypanosoma brucei beta tubulin 0.0574 0.333 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major beta tubulin 0.0574 0.333 1
Plasmodium falciparum glutathione reductase 0.0046 0.0142 0.0363
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Trypanosoma brucei heat shock protein, putative 0.0065 0.0252 0.0696
Echinococcus multilocularis tubulin alpha 3 chain 0.0413 0.2354 0.2338
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0157 0.0184
Mycobacterium tuberculosis Cell division protein FtsZ 0.0131 0.0654 1
Echinococcus granulosus tubulin alpha 0.0302 0.1686 0.5032
Entamoeba histolytica tubulin gamma chain 0.0302 0.1686 0.5065
Trypanosoma brucei trypanothione reductase 0.0046 0.0142 0.0363
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Schistosoma mansoni hypothetical protein 0.0374 0.2123 0.635
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0571 0.8737
Schistosoma mansoni tubulin subunit beta 0.0574 0.333 1
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0172 0.0456
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Echinococcus multilocularis tubulin delta chain 0.0131 0.0654 0.0634
Trichomonas vaginalis heat shock protein, putative 0.004 0.0101 0.024
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Trichomonas vaginalis tubulin beta chain, putative 0.0574 0.333 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Echinococcus granulosus tubulin subunit beta 0.0574 0.333 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major beta tubulin 0.0574 0.333 1
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0153 0.0396
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0038 0.009 0.0207
Plasmodium vivax tubulin beta chain, putative 0.0574 0.333 1
Leishmania major trypanothione reductase 0.0046 0.0142 0.0425
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.05 0.7647
Schistosoma mansoni tubulin subunit beta 0.0574 0.333 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.009 0.0207
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Giardia lamblia Gamma tubulin 0.0302 0.1686 0.4927
Echinococcus multilocularis tubulin alpha 1C chain 0.0413 0.2354 0.2338
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.009 0.0207
Echinococcus granulosus geminin 0.0374 0.2123 0.635
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0142 0.012
Brugia malayi Cell division protein ftsZ 0.0131 0.0654 0.077
Trichomonas vaginalis tubulin gamma chain, putative 0.0302 0.1686 0.5032
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0038 0.009 0.0069
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Trichomonas vaginalis tubulin, putative 0.0131 0.0654 0.1912
Echinococcus multilocularis tubulin subunit beta 0.0574 0.333 0.3316
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0157 0.0184
Toxoplasma gondii beta-tubulin, putative 0.0574 0.333 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0106
Trichomonas vaginalis tubulin beta chain, putative 0.0413 0.2354 0.7051
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Brugia malayi Endoplasmin precursor 0.0065 0.0252 0.0296
Trypanosoma cruzi zeta tubulin, putative 0.0131 0.0654 0.1912
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0038 0.009 0.0207
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0671 0.1962
Loa Loa (eye worm) hypothetical protein 0.0045 0.0132 0.0155
Echinococcus multilocularis tubulin epsilon chain 0.0302 0.1686 0.1669
Echinococcus granulosus Tubulin beta 2C chain 0.0574 0.333 1
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0252 0.0696
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0132 0.0334
Echinococcus multilocularis heat shock protein 90 0.0065 0.0252 0.0231
Toxoplasma gondii alpha-tubulin I, putative 0.0413 0.2354 0.7051
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0671 0.1962
Loa Loa (eye worm) hypothetical protein 0.0282 0.1562 0.1838
Trichomonas vaginalis tubulin beta chain, putative 0.0413 0.2354 0.7051
Echinococcus multilocularis Tubulin alpha 1 chain 0.0413 0.2354 0.2338
Schistosoma mansoni heat shock protein 0.0065 0.0252 0.0696
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0038 0.009 0.0207
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0038 0.009 0.0207
Loa Loa (eye worm) hypothetical protein 0.0097 0.0449 0.0529
Plasmodium vivax delta tubulin, putative 0.0131 0.0654 0.1912
Entamoeba histolytica tubulin alpha-1 chain 0.0413 0.2354 0.707
Brugia malayi beta-tubulin, identical 0.0574 0.333 0.3918
Echinococcus granulosus alpha tubulin 0.0413 0.2354 0.7051
Loa Loa (eye worm) tubulin beta-2A chain 0.0574 0.333 0.3918
Leishmania major delta tubulin, putative 0.0131 0.0654 0.1964
Giardia lamblia Alpha-tubulin 0.0413 0.2354 0.6989
Trichomonas vaginalis tubulin beta chain, putative 0.0413 0.2354 0.7051
