Detailed information for compound 449467

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 494.415 | Formula: C17H16N7O9S-
  • H donors: 4 H acceptors: 10 LogP: -1.35 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1[C@H](COS(=O)(=O)[N-]C(=O)c2ccccc2[N+](=O)[O-])O[C@@H]([C@H]1O)n1cnc2c1ncnc2N
  • InChi: 1S/C17H17N7O9S/c18-14-11-15(20-6-19-14)23(7-21-11)17-13(26)12(25)10(33-17)5-32-34(30,31)22-16(27)8-3-1-2-4-9(8)24(28)29/h1-4,6-7,10,12-13,17,25-26H,5H2,(H3,18,19,20,22,27)/p-1/t10-,12-,13-,17-/m1/s1
  • InChiKey: OLYONFZRPKCNID-CNEMSGBDSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lysine specific demethylase 5A 0.0079 0.0362 0.0362
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0249 0.1987
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0252 1
Brugia malayi Pre-SET motif family protein 0.0225 0.122 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0109 0.0109
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0081 0.0081
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0133 0.1091
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0723 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0362 0.0362
Leishmania major hypothetical protein, conserved 0.0019 0.0013 0.0526
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0054 0.0054
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0013 0.0013
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0675 0.3866 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1584 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0104 0.0104
Schistosoma mansoni intermediate filament proteins 0.0027 0.0057 0.0057
Brugia malayi jmjC domain containing protein 0.0079 0.0362 0.2969
Loa Loa (eye worm) histone methyltransferase 0.0039 0.0127 0.1043
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0109 0.031
Plasmodium vivax SET domain protein, putative 0.0034 0.0104 0.4163
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0109 0.0892
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1584 1
Schistosoma mansoni hypothetical protein 0.0065 0.0281 0.0281
Brugia malayi CXXC zinc finger family protein 0.0121 0.061 0.5
Echinococcus multilocularis musashi 0.0027 0.0057 0.0057
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0013 0.0013
Giardia lamblia PHD finger protein 15 0.0059 0.0249 0.0796
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0281 0.0281
Echinococcus granulosus GPCR family 2 0.0065 0.0281 0.0281
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0133 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0104 0.0104
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0109 0.031
Leishmania major hypothetical protein, conserved 0.0035 0.0109 0.4328
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0281 0.2306
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0109 0.0282
Onchocerca volvulus 0.0121 0.061 0.4119
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0013 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.1103 0.904
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0104 0.0104
Toxoplasma gondii histone lysine methyltransferase SET1 0.023 0.1251 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0109 0.8181
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0252 0.0252
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0013 0.0013
Plasmodium vivax JmjC domain containing protein 0.0019 0.0013 0.0533
Loa Loa (eye worm) hypothetical protein 0.0027 0.0057 0.0465
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0109 0.8181
Schistosoma mansoni hypothetical protein 0.0879 0.5061 0.5061
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0015 0.0117
Echinococcus granulosus intermediate filament protein 0.0027 0.0057 0.0057
Mycobacterium tuberculosis Conserved protein 0.0035 0.0109 0.0282
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0109
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0051 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0065 0.0281 0.2306
Echinococcus multilocularis cpg binding protein 0.0128 0.0651 0.0651
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0013 0.0106
Echinococcus granulosus neuropeptide receptor A26 0.046 0.2601 0.2601
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0015 0.0117
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0133 0.0469
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0723 0.5923
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0133 0.5352
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0015 0.1101
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.1103 0.904
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0252 0.0252
Echinococcus granulosus neuropeptide s receptor 0.046 0.2601 0.2601
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.393 0.393
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0031 0.0084 0.0084
Schistosoma mansoni ap endonuclease 0.004 0.0133 0.0133
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0013 0.0995
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0281 0.0281
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0598 0.4901
Brugia malayi beta-lactamase family protein 0.0035 0.0109 0.0892
Schistosoma mansoni lamin 0.0027 0.0057 0.0057
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0133 0.5352
Echinococcus multilocularis lamin 0.0027 0.0057 0.0057
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0013 0.0013
Trichomonas vaginalis esterase, putative 0.0035 0.0109 0.031
Schistosoma mansoni cpg binding protein 0.0121 0.061 0.061
Onchocerca volvulus Alhambra homolog 0.0059 0.0249 0.1429
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1584 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0249 0.2038
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0013 0.0013
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.172 1 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0109 0.0282
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0109
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0133 0.0064
Loa Loa (eye worm) hypothetical protein 0.0035 0.0109 0.0892
Echinococcus granulosus cpg binding protein 0.0128 0.0651 0.0651
Echinococcus granulosus geminin 0.0879 0.5061 0.5061
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0133 0.0469
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0252 0.0651
Echinococcus multilocularis lamin dm0 0.0027 0.0057 0.0057
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0252 0.038
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0057 0.0465
Echinococcus granulosus peregrin 0.0059 0.0249 0.0249
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0598 0.4901
Echinococcus multilocularis dnaJ subfamily B 0.172 1 1
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.0109
Schistosoma mansoni hypothetical protein 0.0065 0.0281 0.0281
Onchocerca volvulus 0.0035 0.0109 0.0388
Loa Loa (eye worm) hypothetical protein 0.0035 0.0109 0.0892
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1584 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0039 0.0127 0.0127
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0057 0.0465
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1584 1
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0441
Brugia malayi Bromodomain containing protein 0.0059 0.0249 0.2038
Mycobacterium tuberculosis Conserved protein 0.0035 0.0109 0.0282
Loa Loa (eye worm) hypothetical protein 0.0034 0.0104 0.0848
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0249 0.0249
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0109 0.4378
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0109 0.0892
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.0109
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0109 0.0282
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.0619 0.5072
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0013 0.0013
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0027 0.0058 0.2328
Brugia malayi PHD-finger family protein 0.0026 0.0055 0.0451
Echinococcus granulosus lamin dm0 0.0027 0.0057 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0104 0.0104
Brugia malayi hypothetical protein 0.0167 0.0883 0.724
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0109 0.0282
Echinococcus multilocularis neuropeptide s receptor 0.046 0.2601 0.2601
