Detailed information for compound 449466

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 483.863 | Formula: C17H16ClN6O7S-
  • H donors: 4 H acceptors: 8 LogP: -0.55 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1[C@H](COS(=O)(=O)[N-]C(=O)c2ccccc2Cl)O[C@@H]([C@H]1O)n1cnc2c1ncnc2N
  • InChi: 1S/C17H17ClN6O7S/c18-9-4-2-1-3-8(9)16(27)23-32(28,29)30-5-10-12(25)13(26)17(31-10)24-7-22-11-14(19)20-6-21-15(11)24/h1-4,6-7,10,12-13,17,25-26H,5H2,(H3,19,20,21,23,27)/p-1/t10-,12-,13-,17-/m1/s1
  • InChiKey: IGIAOKHVWMKVFY-CNEMSGBDSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0016 0.0018 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0033 0.0103 0.5921
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0528 0.1589
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.003 0.0088 0.0086
Loa Loa (eye worm) cytochrome P450 0.0015 0.0016 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.004
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0033 0.003
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0101 0.0333
Echinococcus granulosus pyruvate kinase 0.0017 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0109
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0033 0.0103 0.0271
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0032 0.003
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0016 0.0018 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.0055 0.021 0.0699
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0033 0.003
Brugia malayi cytochrome P450 0.0015 0.0016 0.0099
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0101 0.5809
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0528 0.1589
Schistosoma mansoni zinc finger protein 0.0026 0.0069 0.0067
Mycobacterium ulcerans beta-lactamase 0.0035 0.0114 0.0304
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0033 0.0103 0.2618
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0033 0.003
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0033 0.003
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0682 0.3244 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0016 0.0019 0.0056
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0664 0.4962
Loa Loa (eye worm) hypothetical protein 0.0042 0.0145 0.048
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0048 0.0172 0.0573
Echinococcus multilocularis geminin 0.0165 0.0742 0.074
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0021
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0163 0.3061
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0163 0.9465
Onchocerca volvulus 0.0016 0.0018 0.0413
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0101 0.2561
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0048 0.0172 0.9986
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.0299
Loa Loa (eye worm) hypothetical protein 0.0035 0.0114 0.0375
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0033 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0033 0.0228
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0528 1
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0018 0.012
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.003 0.0088 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0018 0.0009
Toxoplasma gondii exonuclease III APE 0.0048 0.0172 0.323
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.003 0.0088 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0033 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0256 0.0254
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0288 0.1336 0.4491
Echinococcus granulosus jumonji domain containing protein 0.0045 0.016 0.0157
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.005 0.2119
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0114 0.6259
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0226 0.0224
Schistosoma mansoni importin beta-1 0.0059 0.0226 0.0224
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0171
Schistosoma mansoni pyruvate kinase 0.0017 0.0024 0.0022
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.066 0.4932
Mycobacterium ulcerans hypothetical protein 0.0035 0.0114 0.0304
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0033 0.0228
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0033 0.0103 0.0295
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0033 0.003
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0033 0.003
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0024 0.0684
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0173 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0016 0.0024
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0014 0.0012
Mycobacterium ulcerans hypothetical protein 0.0033 0.0103 0.0271
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0016 0.0018 0.0712
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0194 0.4933
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0038 0.0036
Brugia malayi mbt repeat family protein 0.0052 0.0194 0.1439
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0018 0.012
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0088 0.3833
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0114 0.4976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0074 0.4184
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0033 0.003
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0101 0.0742
Echinococcus granulosus intermediate filament protein 0.0031 0.0091 0.0089
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0014 0.0012
Plasmodium falciparum pyruvate kinase 0.0033 0.0101 0.2891
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0016 0.0018 0.0943
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0256 0.0254
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0114 0.6549
Echinococcus multilocularis pyruvate kinase 0.0033 0.0101 0.0099
Schistosoma mansoni coup transcription factor 0.0019 0.0033 0.003
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0101 0.4414
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0018 0.0009
Giardia lamblia PHD finger protein 15 0.0032 0.0099 0.5025
Echinococcus multilocularis muscleblind protein 1 0.0156 0.0698 0.0696
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0016 0.0018 0.0303
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0038 0.1425