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0571 0.8737
Loa Loa (eye worm) tubulin alpha 2 0.0111 0.053 0.0623
Echinococcus multilocularis Tubulin beta 2C chain 0.0574 0.333 0.3316
Trichomonas vaginalis heat shock protein, putative 0.0065 0.0252 0.0696
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Echinococcus granulosus Tubulin alpha 1 chain 0.0413 0.2354 0.7051
Echinococcus multilocularis tubulin alpha chain 0.0413 0.2354 0.2338
Plasmodium falciparum tubulin gamma chain 0.0302 0.1686 0.5032
Echinococcus multilocularis geminin 0.0374 0.2123 0.2106
Loa Loa (eye worm) tubulin gamma chain 0.0302 0.1686 0.1984
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0038 0.009 0.0271
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0051 0.0172 0.0518
Echinococcus granulosus tubulin gamma 1 chain 0.0302 0.1686 0.5032
Trypanosoma brucei beta tubulin 0.0574 0.333 1
Trichomonas vaginalis tubulin beta chain, putative 0.0413 0.2354 0.7051
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0092 0.0213
Leishmania major epsilon tubulin, putative 0.0302 0.1686 0.5065
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0038 0.009 0.0207
Trypanosoma cruzi zeta tubulin, putative 0.0131 0.0654 0.1912
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.009 0.0207
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0302 0.1686 0.5032
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0038 0.009 0.0207
Echinococcus multilocularis Tubulin beta 2C chain 0.0574 0.333 0.3316
Schistosoma mansoni chromobox protein 0.008 0.0344 0.0975
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Onchocerca volvulus 0.0035 0.0074 0.0824
Echinococcus granulosus tubulin alpha 3 chain 0.0413 0.2354 0.7051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0132 0.1477
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0038 0.009 0.0207
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.009 0.0207
Trypanosoma brucei epsilon tubulin 0.0302 0.1686 0.5032
Leishmania major beta tubulin 0.0574 0.333 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0171 0.0894 0.2638
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.05 0.7647
Schistosoma mansoni tubulin subunit alpha 0.0413 0.2354 0.7051
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.009 0.0207
Echinococcus granulosus tubulin alpha 1C chain 0.0413 0.2354 0.7051
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.009 0.0207
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.009 0.0207
Trichomonas vaginalis tubulin epsilon chain, putative 0.0131 0.0654 0.1912
Loa Loa (eye worm) hypothetical protein 0.0049 0.0157 0.0184
Leishmania major beta tubulin 0.0574 0.333 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0038 0.009 0.0207
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0172 0.0456
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0038 0.009 0.0207
Trichomonas vaginalis endoplasmin, putative 0.004 0.0101 0.024
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.009 0.0207
Leishmania major cAMP-specific phosphodiesterase, putative 0.0038 0.009 0.0271
Loa Loa (eye worm) hypothetical protein 0.143 0.8499 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0038 0.009 0.0207
Trypanosoma brucei alpha tubulin 0.0413 0.2354 0.7051
Trichomonas vaginalis tubulin alpha chain, putative 0.0171 0.0894 0.2638
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0153 0.1706
Giardia lamblia Beta tubulin 0.0574 0.333 1
Trypanosoma cruzi beta tubulin, putative 0.0574 0.333 1
Echinococcus granulosus Tubulin beta 2C chain 0.0574 0.333 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0051 0.0172 0.2636
Trichomonas vaginalis tubulin beta chain, putative 0.0413 0.2354 0.7051
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.0252 0.0696
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0026 0.0022 0.0241
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0132 0.0334
Loa Loa (eye worm) RNA binding protein 0.0134 0.0671 0.0789
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0038 0.009 0.0106
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0038 0.009 0.0106
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0038 0.009 0.0207
Trypanosoma brucei Heat shock protein 83, putative 0.0065 0.0252 0.0696
Echinococcus granulosus tubulin alpha 3 chain 0.0413 0.2354 0.7051
Leishmania major beta tubulin 0.0574 0.333 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0038 0.009 0.0207
Loa Loa (eye worm) tubulin alpha 2 0.0282 0.1562 0.1838
Leishmania major beta tubulin 0.0574 0.333 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Echinococcus granulosus chromobox protein 1 0.008 0.0344 0.0975
Trypanosoma cruzi heat shock protein 90, putative 0.0051 0.0172 0.0456
Echinococcus multilocularis tubulin beta 1 chain 0.0574 0.333 0.3316
