Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor | 0.0022 | 0.0022 | 0.0124 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.0551 | 0.3682 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0047 | 0.0178 | 0.1189 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0047 | 0.0179 | 0.0558 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.0156 | 0.038 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0047 | 0.0179 | 0.0558 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.015 | 0.0366 |
Echinococcus granulosus | tumor protein p63 | 0.0671 | 0.4098 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0047 | 0.0179 | 0.0884 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.0516 | 0.1607 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0036 | 0.0201 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.0156 | 0.1041 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.015 | 0.0834 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0047 | 0.0179 | 0.0997 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0047 | 0.0179 | 0.0997 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0269 | 0.1496 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0022 | 0.0022 | 0.0022 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0047 | 0.0179 | 0.0884 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0047 | 0.0179 | 0.0997 |
Brugia malayi | AMP-binding enzyme family protein | 0.0047 | 0.0178 | 0.0988 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0142 | 0.0775 | 0.189 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.014 | 0.0437 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0022 | 0.0022 | 0.007 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0178 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0047 | 0.0179 | 0.0179 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0022 | 0.0022 | 0.0124 |
Brugia malayi | steroid hormone receptor | 0.0047 | 0.0179 | 0.0997 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0639 | 0.3554 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0025 | 0.0041 | 0.1335 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0507 | 0.2816 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0047 | 0.0178 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0025 | 0.0039 | 0.0096 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0047 | 0.0178 | 0.1189 |
Echinococcus granulosus | flap endonuclease 1 | 0.0025 | 0.0041 | 0.0101 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.0156 | 0.1041 |
Schistosoma mansoni | thyroid hormone receptor | 0.0047 | 0.0179 | 0.0558 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0047 | 0.0179 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0047 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0156 | 0.0865 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0022 | 0.0022 | 0.0124 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0269 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 0.1799 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0047 | 0.0178 | 0.1189 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.0551 | 0.3682 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0047 | 0.0179 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0103 | 0.0573 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.0074 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.0022 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Schistosoma mansoni | nuclear receptor | 0.0022 | 0.0022 | 0.007 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0047 | 0.0179 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0178 | 0.0988 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0047 | 0.0179 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0022 | 0.0022 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0179 | 0.0997 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0047 | 0.0179 | 0.0997 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0047 | 0.0179 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0179 | 0.0997 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0022 | 0.0022 | 0.0054 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0047 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0257 | 0.1496 | 0.8313 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0022 | 0.0022 | 0.0022 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.0022 | 0.0054 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0257 | 0.1496 | 0.4655 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0039 | 0.0218 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0047 | 0.0179 | 0.0558 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0257 | 0.1496 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.083 | 0.4611 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0047 | 0.0179 | 0.0438 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.053 | 0.3213 | 0.7841 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0257 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0257 | 0.1496 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0022 | 0.0022 | 0.0022 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0269 | 0.0838 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0047 | 0.0178 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0257 | 0.1496 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0039 | 0.0218 |
Onchocerca volvulus | 0.0098 | 0.0499 | 0.2683 | |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0047 | 0.0179 | 0.0997 |
Brugia malayi | hypothetical protein | 0.0106 | 0.0551 | 0.3061 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0505 | 0.3056 | 0.3056 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.0074 | 0.0497 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.0074 | 0.0497 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0025 | 0.0039 | 0.0218 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.0026 | 0.0081 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0257 | 0.1496 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0047 | 0.0179 | 0.0558 |
Brugia malayi | AMP-binding enzyme family protein | 0.0047 | 0.0178 | 0.0988 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0106 | 0.0551 | 0.1344 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0047 | 0.0179 | 0.0997 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0041 | 0.0275 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.0551 | 0.3682 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0269 | 0.0838 |
Loa Loa (eye worm) | DR-78 | 0.0022 | 0.0022 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0103 | 0.0573 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0039 | 0.0218 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.0507 | 0.2816 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0179 | 0.0997 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0149 | 0.0816 | 0.1992 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0047 | 0.0179 | 0.0997 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0257 | 0.1496 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0022 | 0.0022 | 0.0124 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0047 | 0.0178 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.015 | 0.0834 |
