TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 262.387 | Formula: C17H26O2
H donors: 0 H acceptors: 0 LogP: 4.09 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: C1CCC2(CC1)OOC1(C2)C2CC3CC1CC(C2)C3
InChi: 1S/C17H26O2/c1-2-4-16(5-3-1)11-17(19-18-16)14-7-12-6-13(9-14)10-15(17)8-12/h12-15H,1-11H2
InChiKey: OABPPMUZQJEDOU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	aurora kinase	0.00730019	0.120586	0.159658
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0340855	0.729228	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0188565	0.383179	0.525458
Schistosoma mansoni	serine/threonine protein kinase	0.0157529	0.312656	0.428749
Echinococcus multilocularis	tyrosine protein kinase Blk	0.00757953	0.126933	0.174065
Loa Loa (eye worm)	hypothetical protein	0.00284918	0.0194454	0.0180068
Echinococcus granulosus	endonuclease reverse transcriptase	0.00284918	0.0194454	0.0266658
Trichomonas vaginalis	AGC family protein kinase	0.0313177	0.666335	1
Loa Loa (eye worm)	hypothetical protein	0.00284918	0.0194454	0.0180068
Leishmania major	protein kinase, putative	0.00730019	0.120586	0.154241
Giardia lamblia	CEGP1 protein	0.00284918	0.0194454	0.0400908
Echinococcus granulosus	serine threonine protein kinase nrc	0.0159086	0.316196	0.433603
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.00310361	0.0252269	0.0345939
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.00838402	0.145214	0.199133
Loa Loa (eye worm)	SRC-1	0.00838402	0.145214	0.14396
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0148816	0.292858	0.431605
Echinococcus multilocularis	protein kinase shaggy	0.0217952	0.449957	0.617032
Echinococcus multilocularis	cyclin b3	0.0020579	0.00146505	0.00200904
Echinococcus multilocularis	rac serine:threonine kinase	0.0164988	0.329606	0.451993
Echinococcus multilocularis	cyclin B	0.00465673	0.0605183	0.0829895
Schistosoma mansoni	vav2	0.00439585	0.0545903	0.0748604
Brugia malayi	Protein kinase c protein 2	0.0126801	0.242834	0.364432
Brugia malayi	serine/threonine protein kinase 6	0.00730019	0.120586	0.180968
Echinococcus granulosus	protein kinase c eta type	0.00298072	0.0224344	0.0307647
Echinococcus granulosus	unc 13 munc13	0.00310361	0.0252269	0.0345939
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.00757953	0.126933	0.174065
Entamoeba histolytica	hypothetical protein	0.00298072	0.0224344	0.0315391
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0020579	0.00146505	0.00200904
Loa Loa (eye worm)	hypothetical protein	0.0302488	0.642048	0.641523
Plasmodium falciparum	conserved protein, unknown function	0.00284918	0.0194454	0.0400908
Loa Loa (eye worm)	AUR protein kinase	0.00730019	0.120586	0.119295
Schistosoma mansoni	serine/threonine-protein kinase	0.0164988	0.329606	0.451993
Toxoplasma gondii	diacylglycerol kinase, putative	0.00298072	0.0224344	0.00471839
Echinococcus granulosus	protein kinase shaggy	0.0217952	0.449957	0.617032
Schistosoma mansoni	serine/threonine protein kinase	0.00334469	0.0307048	0.0421059
Loa Loa (eye worm)	hypothetical protein	0.00357088	0.0358445	0.0344299
Brugia malayi	Protein kinase domain containing protein	0.0157529	0.312656	0.469217
Entamoeba histolytica	protein kinase, putative	0.0307275	0.652925	0.979831
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.00380569	0.0411802	0.056471
Trypanosoma cruzi	cdc2-related kinase 1	0.0148816	0.292858	0.596602
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.00838402	0.145214	0.199133
Trichomonas vaginalis	AGC family protein kinase	0.0313177	0.666335	1
Trichomonas vaginalis	CMGC family protein kinase	0.0148816	0.292858	0.438271
Schistosoma mansoni	serine/threonine protein kinase	0.0039147	0.0436571	0.0598676
Trichomonas vaginalis	cyclins, putative	0.00465673	0.0605183	0.0888192
Trichomonas vaginalis	AGC family protein kinase	0.0313177	0.666335	1
