Detailed information for compound 450506

Basic information

Technical information
  • TDR Targets ID: 450506
  • Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S)-1- (3,3-dimethyl-2-methylidenebutoxy)propan-2-yl ]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4 -ylidene]ethylidene]-4-methylidenecyclohexane -1,3-diol
  • MW: 442.674 | Formula: C29H46O3
  • H donors: 2 H acceptors: 2 LogP: 6.31 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1C[C@H](O)C(=C)/C(=C\C=C\2/CCC[C@]3([C@H]2CC[C@@H]3[C@@H](COCC(=C)C(C)(C)C)C)C)/C1
  • InChi: 1S/C29H46O3/c1-19(17-32-18-20(2)28(4,5)6)25-12-13-26-22(9-8-14-29(25,26)7)10-11-23-15-24(30)16-27(31)21(23)3/h10-11,19,24-27,30-31H,2-3,8-9,12-18H2,1,4-7H3/b22-10+,23-11-/t19-,24-,25-,26+,27+,29-/m1/s1
  • InChiKey: UAFNLUQZVDRWEB-MOFNPVRRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1S)-2-(3,3-dimethyl-2-methylene-butoxy)-1-methyl-ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1S)-2-(3,3-dimethyl-2-methylenebutoxy)-1-methylethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylenecyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S)-1-(3,3-dimethyl-2-methylidene-butoxy)propan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1S)-2-(2-tert-butylallyloxy)-1-methyl-ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1S)-2-(2-tert-butylprop-2-enoxy)-1-methyl-ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0072 0.0512 0.3456
Echinococcus granulosus death domain containing protein 0.0014 0.0041 0.0064
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0646
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0025 0.0039
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0096 0.0096
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0158 0.0244
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0025 0.0039
Echinococcus granulosus geminin 0.0179 0.1376 0.2129
Echinococcus multilocularis cysteine protease 0.0018 0.0069 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0206 0.1313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0096 0.0096
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0096 0.0234
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0009 0.002
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Onchocerca volvulus 0.0057 0.0385 0.2168
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0025 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0025 0.0039
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0158 0.023
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.045 0.2973
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0304 0.2052
Brugia malayi Cytochrome P450 family protein 0.0034 0.0206 0.1387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Schistosoma mansoni carbonic anhydrase 0.0514 0.41 0.6344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0304 0.0471
Brugia malayi bZIP transcription factor family protein 0.0089 0.0649 0.4376
Echinococcus granulosus neuropeptide s receptor 0.0487 0.3882 0.6006
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0069 0.1472
Echinococcus multilocularis neuropeptide s receptor 0.0487 0.3882 0.5656
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0425 0.8997
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0206 0.4358
Echinococcus multilocularis lipoxygenase domain containing protein 0.0099 0.0728 0.1061
Onchocerca volvulus 0.0058 0.0399 0.2251
Onchocerca volvulus Putative sulfate transporter 0.0208 0.1614 0.9504
Mycobacterium ulcerans hypothetical protein 0.0111 0.0823 0.0763
Onchocerca volvulus 0.0218 0.1697 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0066 0.139
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0025 0.0039
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0025 0.017
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0025 0.017
Schistosoma mansoni cpg binding protein 0.006 0.0411 0.0636
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0000000004757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0025 0.0019
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0855 0.6863 1
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Echinococcus granulosus Polycystic kidney disease protein 0.0099 0.0728 0.1127
Plasmodium vivax SET domain protein, putative 0.0029 0.0158 0.0334
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0158 0.0244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0038 0.0234 0.0362
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0025 0.0086
Onchocerca volvulus 0.0159 0.1219 0.7146
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0025 0.0037
Leishmania major cytochrome p450-like protein 0.0034 0.0206 0.0347
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Echinococcus multilocularis RUN 0.0099 0.0728 0.1061
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0566
Loa Loa (eye worm) hypothetical protein 0.0058 0.0399 0.263
Toxoplasma gondii 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase domain-containing protein 0.0592 0.4733 1
Onchocerca volvulus 0.0029 0.0158 0.0811
Loa Loa (eye worm) hypothetical protein 0.0046 0.0297 0.1932
Schistosoma mansoni lipoxygenase 0.0224 0.1745 0.2701
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0022 0.0022
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0041 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.0297 0.2001
Brugia malayi Protein kinase domain containing protein 0.0014 0.0041 0.0278
Schistosoma mansoni loxhd1 0.0099 0.0728 0.1127
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0066 0.139
Echinococcus multilocularis neuropeptide receptor A26 0.0487 0.3882 0.5656