Schistosoma mansoni hypothetical protein 0.0059 0.0249 0.0249
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0058 0.2328
Echinococcus granulosus lamin 0.0027 0.0057 0.0057
Onchocerca volvulus 0.0255 0.14 1
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.1584 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0675 0.3866 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0109 0.0892
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0205 0.1103 0.904
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0109 0.0109
Toxoplasma gondii exonuclease III APE 0.004 0.0133 0.1064
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0249 0.2038
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0385 0.0385
Loa Loa (eye worm) CXXC zinc finger family protein 0.0121 0.061 0.5
Echinococcus granulosus phd:f box containing protein 0.0019 0.0013 0.0013
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0109 0.0109
Schistosoma mansoni hypothetical protein 0.014 0.0723 0.0723
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0013 0.0109
Schistosoma mansoni jumonji domain containing protein 0.0154 0.0806 0.0806
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0362 0.2969
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0109 0.0109
Brugia malayi intermediate filament protein 0.0027 0.0057 0.0465
Brugia malayi beta-lactamase family protein 0.0035 0.0109 0.0892
Schistosoma mansoni hypothetical protein 0.0065 0.0281 0.0281
Echinococcus multilocularis GPCR, family 2 0.0065 0.0281 0.0281
Echinococcus multilocularis geminin 0.0879 0.5061 0.5061
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0084 0.0084
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0109 0.031
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0013 0.0533
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0109 0.0282
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0104 0.0104
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.393 0.393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0104 0.0104
Onchocerca volvulus 0.0034 0.0104 0.0348
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0322 0.0322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.1103 0.904
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0133 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1584 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0109 0.031
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1229 0.3179
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0035 0.0109 0.0892
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0723 0.1636
Brugia malayi F/Y-rich N-terminus family protein 0.0057 0.0238 0.1951
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0013 0.0013
Schistosoma mansoni lamin 0.0027 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0109 0.0892
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.2601 0.2601
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0013 0.0109
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0039 0.0127 0.0127
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0133 0.5291
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0281 0.0281
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0194 0.104 0.104
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0015 0.1101
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0723 0.1871
Schistosoma mansoni hypothetical protein 0.0065 0.0281 0.0281
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0385 0.0385
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0109 0.031
Plasmodium falciparum phd finger protein, putative 0.0059 0.0249 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0257 0.1412 0.1412
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0133 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0252 0.201
Brugia malayi Pre-SET motif family protein 0.0034 0.0104 0.0848
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.1584 1
Brugia malayi PHD-finger family protein 0.0059 0.0249 0.2038
Brugia malayi MH2 domain containing protein 0.0119 0.0598 0.4901
Echinococcus multilocularis peregrin 0.0059 0.0249 0.0249
Schistosoma mansoni cpg binding protein 0.0128 0.0651 0.0651
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0104 0.0827
Onchocerca volvulus 0.0167 0.0883 0.6153
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0249 0.0249
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0252 0.038
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0109 0.0892
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0249 1
Schistosoma mansoni ap endonuclease 0.004 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0167 0.0883 0.724
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.0109
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0133 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0109 0.8181
Brugia malayi jmjC domain containing protein 0.0194 0.104 0.852
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0104 0.0104
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0013 0.0013
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0013 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0057 0.0465
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0252 0.038
Schistosoma mansoni hypothetical protein 0.0879 0.5061 0.5061
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0013 0.0995
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0013 0.0995
Onchocerca volvulus 0.0035 0.0109 0.0388
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0054 0.0054
Brugia malayi AF-10 protein 0.0019 0.0015 0.012
Brugia malayi jmjC domain containing protein 0.0019 0.0013 0.0109
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0252 0.0252
Brugia malayi beta-lactamase 0.0035 0.0109 0.0892
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1584 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0451
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0133 0.0344
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0362 0.0362
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0109 0.0282
Trichomonas vaginalis set domain proteins, putative 0.0255 0.14 0.8791
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0013 0.0106
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0194 0.104 0.104
Echinococcus granulosus microtubule associated protein 2 0.0686 0.393 0.393
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0133 0.1091
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.014 0.0723 0.5923
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1584 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.001 0.001
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0249 0.1987
Loa Loa (eye worm) hypothetical protein 0.0101 0.0497 0.4073
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0013 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1584 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0249 0.0249
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0281 0.2306
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0109 0.0282
Schistosoma mansoni cpg binding protein 0.0128 0.0651 0.0651
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0109 0.0282
Onchocerca volvulus 0.0035 0.0109 0.0388
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0281 0.2306
Echinococcus granulosus mixed lineage leukemia protein mll 0.0031 0.0084 0.0084
Loa Loa (eye worm) beta-lactamase 0.0035 0.0109 0.0892
Toxoplasma gondii ABC1 family protein 0.0035 0.0109 0.087
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.122 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0133 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1584 1

Activities

Activity type Activity value Assay description Source Reference
Ki app (binding) = 7.32 uM Inhibition of Mycobacterium tuberculosis recombinant MbtA expressed in Escherichia coli by ATP/PPi exchange assay ChEMBL. 17967002
MIC99 (functional) > 200 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in iron deficient GAST medium ChEMBL. 17967002
MIC99 (functional) > 200 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in iron rich GAST medium ChEMBL. 17967002

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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