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0217952	0.449957	1
Entamoeba histolytica	protein kinase , putative	0.00730019	0.120586	0.179164
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0164988	0.329606	0.493541
Plasmodium falciparum	glycogen synthase kinase 3	0.0217952	0.449957	1
Schistosoma mansoni	hypothetical protein	0.00284918	0.0194454	0.0266658
Loa Loa (eye worm)	hypothetical protein	0.00284918	0.0194454	0.0180068
Schistosoma mansoni	serine/threonine kinase	0.0157529	0.312656	0.428749
Giardia lamblia	Kinase, AGC PKA	0.0159086	0.316196	0.701753
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.00730019	0.120586	0.179164
Echinococcus multilocularis	cyclins	0.0020579	0.00146505	0.00200904
Echinococcus granulosus	tyrosine protein kinase Src42A	0.00721557	0.118663	0.162724
Brugia malayi	RhoGAP domain containing protein	0.00380569	0.0411802	0.061801
Echinococcus granulosus	RNA directed DNA polymerase	0.00864252	0.151088	0.207188
Schistosoma mansoni	unc-13 (munc13)	0.00310361	0.0252269	0.0345939
Echinococcus multilocularis	cyclin dependent kinase 1	0.0148816	0.292858	0.4016
Echinococcus granulosus	tyrosine protein kinase Src42A	0.00838402	0.145214	0.199133
Schistosoma mansoni	serine/threonine protein kinase	0.0039147	0.0436571	0.0598676
Loa Loa (eye worm)	hypothetical protein	0.0139476	0.271636	0.270567
Schistosoma mansoni	ephrin receptor	0.0123242	0.234746	0.321911
Loa Loa (eye worm)	hypothetical protein	0.00298072	0.0224344	0.0210002
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0157529	0.312656	0.311647
Entamoeba histolytica	protein kinase, putative	0.0313177	0.666335	1
Schistosoma mansoni	diacylglycerol kinase theta	0.00298072	0.0224344	0.0307647
Loa Loa (eye worm)	hypothetical protein	0.00298072	0.0224344	0.0210002
Echinococcus granulosus	tyrosine protein kinase Src64B	0.00838402	0.145214	0.199133
Loa Loa (eye worm)	hypothetical protein	0.00608656	0.0930084	0.0916776
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0149747	0.294973	0.4045
Echinococcus granulosus	NDR protein kinase	0.0157529	0.312656	0.428749
Entamoeba histolytica	hypothetical protein	0.00284918	0.0194454	0.0270435
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0039147	0.0436571	0.042254
Echinococcus granulosus	tyrosine kinase	0.00757953	0.126933	0.174065
Echinococcus multilocularis	cyclins	0.0020579	0.00146505	0.00200904
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0157529	0.312656	0.428749
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0148816	0.292858	0.291821
Brugia malayi	diacylglycerol kinase	0.00298072	0.0224344	0.0336684
Entamoeba histolytica	protein kinase, putative	0.0157529	0.312656	0.468047
Trichomonas vaginalis	AGC family protein kinase	0.00730019	0.120586	0.179164
Trichomonas vaginalis	CMGC family protein kinase	0.0148816	0.292858	0.438271
Giardia lamblia	Kinase, AGC AKT	0.0192666	0.392498	0.871886
Echinococcus granulosus	mitogen activated protein kinase 3	0.0120006	0.227394	0.311828
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0217952	0.449957	0.44915
Entamoeba histolytica	protein kinase 2, putative	0.0159086	0.316196	0.473372
Brugia malayi	Variant SH3 domain containing protein	0.00380569	0.0411802	0.061801
Brugia malayi	cell division control protein 2 homolog	0.0148816	0.292858	0.439506
Loa Loa (eye worm)	hypothetical protein	0.00310361	0.0252269	0.0237967
Loa Loa (eye worm)	hypothetical protein	0.00284918	0.0194454	0.0180068
Plasmodium vivax	protein kinase Crk2	0.0148816	0.292858	0.635088
Schistosoma mansoni	protein kinase	0.00730019	0.120586	0.165361
Onchocerca volvulus		0.0217952	0.449957	0.691471
Schistosoma mansoni	serine/threonine protein kinase	0.0157529	0.312656	0.428749
Echinococcus multilocularis	endonuclease reverse transcriptase	0.00284918	0.0194454	0.0266658
Loa Loa (eye worm)	TK protein kinase	0.00675456	0.108187	0.106879