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0048 0.0075
Loa Loa (eye worm) hypothetical protein 0.0099 0.0728 0.4871
Echinococcus multilocularis cpg binding protein 0.006 0.0411 0.0599
Schistosoma mansoni jun-related protein 0.0073 0.0519 0.0802
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0192 0.1482 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1219 0.8208
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0043 0.0209
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0025 0.0039
Schistosoma mansoni cpg binding protein 0.006 0.0411 0.0636
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0025 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0025 0.0039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0025 0.0037
Brugia malayi Death domain containing protein 0.0014 0.0041 0.0278
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0069 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0025 0.0037
Onchocerca volvulus 0.0018 0.0069 0.0283
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0025 0.0086
Onchocerca volvulus 0.0018 0.0069 0.0283
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0304 0.0443
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0646
Echinococcus granulosus cathepsin l1 0.0012 0.0022 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0025 0.0037
Schistosoma mansoni ephrin receptor 0.0059 0.0404 0.0626
Onchocerca volvulus 0.0067 0.0471 0.2681
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0096 0.2029
Loa Loa (eye worm) RNA binding protein 0.0064 0.045 0.2973
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0991 0.7964 1
Leishmania major cathepsin L-like protease 0.0067 0.0472 0.1007
Mycobacterium ulcerans integral membrane transporter 0.0033 0.0195 0.013
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0025 0.0019
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0013 0.0268
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0025 0.0039
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0069 0.0169
Loa Loa (eye worm) hypothetical protein 0.0099 0.0728 0.4871
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0043 0.0067
Leishmania major cathepsin L-like protease 0.0067 0.0472 0.1007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0043 0.0063
Treponema pallidum hypothetical protein 0.0592 0.4733 1
Echinococcus granulosus microtubule associated protein 2 0.0727 0.5829 0.9019
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0022 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0064
Loa Loa (eye worm) cytochrome P450 family protein 0.0072 0.0512 0.34
Schistosoma mansoni netrin receptor unc5 0.0014 0.0041 0.0064
Schistosoma mansoni rab6-interacting 0.0099 0.0728 0.1127
Echinococcus multilocularis ephrin type A receptor 4 A 0.0059 0.0404 0.0589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0025 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Loa Loa (eye worm) RecQ helicase 0.0021 0.0096 0.0566
Plasmodium vivax 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, putative 0.0592 0.4733 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0025 0.0086
Echinococcus granulosus neuropeptide receptor A26 0.0487 0.3882 0.6006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.0297 0.1932
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0096 0.014
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0096 0.014
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0183
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0076 0.0434
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0304 0.0471
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0096 0.014
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0096 0.0096
Brugia malayi CXXC zinc finger family protein 0.0057 0.0385 0.2599
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Echinococcus granulosus GPCR family 2 0.0014 0.0043 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0025 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Trichomonas vaginalis conserved hypothetical protein 0.1241 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0025 0.017
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0033 0.0195 0.013
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0514 0.41 1
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0025 0.017
Echinococcus granulosus tar DNA binding protein 0.0064 0.045 0.0696
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0022 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Brugia malayi RNA binding protein 0.0064 0.045 0.3033
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0206 0.0141
Brugia malayi hypothetical protein 0.0099 0.0728 0.4915
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0365
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Onchocerca volvulus 0.0018 0.0069 0.0283
Brugia malayi Cathepsin L-like precursor 0.0012 0.0022 0.0149
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0041 0.0114
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0025 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0025 0.0039
Trichomonas vaginalis helicase, putative 0.0013 0.003 0.003
Schistosoma mansoni microtubule-associated protein tau 0.0727 0.5829 0.9019
Brugia malayi cytochrome P450 0.0017 0.0066 0.0443
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0096 0.0646
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0025 0.0039
Brugia malayi steroid hormone receptor 0.0012 0.0025 0.017
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Schistosoma mansoni DNA helicase recq1 0.0021 0.0096 0.0148