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0018 0.012
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.2204 0.2202
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.005 0.0357
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0194 0.0192
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0256 0.0254
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.0038 0.1425
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.0038 0.1425
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0032 0.003
Leishmania major pyruvate kinase 0.0033 0.0101 0.1671
Echinococcus granulosus pyruvate kinase 0.0017 0.0024 0.0022
Brugia malayi Bromodomain containing protein 0.0038 0.0128 0.0945
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0101 0.5457
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0114 0.0112
Brugia malayi exodeoxyribonuclease III family protein 0.0048 0.0172 0.1275
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0099 0.2814
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0288 0.1336 0.1334
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0114 0.0112
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0091 0.0299
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0074 0.3695
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0033 0.0103 0.0271
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0114 0.0112
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0016 0.0018 0.0181
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0169 0.1254
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0134 0.739
Onchocerca volvulus 0.0052 0.0194 0.4933
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0053 0.0171
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0114 0.0375
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0528 0.0526
Echinococcus granulosus ubiquitin specific protease 41 0.003 0.0088 0.0086
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0038 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0528 0.1589
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0049 0.0159
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0038 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0033 0.0228
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0033 0.0228
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0016 0.0018 0.0009
Entamoeba histolytica Ran family GTPase 0.0022 0.005 0.2793
Trypanosoma cruzi ISWI complex protein 0.0017 0.0023 0.0489
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0088 0.463
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0114 0.2937
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.005 0.016
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0099 0.1826
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0256 0.0254
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0194 0.0192
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0016 0.0018 0.0525
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0033 0.0103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0074 0.0534
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0194 0.0192
Schistosoma mansoni hypothetical protein 0.0047 0.0169 0.0167
Giardia lamblia Pyruvate kinase 0.0033 0.0101 0.5208
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.005 0.0902
Leishmania major 4-coumarate:coa ligase-like protein 0.0033 0.0103 0.1708
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.0038 0.0436
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0035 0.0032
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0048 0.0172 0.017
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0048 0.0172 0.4922
Schistosoma mansoni hypothetical protein 0.0032 0.0099 0.0096
Plasmodium vivax acetyl-CoA synthetase, putative 0.0016 0.0018 0.0525
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0265 0.0883
Schistosoma mansoni intermediate filament proteins 0.0031 0.0091 0.0089
Brugia malayi nuclear receptor NHR-88 0.0019 0.0033 0.0228
Echinococcus multilocularis snurportin 1 0.0626 0.2972 0.297
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0016 0.0018 0.0085
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.066 0.2215
Onchocerca volvulus 0.0033 0.0103 0.2592
Echinococcus granulosus pyruvate kinase 0.0033 0.0101 0.0099
Brugia malayi beta-lactamase family protein 0.0035 0.0114 0.0836
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0114 0.0328
Loa Loa (eye worm) hypothetical protein 0.0035 0.0114 0.0375
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0664 0.0662
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0088 0.5047
Brugia malayi RNA binding protein 0.0065 0.0256 0.1901
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.035 0.1036
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.021 0.0624
Brugia malayi PHD-finger family protein 0.0014 0.001 0.0055
Onchocerca volvulus Huntingtin homolog 0.0093 0.0391 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0169 0.0167
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.003 0.0088 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0119
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0016 0.0024
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.002 0.0038 0.209
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0169 0.0563
Schistosoma mansoni ap endonuclease 0.0048 0.0172 0.017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0169 0.1254
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.021 0.0207
Plasmodium falciparum importin beta, putative 0.0059 0.0226 0.6462
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0016 0.0018 0.0085
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0033 0.003
Brugia malayi intermediate filament protein 0.0031 0.0091 0.0665
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0339
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0215 0.0981 0.0979
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0339
Echinococcus granulosus pyruvate kinase 0.0033 0.0101 0.0099
Echinococcus granulosus lamin 0.0031 0.0091 0.0089
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.035 0.1036
Echinococcus granulosus lamin dm0 0.0031 0.0091 0.0089
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0226 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0114 0.0112
Echinococcus granulosus muscleblind protein 0.0156 0.0698 0.0696