Onchocerca volvulus		0.0302488	0.642048	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.00838402	0.145214	0.199133
Plasmodium falciparum	cysteine repeat modular protein 1	0.00284918	0.0194454	0.0400908
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0157529	0.312656	0.428749
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.00730019	0.120586	0.165361
Brugia malayi	Ras association domain family 1 isoform A	0.00298072	0.0224344	0.0336684
Echinococcus granulosus	tyrosine protein kinase Fyn	0.00838402	0.145214	0.199133
Brugia malayi	GCC2 and GCC3 family protein	0.00284918	0.0194454	0.0291827
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.00838402	0.145214	0.199133
Echinococcus granulosus	protein kinase C gamma type	0.0245183	0.511832	0.701882
Trichomonas vaginalis	cyclin B, putative	0.00465673	0.0605183	0.0888192
Entamoeba histolytica	diacylglycerol kinase, putative	0.00298072	0.0224344	0.0315391
Echinococcus granulosus	cyclin B	0.00465673	0.0605183	0.0829895
Schistosoma mansoni	cyclin B	0.00465673	0.0605183	0.0829895
Trichomonas vaginalis	CMGC family protein kinase	0.0120006	0.227394	0.339809
Trichomonas vaginalis	cyclin A, putative	0.00465673	0.0605183	0.0888192
Echinococcus granulosus	protein kinase c epsilon type	0.0188565	0.383179	0.525458
Trichomonas vaginalis	CMGC family protein kinase	0.0148816	0.292858	0.438271
Echinococcus granulosus	cyclin dependent kinase	0.0148816	0.292858	0.4016
Echinococcus granulosus	tyrosine protein kinase Fyn	0.00838402	0.145214	0.199133
Brugia malayi	Protein kinase domain containing protein	0.0313177	0.666335	1
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0340855	0.729228	0.728831
Trichomonas vaginalis	CMGC family protein kinase	0.0217952	0.449957	0.674555
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.00838402	0.145214	0.199133
Trichomonas vaginalis	CMGC family protein kinase	0.0120006	0.227394	0.339809
Trichomonas vaginalis	AGC family protein kinase	0.0313177	0.666335	1
Echinococcus granulosus	cyclin B3 1	0.0020579	0.00146505	0.00200904
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.00730019	0.120586	0.234931
Trichomonas vaginalis	cyclins, putative	0.0031247	0.0257059	0.0364595
Plasmodium falciparum	cysteine repeat modular protein 4	0.00284918	0.0194454	0.0400908
Brugia malayi	Protein kinase domain containing protein	0.0157529	0.312656	0.469217
Brugia malayi	ribosomal protein S6 kinase alpha 3	0.0192666	0.392498	0.589041
Entamoeba histolytica	cysteine-rich surface protein, putative	0.00284918	0.0194454	0.0270435
Echinococcus granulosus	serine/threonine protein kinase	0.0164988	0.329606	0.451993
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0120006	0.227394	0.275455
Onchocerca volvulus		0.00357088	0.0358445	0.0263396
Giardia lamblia	Aurora kinase	0.00730019	0.120586	0.265603
Entamoeba histolytica	protein kinase domain containing protein	0.0217952	0.449957	0.674555
Trichomonas vaginalis	AGC family protein kinase	0.0313177	0.666335	1
Brugia malayi	MAP kinase sur-1	0.0120006	0.227394	0.34126
Brugia malayi	protein kinase C3,putative	0.0039147	0.0436571	0.0655183
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0039147	0.0436571	0.0655183
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.00298072	0.0224344	0.0210002
Brugia malayi	GCC2 and GCC3 family protein	0.00284918	0.0194454	0.0291827
Brugia malayi	Pleckstrin Homology Domain	0.00357088	0.0358445	0.0537935
Schistosoma mansoni	serine/threonine-protein kinase	0.0164988	0.329606	0.451993
Echinococcus multilocularis	unc 13 (munc13)	0.00310361	0.0252269	0.0345939
Brugia malayi	Hr1 repeat family protein	0.0157529	0.312656	0.469217
Echinococcus granulosus	Diacylglycerol kinase theta	0.00298072	0.0224344	0.0307647
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.00380569	0.0411802	0.056471
