Detailed information for compound 450802

Basic information

Technical information
  • TDR Targets ID: 450802
  • Name: (4Z)-2-(2,4-dichlorophenyl)-4-(thiophen-2-ylm ethylidene)-1,3-oxazol-5-one
  • MW: 324.182 | Formula: C14H7Cl2NO2S
  • H donors: 0 H acceptors: 1 LogP: 4.53 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)C1=N/C(=C\c2cccs2)/C(=O)O1
  • InChi: 1S/C14H7Cl2NO2S/c15-8-3-4-10(11(16)6-8)13-17-12(14(18)19-13)7-9-2-1-5-20-9/h1-7H/b12-7-
  • InChiKey: GXTYCIXGTOUVQS-GHXNOFRVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4Z)-2-(2,4-dichlorophenyl)-4-(2-thienylmethylene)oxazol-5-one
  • (4Z)-2-(2,4-dichlorophenyl)-4-(2-thienylmethylene)-5-oxazolone
  • (4Z)-2-(2,4-dichlorophenyl)-4-(2-thenylidene)-2-oxazolin-5-one
  • 2-(2,4-dichlorophenyl)-4-(thiophen-2-ylmethylidene)-1,3-oxazol-5-one
  • 2-(2,4-dichlorophenyl)-4-(2-thienylmethylene)oxazol-5-one
  • 2-(2,4-dichlorophenyl)-4-(2-thienylmethylene)-5-oxazolone
  • 2-(2,4-Dichloro-phenyl)-4-thiophen-2-ylmethylene-4H-oxazol-5-one
  • BAS 00490934
  • STOCK4S-61172
  • ZINC00055303
  • T5992248

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase domain containing protein 0.0157 0.5299 0.8656
Entamoeba histolytica phosphoglycerate kinase, putative 0.0178 0.6116 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0421 0.0689
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0222 0.0297
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0042 0.0853 0.1394
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.31 0.5068
Toxoplasma gondii ck2 beta subunit 0.0043 0.0894 0.1461
Echinococcus granulosus dna polymerase eta 0.0082 0.2416 0.395
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.1767 0.284
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0083 0.2461 0.3798
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0656 0.0736
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0157 0.5299 0.8656
Echinococcus granulosus peregrin 0.0031 0.0421 0.0689
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0178 0.6116 1
Schistosoma mansoni DNA polymerase eta 0.0082 0.2416 0.395
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0421 0.0421
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.00000000034419 0.00000000056277
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0022 0.0098 0.0098
Brugia malayi Csnk2b protein 0.0043 0.0894 0.0894
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0178 0.6116 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0022 0.0098 0.016
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0022 0.0098 0.016
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Brugia malayi beta-NAC-like protein 0.0037 0.0656 0.0656
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.5299 0.8615
Brugia malayi Bloom's syndrome protein homolog 0.0047 0.1075 0.1075
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0669 0.1094
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.5299 0.8615
Brugia malayi hypothetical protein 0.008 0.2327 0.2327
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Brugia malayi metalloprotease 0.0038 0.0702 0.0702
Toxoplasma gondii DNA methyltransferase 2, putative 0.0021 0.0042 0.0068
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.1767 0.262
Trichomonas vaginalis DNA polymerase eta, putative 0.0083 0.2461 0.3798
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.1767 0.262
Loa Loa (eye worm) hypothetical protein 0.0042 0.087 0.087
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0988 0.1558
Echinococcus multilocularis cpg binding protein 0.0035 0.0597 0.0976
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.2461 0.3982
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0043 0.0894 0.1402
Echinococcus granulosus DNA methyltransferase 2, putative 0.0021 0.0042 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.2461 0.3982
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0157 0.5299 0.5299
Echinococcus granulosus adam 0.008 0.2327 0.3806
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0178 0.6116 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Loa Loa (eye worm) hypothetical protein 0.0144 0.481 0.481
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0056 0.1387 0.2268
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0021 0.0042 0.0068
Leishmania major basic transcription factor 3a, putative 0.0037 0.0656 0.1011
Trypanosoma brucei unspecified product 0.0038 0.0722 0.112
Trypanosoma brucei DNA polymerase IV, putative 0.0083 0.2461 0.3982
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0178 0.6116 1
Schistosoma mansoni protein kinase 0.0157 0.5299 0.8665