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0025 0.0039
Echinococcus granulosus RUN 0.0099 0.0728 0.1127
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0096 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0158 0.0244
Chlamydia trachomatis 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 1
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0206 0.4358
Echinococcus granulosus cpg binding protein 0.006 0.0411 0.0636
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0158 0.0315
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0042 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0201
Brugia malayi Cytochrome P450 family protein 0.0017 0.0066 0.0443
Schistosoma mansoni hypothetical protein 0.0073 0.0519 0.0802
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0179 0.1376 0.2129
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0025 0.0037
Plasmodium vivax vivapain-2 0.0018 0.0069 0.0147
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0025 0.017
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0033 0.0195 0.013
Schistosoma mansoni hypothetical protein 0.0806 0.6463 1
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0195 0.4132
Echinococcus multilocularis tar DNA binding protein 0.0064 0.045 0.0655
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0096 0.0148
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Schistosoma mansoni lipoxygenase 0.0402 0.3189 0.4935
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0472 1
Onchocerca volvulus 0.0018 0.0069 0.0283
Onchocerca volvulus 0.0012 0.0025 0.0019
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0096 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0025 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Loa Loa (eye worm) cytochrome P450 0.0017 0.0066 0.0361
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0234 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.105
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0025 0.0039
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0069 0.0101
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0025 0.0037
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0041 0.006
Onchocerca volvulus 0.0018 0.0069 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0069 0.0387
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0025 0.0039
Loa Loa (eye worm) ctsf protein 0.0018 0.0069 0.0387
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0043 0.0063
Brugia malayi hypothetical protein 0.0038 0.0234 0.1579
Echinococcus granulosus dnaJ subfamily B 0.0806 0.6463 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0069 0.0101
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0183
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0043 0.0293
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0304 0.0471
Brugia malayi TAR-binding protein 0.0064 0.045 0.3033
Schistosoma mansoni cytochrome P450 0.0017 0.0066 0.0102
Onchocerca volvulus 0.0208 0.1614 0.9504
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0096 0.0202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0304 0.0471
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0472 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0064
Echinococcus multilocularis geminin 0.0179 0.1376 0.2005
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0069 0.0283
Wolbachia endosymbiont of Brugia malayi 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 0.5
Mycobacterium leprae Probable transmembrane transport protein 0.024 0.1875 0.4485
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0025 0.017
Loa Loa (eye worm) TK/EPH protein kinase 0.0075 0.0534 0.3548
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0195 0.4132
Echinococcus granulosus cathepsin l1 0.0018 0.0069 0.0107
Echinococcus multilocularis cysteine protease 0.0018 0.0069 0.0101
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0033 0.0195 0.0393
Brugia malayi hypothetical protein 0.0099 0.0728 0.4915
Onchocerca volvulus 0.0018 0.0069 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0025 0.017
Brugia malayi hypothetical protein 0.0067 0.0471 0.3178
Echinococcus granulosus lipoxygenase domain containing protein 0.0099 0.0728 0.1127
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0041 0.0064
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0402 0.3189 0.4935
Brugia malayi ecdysteroid receptor 0.0012 0.0025 0.017
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0096 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Echinococcus multilocularis dnaJ subfamily B 0.0806 0.6463 0.9418
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0013 0.0027
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0048 0.0075
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0158 0.023
Schistosoma mansoni polycystin 1-related 0.0099 0.0728 0.1127
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0041 0.0278
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0033 0.0195 0.0412
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0402 0.3189 0.4647
Echinococcus multilocularis lipoxygenase domain containing protein 0.0099 0.0728 0.1061
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0025 0.0039
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0491 0.3912 0.4869
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0041 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0025 0.0086
Onchocerca volvulus 0.0099 0.0728 0.4218
Echinococcus multilocularis microtubule associated protein 2 0.0727 0.5829 0.8494
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0158 0.0244