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0157529	0.312656	0.428749
Echinococcus multilocularis	aurora kinase A	0.00730019	0.120586	0.165361
Trypanosoma brucei	cdc2-related kinase 3	0.0148816	0.292858	0.383515
Echinococcus granulosus	cyclin dependent kinase 5	0.0148816	0.292858	0.4016
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.00730019	0.120586	0.165361
Schistosoma mansoni	cyclins	0.0020579	0.00146505	0.00200904
Schistosoma mansoni	serine/threonine protein kinase	0.0188565	0.383179	0.525458
Loa Loa (eye worm)	TK protein kinase	0.00757953	0.126933	0.125652
Giardia lamblia	Hypothetical protein	0.00284918	0.0194454	0.0400908
Echinococcus granulosus	cyclins	0.0020579	0.00146505	0.00200904
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.00730019	0.120586	0.179164
Brugia malayi	diacylglycerol kinase	0.00298072	0.0224344	0.0336684
Echinococcus multilocularis	nervana 2	0.0149747	0.294973	0.4045
Plasmodium falciparum	protein kinase 5	0.0148816	0.292858	0.649718
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.00838402	0.145214	0.199133
Brugia malayi	RhoGEF domain containing protein	0.00298072	0.0224344	0.0336684
Trichomonas vaginalis	cyclins, putative	0.00465673	0.0605183	0.0888192
Trichomonas vaginalis	CMGC family protein kinase	0.0120006	0.227394	0.339809
Echinococcus granulosus	tyrosine protein kinase Lyn	0.009318	0.166436	0.228236
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0217952	0.449957	1
Entamoeba histolytica	protein kinase domain containing protein	0.00730019	0.120586	0.179164
Schistosoma mansoni	rac gtpase activating protein	0.00298072	0.0224344	0.0307647
Onchocerca volvulus		0.00310361	0.0252269	0.00928591
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0148816	0.292858	0.4016
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0217952	0.449957	0.617032
Trypanosoma cruzi	aurora B kinase, putative	0.00730019	0.120586	0.154241
Entamoeba histolytica	hypothetical protein	0.00284918	0.0194454	0.0270435
Plasmodium falciparum	cysteine repeat modular protein 2	0.00284918	0.0194454	0.0400908
Echinococcus multilocularis	cyclin dependent kinase	0.0148816	0.292858	0.4016
Entamoeba histolytica	protein kinase, putative	0.0217952	0.449957	0.674555
Entamoeba histolytica	protein kinase, putative	0.00730019	0.120586	0.179164
Echinococcus granulosus	cyclins	0.0020579	0.00146505	0.00200904
Echinococcus multilocularis	nervana 2	0.0149747	0.294973	0.4045
Loa Loa (eye worm)	hypothetical protein	0.00298072	0.0224344	0.0210002
Echinococcus multilocularis	tyrosine protein kinase Srms	0.00757953	0.126933	0.174065
Echinococcus granulosus	Rac GTPase activating protein 1	0.00298072	0.0224344	0.0307647
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0120006	0.227394	0.428502
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.00380569	0.0411802	0.0397734
Giardia lamblia	Kinase, CMGC GSK	0.0217952	0.449957	1
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0148816	0.292858	0.596602
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0198567	0.405909	0.886893
Trichomonas vaginalis	cyclin B, putative	0.00465673	0.0605183	0.0888192
Echinococcus multilocularis	cyclin B3 1	0.0020579	0.00146505	0.00200904
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0307275	0.652925	0.652416
Entamoeba histolytica	protein kinase, putative	0.0313177	0.666335	1
Brugia malayi	protein-tyrosine kinase	0.00757953	0.126933	0.190494
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0120006	0.227394	0.428502
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0157529	0.312656	0.428749
Brugia malayi	Protein kinase domain containing protein	0.0039147	0.0436571	0.0655183
Loa Loa (eye worm)	AUR protein kinase	0.00730019	0.120586	0.119295
Echinococcus granulosus	cyclin b3	0.0020579	0.00146505	0.00200904
Echinococcus granulosus	cyclin dependent kinase 1	0.0148816	0.292858	0.4016
