TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 253.296 | Formula: C16H15NO2
H donors: 2 H acceptors: 2 LogP: 3.25 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CCn1c(cc2c1cc(O)cc2)c1cccc(c1)O
InChi: 1S/C16H15NO2/c1-2-17-15(11-4-3-5-13(18)8-11)9-12-6-7-14(19)10-16(12)17/h3-10,18-19H,2H2,1H3
InChiKey: GRBGYCVKMLCMNJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	ecdysteroid receptor	0.0198	0.3913	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0023	0.0042	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0049	0.0608	0.1554
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0049	0.0608	0.1554
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0034	0.0292	0.036
Brugia malayi	nuclear receptor NHR-67	0.0023	0.0042	0.0108
Brugia malayi	ecdysone receptor	0.0023	0.0042	0.0108
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0041	0.0443	0.0443
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0026	0.0109	0.0939
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0292	0.0745
Plasmodium falciparum	nitric oxide synthase, putative	0.0026	0.0109	0.036
Brugia malayi	nuclear hormone receptor	0.0049	0.0608	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0049	0.0608	0.0752
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0034	0.0292	0.0961
Echinococcus granulosus	peroxidasin	0.0064	0.0945	0.1169
Schistosoma mansoni	alpha-amylase	0.0071	0.1109	0.1109
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0236	0.1109
Echinococcus granulosus	neuroligin	0.0034	0.0292	0.036
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0026	0.0109	0.0939
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0026	0.0103	0.0262
Mycobacterium tuberculosis	Trehalose synthase TreS	0.0071	0.1109	0.1801
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0159	0.3033	0.375
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0049	0.0608	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0103	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Mycobacterium ulcerans	trehalose synthase TreS	0.0071	0.1109	0.1801
Giardia lamblia	Rab geranylgeranyltransferase	0.0041	0.0443	0.1461
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0049	0.0608	0.1554
Onchocerca volvulus	Protein ultraspiracle homolog	0.0049	0.0608	0.1462
Onchocerca volvulus		0.0034	0.0292	0.0644
Brugia malayi	photoreceptor-specific nuclear receptor	0.0049	0.0608	0.1554
Echinococcus multilocularis	para nitrobenzyl esterase	0.0034	0.0292	0.036
Schistosoma mansoni	coup transcription factor	0.0049	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0608	0.1554
Trichomonas vaginalis	rotamase, putative	0.0032	0.0236	0.0777
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0026	0.0109	0.0939
Loa Loa (eye worm)	animal heme peroxidase	0.0064	0.0945	0.2416
Schistosoma mansoni	peroxidasin	0.0064	0.0945	0.0945
Mycobacterium tuberculosis	Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas	0.0071	0.1109	0.1801
Echinococcus multilocularis	acetylcholinesterase	0.0034	0.0292	0.036
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0049	0.0608	0.1554
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0443	0.3813
Echinococcus granulosus	carboxylesterase 5A	0.0034	0.0292	0.036
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0159	0.3033	0.3033
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0023	0.0042	0.0052
Onchocerca volvulus	Dual oxidase homolog	0.0064	0.0945	0.2333
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0	0.5
Echinococcus granulosus	para nitrobenzyl esterase	0.0034	0.0292	0.036
Loa Loa (eye worm)	blistered cuticle protein 3	0.0064	0.0945	0.2416
Echinococcus multilocularis	expressed protein	0.0388	0.8087	1
Echinococcus multilocularis	acetylcholinesterase	0.0034	0.0292	0.036
Echinococcus multilocularis	peroxidasin	0.0064	0.0945	0.1169
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0049	0.0608	0.1554
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0026	0.0109	0.0939
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0117	0.2126	0.7011
Schistosoma mansoni	thyroid hormone receptor	0.0049	0.0608	0.0608
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0049	0.0608	0.1554
Giardia lamblia	Rab geranylgeranyltransferase	0.0159	0.3033	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0292	0.0745
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0071	0.1109	0.2834
Brugia malayi	Nuclear hormone receptor E75	0.0023	0.0042	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Schistosoma mansoni	nuclear receptor	0.0023	0.0042	0.0042
Schistosoma mansoni	nuclear receptor nhr-48	0.0023	0.0042	0.0042
Echinococcus granulosus	nuclear receptor nhr 48	0.0023	0.0042	0.0052
Brugia malayi	Carboxylesterase family protein	0.0034	0.0292	0.0745
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0	0.5
Schistosoma mansoni	microsomal glutathione s-transferase	0.0109	0.1935	0.1935
Loa Loa (eye worm)	DR-78	0.0023	0.0042	0.0108
Trichomonas vaginalis	spcc417.12 protein, putative	0.0034	0.0292	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0103	0.0262
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0026	0.0109	0.0135
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0049	0.0608	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0292	0.0745
