Detailed information for compound 450069

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 241.245 | Formula: C13H11N3O2
  • H donors: 1 H acceptors: 3 LogP: 2.17 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1nc(C)c2c(c1)c1cccnc1[nH]2
  • InChi: 1S/C13H11N3O2/c1-7-11-9(6-10(15-7)13(17)18-2)8-4-3-5-14-12(8)16-11/h3-6H,1-2H3,(H,14,16)
  • InChiKey: WCOMZIJJEROAJF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0137 0.4498 0.687
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0277 0.0277
Schistosoma mansoni zinc finger protein 0.0065 0.1928 0.2944
Brugia malayi Nuclear hormone receptor-like 1 0.0137 0.4498 0.4498
Onchocerca volvulus Phospholipase A2 homolog 0.0292 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0823 0.0823
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.002 0.0345 0.0527
Brugia malayi nuclear hormone receptor 0.0065 0.1928 0.1928
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0823 0.1257
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.4498 0.687
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0302 0.175
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0137 0.4498 0.4498
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1828 0.1828
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0851 0.1299
Schistosoma mansoni nuclear receptor 0.0065 0.1928 0.2944
Echinococcus granulosus geminin 0.0195 0.6548 1
Echinococcus granulosus GPCR family 2 0.0034 0.0823 0.1257
Schistosoma mansoni thyroid hormone receptor 0.0137 0.4498 0.687
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.1928 0.2944
Loa Loa (eye worm) hypothetical protein 0.0137 0.4498 0.4498
Schistosoma mansoni nuclear receptor 0.0065 0.1928 0.2944
Loa Loa (eye worm) hypothetical protein 0.0137 0.4498 0.4498
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0137 0.4498 0.687
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0137 0.4498 0.687
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0137 0.4498 0.4498
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0137 0.4498 0.4498
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.2203 0.2203
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0302 0.3047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0302 0.175
Trypanosoma brucei unspecified product 0.0019 0.0302 0.3047
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0277 0.0277
Brugia malayi tailless protein 0.0065 0.1928 0.1928
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0851 0.1299
Echinococcus granulosus dna polymerase eta 0.0019 0.0302 0.0461
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.3395 0.3395
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0416 0.0635
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0416 1
Echinococcus granulosus FTZ F1 alpha 0.0137 0.4498 0.687
Loa Loa (eye worm) RNA binding protein 0.0062 0.1828 0.1828
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0302 0.3047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0851 0.1299
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.003 0.0705 0.0705
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0416 0.5363
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.2205 0.2205
Onchocerca volvulus 0.0065 0.1928 0.1177
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.1928 0.1177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.1928 0.2944
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0823 0.0823
Echinococcus multilocularis dna polymerase eta 0.0019 0.0302 0.0461
Brugia malayi Nuclear hormone receptor E75 0.0065 0.1928 0.1928
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1828 0.2792
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0137 0.4498 0.4498
Brugia malayi hypothetical protein 0.0072 0.2203 0.2203
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0137 0.4498 0.4498
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Loa Loa (eye worm) hypothetical protein 0.0137 0.4498 0.4498
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0302 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0302 0.3047
Brugia malayi steroid hormone receptor 0.0137 0.4498 0.4498
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Loa Loa (eye worm) steroid hormone receptor 0.0137 0.4498 0.4498
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1828 0.2792
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0137 0.4498 0.687
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.1928 0.2944
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0137 0.4498 0.687
Echinococcus granulosus nuclear receptor nhr 48 0.0065 0.1928 0.2944
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.1928 0.2944
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0302 0.5
Brugia malayi nuclear receptor RXR 0.0065 0.1928 0.1928
Brugia malayi nuclear hormone receptor family member odr-7 0.0065 0.1928 0.1928
Echinococcus multilocularis FTZ F1 alpha 0.0137 0.4498 0.687
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.002 0.0345 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0416 0.5363
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0302 0.3047
Toxoplasma gondii AGC kinase 0.003 0.0705 0.7455
Schistosoma mansoni hypothetical protein 0.0195 0.6548 1
Brugia malayi Steroid receptor seven-up type 2 0.0137 0.4498 0.4498
Loa Loa (eye worm) hypothetical protein 0.0034 0.0823 0.0823
Brugia malayi ecdysteroid receptor 0.0137 0.4498 0.4498
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0775 0.0834
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.1928 0.2944
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0065 0.1928 0.2944
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Schistosoma mansoni hypothetical protein 0.0034 0.0823 0.1257
Loa Loa (eye worm) hypothetical protein 0.0106 0.3395 0.3395
Trypanosoma cruzi rac serine-threonine kinase, putative 0.002 0.0345 0.4908
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.002 0.0345 0.0527
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0302 0.3047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0137 0.4498 0.687
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0851 1
Onchocerca volvulus 0.0272 0.9299 0.9234
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0775 0.0834
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1828 0.1828
Onchocerca volvulus 0.0065 0.1928 0.1177
Loa Loa (eye worm) hypothetical protein 0.0137 0.4498 0.4498
Brugia malayi hypothetical protein 0.0072 0.2203 0.2203
Brugia malayi hypothetical protein 0.0065 0.1928 0.1928
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0302 0.3047