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0009 0.0014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0234 0.0362
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0013 0.0268
Echinococcus multilocularis 0.0017 0.0066 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0069 0.0147
Brugia malayi Cathepsin L-like precursor 0.0012 0.0022 0.0149
Schistosoma mansoni hypothetical protein 0.0179 0.1376 0.2129
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0022 0.0034
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0206 0.1313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0069 0.0283
Schistosoma mansoni hypothetical protein 0.0099 0.0728 0.1127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0025 0.0039
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0025 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0069 0.0107
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0989
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Plasmodium vivax sulfate transporter, putative 0.0033 0.0195 0.0412
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0025 0.0086
Echinococcus granulosus lipoxygenase domain containing protein 0.0099 0.0728 0.1127
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0076 0.0118
Schistosoma mansoni cpg binding protein 0.0057 0.0385 0.0596
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0013 0.0007
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0069 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0387
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0234 0.0341
Plasmodium falciparum LCCL domain-containing protein 0.0099 0.0728 0.1539
Loa Loa (eye worm) hypothetical protein 0.0083 0.0601 0.4004
Mycobacterium leprae Probable 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) (MECDP-synthase ) 0.0475 0.3781 0.9207
Plasmodium falciparum 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0025 0.017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0908 0.1405
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0025 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Brugia malayi nuclear receptor NHR-88 0.0012 0.0025 0.017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.0297 0.2001
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0066 0.139
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0069 0.0387
Schistosoma mansoni DNA helicase recq5 0.0021 0.0096 0.0148
Entamoeba histolytica cysteine protease, putative 0.0018 0.0069 0.0169
Echinococcus multilocularis Ankyrin 0.0014 0.0042 0.0061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0304 0.1984
Loa Loa (eye worm) fibroinase 0.0018 0.0069 0.0387
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0025 0.017
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0066 0.139
Echinococcus multilocularis Polycystic kidney disease protein 0.0099 0.0728 0.1061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0043 0.0293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0025 0.0086
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0066 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.1241 1 1
Plasmodium vivax vivapain-2 0.0018 0.0069 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0304 0.0471
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0069 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0096 0.2029
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0066 0.0102
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0096 0.0202
Echinococcus granulosus ephrin type A receptor 4 A 0.0059 0.0404 0.0626
Schistosoma mansoni coup transcription factor 0.0012 0.0025 0.0039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0195
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0025 0.017
Leishmania major carbonic anhydrase family protein, putative 0.0514 0.41 1
Echinococcus multilocularis GPCR, family 2 0.0014 0.0043 0.0063
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0013 0.002
Onchocerca volvulus 0.0018 0.0069 0.0283
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0069 0.0283
Trichomonas vaginalis set domain proteins, putative 0.0218 0.1696 0.1696
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0515 0.0751
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0206 0.4358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Brugia malayi Pre-SET motif family protein 0.0029 0.0158 0.1066
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0102
Leishmania major cathepsin L-like protease 0.0067 0.0472 0.1007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Echinococcus granulosus bloom syndrome protein 0.0021 0.0096 0.0148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0158 0.0244
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Brugia malayi Pre-SET motif family protein 0.0192 0.1482 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0025 0.0019
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0069 0.0107
Mycobacterium tuberculosis Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) 0.0475 0.3781 0.4704
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0209
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0195 0.4132
Loa Loa (eye worm) doublecortin family protein 0.0099 0.0728 0.4871
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0096 0.0566
Brugia malayi Uncoordinated protein 44 0.0014 0.0041 0.0278
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0075 0.0503
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0048 0.0071
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0025 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0472 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0048 0.0071