Schistosoma mansoni hypothetical protein 0.0165 0.0742 0.074
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.021 0.0624
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0048 0.0172 0.7591
Loa Loa (eye worm) hypothetical protein 0.0035 0.0114 0.0375
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.005 0.0048
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0033 0.0103 0.0271
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0024 0.0684
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0038 0.1585
Onchocerca volvulus Alhambra homolog 0.0032 0.0099 0.2473
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0229 0.0227
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0281 0.0279
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0148 0.0145
Mycobacterium tuberculosis Conserved protein 0.0035 0.0114 0.0328
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0194 0.0192
Brugia malayi Cytochrome P450 family protein 0.0025 0.0061 0.0443
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0101 0.4414
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0027 0.006
Entamoeba histolytica acyl-coA synthetase, putative 0.0033 0.0103 0.5921
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0215 0.0981 0.0979
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0027 0.006
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0018 0.0055
Brugia malayi Bromodomain containing protein 0.0045 0.0162 0.1197
Schistosoma mansoni cpg binding protein 0.0025 0.0066 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0031
Loa Loa (eye worm) beta-lactamase 0.0035 0.0114 0.0375
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.005 0.2187
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0018 0.0712
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0016 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0288 0.1336 0.1334
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0083 0.2368
Onchocerca volvulus 0.0019 0.0033 0.0783
Brugia malayi beta-lactamase family protein 0.0035 0.0114 0.0836
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0038 0.1585
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0038 0.0267
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0038 0.0093
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0194 0.0646
Loa Loa (eye worm) MBCTL1 0.0059 0.0229 0.0763
Leishmania major pyruvate kinase 0.0033 0.0101 0.1671
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0115 0.0381
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0018 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.002 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0288 0.1336 0.1334
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0163 0.0161
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0061 0.0199
Echinococcus multilocularis pyruvate kinase 0.0017 0.0024 0.0022
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.0038 0.0436
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0646
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0033 0.0783
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0033 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Echinococcus multilocularis 0.0015 0.0016 0.0013
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0018 0.0181
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0101 0.2891
Schistosoma mansoni hypothetical protein 0.0101 0.0433 0.0431
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0103
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0016 0.0024
Brugia malayi ecdysteroid receptor 0.0019 0.0033 0.0228
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0173 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0035 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0103 0.0271
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0119
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0114 0.6549
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0169 0.0167
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0038 0.1585
Echinococcus multilocularis pyruvate kinase 0.0033 0.0101 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Schistosoma mansoni hypothetical protein 0.0626 0.2972 0.297
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0016 0.0024
Brugia malayi CXXC zinc finger family protein 0.0022 0.0049 0.0353
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.0453 0.0451
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0038 0.1079
Brugia malayi Cytochrome P450 family protein 0.0025 0.0061 0.0443
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0114 0.0328
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0016 0.0013
Brugia malayi Cytochrome P450 family protein 0.0015 0.0016 0.0099
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0032 0.003
Echinococcus multilocularis lamin dm0 0.0031 0.0091 0.0089
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0289
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0027 0.006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0528 0.0526
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0016 0.0018 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0103 0.0756
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.003 0.0088 0.5047
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0036 0.0254
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0033 0.003
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0048 0.0172 0.0508
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0033 0.0228
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0061 0.2919
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.0175 0.3279
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0033 0.003
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0016 0.0018 0.012
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0018 0.012
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0018 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.0169 0.0167
Schistosoma mansoni zinc finger protein 0.0017 0.0023 0.0021
Toxoplasma gondii hypothetical protein 0.0029 0.0083 0.153
Toxoplasma gondii ABC1 family protein 0.0035 0.0114 0.2117
Leishmania major importin beta-1 subunit, putative 0.0048 0.0173 0.3062
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0099 0.0096
