Detailed information for compound 449468

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 499.862 | Formula: C17H16ClN6O8S-
  • H donors: 5 H acceptors: 9 LogP: -0.36 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1[C@H](COS(=O)(=O)[N-]C(=O)c2cccc(c2O)Cl)O[C@@H]([C@H]1O)n1cnc2c1ncnc2N
  • InChi: 1S/C17H17ClN6O8S/c18-8-3-1-2-7(11(8)25)16(28)23-33(29,30)31-4-9-12(26)13(27)17(32-9)24-6-22-10-14(19)20-5-21-15(10)24/h1-3,5-6,9,12-13,17,26-27H,4H2,(H4,19,20,21,23,25,28)/p-1/t9-,12-,13-,17-/m1/s1
  • InChiKey: KTSHHQSPIXKLMA-DMEFTLKTSA-M  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.015 0.0643 0.1384
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1188 0.9552
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0212 0.0564
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0608 0.4433
Plasmodium vivax importin-beta 2, putative 0.0085 0.0336 0.5193
Echinococcus multilocularis geminin 0.1384 0.6557 0.6557
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0039 0.0025
Echinococcus multilocularis cpg binding protein 0.0062 0.0225 0.0225
Entamoeba histolytica acyl-CoA synthetase, putative 0.0059 0.0212 0.5229
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0039 0.0025
Trichomonas vaginalis set domain proteins, putative 0.0183 0.0803 0.645
Onchocerca volvulus 0.003 0.007 0.0385
Schistosoma mansoni hypothetical protein 0.008 0.0309 0.0309
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0039 0.0035
Echinococcus granulosus neuropeptide receptor A26 0.0448 0.2073 0.2073
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0754 0.6052
Trichomonas vaginalis esterase, putative 0.015 0.0643 0.516
Schistosoma mansoni hypothetical protein 0.0035 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.009
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.1188 0.6564
Loa Loa (eye worm) hypothetical protein 0.015 0.0643 0.1497
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0063 0.0228 0.3502
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0039 0.028
Loa Loa (eye worm) hypothetical protein 0.0082 0.0318 0.0741
Schistosoma mansoni gabp alpha 0.0079 0.0304 0.0304
Brugia malayi hypothetical protein 0.0391 0.1801 0.9954
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.013 0.013
Schistosoma mansoni methionine-tRNA synthetase 0.0086 0.0339 0.0339
Brugia malayi MH2 domain containing protein 0.0018 0.0012 0.0068
Schistosoma mansoni zinc finger protein 0.0018 0.0011 0.0011
Echinococcus multilocularis muscleblind protein 0.0227 0.1015 0.1015
Plasmodium falciparum methionine--tRNA ligase, putative 0.0033 0.0084 0.2387
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.008 0.0309 0.1708
Onchocerca volvulus 0.015 0.0643 0.3556
Echinococcus multilocularis translational activator gcn1 0.0016 0.0004 0.0004
Brugia malayi TAR-binding protein 0.02 0.0887 0.49
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0129 0.0869
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0304 0.0304
Loa Loa (eye worm) runx1 0.0049 0.0163 0.0379
Schistosoma mansoni tar DNA-binding protein 0.02 0.0887 0.0887
Schistosoma mansoni hypothetical protein 0.0069 0.0257 0.0257
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0042 0.0042
Echinococcus granulosus zinc finger protein 0.0029 0.0068 0.0068
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0063 0.0228 0.1644
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0754 0.6052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.1025 0.1025
Schistosoma mansoni glutaminase 0.0275 0.1243 0.1243
Plasmodium vivax methionine--tRNA ligase, putative 0.0033 0.0084 0.125
Schistosoma mansoni tar DNA-binding protein 0.02 0.0887 0.0887
Schistosoma mansoni ran 0.0063 0.0228 0.0228
Schistosoma mansoni lamin 0.0019 0.0019 0.0019
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0063 0.0228 0.126
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0039 0.0542
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.008 0.008
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0148 0.2249
Onchocerca volvulus 0.0037 0.0103 0.0571
Echinococcus granulosus histone lysine methyltransferase setb 0.0044 0.0137 0.0137
Mycobacterium ulcerans lipase LipD 0.015 0.0643 0.1913
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.1025 0.1025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0044 0.0137 0.0137
Schistosoma mansoni ap endonuclease 0.0022 0.0031 0.0031
Entamoeba histolytica acyl-CoA synthetase, putative 0.0059 0.0212 0.5229
Leishmania major leucyl-tRNA synthetase, putative 0.0033 0.0084 0.0587
Echinococcus multilocularis smad 0.0018 0.0012 0.0012
Echinococcus multilocularis muscleblind protein 1 0.0227 0.1015 0.1015
Echinococcus multilocularis importin subunit beta 1 0.0085 0.0336 0.0336
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0643 0.516
Loa Loa (eye worm) RNA binding protein 0.02 0.0887 0.2063
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0059 0.0212 0.0564
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0754 0.6052
Schistosoma mansoni ap endonuclease 0.0022 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0078 0.0303 0.0704
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0067 0.0067