Mycobacterium ulcerans carbonic anhydrase 0.0514 0.41 0.4062
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0206 0.1313
Loa Loa (eye worm) hypothetical protein 0.0031 0.0179 0.1134
Entamoeba histolytica recQ family helicase, putative 0.001 0.0009 0.0023
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Brugia malayi ephrin receptor 1 precursor 0.0028 0.0154 0.1041
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0025 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0025 0.0039
Plasmodium vivax multidomain scavenger receptor, putative 0.0099 0.0728 0.1539
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0069 0.0107
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0515 0.0797
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0025 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0304 0.0443
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0069 0.0469
Echinococcus multilocularis jun protein 0.0089 0.0649 0.0945
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0041 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0025 0.0039
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0022 0.0149
Echinococcus granulosus jun protein 0.0089 0.0649 0.1003
Entamoeba histolytica carbonic anhydrase, putative 0.0514 0.41 1
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0179 0.121
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0649 0.0945
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0385 0.2535
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0013 0.0031
Echinococcus granulosus Ankyrin 0.0014 0.0042 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0025 0.017
Toxoplasma gondii cathepsin CPL 0.0018 0.0069 0.0127
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.014 0.0216
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0043 0.0067
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0069 0.0147
Loa Loa (eye worm) cysteine protease 0.0018 0.0069 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.003
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0263 0.2064 0.2531
Onchocerca volvulus 0.0099 0.0728 0.4218
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0472 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Brugia malayi nuclear hormone receptor 0.0012 0.0025 0.017
Brugia malayi hypothetical protein 0.0159 0.1219 0.8223
Schistosoma mansoni rab6-interacting 0.0099 0.0728 0.1127
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0041 0.006
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0804 0.1682
Mycobacterium ulcerans 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 0.4699
Brugia malayi cathepsin L-like precursor 0.0012 0.0022 0.0149
Loa Loa (eye worm) TAR-binding protein 0.0064 0.045 0.2973
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.045 0.3033
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0076 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0069 0.0101
Schistosoma mansoni hypothetical protein 0.0014 0.0041 0.0064
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0025 0.017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0069 0.0101
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0025 0.017
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0069 0.0169
Schistosoma mansoni hypothetical protein 0.0031 0.0179 0.0277
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0025 0.0039
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0048 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0025 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Brugia malayi Doublecortin family protein 0.0099 0.0728 0.4915
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.024 0.1875 0.2291
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0649 0.1003
Brugia malayi Cytochrome P450 family protein 0.0034 0.0206 0.1387
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0355 0.7525
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Induction of CYP24 mRNA transcriptional activity in C57BL/6 mouse duodenum at 25 ug/kg, ip after 4 hrs ChEMBL. 17924616
Activity (functional) Induction of TRPV6 mRNA transcriptional activity in C57BL/6 mouse duodenum at 25 ug/kg, ip after 4 hrs ChEMBL. 17924616
Activity (functional) 0 Induction of CYP24 mRNA transcriptional activity in C57BL/6 mouse duodenum at 25 ug/kg, ip after 4 hrs ChEMBL. 17924616
Activity (functional) 0 Induction of TRPV6 mRNA transcriptional activity in C57BL/6 mouse duodenum at 25 ug/kg, ip after 4 hrs ChEMBL. 17924616
Activity (functional) < 0.02 Calciuric activity in rat utrine assessed as vitamine D3 level relative to calcitriol ChEMBL. 17924616
ED50 (binding) = 6 nM Activity at human recombinant VDR in ROS 17/2.8 cells transfected with growth hormone fusion gene VDRE assessed as growth hormone level by transcriptional assay ChEMBL. 17924616
ED50 (binding) = 6 nM Activity at human recombinant VDR in ROS 17/2.8 cells transfected with growth hormone fusion gene VDRE assessed as growth hormone level by transcriptional assay ChEMBL. 17924616
IC50 (functional) = 20 nM Antiproliferative activity against mouse keratinocytes ChEMBL. 17924616
IC50 (binding) = 85 nM Displacement of 1alpha, 25-(OH)[3H]D3 from human VDR expressed in COS1 cells ChEMBL. 17924616
IC50 (binding) = 85 nM Displacement of 1alpha, 25-(OH)[3H]D3 from human VDR expressed in COS1 cells ChEMBL. 17924616
LogP = 4.7 Lipophilicity, log D of the compound ChEMBL. 17924616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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