Brugia malayi glutathione reductase 0.0046 0.0142 0.0167
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0038 0.009 0.0106
Echinococcus granulosus tubulin beta 4A class IVa 0.0574 0.333 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0053 0.0095
Loa Loa (eye worm) tubulin alpha-3 chain 0.0242 0.1322 0.1555
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.009 0.0207
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0038 0.009 0.0207
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0344 0.0405
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.05 0.7647
Echinococcus multilocularis tubulin gamma 1 chain 0.0302 0.1686 0.1669
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Loa Loa (eye worm) alpha-tubulin 0.0413 0.2354 0.277
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0171 0.0894 0.2638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0713 0.2089
Plasmodium vivax tubulin alpha chain, putative 0.0413 0.2354 0.7051
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0038 0.009 0.0069
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.05 0.7647
Schistosoma mansoni alpha tubulin 0.0413 0.2354 0.7051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Echinococcus granulosus tubulin alpha chain 0.0413 0.2354 0.7051
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0038 0.009 0.0069
Echinococcus multilocularis tubulin alpha 1C chain 0.0413 0.2354 0.2338
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0038 0.009 0.0207
Brugia malayi hypothetical protein 0.0097 0.0449 0.0529
Toxoplasma gondii beta tubulin 0.0574 0.333 1
Schistosoma mansoni tubulin subunit epsilon 0.0302 0.1686 0.5032
Loa Loa (eye worm) heat shock protein 90 0.0065 0.0252 0.0296
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0671 0.1962
Trypanosoma cruzi Heat shock protein 83, putative 0.0065 0.0252 0.0696
Plasmodium falciparum heat shock protein 90 0.0065 0.0252 0.0696
Entamoeba histolytica tubulin alpha chain, putative 0.0413 0.2354 0.707
Leishmania major zeta tubulin, putative 0.0131 0.0654 0.1964
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Trichomonas vaginalis tubulin gamma chain, putative 0.0131 0.0654 0.1912
Trypanosoma brucei zeta tubulin, putative 0.0131 0.0654 0.1912
Echinococcus multilocularis endoplasmin 0.0051 0.0172 0.0151
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major beta tubulin 0.0574 0.333 1
Leishmania major beta tubulin 0.0574 0.333 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0038 0.009 0.0207
Brugia malayi Tubulin beta chain 0.0171 0.0894 0.1052
Trypanosoma brucei heat shock protein, putative 0.0065 0.0252 0.0696
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0038 0.009 0.0069
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0038 0.009 0.0069
Schistosoma mansoni tubulin subunit beta 0.0574 0.333 1
Echinococcus granulosus tubulin epsilon chain 0.0302 0.1686 0.5032
Echinococcus granulosus Tubulin beta 2C chain 0.0574 0.333 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0038 0.009 0.0207
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0413 0.2354 0.7051
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.0654 0.1912
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Giardia lamblia Beta tubulin 0.0574 0.333 1
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Trichomonas vaginalis tubulin beta chain, putative 0.0413 0.2354 0.7051
Plasmodium falciparum tubulin beta chain 0.0574 0.333 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Trypanosoma brucei heat shock protein, putative 0.0065 0.0252 0.0696
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major gamma-tubulin 0.0302 0.1686 0.5065
Echinococcus granulosus tubulin alpha chain 0.0413 0.2354 0.7051
Echinococcus multilocularis Tubulin alpha 1 chain 0.0413 0.2354 0.2338
Brugia malayi Thioredoxin reductase 0.0046 0.0142 0.0167
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0131 0.0654 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0038 0.009 0.0207
Trypanosoma brucei alpha tubulin, putative 0.0171 0.0894 0.2638
Entamoeba histolytica tubulin family protein 0.0574 0.333 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0671 0.1962
Loa Loa (eye worm) tubulin beta chain 0.0574 0.333 0.3918
Plasmodium vivax tubulin gamma chain, putative 0.0302 0.1686 0.5032
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0252 0.0696
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Echinococcus multilocularis heat shock protein 0.0065 0.0252 0.0231
Loa Loa (eye worm) glutathione reductase 0.0046 0.0142 0.0167
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0252 0.0756
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0038 0.009 0.0207
Trypanosoma brucei heat shock protein, putative 0.0065 0.0252 0.0696