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0894 0.1402
Trypanosoma brucei DNA polymerase IV, putative 0.0083 0.2461 0.3982
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.2461 0.3982
Plasmodium falciparum casein kinase II beta chain 0.0043 0.0894 0.1461
Chlamydia trachomatis phosphoglycerate kinase 0.0178 0.6116 0.5
Brugia malayi Reprolysin 0.0038 0.0702 0.0702
Brugia malayi Bromodomain containing protein 0.0031 0.0421 0.0421
Trypanosoma brucei Casein kinase II 0.0157 0.5299 0.8656
Echinococcus granulosus casein kinase ii subunit beta 0.0043 0.0894 0.1461
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.1767 0.262
Schistosoma mansoni cpg binding protein 0.0035 0.0597 0.0976
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0089 0.2661 0.4351
Loa Loa (eye worm) hypothetical protein 0.0038 0.0702 0.0702
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0043 0.0894 0.2129
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.5299 0.8615
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1675 0.1675
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0656 0.0656
Brugia malayi Casein kinase II, alpha chain 0.0157 0.5299 0.5299
Onchocerca volvulus 0.0035 0.0597 0.0792
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.31 0.5068
Brugia malayi jmjC domain containing protein 0.0037 0.0669 0.0669
Schistosoma mansoni casein kinase II beta subunit 0.0043 0.0894 0.1461
Plasmodium falciparum phosphoglycerate kinase 0.0178 0.6116 1
Trypanosoma brucei phosphoglycerate kinase 0.0065 0.1767 0.284
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.004 0.08 0.1307
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0421 0.0689
Loa Loa (eye worm) metalloprotease 0.0038 0.0702 0.0702
Brugia malayi angiogenesis inhibito 0.0086 0.2543 0.2543
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0222 0.0297
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.2416 0.2416
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0597 0.0597
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Brugia malayi jmjC domain containing protein 0.01 0.31 0.31
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0022 0.0098 0.0098
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0421 0.0689
Entamoeba histolytica deoxycytidyl transferase, putative 0.0056 0.1387 0.2215
Loa Loa (eye worm) hypothetical protein 0.0279 1 1
Echinococcus granulosus transcription factor btf3 0.0037 0.0656 0.1072
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0038 0.0702 0.1147
Brugia malayi polk-prov protein 0.0045 0.0983 0.0983
Plasmodium falciparum phd finger protein, putative 0.0031 0.0421 0.0689
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Echinococcus granulosus phosphoglycerate kinase 1 0.0178 0.6116 1
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.5299 0.8615
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0038 0.0702 0.1147
Echinococcus granulosus cpg binding protein 0.0035 0.0597 0.0976
Trypanosoma cruzi DNA polymerase eta, putative 0.0082 0.2416 0.3721
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0117 0.3737 0.611
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0178 0.6116 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0056 0.1387 0.1387
Brugia malayi CXXC zinc finger family protein 0.0035 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0052 0.1262 0.1262
Giardia lamblia PHD finger protein 15 0.0031 0.0421 0.0689
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0022 0.0098 0.0092
Brugia malayi PHD-finger family protein 0.0031 0.0421 0.0421
Echinococcus granulosus disco interacting protein 2 0.004 0.08 0.1307
Echinococcus multilocularis peregrin 0.0031 0.0421 0.0689
Plasmodium vivax casein kinase II beta chain, putative 0.0043 0.0894 0.1402
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.2461 0.3798
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0938 0.1533
Loa Loa (eye worm) hypothetical protein 0.0088 0.264 0.264
Giardia lamblia Kinase, CMGC CK2 0.0157 0.5299 0.8665
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.2461 0.3798
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.2461 0.3798
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0938 0.1214
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0178 0.6116 1
Echinococcus multilocularis disco interacting protein 2 0.004 0.08 0.1307
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.2461 0.3982
Loa Loa (eye worm) reprolysin 0.0038 0.0702 0.0702
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0176 0.0287
Echinococcus granulosus dna polymerase kappa 0.0083 0.2461 0.4023
Schistosoma mansoni jumonji domain containing protein 0.0079 0.2307 0.3772