Echinococcus multilocularis	cyclins	0.0020579	0.00146505	0.00200904
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0148816	0.292858	0.291821
Trichomonas vaginalis	AGC family protein kinase	0.0313177	0.666335	1
Trichomonas vaginalis	AGC family protein kinase	0.0157529	0.312656	0.468047
Loa Loa (eye worm)	hypothetical protein	0.00864252	0.151088	0.149842
Brugia malayi	GCC2 and GCC3 family protein	0.00284918	0.0194454	0.0291827
Trichomonas vaginalis	AGC family protein kinase	0.00730019	0.120586	0.179164
Trichomonas vaginalis	CMGC family protein kinase	0.0217952	0.449957	0.674555
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.00757953	0.126933	0.174065
Trichomonas vaginalis	cyclins, putative	0.00465673	0.0605183	0.0888192
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.00298072	0.0224344	0.0210002
Giardia lamblia	Kinase, CMGC GSK	0.0217952	0.449957	1
Echinococcus granulosus	Glutaredoxin protein 5	0.0149747	0.294973	0.4045
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0120006	0.227394	0.22626
Loa Loa (eye worm)	hypothetical protein	0.00298072	0.0224344	0.0210002
Loa Loa (eye worm)	hypothetical protein	0.0302488	0.642048	0.641523
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0039147	0.0436571	0.0598676
Entamoeba histolytica	hypothetical protein, conserved	0.00284918	0.0194454	0.0270435
Echinococcus granulosus	tyrosine protein kinase Blk	0.00757953	0.126933	0.174065
Brugia malayi	protein kinase C II.	0.0188565	0.383179	0.575054
Echinococcus granulosus	cyclins	0.0020579	0.00146505	0.00200904
Trichomonas vaginalis	AGC family protein kinase	0.016343	0.326066	0.488216
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0313177	0.666335	0.665846
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.00864252	0.151088	0.207188
Loa Loa (eye worm)	hypothetical protein	0.00298072	0.0224344	0.0210002
Echinococcus granulosus	tyrosine protein kinase HCK	0.00675456	0.108187	0.148359
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0157529	0.312656	0.428749
Trichomonas vaginalis	CMGC family protein kinase	0.0120006	0.227394	0.339809
Entamoeba histolytica	protein kinase, putative	0.00730019	0.120586	0.179164
Schistosoma mansoni	cyclin B3	0.0020579	0.00146505	0.00200904
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.00310361	0.0252269	0.0345939
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0157529	0.312656	0.428749
Trichomonas vaginalis	AGC family protein kinase	0.00730019	0.120586	0.179164
Schistosoma mansoni	serine/threonine protein kinase	0.0340855	0.729228	1
Entamoeba histolytica	cyclin, putative	0.00465673	0.0605183	0.0888192
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0157529	0.312656	0.428749
Trypanosoma brucei	protein kinase, putative	0.0217952	0.449957	0.642832
Echinococcus multilocularis	cyclins	0.0020579	0.00146505	0.00200904
Echinococcus granulosus	protein kinase c iota type	0.0187336	0.380387	0.521629
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0157529	0.312656	0.311647
Trichomonas vaginalis	cyclin B, putative	0.00465673	0.0605183	0.0888192
Giardia lamblia	G2/mitotic-specific cyclin B	0.00465673	0.0605183	0.131671
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0148816	0.292858	0.291821
Schistosoma mansoni	serine/threonine protein kinase	0.027499	0.579563	0.794763
Plasmodium falciparum	cysteine repeat modular protein 3	0.00284918	0.0194454	0.0400908
Schistosoma mansoni	protein kinase C mu	0.00298072	0.0224344	0.0307647
Entamoeba histolytica	protein kinase domain containing protein	0.0217952	0.449957	0.674555
Echinococcus multilocularis	Rac GTPase activating protein 1	0.00298072	0.0224344	0.0307647
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.00380569	0.0411802	0.056471
Loa Loa (eye worm)	hypothetical protein	0.00465673	0.0605183	0.0591399