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0277 0.0423
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0806 0.1231
Schistosoma mansoni hypothetical protein 0.0034 0.0823 0.1257
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0302 0.0324
Schistosoma mansoni nuclear receptor nhr-48 0.0065 0.1928 0.2944
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.002 0.0345 0.1186
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Loa Loa (eye worm) hypothetical protein 0.0292 1 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Loa Loa (eye worm) hypothetical protein 0.0072 0.2205 0.2205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0851 0.1299
Loa Loa (eye worm) hypothetical protein 0.0072 0.2203 0.2203
Echinococcus granulosus tar DNA binding protein 0.0062 0.1828 0.2792
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0137 0.4498 0.4498
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Loa Loa (eye worm) hypothetical protein 0.0072 0.2203 0.2203
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0302 0.0461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0137 0.4498 0.4498
Echinococcus multilocularis geminin 0.0195 0.6548 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0065 0.1928 0.2944
Brugia malayi photoreceptor-specific nuclear receptor 0.0137 0.4498 0.4498
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0775 0.0775
Schistosoma mansoni hypothetical protein 0.0195 0.6548 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0137 0.4498 0.4498
Brugia malayi nuclear receptor NHR-67 0.0065 0.1928 0.1928
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0775 0.0834
Entamoeba histolytica protein kinase, putative 0.003 0.0705 0.909
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0775 0.0834
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0065 0.1928 0.2944
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0775 0.0834
Entamoeba histolytica protein kinase, putative 0.0032 0.0775 1
Trypanosoma cruzi Protein kinase B 0.0022 0.0416 1
Brugia malayi orphan nuclear receptor NR2E1 0.0065 0.1928 0.1928
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0072 0.2203 0.3364
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.1928 0.2944
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0072 0.2203 0.3364
Onchocerca volvulus Phospholipase A2 homolog 0.0292 1 1
Brugia malayi RNA binding protein 0.0062 0.1828 0.1828
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0302 0.0461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0137 0.4498 0.4498
Plasmodium vivax SET domain protein, putative 0.0034 0.0851 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0137 0.4498 0.4498
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0137 0.4498 0.4498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0137 0.4498 0.4498
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1828 0.2792
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.4498 0.687
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0137 0.4498 0.687
Brugia malayi nuclear receptor NHR-88 0.0065 0.1928 0.1928
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.8126 0.8126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0851 0.1299
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0302 0.3047
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0302 0.0461
Loa Loa (eye worm) hypothetical protein 0.0137 0.4498 0.4498
Loa Loa (eye worm) hypothetical protein 0.0019 0.0302 0.0302
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1828 0.2792
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.2203 0.2203
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0337 0.0515
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0137 0.4498 0.3986
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0302 0.175
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0851 0.1299
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0302 0.3047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.2203 0.3364
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0137 0.4498 0.687
Loa Loa (eye worm) hypothetical protein 0.0072 0.2203 0.2203
Schistosoma mansoni hypothetical protein 0.0034 0.0823 0.1257
Loa Loa (eye worm) DR-78 0.0065 0.1928 0.1928
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0416 0.0635
Brugia malayi nuclear hormone receptor family member nhr-6 0.0065 0.1928 0.1928
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0302 0.3889
Onchocerca volvulus 0.0137 0.4498 0.3986
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0137 0.4498 0.687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0137 0.4498 0.4498
Brugia malayi nuclear receptor RXR 0.0072 0.2203 0.2203
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0302 0.0461
Schistosoma mansoni nuclear hormone receptor 0.0137 0.4498 0.687
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0065 0.1928 0.1928
Schistosoma mansoni RAR-like nuclear receptor 0.0137 0.4498 0.687
Leishmania major DNA polymerase eta, putative 0.0019 0.0302 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0065 0.1928 0.2944
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0416 0.0635
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0302 0.0461
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0302 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0277 0.2691
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0302 0.0302
Leishmania major DNA polymerase kappa, putative 0.0019 0.0302 1
Brugia malayi ecdysone receptor 0.0065 0.1928 0.1928
Trichomonas vaginalis set domain proteins, putative 0.0272 0.9299 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0302 0.3047
Brugia malayi hypothetical protein 0.0065 0.1928 0.1928
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0302 0.3047
Entamoeba histolytica protein kinase, putative 0.0032 0.0775 1
Echinococcus granulosus ecdysone induced protein 78C 0.0137 0.4498 0.687
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0065 0.1928 0.1928
Trypanosoma brucei rac serine-threonine kinase, putative 0.0032 0.0775 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0277 0.0423
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0137 0.4498 0.687
Loa Loa (eye worm) hypothetical protein 0.0072 0.2203 0.2203
Brugia malayi Nuclear hormone receptor E75 0.0065 0.1928 0.1928
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.4498 0.687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0137 0.4498 0.4498
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0337 0.0515
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0302 0.3047