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.5299 0.8615
Leishmania major casein kinase II, putative 0.0157 0.5299 0.8656
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.2461 0.3982
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0038 0.0702 0.1147
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0022 0.0098 0.0098
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0043 0.0894 0.1402
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0056 0.1387 0.2268
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.1767 0.262
Plasmodium vivax phosphoglycerate kinase, putative 0.0178 0.6116 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.2461 0.3982
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0022 0.0098 0.016
Treponema pallidum phosphoglycerate kinase 0.0178 0.6116 0.5
Toxoplasma gondii proteasome regulatory subunit 0.0022 0.0098 0.016
Trypanosoma brucei phosphoglycerate kinase 0.0178 0.6116 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0043 0.0894 0.2129
Echinococcus multilocularis dna polymerase kappa 0.0083 0.2461 0.4023
Echinococcus granulosus bloom syndrome protein 0.0047 0.1075 0.1758
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0983 0.155
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.5299 0.8615
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0117 0.3737 0.611
Trypanosoma brucei DNA polymerase eta, putative 0.0082 0.2416 0.3908
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0656 0.1011
Schistosoma mansoni cpg binding protein 0.0035 0.0597 0.0976
Trypanosoma cruzi casein kinase II, putative 0.0157 0.5299 0.8615
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0894 0.1402
Loa Loa (eye worm) hypothetical protein 0.0031 0.0421 0.0421
Brugia malayi Disco-interacting protein 2 homolog 0.004 0.08 0.08
Echinococcus multilocularis transcription factor btf3 0.0037 0.0656 0.1072
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0656 0.0736
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.008 0.2327 0.3806
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.1653 0.0563
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.1653 0.2653
Loa Loa (eye worm) hypothetical protein 0.0045 0.0983 0.0983
Echinococcus multilocularis phosphoglycerate kinase 1 0.0178 0.6116 1
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0117 0.3737 0.611
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.5299 0.8615
Plasmodium vivax unspecified product 0.0157 0.5299 0.8656
Loa Loa (eye worm) hypothetical protein 0.0082 0.2416 0.2416
Trichomonas vaginalis DNA helicase recq, putative 0.0047 0.1075 0.1447
Brugia malayi Phosphoglycerate kinase 0.0065 0.1767 0.1767
Echinococcus multilocularis bloom syndrome protein 0.0047 0.1075 0.1758
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0021 0.0042 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0421 0.0625
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0656 0.1072
Echinococcus granulosus casein kinase ii subunit alpha 0.0157 0.5299 0.8665
Trichomonas vaginalis DNA helicase recq1, putative 0.0047 0.1075 0.1447
Loa Loa (eye worm) angiogenesis inhibito 0.0043 0.0917 0.0917
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.2461 0.3982
Giardia lamblia Phosphoglycerate kinase 0.0178 0.6116 1
Loa Loa (eye worm) Csnk2b protein 0.0043 0.0894 0.0894
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0468 0.0764
Trypanosoma brucei unspecified product 0.0038 0.0722 0.112
Loa Loa (eye worm) hypothetical protein 0.004 0.08 0.08
Echinococcus multilocularis casein kinase ii subunit alpha 0.0157 0.5299 0.8665
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.2461 0.3798
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0669 0.0669
Brugia malayi Phosphoglycerate kinase 0.0178 0.6116 0.6116
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0038 0.0702 0.1147
Entamoeba histolytica casein kinase, putative 0.0157 0.5299 0.8656
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0988 0.1558
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.2461 0.3982
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0043 0.0894 0.1461
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0178 0.6116 0.5
Schistosoma mansoni transcription factor btf3 0.0037 0.0656 0.1072
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0178 0.6116 0.5
Giardia lamblia Casein kinase II beta chain 0.0043 0.0894 0.1461
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0656 0.0736
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0656 0.1011
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0669 0.1094
Leishmania major DNA polymerase eta, putative 0.0044 0.0938 0.1475