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0031 0.0418
Echinococcus granulosus methionine tRNA synthetase 0.0086 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0227 0.1015 0.2361
Schistosoma mansoni hypothetical protein 0.1384 0.6557 0.6557
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1188 0.9552
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.069 0.3233 1
Plasmodium falciparum methionine--tRNA ligase 0.0086 0.0339 1
Echinococcus granulosus muscleblind protein 0.0227 0.1015 0.1015
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0608 0.4433
Echinococcus granulosus snurportin 1 0.0912 0.4297 0.4297
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0039 0.0025
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0031 0.0171
Mycobacterium tuberculosis Probable lipase LipE 0.015 0.0643 0.1384
Echinococcus granulosus survival motor neuron protein 1 0.0391 0.1801 0.1801
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0039 0.009
Onchocerca volvulus 0.0023 0.0039 0.0215
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0608 0.4403
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0039 0.0215
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0754 0.6052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.0643 0.0643
Schistosoma mansoni tar DNA-binding protein 0.02 0.0887 0.0887
Schistosoma mansoni cpg binding protein 0.0062 0.0225 0.0225
Brugia malayi Fli-1 protein 0.0239 0.1072 0.5923
Loa Loa (eye worm) TAR-binding protein 0.02 0.0887 0.2063
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0015 0.0015
Schistosoma mansoni zinc finger protein 0.0029 0.0068 0.0068
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0303 0.8916
Loa Loa (eye worm) hypothetical protein 0.0101 0.041 0.0955
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0031 0.0017
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0039 0.0255
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1746 0.8292 0.8292
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0401 0.0401
Echinococcus multilocularis protein patched 0.0042 0.013 0.013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0031 0.0196
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.008 0.0441
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0799 0.6412
Trypanosoma brucei ISWI complex protein 0.0018 0.0011 0.0053
Echinococcus multilocularis expressed conserved protein 0.0093 0.0372 0.0372
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0059 0.0212 0.2858
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0099 0.0401 0.0933
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.009
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.1366 1
Loa Loa (eye worm) hypothetical protein 0.015 0.0643 0.1497
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0012 0.0012
Echinococcus granulosus expressed conserved protein 0.0093 0.0372 0.0372
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0033 0.0084 0.0084
Entamoeba histolytica Ran family GTPase 0.0063 0.0228 0.5644
Brugia malayi hypothetical protein 0.0316 0.1443 0.7974
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0039 0.0255
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0039 0.0025
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0063 0.0228 0.3502
Brugia malayi hypothetical protein 0.0078 0.0303 0.1673
Brugia malayi PHD-finger family protein 0.0036 0.0098 0.0539
Loa Loa (eye worm) hypothetical protein 0.0227 0.1015 0.2361
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0033 0.0084 0.2014
Mycobacterium tuberculosis Probable conserved lipoprotein 0.015 0.0643 0.1384
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0025
Mycobacterium ulcerans esterase/lipase LipP 0.015 0.0643 0.1913
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0129 0.0869
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0069 0.0259 0.2054
Brugia malayi AMP-binding enzyme family protein 0.0059 0.0212 0.117
Toxoplasma gondii ABC1 family protein 0.015 0.0643 1
Mycobacterium leprae Probable lipase LipE 0.015 0.0643 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0039 0.0025
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0039 0.0202
Loa Loa (eye worm) hypothetical protein 0.0305 0.1389 0.3233
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0148 0.2249
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.025 0.6205
Loa Loa (eye worm) acetyltransferase 0.015 0.0648 0.1507
Echinococcus multilocularis microtubule associated protein 2 0.2102 1 1
Brugia malayi Importin beta-1 subunit 0.0085 0.0336 0.1858
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.013 0.0303
Leishmania major hypothetical protein, conserved 0.0018 0.0011 0.0053
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.025 0.1764
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.0186
Mycobacterium tuberculosis Probable lipase LipD 0.015 0.0643 0.1384
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.025 0.025
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0212 0.0564
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0086 0.0339 0.0962
