Detailed information for compound 450065

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 341.447 | Formula: C20H27N3O2
  • H donors: 1 H acceptors: 2 LogP: 3.43 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1NC(C2CCCCC2)c2c(C1)c1cc(C)cnc1n2C
  • InChi: 1S/C20H27N3O2/c1-12-9-15-14-10-16(20(24)25-3)22-17(13-7-5-4-6-8-13)18(14)23(2)19(15)21-11-12/h9,11,13,16-17,22H,4-8,10H2,1-3H3
  • InChiKey: FREOZMUYJNGELC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi G protein-coupled receptor 0.0036 0.0776 0.1053
Brugia malayi nuclear receptor RXR 0.0132 0.3745 0.5079
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.0776 0.0776
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0776 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-25 0.025 0.7373 1
Brugia malayi MH2 domain containing protein 0.0116 0.3258 0.4419
Brugia malayi Serotonin receptor 0.0036 0.0776 0.1053
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis nuclear receptor nhr 48 0.0118 0.3309 0.3309
Brugia malayi follicle stimulating hormone receptor 0.0036 0.0776 0.1053
Brugia malayi hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.025 0.7373 0.7373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0604 0.0604
Schistosoma mansoni retinoid-x-receptor (RXR) 0.025 0.7373 0.7373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Brugia malayi larval opioid receptor 0.0036 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0293 0.0293
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0776 0.0776
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0776 0.0776
Brugia malayi hypothetical protein 0.0036 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0169 0.0169
Brugia malayi Pre-SET motif family protein 0.003 0.0604 0.0819
Brugia malayi nuclear receptor NHR-67 0.0118 0.3309 0.4488
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0118 0.3309 0.3309
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.0776 0.0776
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.025 0.7373 0.7373
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0776 0.0776
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.0776 0.1053
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0604 0.9813
Onchocerca volvulus 0.0036 0.0776 0.0254
Loa Loa (eye worm) hypothetical protein 0.025 0.7373 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.025 0.7373 0.7373
Brugia malayi Steroid receptor seven-up type 2 0.025 0.7373 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis sex peptide receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.025 0.7373 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1223 0.1658
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Brugia malayi Nuclear hormone receptor family member nhr-31 0.025 0.7373 1
Schistosoma mansoni nuclear hormone receptor 0.0118 0.3309 0.3309
Onchocerca volvulus Protein ultraspiracle homolog 0.025 0.7373 1
Brugia malayi Protein kinase domain containing protein 0.0032 0.0674 0.0914
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.0776 0.1053
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0776 0.0776
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.025 0.7373 0.7373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis somatostatin receptor 0.0036 0.0776 0.0776
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0776 0.0776
Loa Loa (eye worm) steroid hormone receptor 0.025 0.7373 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.0776 0.0776
Brugia malayi ORL1-like opioid receptor 0.0036 0.0776 0.1053
Giardia lamblia Kinase, AGC PKA 0.002 0.03 0.5
Brugia malayi AKH receptor 0.0036 0.0776 0.1053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0118 0.3309 0.3309
Onchocerca volvulus 0.0036 0.0776 0.0254
Schistosoma mansoni hypothetical protein 0.0036 0.0776 0.0776
Brugia malayi G-protein coupled receptor 0.0036 0.0776 0.1053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.025 0.7373 0.7373
Schistosoma mansoni hypothetical protein 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0132 0.3745 0.5079
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.025 0.7373 1
Onchocerca volvulus 0.0118 0.3309 0.3997
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0604 0.0604
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.0776 0.1053
Echinococcus granulosus serotonin receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Echinococcus granulosus nervana 2 0.002 0.0293 0.0293
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.0776 0.0776
Loa Loa (eye worm) DR-78 0.0118 0.3309 0.4488
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0118 0.3309 0.3309
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.0776 0.0776
Brugia malayi neuropeptide F receptor 0.0036 0.0776 0.1053
Onchocerca volvulus 0.0036 0.0776 0.0254
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.0776 0.0776
Echinococcus multilocularis GPCR, family 2 0.0016 0.0169 0.0169
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0169 0.0229
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.0776 0.0776
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0776 0.0776
Onchocerca volvulus 0.0036 0.0776 0.0254
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis thyroid hormone receptor alpha 0.025 0.7373 0.7373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Onchocerca volvulus 0.0036 0.0776 0.0254