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0042	0.0042
Brugia malayi	nuclear receptor RXR	0.0023	0.0042	0.0108
Echinococcus granulosus	acetylcholinesterase	0.0034	0.0292	0.036
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0292	0.0745
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0049	0.0608	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0608	0.1554
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0032	0.0253	0.0646
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0049	0.0608	0.0752
Brugia malayi	steroid hormone receptor	0.0049	0.0608	0.1554
Onchocerca volvulus		0.0034	0.0292	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0042	0.0052
Onchocerca volvulus		0.0064	0.0945	0.2333
Brugia malayi	Animal haem peroxidase family protein	0.0064	0.0945	0.2416
Loa Loa (eye worm)	nuclear hormone receptor	0.0023	0.0042	0.0108
Schistosoma mansoni	acetylcholinesterase	0.0034	0.0292	0.0292
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0049	0.0608	0.0752
Brugia malayi	Nuclear hormone receptor-like 1	0.0026	0.0103	0.0262
Schistosoma mansoni	zinc finger protein	0.0023	0.0042	0.0042
Echinococcus multilocularis	nuclear receptor nhr 48	0.0023	0.0042	0.0052
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0034	0.0292	0.036
Schistosoma mansoni	alpha-amylase	0.0071	0.1109	0.1109
Loa Loa (eye worm)	steroid hormone receptor	0.0049	0.0608	0.1554
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0023	0.0042	0.0052
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0049	0.0608	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0608	0.1554
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0023	0.0044	0.0146
Echinococcus granulosus	thyroid hormone receptor alpha	0.0023	0.0042	0.0052
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.0292	0.0292
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0074	0.1162	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0023	0.0042	0.0108
Schistosoma mansoni	gliotactin	0.0034	0.0292	0.0292
Loa Loa (eye worm)	alpha amylase	0.0071	0.1109	0.2834
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0041	0.0443	0.0548
Schistosoma mansoni	RAR-like nuclear receptor	0.0049	0.0608	0.0608
Brugia malayi	conserved hypotetical protein	0.0023	0.0042	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0103	0.0262
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0026	0.0103	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0041	0.0443	0.3813
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0026	0.0109	0.036
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0026	0.0109	0.0135
Brugia malayi	Carboxylesterase family protein	0.0034	0.0292	0.0745
Brugia malayi	Carboxylesterase family protein	0.0034	0.0292	0.0745
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0074	0.1162	0.2971
Toxoplasma gondii	MAPEG family protein	0.0109	0.1935	0.9099
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0292	0.0745
Brugia malayi	nuclear hormone receptor	0.0023	0.0042	0.0108
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.0292	0.0292
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0049	0.0608	0.1462
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0049	0.0608	0.1554
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0236	0.0777
Brugia malayi	Animal haem peroxidase family protein	0.0064	0.0945	0.2416
Onchocerca volvulus		0.0034	0.0292	0.0644
Loa Loa (eye worm)	alpha amylase	0.0071	0.1109	0.2834
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0026	0.0103	0.0103
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0041	0.0443	0.0548
Brugia malayi	nuclear receptor RXR	0.0026	0.0103	0.0262
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0159	0.3033	0.375
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Schistosoma mansoni	retinoic acid receptor RXR	0.0049	0.0608	0.0608
Echinococcus granulosus	expressed protein	0.0032	0.0253	0.0312
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0042	0.0108
Brugia malayi	Steroid receptor seven-up type 2	0.0049	0.0608	0.1554
Brugia malayi	Animal haem peroxidase family protein	0.0064	0.0945	0.2416
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0159	0.3033	0.7751
Entamoeba histolytica	oligo-1,6-glucosidase, putative	0.0071	0.1109	0.3657
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0049	0.0608	0.0608
Brugia malayi	hypothetical protein	0.0034	0.0292	0.0745
Mycobacterium tuberculosis	Carboxylesterase LipT	0.03	0.6158	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0159	0.3033	1
Echinococcus multilocularis	carboxylesterase 5A	0.0034	0.0292	0.036
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0023	0.0042	0.0108
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0023	0.0042	0.0052
Loa Loa (eye worm)	acetylcholinesterase 1	0.0034	0.0292	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0026	0.0109	0.0177
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0049	0.0608	0.0752
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0049	0.0608	0.1554
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0023	0.0042	0.0108
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0074	0.1162	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0608	0.1554
Brugia malayi	hypothetical protein	0.0026	0.0103	0.0262
Brugia malayi	hypothetical protein	0.0023	0.0042	0.0108