Toxoplasma gondii hypothetical protein 0.0048 0.0159 0.242
Leishmania major 4-coumarate:coa ligase-like protein 0.0059 0.0212 0.1523
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0039 0.0025
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.02 0.0887 0.2063
Toxoplasma gondii HEAT repeat-containing protein 0.0085 0.0336 0.5193
Schistosoma mansoni microtubule-associated protein tau 0.2102 1 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0039 0.0025
Brugia malayi Pre-SET motif family protein 0.0024 0.0042 0.0234
Brugia malayi intermediate filament protein 0.0019 0.0019 0.0106
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0039 0.0255
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.01 0.017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.008 0.008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0015 0.0015
Brugia malayi RNA binding protein 0.02 0.0887 0.49
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0115 0.0263
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.01 0.017
Echinococcus multilocularis neuropeptide s receptor 0.0448 0.2073 0.2073
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0229 0.1025 0.2386
Brugia malayi protein ZK524.3 0.0033 0.0084 0.0465
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1188 0.9552
Loa Loa (eye worm) hypothetical protein 0.0051 0.017 0.0395
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0303 0.2191
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.008 0.008
Echinococcus granulosus intermediate filament protein 0.0019 0.0019 0.0019
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0115 1
Loa Loa (eye worm) intermediate filament protein 0.0019 0.0019 0.0045
Echinococcus multilocularis GPCR, family 2 0.0032 0.008 0.008
Echinococcus granulosus translational activator gcn1 0.0016 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0011
Onchocerca volvulus 0.0057 0.0199 0.1101
Echinococcus multilocularis zinc finger protein 0.0029 0.0068 0.0068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.1025 0.1025
Schistosoma mansoni importin beta-1 0.0085 0.0336 0.0336
Brugia malayi beta-lactamase family protein 0.015 0.0643 0.3556
Loa Loa (eye worm) hypothetical protein 0.0393 0.1809 0.4211
Echinococcus granulosus lamin 0.0019 0.0019 0.0019
Brugia malayi MH1 domain containing protein 0.0018 0.0012 0.0068
Echinococcus multilocularis snurportin 1 0.0912 0.4297 0.4297
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.008 0.008
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0033 0.0084 0.0084
Brugia malayi kap beta 3 protein 0.0016 0.0004 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0103 0.0241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.1025 0.1025
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0086 0.0339 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0059 0.0212 0.1523
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0039 0.0202
Brugia malayi AMP-binding enzyme family protein 0.0059 0.0212 0.117
Trypanosoma brucei importin beta-1 subunit, putative 0.0085 0.0336 0.2438
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0039 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0025
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0059 0.0212 0.042
Schistosoma mansoni tar DNA-binding protein 0.02 0.0887 0.0887
Plasmodium vivax hypothetical protein, conserved 0.015 0.0643 1
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0304 0.0304
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.015 0.0643 0.1913
Loa Loa (eye worm) importin-beta domain-containing protein 0.0016 0.0004 0.001
Brugia malayi Pre-SET motif family protein 0.0161 0.0698 0.3856
Onchocerca volvulus 0.008 0.0309 0.1708
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1188 0.9552
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0401 1
Echinococcus granulosus beta LACTamase domain containing family member 0.015 0.0643 0.0643
Schistosoma mansoni lamin 0.0019 0.0019 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0039 0.0215
Echinococcus granulosus tar DNA binding protein 0.02 0.0887 0.0887
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0025 0.0136
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0059 0.0212 0.0564
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.008 0.0186
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.025 0.025
Echinococcus multilocularis tar DNA binding protein 0.02 0.0887 0.0887
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0118 0.2857
Loa Loa (eye worm) hypothetical protein 0.0052 0.0176 0.041
Loa Loa (eye worm) hypothetical protein 0.0044 0.0139 0.0324
Leishmania major importin beta-1 subunit, putative 0.0069 0.0259 0.1869
Loa Loa (eye worm) hypothetical protein 0.0039 0.0115 0.0268
Schistosoma mansoni importin-beta 2 0.0016 0.0004 0.0004
Onchocerca volvulus 0.0019 0.0019 0.0106
Loa Loa (eye worm) Smad1 0.0018 0.0012 0.0029
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0063 0.0228 0.6688
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0063 0.0228 0.0228
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0643 0.516
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0118 0.3386