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0137 0.4498 0.687
Echinococcus multilocularis GPCR, family 2 0.0034 0.0823 0.1257
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0302 0.3047
Onchocerca volvulus Protein ultraspiracle homolog 0.0137 0.4498 0.3986
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1828 0.2792
Echinococcus granulosus dna polymerase kappa 0.0019 0.0302 0.0461
Loa Loa (eye worm) hypothetical protein 0.0072 0.2203 0.2203
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0137 0.4498 0.4498
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0775 0.0834
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0137 0.4498 0.4498
Echinococcus multilocularis nervana 2 0.002 0.0337 0.0515
Brugia malayi Pre-SET motif family protein 0.0239 0.8126 0.8126
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0072 0.2203 0.3364
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0137 0.4498 0.4498
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0302 0.0324
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0137 0.4498 0.687
Echinococcus multilocularis nuclear receptor nhr 48 0.0065 0.1928 0.2944
Loa Loa (eye worm) hypothetical protein 0.0137 0.4498 0.4498
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0823 0.1257
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.4498 0.687
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0823 0.1257
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0277 0.0423
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0302 0.175
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0302 0.0302
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0277 0.0423
Echinococcus multilocularis ecdysone induced protein 78C 0.0137 0.4498 0.687
Schistosoma mansoni hypothetical protein 0.0072 0.2205 0.3367
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0137 0.4498 0.687
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0137 0.4498 0.687
Loa Loa (eye worm) hypothetical protein 0.0137 0.4498 0.4498
Schistosoma mansoni thyroid hormone receptor 0.0137 0.4498 0.687
Loa Loa (eye worm) hypothetical protein 0.0137 0.4498 0.4498
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0065 0.1928 0.2944
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0416 0.0635
Loa Loa (eye worm) nuclear hormone receptor 0.0065 0.1928 0.1928
Entamoeba histolytica protein kinase 2, putative 0.002 0.0345 0.4453
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0302 0.3047
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0337 0.0515
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0277 0.2691
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0823 0.1257
Echinococcus granulosus nervana 2 0.002 0.0337 0.0515
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1828 0.2792
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.4498 0.687
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Brugia malayi nuclear receptor NHR-88 0.0137 0.4498 0.4498
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0277 0.0423
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0137 0.4498 0.687
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0337 0.0515
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0071 0.0076
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Onchocerca volvulus Bile acid receptor homolog 0.0137 0.4498 0.3986
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0302 0.3047
Giardia lamblia Kinase, AGC PKA 0.002 0.0345 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.1928 0.1928
Loa Loa (eye worm) hypothetical protein 0.0292 1 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0302 0.0461
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0775 0.0834
Loa Loa (eye worm) nuclear receptor NHR-67 0.0065 0.1928 0.1928
Schistosoma mansoni hypothetical protein 0.0034 0.0823 0.1257
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0302 1
Schistosoma mansoni nuclear hormone receptor 0.0065 0.1928 0.2944
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0277 0.0423
Schistosoma mansoni steroid hormone receptor ad4bp 0.0137 0.4498 0.687
Schistosoma mansoni coup transcription factor 0.0137 0.4498 0.687
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0277 0.0423
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0302 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0823 0.0823
Echinococcus granulosus serine threonine protein kinase nrc 0.002 0.0345 0.0527
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.3395 0.3395
Schistosoma mansoni nuclear hormone receptor 0.0065 0.1928 0.2944
Loa Loa (eye worm) hypothetical protein 0.0034 0.0851 0.0851
Schistosoma mansoni retinoic acid receptor RXR 0.0137 0.4498 0.687
Brugia malayi conserved hypotetical protein 0.0065 0.1928 0.1928
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.1928 0.1177
Brugia malayi Protein kinase domain containing protein 0.0032 0.0775 0.0775
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0137 0.4498 0.4498
Brugia malayi isocitrate dehydrogenase 0.0018 0.0277 0.0277
Echinococcus granulosus nervana 2 0.002 0.0337 0.0515
Brugia malayi p70 ribosomal S6 kinase beta 0.003 0.0705 0.0705
Brugia malayi TAR-binding protein 0.0062 0.1828 0.1828
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0137 0.4498 0.4498
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0137 0.4498 0.4498
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0072 0.2203 0.2203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0851 0.1299
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1828 0.1828
Echinococcus multilocularis nervana 2 0.002 0.0337 0.0515
Brugia malayi Pre-SET motif family protein 0.0034 0.0851 0.0851
Brugia malayi nuclear hormone receptor 0.0137 0.4498 0.4498
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0302 0.175
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0302 0.0302
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.3395 0.3395
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0065 0.1928 0.2944

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 11 pg/microg/hr Effect on glucose-dependent insulin secretion activity per ug of total protein in rat RIN5F cells at 0.1 uM after 30 mins ChEMBL. 17583514
Activity (functional) = 12.1 pg/microg/hr Effect on glucose-dependent insulin secretion activity per ug of total protein in rat RIN5F cells at 1 uM after 30 mins ChEMBL. 17583514
Activity (functional) = 12.5 pg/microg/hr Effect on glucose-dependent insulin secretion activity per ug of total protein in rat RIN5F cells at 10 uM after 30 mins ChEMBL. 17583514

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.