Brugia malayi Serotonin receptor 0.0036 0.0776 0.1053
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0169 0.0169
Brugia malayi Dopamine receptor 0.0036 0.0776 0.1053
Echinococcus granulosus ecdysone induced protein 78C 0.025 0.7373 0.7373
Brugia malayi nuclear receptor RXR 0.0118 0.3309 0.4488
Schistosoma mansoni adenoreceptor 0.0036 0.0776 0.0776
Brugia malayi neuropeptide F receptor 0.0036 0.0776 0.1053
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.0776 0.0776
Schistosoma mansoni thyroid hormone receptor 0.025 0.7373 0.7373
Onchocerca volvulus 0.0036 0.0776 0.0254
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0132 0.3745 0.3745
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0169 0.0229
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.025 0.7373 0.7373
Echinococcus multilocularis geminin 0.0336 1 1
Onchocerca volvulus 0.0036 0.0776 0.0254
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0674 0.0961
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0674 0.0961
Schistosoma mansoni amine GPCR 0.0036 0.0776 0.0776
Trypanosoma cruzi rac serine-threonine kinase, putative 0.002 0.03 0.6805
Echinococcus multilocularis nervana 2 0.002 0.0293 0.0293
Echinococcus granulosus g protein coupled receptor 0.0036 0.0776 0.0776
Echinococcus granulosus allatostatin A receptor 0.0036 0.0776 0.0776
Schistosoma mansoni amine GPCR 0.0036 0.0776 0.0776
Schistosoma mansoni amine GPCR 0.0036 0.0776 0.0776
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0132 0.3745 0.5079
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.025 0.7373 1
Echinococcus granulosus FTZ F1 alpha 0.025 0.7373 0.7373
Echinococcus granulosus neuropeptide s receptor 0.0036 0.0776 0.0776
Onchocerca volvulus 0.025 0.7373 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0776 0.1053
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.0776 0.0776
Schistosoma mansoni nuclear receptor 0.0118 0.3309 0.3309
Echinococcus granulosus GPCR family 2 0.0016 0.0169 0.0169
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0776 0.0776
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis serotonin receptor 0.0036 0.0776 0.0776
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1223 0.1658
Onchocerca volvulus 0.0036 0.0776 0.0254
Brugia malayi putative neuropeptide receptor 0.0036 0.0776 0.1053
Echinococcus granulosus sex peptide receptor 0.0036 0.0776 0.0776
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0776 0.0776
Onchocerca volvulus 0.0036 0.0776 0.0254
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.025 0.7373 1
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0061 0.0087
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.0776 0.1053
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.0776 0.0776
Schistosoma mansoni histamine h1 receptor 0.0036 0.0776 0.0776
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.0776 0.0776
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.002 0.03 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.025 0.7373 0.7373
Brugia malayi Nuclear hormone receptor family member nhr-19 0.025 0.7373 1
Brugia malayi hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0776 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-1 0.025 0.7373 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0032 0.0674 1
Brugia malayi hypothetical protein 0.0118 0.3309 0.4488
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0361 0.5363
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0169 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-40 0.025 0.7373 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.0776 0.0776
Brugia malayi tailless protein 0.0118 0.3309 0.4488
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0118 0.3309 0.3309
Brugia malayi Nuclear hormone receptor-like 1 0.025 0.7373 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.025 0.7373 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0776 0.0776
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0776 0.0776
Onchocerca volvulus 0.0036 0.0776 0.0254
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Trichomonas vaginalis set domain proteins, putative 0.0238 0.7008 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.0776 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.025 0.7373 1
Echinococcus multilocularis FTZ F1 alpha 0.025 0.7373 0.7373
Schistosoma mansoni opsin-like receptor 0.0036 0.0776 0.0776
Brugia malayi GnHR receptor homolog 0.0036 0.0776 0.1053
Loa Loa (eye worm) nuclear receptor NHR-67 0.0118 0.3309 0.4488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.003 0.0604 0.0819
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0674 0.0961
Schistosoma mansoni amine GPCR 0.0036 0.0776 0.0776
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Schistosoma mansoni biogenic amine receptor 0.0036 0.0776 0.0776
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0361 0.5363
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0132 0.3745 0.5079
Echinococcus granulosus retinoic acid receptor rxr beta a 0.025 0.7373 0.7373
Brugia malayi Melatonin receptor type 1A 0.0036 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.005 0.1223 0.1658
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.3258 0.4419