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0039 0.0542
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0912 0.4297 1
Brugia malayi Smad1 0.0018 0.0012 0.0068
Echinococcus granulosus neuropeptide s receptor 0.0448 0.2073 0.2073
Plasmodium falciparum importin beta, putative 0.0085 0.0336 0.9918
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.025 0.1764
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.0648 0.3579
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.1025 0.1025
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0031 0.0673
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0042 0.0042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0161 0.0698 0.1623
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.041 0.2269
Echinococcus multilocularis neuropeptide receptor A26 0.0448 0.2073 0.2073
Echinococcus granulosus importin 5 0.0016 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.008
Loa Loa (eye worm) glutaminase 2 0.0275 0.1243 0.2893
Brugia malayi CXXC zinc finger family protein 0.0057 0.0199 0.1101
Onchocerca volvulus 0.0023 0.0039 0.0215
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0115 0.0205
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0021 0.0021
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0126 0.0126
Brugia malayi RNA recognition motif domain containing protein 0.02 0.0887 0.49
Schistosoma mansoni intermediate filament proteins 0.0019 0.0019 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0229 0.1025 0.5667
Schistosoma mansoni bromodomain containing protein 0.008 0.031 0.031
Brugia malayi MH1 domain containing protein 0.0018 0.0012 0.0068
Loa Loa (eye worm) fli-1 protein 0.0239 0.1072 0.2494
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0033 0.0084 0.0166
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.025 0.025
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0039 0.0035
Leishmania major methionyl-tRNA synthetase, putative 0.0086 0.0339 0.2458
Brugia malayi beta-lactamase family protein 0.015 0.0643 0.3556
Loa Loa (eye worm) hypothetical protein 0.015 0.0643 0.1497
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0041
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0031 0.0196
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0039 0.0202
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0148 0.116
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0303 0.4668
Schistosoma mansoni hypothetical protein 0.0291 0.1321 0.1321
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0086 0.0339 0.0704
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0115 0.3314
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0032 0.0032
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0118 0.2813
Echinococcus multilocularis dnaJ subfamily B 0.0291 0.1321 0.1321
Brugia malayi hypothetical protein 0.0051 0.0169 0.0936
Brugia malayi CHE-14 protein 0.0042 0.013 0.072
Treponema pallidum leucyl-tRNA synthetase 0.0033 0.0084 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0012 0.0029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.0643 0.0643
Schistosoma mansoni patched 1 0.0042 0.013 0.013
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0393 0.1809 0.4211
Schistosoma mansoni smad1 5 8 and 0.0018 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0033 0.0084 0.1727
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0039 0.0202
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0021 0.0021
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0039 0.009
Schistosoma mansoni smad1 5 8 and 0.0018 0.0012 0.0012
Brugia malayi MH2 domain containing protein 0.0262 0.1182 0.6535
Echinococcus granulosus lamin dm0 0.0019 0.0019 0.0019
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0012 0.0029
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0477 0.7402
Echinococcus multilocularis leucyl tRNA synthetase 0.0033 0.0084 0.0084
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0086 0.0339 0.2458
Brugia malayi beta-lactamase 0.015 0.0643 0.3556
Loa Loa (eye worm) hypothetical protein 0.0069 0.0257 0.0599
Loa Loa (eye worm) hypothetical protein 0.0033 0.0084 0.0196
Schistosoma mansoni hypothetical protein 0.0041 0.0123 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1188 0.9552
Loa Loa (eye worm) hypothetical protein 0.0039 0.0115 0.0268
Loa Loa (eye worm) hypothetical protein 0.0039 0.0115 0.0268
Onchocerca volvulus 0.0059 0.0212 0.117
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0045
Brugia malayi Intermediate filament tail domain containing protein 0.0019 0.0019 0.0106
Schistosoma mansoni hypothetical protein 0.0912 0.4297 0.4297
Schistosoma mansoni ets-related 0.0239 0.1072 0.1072
Onchocerca volvulus 0.0024 0.0042 0.0234
Brugia malayi Latrophilin receptor protein 2 0.0032 0.008 0.0441
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0031 0.0143
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.025 0.1384
Echinococcus granulosus geminin 0.1384 0.6557 0.6557
Schistosoma mansoni methionine-tRNA synthetase 0.0033 0.0084 0.0084
Onchocerca volvulus 0.0019 0.0019 0.0106
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0021 0.0021