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0051 0.0172 0.2636
Loa Loa (eye worm) tubulin beta-4 chain 0.0574 0.333 0.3918
Brugia malayi Tubulin alpha chain 0.0131 0.0654 0.077
Leishmania major beta tubulin 0.0574 0.333 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Trichomonas vaginalis tubulin, putative 0.0171 0.0894 0.2638
Trichomonas vaginalis tubulin epsilon chain, putative 0.0413 0.2354 0.7051
Echinococcus multilocularis Tubulin beta 2C chain 0.0574 0.333 0.3316
Schistosoma mansoni eyes absent homolog 0.0097 0.0449 0.1293
Schistosoma mansoni hypothetical protein 0.0374 0.2123 0.635
Plasmodium vivax phosphodiesterase gamma, putative 0.0038 0.009 0.0207
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0157 0.0184
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0106
Toxoplasma gondii alpha tubulin TUBA1 0.0413 0.2354 0.7051
Leishmania major beta tubulin 0.0574 0.333 1
Echinococcus granulosus peroxisome assembly protein 26 0.0413 0.2354 0.7051
Trichomonas vaginalis tubulin alpha chain, putative 0.0171 0.0894 0.2638
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0038 0.009 0.0069
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0571 0.8737
Trypanosoma cruzi alpha tubulin, putative 0.0413 0.2354 0.7051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Echinococcus granulosus tubulin beta 1 chain 0.0574 0.333 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0713 0.2089
Brugia malayi alpha-tubulin 0.0413 0.2354 0.277
Schistosoma mansoni tubulin subunit beta 0.0574 0.333 1
Mycobacterium ulcerans cell division protein FtsZ 0.0131 0.0654 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0038 0.009 0.0207
Trichomonas vaginalis tubulin, putative 0.0171 0.0894 0.2638
Giardia lamblia Alpha-tubulin 0.0413 0.2354 0.6989
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Echinococcus multilocularis peroxisome assembly protein 26 0.0413 0.2354 0.2338
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0142 0.0363
Trichomonas vaginalis tubulin beta chain, putative 0.0171 0.0894 0.2638
Brugia malayi Tubulin gamma chain 0.0302 0.1686 0.1984
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0063 0.0075
Leishmania major beta tubulin 0.0574 0.333 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.009 0.0207
Echinococcus multilocularis tubulin alpha chain 0.0413 0.2354 0.2338
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0131 0.0654 0.1912
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0131 0.0654 0.1912
Brugia malayi Tubulin alpha-2 chain 0.0413 0.2354 0.277
Trypanosoma brucei beta tubulin 0.0574 0.333 1
Schistosoma mansoni tubulin subunit beta 0.0574 0.333 1
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0153 0.0396
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0038 0.009 0.0106
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0713 0.0693
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Echinococcus multilocularis tubulin subunit TubB 0.0413 0.2354 0.2338
Brugia malayi RNA binding protein 0.0134 0.0671 0.0789
Trypanosoma brucei heat shock protein, putative 0.0065 0.0252 0.0696
Echinococcus granulosus endoplasmin 0.0051 0.0172 0.0456
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0038 0.009 0.0106
Trypanosoma brucei heat shock protein, putative 0.0065 0.0252 0.0696
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Loa Loa (eye worm) tubulin beta chain 0.0131 0.0654 0.077
Plasmodium falciparum phosphodiesterase delta, putative 0.0038 0.009 0.0207
Plasmodium falciparum thioredoxin reductase 0.0046 0.0142 0.0363
Schistosoma mansoni hypothetical protein 0.0033 0.0063 0.0127
Leishmania major beta tubulin 0.0574 0.333 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.05 0.7647
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0574 0.333 0.3316
Toxoplasma gondii heat shock protein 90, putative 0.0065 0.0252 0.0696
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Loa Loa (eye worm) hypothetical protein 0.0413 0.2354 0.277
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Echinococcus granulosus chromobox protein 1 0.008 0.0344 0.0975
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0713 0.0693
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.009 0.0207
Schistosoma mansoni alpha tubulin 0.0413 0.2354 0.7051
Echinococcus multilocularis tubulin alpha 3 chain 0.0413 0.2354 0.2338
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0282 0.1562 0.1838
Echinococcus multilocularis tubulin alpha chain 0.0413 0.2354 0.2338
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.009 0.0207
Leishmania major beta tubulin 0.0574 0.333 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0038 0.009 0.0207
Leishmania major beta tubulin 0.0574 0.333 1