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0068 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0033 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0288 0.1336 0.1334
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0528 0.0526
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0033 0.0783
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0032 0.003
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0038 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.005 0.0048
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0114 0.0836
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0099 0.0324
Loa Loa (eye worm) RNA binding protein 0.0065 0.0256 0.0854
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0018 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Leishmania major GTP-binding protein, putative 0.0022 0.005 0.067
Loa Loa (eye worm) hypothetical protein 0.0156 0.0698 0.2344
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.029
Echinococcus multilocularis muscleblind protein 0.0156 0.0698 0.0696
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0194 0.0192
Mycobacterium tuberculosis Conserved protein 0.0035 0.0114 0.0328
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.0038 0.0436
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0038 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0016 0.0024
Entamoeba histolytica hypothetical protein 0.0048 0.0173 1
Brugia malayi beta-lactamase 0.0035 0.0114 0.0836
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0016 0.0018 0.0009
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.0038 0.1425
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0048 0.0172 0.017
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0074 0.0071
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0016 0.0018 0.0009
Onchocerca volvulus 0.0016 0.0018 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0635
Echinococcus granulosus GPCR family 2 0.0047 0.0169 0.0167
Brugia malayi steroid hormone receptor 0.0019 0.0033 0.0228
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0018 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0016 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0528 0.0526
Leishmania major 4-coumarate:coa ligase-like protein 0.0033 0.0103 0.1708
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0016 0.0024
Echinococcus granulosus zinc finger protein 0.0026 0.0069 0.0067
Brugia malayi RNA, U transporter 1 0.0167 0.0749 0.5603
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0033 0.0228
Entamoeba histolytica hypothetical protein 0.0027 0.0074 0.4184
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0682 0.3244 1
Leishmania major acetyl-CoA synthetase, putative 0.0016 0.0018 0.0055
Schistosoma mansoni hypothetical protein 0.0015 0.0016 0.0013
Echinococcus multilocularis pyruvate kinase 0.0017 0.0024 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0033 0.0228
Onchocerca volvulus Huntingtin homolog 0.0093 0.0391 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0048 0.0172 0.3057
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0114 0.0304
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0256 0.0254
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.005 0.2187
Leishmania major hypothetical protein, conserved 0.0017 0.0023 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0022 0.0148
Echinococcus multilocularis dnaJ subfamily B 0.0315 0.1465 0.1463
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0173 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0018 0.0033
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0664 0.0662
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0033 0.003
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0061 0.0142
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0016 0.0018 0.0033
Trichomonas vaginalis ap endonuclease, putative 0.0048 0.0172 0.9986
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0002 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Onchocerca volvulus 0.0031 0.0091 0.2281
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0134 0.7711
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0288 0.1336 0.1334
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0033 0.0228
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.2204 0.2202
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0033 0.0228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0103
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0088 0.5047
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0114 0.6549
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0033 0.003
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0016 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0114 0.3251
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0114 0.0328
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0018 0.0033
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0061 0.2919
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.035 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0016 0.0018 0.0943
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0033 0.0103 0.0271
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0091 0.0299
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0016 0.0024
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0016 0.0018 0.0009
Loa Loa (eye worm) hypothetical protein 0.0035 0.0114 0.0375
Brugia malayi PHD-finger family protein 0.0032 0.0099 0.0721
Brugia malayi Muscleblind-like protein 0.0156 0.0698 0.5221
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Onchocerca volvulus 0.0031 0.0091 0.2281
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.003 0.0088 0.1418
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0101 0.5457
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0068 0.0065
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0099 0.0096
Echinococcus granulosus importin subunit beta 1 0.0059 0.0226 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0033 0.0103
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0016 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0038 0.1079
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0022 0.0067
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0101 0.2543
Loa Loa (eye worm) hypothetical protein 0.0156 0.0698 0.2344
