Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0041 | 0.0169 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0169 | 0.0348 |
Echinococcus multilocularis | neuroligin | 0.0041 | 0.0169 | 0.0126 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.4844 | 0.4821 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.1957 | 0.404 |
Onchocerca volvulus | 0.0041 | 0.0169 | 0.5 | |
Onchocerca volvulus | 0.0041 | 0.0169 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.4844 | 0.4821 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0169 | 0.0348 |
Schistosoma mansoni | gliotactin | 0.0041 | 0.0169 | 0.0348 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.0169 | 0.0348 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0041 | 0.0169 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0041 | 0.0169 | 0.0126 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.4844 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.4844 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0362 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0169 | 0.0348 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0044 | 0.009 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0044 | 0.009 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0471 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.4844 | 0.4821 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0041 | 0.0169 | 0.0126 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0041 | 0.0169 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0044 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0041 | 0.0169 | 0.0126 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0362 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.4844 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0041 | 0.0169 | 0.0126 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.4844 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0362 | 0.0747 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0041 | 0.0169 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0169 | 0.0348 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.0169 | 0.0348 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.4844 | 0.4821 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.0169 | 0.0348 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0041 | 0.0169 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.4844 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0041 | 0.0169 | 0.0348 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.4844 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0041 | 0.0169 | 0.0348 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0044 | 0.5 |
Onchocerca volvulus | 0.0041 | 0.0169 | 0.5 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.1957 | 0.404 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0362 | 0.0747 |
Onchocerca volvulus | 0.0041 | 0.0169 | 0.5 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0041 | 0.0169 | 0.0126 |
Echinococcus granulosus | neuroligin | 0.0041 | 0.0169 | 0.0126 |
Onchocerca volvulus | 0.0041 | 0.0169 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0041 | 0.0169 | 0.0348 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0041 | 0.0169 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0041 | 0.0169 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.1957 | 0.404 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0169 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0169 | 0.0348 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0169 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0169 | 0.0348 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0044 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0044 | 0.009 |
Schistosoma mansoni | acetylcholinesterase | 0.0041 | 0.0169 | 0.0348 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.4844 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0041 | 0.0169 | 0.0348 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.4844 | 0.4821 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0041 | 0.0169 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.0169 | 0.0348 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.4844 | 0.4821 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0041 | 0.0169 | 0.0126 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0044 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0041 | 0.0169 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 230.8 nM | Inhibition of human serum AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
IC50 (binding) | = 230.8 nM | Inhibition of human serum AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
IC50 (binding) | = 233.8 nM | Inhibition of Wistar rat brain AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
IC50 (binding) | = 233.8 nM | Inhibition of Wistar rat brain AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
IC50 (binding) | = 250.1 nM | Inhibition of electric eel AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
IC50 (binding) | = 250.1 nM | Inhibition of electric eel AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.