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.0776 0.1053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0674 0.0914
Brugia malayi Nuclear hormone receptor-like 1 0.0132 0.3745 0.5079
Brugia malayi hypothetical protein 0.0036 0.0776 0.1053
Onchocerca volvulus 0.0118 0.3309 0.3997
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0674 0.0961
Brugia malayi nuclear receptor NHR-88 0.0118 0.3309 0.4488
Brugia malayi hypothetical protein 0.0036 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Onchocerca volvulus 0.0036 0.0776 0.0254
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0776 0.0776
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0118 0.3309 0.3309
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.0776 0.0776
Brugia malayi photoreceptor-specific nuclear receptor 0.025 0.7373 1
Loa Loa (eye worm) hypothetical protein 0.025 0.7373 1
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0674 0.0961
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.0776 0.1053
Brugia malayi isocitrate dehydrogenase 0.0016 0.0169 0.023
Echinococcus granulosus thyroid hormone receptor alpha 0.0118 0.3309 0.3309
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0674 0.0961
Schistosoma mansoni hypothetical protein 0.0036 0.0776 0.0776
Brugia malayi Pre-SET motif family protein 0.0209 0.6119 0.8298
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0604 0.0604
Brugia malayi steroid hormone receptor 0.025 0.7373 1
Brugia malayi nuclear hormone receptor 0.025 0.7373 1
Onchocerca volvulus 0.0036 0.0776 0.0254
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni nuclear hormone receptor 0.0118 0.3309 0.3309
Loa Loa (eye worm) hypothetical protein 0.025 0.7373 1
Echinococcus multilocularis orexin receptor type 2 0.0036 0.0776 0.0776
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.025 0.7373 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni neuropeptide receptor 0.0036 0.0776 0.0776
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Onchocerca volvulus 0.0238 0.7008 0.946
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.025 0.7373 0.7373
Brugia malayi Nuclear hormone receptor family member nhr-19 0.025 0.7373 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0361 1
Onchocerca volvulus 0.0036 0.0776 0.0254
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni RAR-like nuclear receptor 0.025 0.7373 0.7373
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0169 0.0169
Entamoeba histolytica protein kinase, putative 0.0032 0.0674 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0169 0.0169
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0361 0.0361
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.0776 0.1053
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0776 0.0776
Brugia malayi p70 ribosomal S6 kinase beta 0.003 0.0612 0.0831
Echinococcus granulosus nervana 2 0.002 0.0293 0.0293
Entamoeba histolytica protein kinase, putative 0.003 0.0612 0.909
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) nuclear hormone receptor 0.0118 0.3309 0.4488
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0118 0.3309 0.4488
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0132 0.3745 0.3745
Schistosoma mansoni opsin-like receptor 0.0036 0.0776 0.0776
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.0776 0.0776
Schistosoma mansoni neuropeptide receptor 0.0036 0.0776 0.0776
Echinococcus multilocularis ecdysone induced protein 78C 0.025 0.7373 0.7373
Brugia malayi Nuclear hormone receptor E75 0.0118 0.3309 0.4488
Brugia malayi conserved hypotetical protein 0.0118 0.3309 0.4488
Brugia malayi orphan nuclear receptor NR2E1 0.0118 0.3309 0.4488
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.0776 0.0776
Onchocerca volvulus Bile acid receptor homolog 0.025 0.7373 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.3745 0.5079
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.0776 0.0776
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0132 0.3745 0.3745
Brugia malayi G-protein coupled receptor 0.0036 0.0776 0.1053
Brugia malayi Nuclear hormone receptor-like 1 0.0132 0.3745 0.5079
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0776 0.0776
Brugia malayi hypothetical protein 0.0036 0.0776 0.1053
Brugia malayi Nuclear hormone receptor family member nhr-49 0.025 0.7373 1
Brugia malayi hypothetical protein 0.0118 0.3309 0.4488
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.025 0.7373 0.7373
Onchocerca volvulus 0.0036 0.0776 0.0254
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Schistosoma mansoni hypothetical protein 0.0034 0.0735 0.0735
Echinococcus multilocularis neuropeptide s receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Brugia malayi nuclear receptor NHR-88 0.025 0.7373 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0169 0.023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni hypothetical protein 0.0016 0.0169 0.0169
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0776 0.0776
Brugia malayi sulfakinin receptor protein 0.0036 0.0776 0.1053
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0169 0.0229
Schistosoma mansoni hypothetical protein 0.0336 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Brugia malayi nuclear hormone receptor 0.0118 0.3309 0.4488
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0293 0.0293