Echinococcus multilocularis	alpha glucosidase	0.0071	0.1109	0.1371
Trypanosoma cruzi	p450 reductase, putative	0.0026	0.0109	0.0939
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Brugia malayi	Nuclear hormone receptor-like 1	0.0026	0.0103	0.0262
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0026	0.0103	0.0127
Echinococcus granulosus	FTZ F1 alpha	0.0049	0.0608	0.0752
Schistosoma mansoni	peroxidasin	0.0064	0.0945	0.0945
Schistosoma mansoni	alpha-amylase	0.0071	0.1109	0.1109
Mycobacterium ulcerans	carboxylesterase, LipT	0.03	0.6158	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0292	0.0745
Onchocerca volvulus		0.0064	0.0945	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0034	0.0292	0.0292
Echinococcus multilocularis	expressed protein	0.0032	0.0253	0.0312
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0049	0.0608	0.1554
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0071	0.1109	0.2834
Echinococcus granulosus	ecdysone induced protein 78C	0.0049	0.0608	0.0752
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0023	0.0042	0.0042
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.0292	0.0292
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0074	0.1162	0.1162
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0049	0.0608	0.1554
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0049	0.0608	0.0608
Brugia malayi	Animal haem peroxidase family protein	0.0064	0.0945	0.2416
Brugia malayi	Nuclear hormone receptor E75	0.0023	0.0042	0.0108
Schistosoma mansoni	rotamase	0.0032	0.0253	0.0253
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0034	0.0292	0.0473
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0041	0.0443	0.3813
Schistosoma mansoni	nuclear hormone receptor	0.0049	0.0608	0.0608
Brugia malayi	hypothetical protein	0.0064	0.0945	0.2416
Echinococcus granulosus	transcription factor Dp 1	0.0043	0.0478	0.0591
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0026	0.0109	0.0939
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0026	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0023	0.0042	0.0108
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0041	0.0443	0.1461
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0049	0.0608	0.1554
Trichomonas vaginalis	rotamase, putative	0.0032	0.0253	0.0833
Onchocerca volvulus		0.0041	0.0443	0.1036
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0159	0.3033	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0049	0.0608	0.0752
Brugia malayi	nuclear receptor NHR-88	0.0049	0.0608	0.1554
Brugia malayi	Carboxylesterase family protein	0.0034	0.0292	0.0745
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0443	0.3813
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0026	0.0109	0.0279
Onchocerca volvulus	Chorion peroxidase homolog	0.0064	0.0945	0.2333
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0026	0.0109	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Onchocerca volvulus	Bile acid receptor homolog	0.0198	0.3913	1
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0159	0.3033	1
Plasmodium vivax	flavodoxin domain containing protein	0.0023	0.0044	0.0146
Brugia malayi	Carboxylesterase family protein	0.0034	0.0292	0.0745
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0049	0.0608	0.1554
Mycobacterium leprae	Putative uncharacterized protein ML2045	0.0071	0.1109	0.5
Leishmania major	p450 reductase, putative	0.0026	0.0109	0.0939
Echinococcus multilocularis	transcription factor Dp 1	0.0043	0.0478	0.0591
Onchocerca volvulus	Peroxidasin homolog	0.0064	0.0945	0.2333
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0236	0.2028
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0023	0.0042	0.0052
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0049	0.0608	0.0608
Brugia malayi	Peroxidasin	0.0064	0.0945	0.2416
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0034	0.0292	0.036
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0041	0.0443	0.3813
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3033	0.7751
Onchocerca volvulus	Peroxidase homolog	0.0064	0.0945	0.2333
Brugia malayi	nuclear hormone receptor family member odr-7	0.0023	0.0042	0.0108
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0041	0.0443	0.1461
Echinococcus granulosus	microsomal glutathione S transferase 3	0.0109	0.1935	0.2392
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0109	0.0279
Brugia malayi	Carboxylesterase family protein	0.0034	0.0292	0.0745
Schistosoma mansoni	alpha-amylase	0.0071	0.1109	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0608	0.1554
Schistosoma mansoni	alpha-amylase	0.0071	0.1109	0.1109
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0026	0.0109	0.0939
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0292	0.0745
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0049	0.0608	0.0752
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0236	0.2028
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0023	0.0042	0.0052
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0041	0.0443	0.1133
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0049	0.0608	0.0752
Loa Loa (eye worm)	animal heme peroxidase	0.0064	0.0945	0.2416
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0023	0.0042	0.0052