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0020579	0.00146505	0.00200904
Brugia malayi	C1-like domain containing protein	0.0039147	0.0436571	0.0655183
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0120006	0.227394	0.428502
Echinococcus granulosus	mitogen activated protein kinase	0.0120006	0.227394	0.311828
Echinococcus multilocularis	Diacylglycerol kinase theta	0.00298072	0.0224344	0.0307647
Echinococcus multilocularis	protein kinase c iota type	0.0187336	0.380387	0.521629
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0120006	0.227394	0.328263
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0159086	0.316196	0.656528
Echinococcus granulosus	cyclins	0.0020579	0.00146505	0.00200904
Echinococcus multilocularis	cyclin dependent kinase 1	0.0148816	0.292858	0.4016
Loa Loa (eye worm)	raf kinase	0.00298072	0.0224344	0.0210002
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0157529	0.312656	0.311647
Trichomonas vaginalis	AGC family protein kinase	0.0157529	0.312656	0.468047
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0148189	0.291433	0.436127
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.00838402	0.145214	0.199133
Loa Loa (eye worm)	hypothetical protein	0.00465673	0.0605183	0.0591399
Echinococcus multilocularis	cyclins	0.0020579	0.00146505	0.00200904
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0217952	0.449957	0.44915
Schistosoma mansoni	serine/threonine protein kinase	0.0148816	0.292858	0.4016
Entamoeba histolytica	protein kinase, putative	0.00675456	0.108187	0.160516
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0217952	0.449957	0.617032
Trichomonas vaginalis	AGC family protein kinase	0.00730019	0.120586	0.179164
Loa Loa (eye worm)	hypothetical protein	0.00357088	0.0358445	0.0344299
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0157529	0.312656	0.311647
Schistosoma mansoni	tyrosine kinase	0.00838402	0.145214	0.199133
Onchocerca volvulus		0.00298072	0.0224344	0.00480082
Echinococcus multilocularis	protein kinase c eta type	0.00298072	0.0224344	0.0307647
Trichomonas vaginalis	AGC family protein kinase	0.0313177	0.666335	1
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0217952	0.449957	1
Schistosoma mansoni	tyrosine kinase	0.00838402	0.145214	0.199133
Loa Loa (eye worm)	hypothetical protein	0.0332296	0.709779	0.709353
Plasmodium falciparum	serine/threonine protein kinase, putative	0.00730019	0.120586	0.265603
Trypanosoma cruzi	Protein kinase B	0.0164988	0.329606	0.690963
Echinococcus multilocularis	cyclin dependent kinase 5	0.0148816	0.292858	0.4016
Brugia malayi	SRC-1	0.00838402	0.145214	0.217929
Echinococcus multilocularis	mitogen activated protein kinase	0.0120006	0.227394	0.311828
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.00730019	0.120586	0.179164
Loa Loa (eye worm)	hypothetical protein	0.0302488	0.642048	0.641523
Echinococcus granulosus	Protein kinase C brain isozyme	0.027499	0.579563	0.794763
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0313177	0.666335	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0120006	0.227394	0.428502
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.00838402	0.145214	0.199133
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0159086	0.316196	0.433603
Giardia lamblia	Kinase, CMGC MAPK	0.0120006	0.227394	0.503752
Giardia lamblia	Kinase, CMGC CDK	0.0148816	0.292858	0.649718
Brugia malayi	Cyclin, N-terminal domain containing protein	0.00465673	0.0605183	0.0908226
Brugia malayi	RhoGAP domain containing protein	0.00298072	0.0224344	0.0336684
Schistosoma mansoni	serine/threonine protein kinase	0.0157529	0.312656	0.428749
Echinococcus granulosus	serine:threonine protein kinase N2	0.0157529	0.312656	0.428749
Echinococcus multilocularis	Glutaredoxin protein 5	0.0149747	0.294973	0.4045
Echinococcus multilocularis	N chimaerin	0.00380569	0.0411802	0.056471