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0604 0.0604
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus granulosus neuropeptide receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0776 0.1053
Echinococcus multilocularis nervana 2 0.002 0.0293 0.0293
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.025 0.7373 0.7373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0118 0.3309 0.3309
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0016 0.0169 0.0169
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0776 0.0776
Schistosoma mansoni steroid hormone receptor ad4bp 0.025 0.7373 0.7373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0776 0.0776
Schistosoma mansoni neuropeptide receptor 0.0036 0.0776 0.0776
Onchocerca volvulus 0.0036 0.0776 0.0254
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0776 0.0776
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0776 0.0776
Schistosoma mansoni coup transcription factor 0.025 0.7373 0.7373
Echinococcus granulosus hypothetical protein 0.0036 0.0776 0.0776
Schistosoma mansoni retinoic acid receptor RXR 0.025 0.7373 0.7373
Brugia malayi ecdysone receptor 0.0118 0.3309 0.4488
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.057 0.057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni opsin-like receptor 0.0036 0.0776 0.0776
Echinococcus granulosus Nuclear hormone receptor HR96 0.0118 0.3309 0.3309
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.003 0.0612 0.0831
Schistosoma mansoni biogenic amine receptor 0.0036 0.0776 0.0776
Brugia malayi hypothetical protein 0.0036 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.0776 0.0776
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0361 0.0361
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Entamoeba histolytica protein kinase 2, putative 0.002 0.03 0.4453
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.0776 0.0776
Schistosoma mansoni neuropeptide receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.025 0.7373 0.7373
Echinococcus granulosus Nuclear hormone receptor HR96 0.0118 0.3309 0.3309
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.025 0.7373 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0118 0.3309 0.3309
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0169 0.5
Toxoplasma gondii AGC kinase 0.003 0.0612 1
Loa Loa (eye worm) hypothetical protein 0.025 0.7373 1
Schistosoma mansoni amine GPCR 0.0036 0.0776 0.0776
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.0776 0.1053
Schistosoma mansoni hypothetical protein 0.0336 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.0776 0.1053
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Echinococcus granulosus neuropeptide receptor 0.0036 0.0776 0.0776
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0776 0.0776
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0118 0.3309 0.3997
Schistosoma mansoni hypothetical protein 0.0016 0.0169 0.0169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0776 0.0776
Trypanosoma cruzi Protein kinase B 0.0022 0.0361 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0118 0.3309 0.4488
Echinococcus granulosus serine threonine protein kinase nrc 0.002 0.03 0.03
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.0776 0.0776
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.025 0.7373 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0118 0.3309 0.3997
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni biogenic amine receptor 0.0036 0.0776 0.0776
Brugia malayi hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.025 0.7373 1
Schistosoma mansoni thyroid hormone receptor 0.025 0.7373 0.7373
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0604 0.0604
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0169 0.0169
Echinococcus granulosus neuropeptide receptor A26 0.0036 0.0776 0.0776
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.025 0.7373 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0169 0.0169
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0169 0.0169
Brugia malayi hypothetical protein 0.0132 0.3745 0.5079
Echinococcus granulosus g-protein coupled receptor 0.0036 0.0776 0.0776
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0604 0.0604
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0776 0.0776
Echinococcus granulosus g protein coupled receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0118 0.3309 0.4488
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Brugia malayi Nuclear hormone receptor family member nhr-14 0.025 0.7373 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.002 0.03 0.03
Brugia malayi Nuclear hormone receptor E75 0.0118 0.3309 0.4488
Loa Loa (eye worm) hypothetical protein 0.0016 0.0169 0.0229
Echinococcus granulosus orexin receptor type 2 0.0036 0.0776 0.0776
Brugia malayi nuclear hormone receptor family member odr-7 0.0118 0.3309 0.4488
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0776 0.0776
Brugia malayi hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0776 0.0776
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.025 0.7373 0.7373
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0118 0.3309 0.3309
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.0776 0.0776
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.002 0.03 0.03