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0038 0.009 0.0207
Echinococcus granulosus beta tubulin 0.0574 0.333 1
Echinococcus multilocularis beta tubulin 0.0574 0.333 0.3316
Trypanosoma cruzi tubulin gamma chain 0.0302 0.1686 0.5032
Trypanosoma brucei epsilon tubulin 0.0302 0.1686 0.5032
Trichomonas vaginalis tubulin gamma chain, putative 0.0574 0.333 1
Leishmania major beta tubulin 0.0574 0.333 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0574 0.333 0.3316
Brugia malayi Tubulin alpha chain 0.0413 0.2354 0.277
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Echinococcus granulosus tubulin subunit TubB 0.0413 0.2354 0.7051
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0038 0.009 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0053 0.0095
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0713 0.0838
Echinococcus granulosus tubulin alpha chain 0.0413 0.2354 0.7051
Schistosoma mansoni tubulin subunit alpha 0.0413 0.2354 0.7051
Echinococcus multilocularis hypothetical protein 0.0413 0.2354 0.2338
Schistosoma mansoni tubulin subunit alpha 0.0131 0.0654 0.1912
Entamoeba histolytica tubulin family protein 0.0574 0.333 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Loa Loa (eye worm) hypothetical protein 0.0097 0.0449 0.0529
Trypanosoma brucei epsilon tubulin 0.0302 0.1686 0.5032
Brugia malayi chromobox protein homolog 3 0.0045 0.0132 0.0155
Plasmodium falciparum endoplasmin, putative 0.004 0.0101 0.024
Schistosoma mansoni alpha tubulin 0.0413 0.2354 0.7051
Trichomonas vaginalis tubulin alpha chain, putative 0.0302 0.1686 0.5032
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Trypanosoma brucei beta tubulin 0.0302 0.1686 0.5032
Loa Loa (eye worm) hypothetical protein 0.1393 0.827 0.9731
Plasmodium vivax heat shock protein 86, putative 0.0065 0.0252 0.0696
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.009 0.0207
Plasmodium falciparum tubulin delta chain, putative 0.0131 0.0654 0.1912
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0713 0.2089
Trichomonas vaginalis tubulin gamma chain, putative 0.0302 0.1686 0.5032
Plasmodium vivax glutathione reductase, putative 0.0046 0.0142 0.0363
Leishmania major beta tubulin 0.0574 0.333 1
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.0654 0.1912
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Loa Loa (eye worm) hypothetical protein 0.0033 0.0063 0.0075
Plasmodium falciparum alpha tubulin 1 0.0413 0.2354 0.7051
Plasmodium vivax tubulin epsilon chain, putative 0.0302 0.1686 0.5032
Loa Loa (eye worm) beta-tubulin 0.0574 0.333 0.3918
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0038 0.009 0.0207
Loa Loa (eye worm) tubulin alpha chain 0.0413 0.2354 0.277
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.009 0.0207
Echinococcus granulosus tubulin alpha chain 0.0413 0.2354 0.7051
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0172 0.0456
Trichomonas vaginalis tubulin alpha chain, putative 0.0574 0.333 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0142 0.0167
Brugia malayi tubulin alpha chain - mouse 0.0413 0.2354 0.277
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.009 0.0207
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0038 0.009 0.0207
Brugia malayi Tubulin beta-1 chain 0.0574 0.333 0.3918
Brugia malayi Heterochromatin protein 1 0.008 0.0344 0.0405
Echinococcus granulosus tubulin delta chain 0.0131 0.0654 0.1912
Leishmania major heat shock protein 83-1 0.0065 0.0252 0.0756
Echinococcus multilocularis tubulin alpha 0.0302 0.1686 0.1669
Schistosoma mansoni endoplasmin 0.0065 0.0252 0.0696
Trichomonas vaginalis chromobox protein, putative 0.008 0.0344 0.0975
Leishmania major alpha tubulin 0.0413 0.2354 0.707
Trypanosoma brucei zeta tubulin 0.0131 0.0654 0.1912
Trichomonas vaginalis chromobox protein, putative 0.008 0.0344 0.0975
Plasmodium falciparum alpha tubulin 2 0.0413 0.2354 0.7051
Loa Loa (eye worm) hypothetical protein 0.0242 0.1322 0.1555
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.143 0.8499 1
Trypanosoma cruzi tubulin delta chain 0.0131 0.0654 0.1912
Plasmodium vivax endoplasmin, putative 0.0065 0.0252 0.0696
Leishmania major heat shock protein, putative 0.0026 0.0022 0.0065
Loa Loa (eye worm) PDE1B protein 0.0038 0.009 0.0106
Trypanosoma brucei heat shock protein, putative 0.0065 0.0252 0.0696
Trypanosoma brucei tubulin delta chain 0.0131 0.0654 0.1912

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 12.3 nM Antimalarial activity against Plasmodium falciparum Nigerian in human erythrocytes after 48 hrs ChEMBL. 18004799
pKa = 11.3 Dissociation constant, pKa of the compound by potentiometric titration ChEMBL. 18004799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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