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0188565	0.383179	0.382274
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0159086	0.316196	0.689297
Trichomonas vaginalis	cyclin B, putative	0.00465673	0.0605183	0.0888192
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0159086	0.316196	0.701753
Schistosoma mansoni	protein kinase C mu	0.0039147	0.0436571	0.0598676
Entamoeba histolytica	cell division protein kinase 2, putative	0.0148816	0.292858	0.438271
Trypanosoma cruzi	cdc2-related kinase 1	0.0148816	0.292858	0.596602
Brugia malayi	Protein kinase domain containing protein	0.0148816	0.292858	0.439506
Entamoeba histolytica	diacylglycerol kinase, putative	0.00298072	0.0224344	0.0315391
Schistosoma mansoni	serine/threonine protein kinase	0.027499	0.579563	0.794763
Echinococcus multilocularis	raf serine:threonine protein kinase	0.00334469	0.0307048	0.0421059
Trypanosoma brucei	aurora B kinase	0.00730019	0.120586	0.0991511
Echinococcus granulosus	ephrin type A receptor 4 A	0.0151734	0.299488	0.410692
Brugia malayi	serine/threonine kinase 12	0.00730019	0.120586	0.180968
Brugia malayi	intracellular kinase	0.0217952	0.449957	0.675271
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0217952	0.449957	0.617032
Trypanosoma cruzi	cdc2-related kinase 3	0.0148816	0.292858	0.596602
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0039147	0.0436571	0.0598676
Brugia malayi	GCC2 and GCC3 family protein	0.00284918	0.0194454	0.0291827
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0159086	0.316196	0.433603
Loa Loa (eye worm)	hypothetical protein	0.00298072	0.0224344	0.0210002
Trichomonas vaginalis	AGC family protein kinase	0.0157529	0.312656	0.468047
Loa Loa (eye worm)	hypothetical protein	0.00298072	0.0224344	0.0210002
Schistosoma mansoni	serine/threonine protein kinase	0.0120006	0.227394	0.311828
Entamoeba histolytica	cell division protein kinase 2, putative	0.0148816	0.292858	0.438271
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0340855	0.729228	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0164988	0.329606	0.493541
Loa Loa (eye worm)	hypothetical protein	0.0119602	0.226476	0.225341
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0120006	0.227394	0.428502
Loa Loa (eye worm)	hypothetical protein	0.00259883	0.0137566	0.0123096
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.00838402	0.145214	0.199133
Onchocerca volvulus		0.0119602	0.226476	0.332524
Echinococcus granulosus	N chimaerin	0.00380569	0.0411802	0.056471
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0120006	0.227394	0.428502
Loa Loa (eye worm)	hypothetical protein	0.0116233	0.218819	0.217672
Echinococcus granulosus	nervana 2	0.0149747	0.294973	0.4045
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0217952	0.449957	0.679598
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0120006	0.227394	0.311828
Brugia malayi	serine/threonine-protein kinase 6	0.00730019	0.120586	0.180968
Trichomonas vaginalis	cyclins, putative	0.00465673	0.0605183	0.0888192
Schistosoma mansoni	unc-13 (munc13)	0.00310361	0.0252269	0.0345939
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.027499	0.579563	0.794763
Echinococcus multilocularis	cyclins	0.0020579	0.00146505	0.00200904
Onchocerca volvulus		0.00465673	0.0605183	0.0659696
Echinococcus multilocularis	RNA directed DNA polymerase	0.00864252	0.151088	0.207188
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.00969939	0.175103	0.173892
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0148816	0.292858	0.596602
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0020579	0.00146505	0.00219867
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0164988	0.329606	0.690963
Echinococcus multilocularis	myotubularin protein 13	0.00357088	0.0358445	0.0491541
Echinococcus multilocularis	cyclins	0.0020579	0.00146505	0.00200904