Onchocerca volvulus 0.0036 0.0776 0.0254
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.025 0.7373 0.7373
Brugia malayi Dopamine receptor protein 2 0.0036 0.0776 0.1053
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0776 0.0776
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.025 0.7373 0.7373
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0776 0.0776
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.025 0.7373 0.7373
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.025 0.7373 0.7373
Echinococcus granulosus nuclear receptor 2DBD gamma 0.025 0.7373 0.7373
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0034 0.0735 0.0997
Echinococcus multilocularis serotonin receptor 0.0036 0.0776 0.0776
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.0776 0.0776
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0169 0.0169
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1223 0.1658
Brugia malayi hypothetical protein 0.0132 0.3745 0.5079
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.0776 0.1053
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.0776 0.1053
Echinococcus multilocularis neuropeptide receptor A26 0.0036 0.0776 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-25 0.025 0.7373 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.0776 0.0254
Loa Loa (eye worm) hypothetical protein 0.0132 0.3745 0.5079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0776 0.0776
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Entamoeba histolytica protein kinase, putative 0.0032 0.0674 1
Schistosoma mansoni hypothetical protein 0.0036 0.0776 0.0776
Schistosoma mansoni nuclear receptor 0.0118 0.3309 0.3309
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.025 0.7373 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.0776 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-41 0.025 0.7373 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0132 0.3745 0.5079
Plasmodium vivax SET domain protein, putative 0.003 0.0604 1
Echinococcus multilocularis allatostatin A receptor 0.0036 0.0776 0.0776
Echinococcus granulosus g protein coupled receptor 0.0036 0.0776 0.0776
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0776 0.0776
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.002 0.03 0.3004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0776 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-3 0.025 0.7373 1
Brugia malayi Dopamine receptor protein 1 0.0036 0.0776 0.1053
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.0776 0.1053
Brugia malayi nuclear hormone receptor family member nhr-6 0.0118 0.3309 0.4488
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0776 0.0776
Schistosoma mansoni nuclear hormone receptor 0.025 0.7373 0.7373
Brugia malayi RE15519p 0.0036 0.0776 0.1053
Brugia malayi ecdysteroid receptor 0.025 0.7373 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0293 0.0293
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0361 0.0361
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.0776 0.1053
Echinococcus granulosus somatostatin receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni myosin xvIII 0.0036 0.0776 0.0776
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0169 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus granulosus nuclear receptor nhr 48 0.0118 0.3309 0.3309
Echinococcus granulosus fmrfamide receptor 0.0036 0.0776 0.0776
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.6119 0.8298
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.0776 0.0776
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0674 0.0961
Loa Loa (eye worm) hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni hypothetical protein 0.0016 0.0169 0.0169
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.3258 0.4419
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0735 0.0997
Brugia malayi hypothetical protein 0.0036 0.0776 0.1053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0132 0.3745 0.3745
Schistosoma mansoni zinc finger protein 0.0118 0.3309 0.3309
Schistosoma mansoni nuclear receptor nhr-48 0.0118 0.3309 0.3309
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0169 0.023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.025 0.7373 1
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0776 0.0776
Onchocerca volvulus 0.0036 0.0776 0.0254
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0118 0.3309 0.3309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.025 0.7373 1
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0776 0.1053
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.0776 0.0776

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 12.4 pg/microg/hr Effect on glucose-dependent insulin secretion activity per ug of total protein in rat RIN5F cells at 0.1 uM after 30 mins ChEMBL. 17583514
Activity (functional) = 13.4 pg/microg/hr Effect on glucose-dependent insulin secretion activity per ug of total protein in rat RIN5F cells at 1 uM after 30 mins ChEMBL. 17583514
Activity (functional) = 14.2 pg/microg/hr Effect on glucose-dependent insulin secretion activity per ug of total protein in rat RIN5F cells at 10 uM after 30 mins ChEMBL. 17583514

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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