Echinococcus multilocularis lamin dm0 0.0019 0.0019 0.0019
Entamoeba histolytica acyl-coA synthetase, putative 0.0059 0.0212 0.5229
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1188 0.9552
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0039 0.0874
Brugia malayi N-terminal motif family protein 0.0305 0.1389 0.7678
Loa Loa (eye worm) hypothetical protein 0.0033 0.0084 0.0196
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0408 0.0408
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0039 0.0039
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0039 0.0035
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0039 0.0542
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0604 0.0604
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0084 0.125
Schistosoma mansoni ran 0.0063 0.0228 0.0228
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.0648 0.0648
Toxoplasma gondii exonuclease III APE 0.0022 0.0031 0.0418
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0401 0.0401
Leishmania major GTP-binding protein, putative 0.0063 0.0228 0.1644
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0025
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0039 0.0035
Plasmodium vivax SET domain protein, putative 0.0024 0.0042 0.0598
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0031 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0754 0.6052
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.013 0.013
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.1366 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.025 0.1808
Loa Loa (eye worm) glutaminase 0.0275 0.1243 0.2893
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0643 0.4666
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0095 0.0095
Echinococcus multilocularis beta LACTamase domain containing family member 0.015 0.0643 0.0643
Leishmania major hypothetical protein, conserved 0.0078 0.0303 0.2191
Echinococcus granulosus importin subunit beta 1 0.0085 0.0336 0.0336
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0148 0.116
Brugia malayi methionyl-tRNA synthetase 0.0033 0.0084 0.0465
Echinococcus multilocularis protein dispatched 1 0.0048 0.0159 0.0159
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0086 0.0339 0.2417
Loa Loa (eye worm) hypothetical protein 0.0316 0.1443 0.3358
Schistosoma mansoni hypothetical protein 0.0024 0.0041 0.0041
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0303 0.4668
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.008
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0063 0.0228 0.1599
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.0643 0.516
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0039 0.0035
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0039 0.0542
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.0212 0.0564
Onchocerca volvulus 0.0183 0.0803 0.444
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.0648 0.0648
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0137 0.0137
Onchocerca volvulus 0.0316 0.1443 0.7974
Schistosoma mansoni cpg binding protein 0.0057 0.0199 0.0199
Schistosoma mansoni hypothetical protein 0.0041 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.015 0.0643 0.1497
Mycobacterium ulcerans beta-lactamase 0.015 0.0643 0.1913
Loa Loa (eye worm) hypothetical protein 0.0059 0.0212 0.0492
Echinococcus granulosus Protein patched homolog 1 0.0042 0.013 0.013
Schistosoma mansoni tar DNA-binding protein 0.02 0.0887 0.0887
Schistosoma mansoni hypothetical protein 0.0041 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0059 0.0212 0.0492
Leishmania major mitochondrial DNA polymerase beta 0.03 0.1366 1
Loa Loa (eye worm) hypothetical protein 0.015 0.0643 0.1497
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.1366 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0069 0.0259 0.2054
Loa Loa (eye worm) hypothetical protein 0.015 0.0643 0.1497
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.01 0.017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.1025 0.1025
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0401 0.2216
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0643 0.516
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0039 0.0035
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0039 0.0215
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0604 0.0604
Brugia malayi Bromodomain containing protein 0.0094 0.0375 0.2072
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0086 0.0339 0.2702
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0039 0.0035
Toxoplasma gondii methionyl-tRNA synthetase 0.0086 0.0339 0.5236
Schistosoma mansoni lozenge 0.0049 0.0163 0.0163
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0031 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.1025 0.1025
Mycobacterium ulcerans hypothetical protein 0.0059 0.0212 0.0564
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0012 0.0012
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0031 0.0072
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0056 0.0196 0.0456