Schistosoma mansoni hypothetical protein 0.0047 0.0169 0.0167
Onchocerca volvulus 0.0035 0.0114 0.2866
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0035 0.0032
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0033 0.003
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.0453 0.0451
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0033 0.003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0132 0.013
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0016 0.0018 0.0181
Giardia lamblia GTOR 0.002 0.0038 0.0941
Mycobacterium ulcerans lipase LipD 0.0035 0.0114 0.0304
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0074 0.0071
Loa Loa (eye worm) hypothetical protein 0.0059 0.0229 0.0763
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0048 0.0172 0.0486
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.016 0.0157
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0033 0.003
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.003 0.0088 0.0644
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.0038 0.0674
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0016 0.0024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0033 0.0103 0.5921
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0033 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0033 0.0103
Brugia malayi Bromodomain containing protein 0.0087 0.0362 0.2695
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.035 1
Schistosoma mansoni lamin 0.0031 0.0091 0.0089
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0053 0.2988
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0101 0.0265
Loa Loa (eye worm) hypothetical protein 0.0093 0.0391 0.131
Brugia malayi jmjC domain containing protein 0.0042 0.0148 0.1089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0033 0.0228
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0018 0.0181
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0288 0.1336 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0016 0.0024
Brugia malayi Importin beta-1 subunit 0.0059 0.0226 0.1679
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0103 0.0271
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0027 0.006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0033 0.0228
Schistosoma mansoni cytochrome P450 0.0015 0.0016 0.0013
Echinococcus multilocularis cpg binding protein 0.0025 0.0066 0.0063
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0016 0.0018 0.0009
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0055 0.2526
Onchocerca volvulus 0.0035 0.0114 0.2866
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0103
Schistosoma mansoni cpg binding protein 0.0025 0.0066 0.0063
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0033 0.003
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0009 0.0007
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.003 0.0088 0.4333
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0033 0.003
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0016 0.0018 0.0085
Echinococcus multilocularis musashi 0.0031 0.0091 0.0089
Schistosoma mansoni jumonji domain containing protein 0.0084 0.0348 0.0346
Schistosoma mansoni hypothetical protein 0.0315 0.1465 0.1463
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0088 0.5047
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0033 0.003
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0016 0.0018 0.0009
Loa Loa (eye worm) hypothetical protein 0.0148 0.066 0.2215
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0074 0.0071
Loa Loa (eye worm) hypothetical protein 0.0093 0.0391 0.131
Schistosoma mansoni bromodomain containing protein 0.0074 0.03 0.0298
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0134 0.3816
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0038 0.1437
Schistosoma mansoni microtubule-associated protein tau 0.2079 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.005 0.1425
Schistosoma mansoni ran 0.0022 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0025
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0061 0.2633
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0033 0.0228
Trypanosoma brucei ISWI complex protein 0.0017 0.0023 0.0928
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.002 0.0038 0.209
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.003 0.0088 0.0086
Brugia malayi nuclear hormone receptor 0.0019 0.0033 0.0228
Echinococcus multilocularis GPCR, family 2 0.0047 0.0169 0.0167
Mycobacterium ulcerans acetyl-CoA synthetase 0.0016 0.0018 0.0009
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0528 0.1609
Brugia malayi Probable ClpP-like protease 0.0084 0.035 0.2608
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0033 0.003
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0101 0.5809
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0119
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0033 0.003
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.021 0.0207
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.035 0.0348
Schistosoma mansoni ran 0.0022 0.005 0.0048
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0101 0.0289
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0018 0.012
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0016 0.0024
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0229 0.0227
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0114 0.0328
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0033 0.003
Brugia malayi Cytochrome P450 family protein 0.0036 0.0115 0.0848
Brugia malayi TAR-binding protein 0.0065 0.0256 0.1901
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0033 0.0103
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0229 0.0227
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0016 0.0018 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0002 0.0007
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0163 0.4669
Leishmania major 4-coumarate:coa ligase-like protein 0.0033 0.0103 0.1708
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0033 0.0103 0.2618
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0018 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0016 0.0024
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0038 0.012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0038 0.0267