Schistosoma mansoni	atypical protein kinase C	0.0187336	0.380387	0.521629
Brugia malayi	Cyclin, N-terminal domain containing protein	0.00465673	0.0605183	0.0908226
Echinococcus granulosus	nervana 2	0.0149747	0.294973	0.4045
Trypanosoma brucei	protein kinase, putative	0.0120006	0.227394	0.275455
Echinococcus granulosus	raf serine:threonine protein kinase	0.00334469	0.0307048	0.0421059
Echinococcus granulosus	aurora kinase A	0.00730019	0.120586	0.165361
Schistosoma mansoni	serine/threonine protein kinase	0.00730019	0.120586	0.165361
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0039147	0.0436571	0.042254
Loa Loa (eye worm)	RasGEF domain-containing protein	0.00298072	0.0224344	0.0210002
Trypanosoma cruzi	cdc2-related kinase 3	0.0148816	0.292858	0.596602
Echinococcus multilocularis	serine threonine protein kinase	0.0245183	0.511832	0.701882
Schistosoma mansoni	serine/threonine protein kinase	0.0148816	0.292858	0.4016
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0151734	0.299488	0.410692
Brugia malayi	p70 ribosomal S6 kinase beta	0.0307275	0.652925	0.979875
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.00838402	0.145214	0.199133
Echinococcus granulosus	myotubularin protein 13	0.00357088	0.0358445	0.0491541
Echinococcus granulosus	cyclins	0.0020579	0.00146505	0.00200904
Schistosoma mansoni	diacylglycerol kinase theta	0.00298072	0.0224344	0.0307647
Loa Loa (eye worm)	AUR protein kinase	0.00730019	0.120586	0.119295
Echinococcus granulosus	tyrosine protein kinase Fyn	0.00838402	0.145214	0.199133
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0149747	0.294973	0.4045
Brugia malayi	ephrin receptor 1 precursor	0.00600039	0.0910504	0.136644
Loa Loa (eye worm)	hypothetical protein	0.0460017	1	1
Schistosoma mansoni	hypothetical protein	0.00298072	0.0224344	0.0307647
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.00721557	0.118663	0.162724
Toxoplasma gondii	AGC kinase	0.0307275	0.652925	1
Giardia lamblia	Kinase, CMGC CDK	0.0148816	0.292858	0.649718
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.00380569	0.0411802	0.056471
Loa Loa (eye worm)	TK/EPH protein kinase	0.0156032	0.309255	0.308242
Schistosoma mansoni	protein kinase C	0.00310361	0.0252269	0.0345939
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.00838402	0.145214	0.199133
Entamoeba histolytica	protein kinase, putative	0.00378316	0.0406681	0.0589635
Echinococcus multilocularis	tyrosine protein kinase HCK	0.00675456	0.108187	0.148359
Trypanosoma brucei	cdc2-related kinase 1	0.0148816	0.292858	0.383515

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 0 %	Antimalarial activity against Plasmodium berghei infected NMRI mouse assessed as parasitemia reduction at 100 mg/kg, po after 3 days of post-infection relative to control	ChEMBL.	17949067
Activity (functional)	= 0 %	Antimalarial activity against Plasmodium berghei infected NMRI mouse assessed as parasitemia reduction at 100 mg/kg, po after 3 days of post-infection relative to control	ChEMBL.	17949067
EC50 (functional)	> 2 uM	Antimalarial activity against Plasmodium falciparum K1	ChEMBL.	18993067
EC50 (functional)	> 2 uM	Antimalarial activity against Plasmodium falciparum NF54	ChEMBL.	18993067
IC50 (functional)	= 660 ng/ml	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54	ChEMBL.	17949067
IC50 (functional)	= 660 ng/ml	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54	ChEMBL.	17949067
IC50 (functional)	= 770 ng/ml	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	ChEMBL.	17949067
IC50 (functional)	= 770 ng/ml	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	ChEMBL.	17949067

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	17949067

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL240997
PubChem: 23657128

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 449606