Schistosoma mansoni | coup transcription factor | 0.0047 | 0.0179 | 0.0558 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0022 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0047 | 0.0179 | 0.0997 |
Echinococcus granulosus | FTZ F1 alpha | 0.0047 | 0.0179 | 0.0438 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0047 | 0.0179 | 0.0438 |
Brugia malayi | ecdysone receptor | 0.0022 | 0.0022 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.014 | 0.0437 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0035 | 0.0103 | 0.5796 |
Brugia malayi | hypothetical protein | 0.0305 | 0.1799 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0022 | 0.0022 | 0.0124 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0257 | 0.1496 | 0.365 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0918 | 0.2856 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0162 | 0.0898 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0047 | 0.0179 | 0.0179 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0036 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0178 | 0.0988 |
Brugia malayi | nuclear receptor NHR-88 | 0.0047 | 0.0179 | 0.0997 |
Brugia malayi | nuclear receptor NHR-67 | 0.0022 | 0.0022 | 0.0124 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0047 | 0.0179 | 0.0997 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0047 | 0.0179 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0103 | 0.0573 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0179 | 0.0997 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0149 | 0.0816 | 0.0816 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0047 | 0.0179 | 0.0179 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0047 | 0.0178 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.083 | 0.4611 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0025 | 0.0039 | 0.0039 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0269 | 0.0838 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0106 | 0.0551 | 0.0551 |
Echinococcus multilocularis | geminin | 0.0165 | 0.0918 | 0.0918 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0022 | 0.0022 | 0.0054 |
Brugia malayi | nuclear hormone receptor | 0.0022 | 0.0022 | 0.0124 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0025 | 0.0039 | 0.0218 |
Schistosoma mansoni | nuclear receptor | 0.0022 | 0.0022 | 0.007 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0106 | 0.0551 | 0.1714 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0047 | 0.0179 | 0.0438 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0022 | 0.0022 | 0.0124 |
Brugia malayi | ecdysteroid receptor | 0.0047 | 0.0179 | 0.0997 |
Echinococcus granulosus | muscleblind protein | 0.0151 | 0.083 | 0.2025 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0039 | 0.0218 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0047 | 0.0179 | 0.0997 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0047 | 0.0178 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0269 | 0.0838 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0162 | 0.0394 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0036 | 0.0241 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0091 | 0.5117 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0022 | 0.0022 | 0.0054 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.015 | 0.015 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0178 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0151 | 0.083 | 0.4611 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0025 | 0.0039 | 0.0218 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0025 | 0.0041 | 0.0762 |
Mycobacterium ulcerans | hypothetical protein | 0.0047 | 0.0178 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0036 | 0.0241 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0639 | 0.3554 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.0156 | 0.0485 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.0507 | 0.1236 |
Brugia malayi | nuclear receptor NHR-88 | 0.0022 | 0.0022 | 0.0124 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0047 | 0.0179 | 0.0438 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.014 | 0.0437 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0047 | 0.0178 | 0.1189 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0047 | 0.0179 | 0.0997 |
Brugia malayi | AMP-binding enzyme family protein | 0.0047 | 0.0178 | 0.0988 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0269 | 0.1496 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0257 | 0.1496 | 0.8313 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.014 | 0.0437 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0091 | 0.5117 |
Brugia malayi | tailless protein | 0.0022 | 0.0022 | 0.0124 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0025 | 0.0041 | 0.2746 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0041 | 0.0275 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0151 | 0.083 | 0.083 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0103 | 0.0573 |
Schistosoma mansoni | thyroid hormone receptor | 0.0047 | 0.0179 | 0.0558 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0269 | 0.1496 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0098 | 0.0499 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.0469 | 0.1144 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.0022 | 0.0022 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0035 | 0.0103 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0047 | 0.0179 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0036 | 0.0241 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0047 | 0.0179 | 0.0997 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0047 | 0.0179 | 0.0997 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0142 | 0.0775 | 0.0775 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0047 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0162 | 0.0898 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0039 | 0.0218 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0091 | 0.5117 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.015 | 0.0467 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0162 | 0.0162 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.0022 | 0.007 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.015 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0047 | 0.0179 | 0.0997 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0025 | 0.0041 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0025 | 0.0039 | 0.0122 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0047 | 0.0179 | 0.0438 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.0156 | 0.0865 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0047 | 0.0178 | 0.5 |