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0148 0.0489
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0018 0.0033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0033 0.003
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.2204 0.2202
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0051 0.0165
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0074 0.3178
Brugia malayi hypothetical protein 0.0093 0.0391 0.2917
Echinococcus multilocularis ubiquitin specific protease 41 0.003 0.0088 0.0086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Plasmodium falciparum phd finger protein, putative 0.0032 0.0099 0.2814
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1682 0.808 0.808
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0173 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Trichomonas vaginalis ap endonuclease, putative 0.0048 0.0172 0.9986
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0256 0.0854
Echinococcus granulosus pyruvate kinase 0.0017 0.0024 0.0022
Leishmania major cytochrome p450-like protein 0.0025 0.0061 0.0894
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0061 0.0199
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0101 0.0742
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0169 0.0167
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0033 0.003
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.035 0.661
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0101 0.0333
Brugia malayi jmjC domain containing protein 0.0106 0.0453 0.3384
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.035 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.021 0.5803
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0016 0.0024
Echinococcus multilocularis pyruvate kinase 0.0017 0.0024 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0114 0.6549
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.005 0.1425
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0033 0.003
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0016 0.0018 0.0033
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0048 0.0172 0.9984
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0038 0.012
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0016 0.0585
Schistosoma mansoni cpg binding protein 0.0022 0.0049 0.0047
Loa Loa (eye worm) oxidoreductase 0.0016 0.0018 0.0054
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0256 0.0854
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0528 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.035 0.1171
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0626 0.2972 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0163 0.3061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0163 0.9465
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0031
Schistosoma mansoni hypothetical protein 0.0326 0.1519 0.1517
Echinococcus granulosus neuropeptide s receptor 0.0468 0.2204 0.2202
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0038 0.0036
Toxoplasma gondii propionate-CoA ligase 0.0016 0.0018 0.0303
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0009 0.0007
Treponema pallidum exodeoxyribonuclease (exoA) 0.0048 0.0172 0.3346
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.035 0.661
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0038 0.1425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0288 0.1336 0.1334
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0048 0.0172 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0114 0.0375
Schistosoma mansoni pyruvate kinase 0.0033 0.0101 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0103
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0061 0.0199
Brugia malayi PHD-finger family protein 0.0032 0.0097 0.0713
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0114 0.6259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0033 0.0103
Echinococcus multilocularis microtubule associated protein 2 0.2079 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0148 0.0145
Loa Loa (eye worm) hypothetical protein 0.0059 0.0226 0.0754
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0103 0.0756
Mycobacterium leprae Probable lipase LipE 0.0035 0.0114 0.2937
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0016 0.0024
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0194 0.0192
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0016 0.0024
Schistosoma mansoni pyruvate kinase 0.0033 0.0101 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0103 0.0756
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0169 0.0167
Echinococcus multilocularis lamin 0.0031 0.0091 0.0089
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0114 0.0328
Trichomonas vaginalis antibiotic synthetase, putative 0.0016 0.0018 0.0943
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0333
Schistosoma mansoni hypothetical protein 0.0165 0.0742 0.074
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.0038 0.0436
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0226 0.4255
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0018 0.0033
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0229 0.0227
Echinococcus multilocularis zinc finger protein 0.0026 0.0069 0.0067
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.035 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.003 0.0088 0.0086
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0194 0.0192
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0018 0.0009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0038 0.0069
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0033 0.003
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0229 0.0227
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0038 0.044
Echinococcus granulosus geminin 0.0165 0.0742 0.074
Loa Loa (eye worm) hypothetical protein 0.0047 0.0169 0.0563
Brugia malayi Variant SH3 domain containing protein 0.0016 0.0019 0.0125
Plasmodium vivax importin-beta 2, putative 0.0059 0.0226 0.6462
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0033 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0038 0.1585
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0114 0.0328
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0068 0.0065
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1037 0.3181