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0656 0.1072
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Schistosoma mansoni cpg binding protein 0.0035 0.0597 0.0976
Entamoeba histolytica hypothetical protein 0.0037 0.0656 0.1011
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0065 0.1767 0.262
Echinococcus multilocularis adam 0.008 0.2327 0.3806
Trypanosoma brucei phosphoglycerate kinase, putative 0.0065 0.1767 0.284
Leishmania major phosphoglycerate kinase B, cytosolic 0.0178 0.6116 1
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0882 0.1443
Schistosoma mansoni phosphoglycerate kinase 0.0178 0.6116 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0983 0.155
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0178 0.6116 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0056 0.1387 0.2268
Loa Loa (eye worm) hypothetical protein 0.008 0.2327 0.2327
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0669 0.1094
Trypanosoma brucei DNA polymerase IV, putative 0.0077 0.2194 0.3544
Plasmodium vivax casein kinase II beta chain, putative 0.0043 0.0894 0.1402
Toxoplasma gondii hypothetical protein 0.0089 0.2661 0.4351
Giardia lamblia DINP protein human, muc B family 0.0062 0.1653 0.2703
Echinococcus multilocularis dna polymerase eta 0.0082 0.2416 0.395
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0021 0.0042 0.0068
Loa Loa (eye worm) hypothetical protein 0.0178 0.6116 0.6116
Mycobacterium ulcerans phosphoglycerate kinase 0.0178 0.6116 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0988 0.1558
Brugia malayi ADAMTS-like protease 0.0086 0.2543 0.2543
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0421 0.0689
Leishmania major DNA polymerase eta, putative 0.0082 0.2416 0.3908
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0032 0.0482 0.0725
Plasmodium falciparum casein kinase 2, alpha subunit 0.0157 0.5299 0.8665
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0882 0.1443
Trypanosoma brucei phosphoglycerate kinase 0.0178 0.6116 1
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0656 0.0736
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0894 0.1402
Brugia malayi ImpB/MucB/SamB family protein 0.0056 0.1387 0.1387
Toxoplasma gondii CMGC kinase, CK2 family 0.0157 0.5299 0.8665
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0043 0.0894 0.1139
Trypanosoma brucei unspecified product 0.0077 0.2194 0.3544
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0222 0.0297
Schistosoma mansoni blooms syndrome DNA helicase 0.0037 0.069 0.1128
Onchocerca volvulus 0.004 0.08 0.1705
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0021 0.0042 0.0068
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0043 0.0894 0.1139
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0421 0.0689
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.1653 0.2653
Schistosoma mansoni terminal deoxycytidyl transferase 0.0056 0.1387 0.2268
Plasmodium falciparum casein kinase II beta chain 0.0043 0.0894 0.1461
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0894 0.1139
Onchocerca volvulus Papilin homolog 0.0088 0.264 1
Schistosoma mansoni hypothetical protein 0.0031 0.0421 0.0689
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0669 0.1094
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0022 0.0098 0.0092
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0656 0.1011
Leishmania major phosphoglycerate kinase C, glycosomal 0.0178 0.6116 1
Schistosoma mansoni phosphoglycerate kinase 0.0178 0.6116 1
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0038 0.0702 0.1147
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.2461 0.3982
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0656 0.0736
Leishmania major DNA polymerase kappa, putative 0.0062 0.1653 0.2653
Echinococcus multilocularis casein kinase ii subunit beta 0.0043 0.0894 0.1461
Loa Loa (eye worm) hypothetical protein 0.0038 0.0702 0.0702
Loa Loa (eye worm) RecQ helicase 0.0047 0.1075 0.1075

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 136.49 % Inhibition of transthyretin amyloidosis assessed as fibril formation pH 4.4 at 100 uM ChEMBL. 17948976
Activity (functional) = 136.49 % Inhibition of transthyretin amyloidosis assessed as fibril formation pH 4.4 at 100 uM ChEMBL. 17948976
Inhibition (functional) = 0 % Inhibition of transthyretin fibril formation at pH 4.4 at 100 uM ChEMBL. 17948976
Inhibition (functional) = 0 % Inhibition of transthyretin fibril formation at pH 4.4 at 100 uM ChEMBL. 17948976

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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