Brugia malayi | Flap endonuclease-1 | 0.0025 | 0.0041 | 0.0229 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0047 | 0.0179 | 0.0997 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0036 | 0.0201 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.0507 | 0.0507 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0047 | 0.0179 | 0.0179 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0047 | 0.0178 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0551 | 0.1714 |
Onchocerca volvulus | 0.0047 | 0.0179 | 0.0884 | |
Brugia malayi | CHE-14 protein | 0.0043 | 0.015 | 0.0834 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0178 | 0.0988 |
Echinococcus multilocularis | tumor protein p63 | 0.0671 | 0.4098 | 0.4098 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.021 | 0.1169 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0162 | 0.0394 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0269 | 0.1496 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0269 | 0.0838 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0639 | 0.3554 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0047 | 0.0179 | 0.0997 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0047 | 0.0179 | 0.0179 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0047 | 0.0179 | 0.0884 |
Brugia malayi | nuclear receptor RXR | 0.0025 | 0.0039 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0039 | 0.0218 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0178 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0499 | 0.2774 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0047 | 0.0179 | 0.0997 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0022 | 0.0022 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Entamoeba histolytica | hypothetical protein | 0.0106 | 0.0551 | 0.3682 |
Brugia malayi | nuclear receptor RXR | 0.0022 | 0.0022 | 0.0124 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.0469 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.0156 | 0.1041 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.015 | 0.0366 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.0507 | 0.3387 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0022 | 0.0022 | 0.0054 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0041 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0179 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0039 | 0.0218 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0047 | 0.0178 | 0.1189 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0047 | 0.0178 | 0.1189 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0047 | 0.0178 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0151 | 0.083 | 0.083 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0047 | 0.0179 | 0.0997 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0025 | 0.0041 | 0.0229 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0179 | 0.0997 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0162 | 0.0503 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0269 | 0.1496 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0162 | 0.0162 |
Echinococcus granulosus | geminin | 0.0165 | 0.0918 | 0.2239 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0047 | 0.0179 | 0.0997 |
Plasmodium falciparum | flap endonuclease 1 | 0.0025 | 0.0041 | 0.0762 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0022 | 0.0022 | 0.0124 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0269 | 0.0269 |
Entamoeba histolytica | Flap nuclease, putative | 0.0025 | 0.0041 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0179 | 0.0997 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0022 | 0.0022 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0162 | 0.0503 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0047 | 0.0179 | 0.0997 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0025 | 0.0039 | 0.0122 |
Onchocerca volvulus | 0.0305 | 0.1799 | 1 | |
Schistosoma mansoni | retinoic acid receptor RXR | 0.053 | 0.3213 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0047 | 0.0179 | 0.0997 |
Onchocerca volvulus | 0.0047 | 0.0178 | 0.0875 | |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0035 | 0.0103 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0022 | 0.007 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0047 | 0.0179 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0091 | 0.5117 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.015 | 0.015 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0025 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0103 | 0.0573 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0162 | 0.0503 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0035 | 0.0103 | 0.5796 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0022 | 0.0022 | 0.0054 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0047 | 0.0179 | 0.0179 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0047 | 0.0179 | 0.0997 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0035 | 0.0103 | 0.5 |
Brugia malayi | conserved hypotetical protein | 0.0022 | 0.0022 | 0.0124 |
Schistosoma mansoni | nuclear hormone receptor | 0.0047 | 0.0179 | 0.0558 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0022 | 0.0022 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0179 | 0.0997 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0047 | 0.0179 | 0.0997 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0269 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0022 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0918 | 0.2856 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 10.31 % | Antiplatelet activity against collagen-induced rabbit platelet aggregation at 100 uM | ChEMBL. | 17689252 |
Activity (functional) | = 13.5 % | Antiplatelet activity against arachidonic acid-induced rabbit platelet aggregation at 100 uM | ChEMBL. | 17689252 |
Activity (functional) | = 90.23 % | Antiplatelet activity against U46619-induced rabbit platelet aggregation in at 100 uM | ChEMBL. | 17689252 |
Activity (functional) | = 94.05 % | Antiplatelet activity against thrombin-induced rabbit platelet aggregation at 100 uM | ChEMBL. | 17689252 |
GI50 (functional) | = 42 uM | Antiproliferative activity against human MT2 cells after 48 hrs by MTT assay | ChEMBL. | 17689252 |
GI50 (functional) | = 42 uM | Antiproliferative activity against human MT2 cells after 48 hrs by MTT assay | ChEMBL. | 17689252 |
GI50 (functional) | > 50 uM | Antiproliferative activity against human NCI-H661 cells after 48 hrs by MTT assay | ChEMBL. | 17689252 |
GI50 (functional) | > 50 uM | Antiproliferative activity against human NPC-Tw01 cells after 48 hrs by MTT assay | ChEMBL. | 17689252 |
GI50 (functional) | > 50 uM | Antiproliferative activity against human NCI-H661 cells after 48 hrs by MTT assay | ChEMBL. | 17689252 |
IC50 (functional) | 0 | Antiplatelet activity against U46619-induced rabbit platelet aggregation | ChEMBL. | 17689252 |
IC50 (functional) | = 35.5 uM | Antiplatelet activity against collagen-induced rabbit platelet aggregation | ChEMBL. | 17689252 |
IC50 (functional) | = 63.21 uM | Antiplatelet activity against arachidonic acid-induced rabbit platelet aggregation | ChEMBL. | 17689252 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.