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0019 0.0019 0.0045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.041 0.2269
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0025
Echinococcus granulosus GTP binding nuclear protein Ran 0.0063 0.0228 0.0228
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0059 0.0212 0.042
Brugia malayi Ets-domain containing protein 0.0079 0.0304 0.168
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0067 0.0067
Giardia lamblia Leucyl-tRNA synthetase 0.0033 0.0084 0.1727
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0039 0.0215
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0039 0.0255
Brugia malayi hypothetical protein 0.0393 0.1809 1
Plasmodium vivax methionine--tRNA ligase, putative 0.0086 0.0339 0.5236
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0031 0.0143
Brugia malayi MH2 domain containing protein 0.0018 0.0012 0.0068
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.015 0.0643 0.1384
Echinococcus multilocularis importin 5 0.0016 0.0004 0.0004
Onchocerca volvulus 0.0393 0.1809 1
Echinococcus multilocularis transportin 1 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0067 0.0249 0.058
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0095 0.0095
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0039 0.0255
Loa Loa (eye worm) oxidoreductase 0.0023 0.0039 0.009
Mycobacterium leprae conserved hypothetical protein 0.015 0.0643 1
Mycobacterium tuberculosis Probable esterase LipL 0.015 0.0643 0.1384
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0039 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0303 0.215
Echinococcus granulosus tumor protein p63 0.0252 0.1134 0.1134
Onchocerca volvulus 0.0023 0.0039 0.0215
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.01 0.017
Onchocerca volvulus 0.0053 0.0182 0.1004
Trypanosoma cruzi importin beta-1 subunit, putative 0.0069 0.0259 0.1825
Echinococcus granulosus GPCR family 2 0.0032 0.008 0.008
Trypanosoma brucei importin beta-1 subunit, putative 0.0085 0.0336 0.2438
Leishmania major hypothetical protein, conserved 0.015 0.0643 0.4694
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0031 0.0798
Schistosoma mansoni smad 0.0018 0.0012 0.0012
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0086 0.0339 0.4963
Schistosoma mansoni survival motor neuron protein 0.008 0.0309 0.0309
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0126 0.0126
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0063 0.0228 0.1599
Onchocerca volvulus 0.015 0.0643 0.3556
Schistosoma mansoni cpg binding protein 0.0062 0.0225 0.0225
Entamoeba histolytica hypothetical protein 0.0069 0.0259 0.6417
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0031 0.0216
Echinococcus multilocularis survival motor neuron protein 1 0.0391 0.1801 0.1801
Toxoplasma gondii tRNA ligases class I (M) protein 0.0033 0.0084 0.125
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0129 0.0917
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0199 0.0464
Echinococcus granulosus dnaJ subfamily B 0.0291 0.1321 0.1321
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0044 0.0137 0.0318
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0042 0.0598
Mycobacterium tuberculosis Conserved protein 0.015 0.0643 0.1384
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.069 0.3233 0.7162
Loa Loa (eye worm) kap beta 3 protein 0.0016 0.0004 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0059 0.0212 0.0564
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0039 0.0025
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0039 0.028
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0685 0.1476
Brugia malayi glutaminase DH11.1 0.0275 0.1243 0.6871
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0063 0.0228 0.6401
Loa Loa (eye worm) hypothetical protein 0.0059 0.0212 0.0492
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.025 0.1808
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0303 0.215
Brugia malayi Muscleblind-like protein 0.0227 0.1015 0.5608
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0754 0.6052
Schistosoma mansoni cellular tumor antigen P53 0.0037 0.0103 0.0103
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0303 0.8916
Mycobacterium ulcerans glutaminase 0.0275 0.1243 0.3785
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0643 0.4666
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0041 0.0095
Brugia malayi methionyl-tRNA synthetase 0.0086 0.0339 0.1873
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0173 0.1196
Echinococcus multilocularis lamin 0.0019 0.0019 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0025
Brugia malayi Bromodomain containing protein 0.0048 0.0156 0.0863
Schistosoma mansoni hypothetical protein 0.0041 0.0123 0.0123
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0956 0.4506 1
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0799 0.6412
Loa Loa (eye worm) hypothetical protein 0.0042 0.013 0.0303
Mycobacterium ulcerans hypothetical protein 0.015 0.0643 0.1913
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.0643 0.516