Schistosoma mansoni hypothetical protein 0.0047 0.0169 0.0167
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0114 0.0375
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0101 0.2543
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0033 0.0228
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.035 1
Schistosoma mansoni hypothetical protein 0.0047 0.0169 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0033 0.0103
Echinococcus granulosus peregrin 0.0038 0.0128 0.0126
Trypanosoma cruzi ISWI complex protein 0.0017 0.0023 0.0489
Echinococcus multilocularis pyruvate kinase 0.0026 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0103
Schistosoma mansoni ap endonuclease 0.0048 0.0172 0.017
Schistosoma mansoni lamin 0.0031 0.0091 0.0089
Onchocerca volvulus 0.0016 0.0018 0.0413
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.035 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0131 0.0129
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0038 0.1585
Onchocerca volvulus 0.0035 0.0114 0.2866
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0229 0.17
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.066 0.4932
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0035 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0114 0.6549
Schistosoma mansoni acetyl-CoA synthetase 0.0016 0.0018 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0016 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0288 0.1336 0.1334
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0016 0.0024
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0091 0.0665
Schistosoma mansoni hypothetical protein 0.0023 0.0051 0.0049
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0281 0.0279
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0101 0.2543
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0119
Echinococcus multilocularis peregrin 0.0038 0.0128 0.0126
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0016 0.0018 0.0033
Onchocerca volvulus 0.0016 0.0018 0.0413
Brugia malayi mbt repeat family protein 0.0052 0.0194 0.1439
Echinococcus granulosus dnaJ subfamily B 0.0315 0.1465 0.1463
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0256 0.0254
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0083 0.2368
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Loa Loa (eye worm) hypothetical protein 0.0048 0.0175 0.0581
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0101 0.1878
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0632 0.0629
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0048 0.0172 0.9984
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0132 0.013
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0018 0.0009
Echinococcus granulosus snurportin 1 0.0626 0.2972 0.297
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.005 0.1747
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0016 0.0018 0.0033
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0016 0.0018 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0103 0.0295
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0148 0.0145
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.035 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0048 0.0172 0.4922
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Mycobacterium tuberculosis Conserved protein 0.0035 0.0114 0.0328
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0053 0.0171
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0101 0.0333
Echinococcus granulosus tar DNA binding protein 0.0065 0.0256 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0018 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0038 0.209
Loa Loa (eye worm) hypothetical protein 0.0032 0.0099 0.0324
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0433 0.3229
Chlamydia trachomatis pyruvate kinase 0.0033 0.0101 0.2031
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.035 0.0348
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0033 0.0783
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0074 0.1352
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0016 0.0018 0.0303
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0038 0.0036
Trichomonas vaginalis esterase, putative 0.0035 0.0114 0.6549
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0033 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0033 0.0228
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0099 0.1826
Echinococcus granulosus cpg binding protein 0.0025 0.0066 0.0063
Schistosoma mansoni vav2 0.0016 0.0019 0.0017
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0024 0.0409
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0226 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0099 0.0096
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0088 0.463
Leishmania major hypothetical protein, conserved 0.0035 0.0114 0.1916
Leishmania major acetyl-CoA synthetase, putative 0.0016 0.0018 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0103 0.0271
Loa Loa (eye worm) hypothetical protein 0.0077 0.0316 0.1055
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0114 0.0304
Trichomonas vaginalis ran, putative 0.0022 0.005 0.2793
Onchocerca volvulus 0.0022 0.0049 0.1211
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0083 0.2014
Loa Loa (eye worm) acetyltransferase 0.0149 0.0664 0.2228
Loa Loa (eye worm) hypothetical protein 0.0101 0.0433 0.145
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0256 0.1901
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0339
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0016 0.0024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0114 0.0328
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.035 0.0348

Activities

Activity type Activity value Assay description Source Reference
Ki app (binding) = 18.1 uM Inhibition of Mycobacterium tuberculosis recombinant MbtA expressed in Escherichia coli by ATP/PPi exchange assay ChEMBL. 17967002
MIC99 (functional) > 200 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in iron deficient GAST medium ChEMBL. 17967002
MIC99 (functional) > 200 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in iron rich GAST medium ChEMBL. 17967002

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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