Loa Loa (eye worm) hypothetical protein 0.0039 0.0115 0.0268
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0039 0.0215
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.025 0.0583
Mycobacterium tuberculosis Probable hydrolase 0.015 0.0643 0.1384
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.0754 0.4168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0137 0.0137
Schistosoma mansoni leucyl-tRNA synthetase 0.0033 0.0084 0.0084
Echinococcus granulosus transportin 1 0.0016 0.0004 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0042 0.0042
Echinococcus multilocularis tumor protein p63 0.0252 0.1134 0.1134
Echinococcus granulosus smad 0.0018 0.0012 0.0012
Echinococcus multilocularis musashi 0.0019 0.0019 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0025
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0042 0.0098
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0114 0.0114
Loa Loa (eye worm) transcription factor SMAD2 0.0262 0.1182 0.2752
Brugia malayi Ets-domain containing protein 0.0079 0.0304 0.168
Echinococcus granulosus Smad4 0.0018 0.0012 0.0012
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0012 0.0012
Onchocerca volvulus 0.015 0.0643 0.3556
Mycobacterium ulcerans hypothetical protein 0.0158 0.0685 0.2042
Echinococcus multilocularis Smad4 0.0018 0.0012 0.0012
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0115 0.1735
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0025
Echinococcus multilocularis methionine tRNA synthetase 0.0086 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0391 0.1801 0.4191
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0305 0.1389 0.7678
Giardia lamblia Methionyl-tRNA synthetase 0.0086 0.0339 1
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0086 0.0339 0.0789
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.041 0.0955
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0039 0.1036
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0063 0.0228 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.013 0.1017
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0031 0.0031
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.015 0.0643 0.3556
Trichomonas vaginalis ran, putative 0.0063 0.0228 0.1807
Brugia malayi RNA, U transporter 1 0.0243 0.1091 0.6029
Schistosoma mansoni smad1 5 8 and 0.0018 0.0012 0.0012
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0053 0.0182 0.0423
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0304 0.0707
Treponema pallidum methionyl-tRNA synthetase 0.0033 0.0084 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0085 0.0336 0.0782
Trichomonas vaginalis glutaminase, putative 0.0275 0.1243 1
Schistosoma mansoni hypothetical protein 0.1384 0.6557 0.6557
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0021 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0212 0.0564
Loa Loa (eye worm) MH2 domain-containing protein 0.0262 0.1182 0.2752
Loa Loa (eye worm) hypothetical protein 0.0039 0.0115 0.0268
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0012 0.0012
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0059 0.0212 0.2858
Brugia malayi AMP-binding enzyme family protein 0.0059 0.0212 0.117
Schistosoma mansoni Smad4 0.0018 0.0012 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0129 0.0869
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0257 0.1423
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0754 0.6052
Leishmania major 4-coumarate:coa ligase-like protein 0.0059 0.0212 0.1523
Echinococcus multilocularis Protein lozenge 0.0049 0.0163 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0039 0.0215
Mycobacterium tuberculosis Conserved protein 0.015 0.0643 0.1384
Trypanosoma brucei hypothetical protein, conserved 0.015 0.0643 0.4694
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0033 0.0084 0.0196
Trichomonas vaginalis importin beta-1, putative 0.0069 0.0259 0.2054
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0114 0.0114
Echinococcus granulosus cpg binding protein 0.0062 0.0225 0.0225
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0015 0.0035
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0148 0.2249
Mycobacterium tuberculosis Conserved protein 0.015 0.0643 0.1384
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.029 0.029
Loa Loa (eye worm) beta-lactamase 0.015 0.0643 0.1497
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0067 0.0067
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.015 0.0643 0.1497
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.029 0.029
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.1188 0.2764

Activities

Activity type Activity value Assay description Source Reference
Ki app (binding) = 0.061 uM Inhibition of Mycobacterium tuberculosis recombinant MbtA expressed in Escherichia coli by ATP/PPi exchange assay ChEMBL. 17967002
MIC99 (functional) = 50 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in iron deficient GAST medium ChEMBL. 17967002
MIC99 (functional) > 200 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in iron rich GAST medium ChEMBL. 17967002

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.