Onchocerca volvulus	Peroxidase homolog	0.0064	0.0945	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0026	0.0109	0.0939
Loa Loa (eye worm)	carboxylesterase	0.0034	0.0292	0.0745
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0041	0.0443	0.3813
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0026	0.0109	0.0939
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0041	0.0443	0.0548
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.0109	0.1935	0.2392
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0049	0.0608	0.1554
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0041	0.0443	0.1461
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0074	0.1162	0.1437
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0443	0.3813
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0049	0.0608	0.0608
Brugia malayi	tailless protein	0.0023	0.0042	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0608	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0103	0.0262
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0049	0.0608	0.1554
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0236	0.2028
Leishmania major	cytochrome P450 reductase, putative	0.0023	0.0044	0.038
Echinococcus granulosus	expressed protein	0.0388	0.8087	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0608	0.1554
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0253	0.0833
Echinococcus multilocularis	neuroligin	0.0034	0.0292	0.036
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0236	0.2028
Brugia malayi	hypothetical protein	0.0023	0.0042	0.0108
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0159	0.3033	0.7751
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0032	0.0253	0.0646
Brugia malayi	orphan nuclear receptor NR2E1	0.0023	0.0042	0.0108
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0049	0.0608	0.0608
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0049	0.0608	0.1554
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0074	0.1162	0.1437
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0049	0.0608	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0159	0.3033	1
Onchocerca volvulus		0.0034	0.0292	0.0644
Loa Loa (eye worm)	carboxylesterase	0.0034	0.0292	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0292	0.0745
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0042	0.0052
Brugia malayi	flavodoxin family protein	0.0026	0.0109	0.0279
Echinococcus multilocularis	ecdysone induced protein 78C	0.0049	0.0608	0.0752
Loa Loa (eye worm)	animal heme peroxidase	0.0064	0.0945	0.2416
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0049	0.0608	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Schistosoma mansoni	cytochrome P450 reductase	0.0026	0.0109	0.0109
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0026	0.0109	0.0135
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0049	0.0608	0.0608
Brugia malayi	Nuclear hormone receptor-like 1	0.0049	0.0608	0.1554
Toxoplasma gondii	hypothetical protein	0.0117	0.2126	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.0292	0.0292
Schistosoma mansoni	thyroid hormone receptor	0.0049	0.0608	0.0608
Brugia malayi	Animal haem peroxidase family protein	0.0064	0.0945	0.2416
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0034	0.0292	0.0473
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0049	0.0608	0.0608
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0159	0.3033	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0074	0.1162	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0159	0.3033	1
Giardia lamblia	Hypothetical protein	0.0023	0.0044	0.0146
Giardia lamblia	Nitric oxide synthase, inducible	0.0023	0.0044	0.0146
Loa Loa (eye worm)	carboxylesterase	0.0034	0.0292	0.0745
Onchocerca volvulus		0.0034	0.0292	0.0644
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0049	0.0608	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0198	0.3913	1
Brugia malayi	Blistered cuticle protein 3	0.0064	0.0945	0.2416
Echinococcus granulosus	acetylcholinesterase	0.0034	0.0292	0.036
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0292	0.0745
Echinococcus granulosus	alpha glucosidase	0.0071	0.1109	0.1371
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0041	0.0443	0.1461
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0103	0.0262
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0041	0.0443	0.3813
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0041	0.0443	0.3813
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0041	0.0443	0.0548
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0049	0.0608	0.0752
Toxoplasma gondii	hypothetical protein	0.0041	0.0443	0.2084
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0041	0.0443	0.3813
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0041	0.0443	0.1133
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0381	0.7946	0.7946
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0049	0.0608	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Echinococcus multilocularis	FTZ F1 alpha	0.0049	0.0608	0.0752
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0074	0.1162	1
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0074	0.1162	0.3833
Schistosoma mansoni	BC026374 protein (S09 family)	0.0034	0.0292	0.0292
Onchocerca volvulus		0.0049	0.0608	0.1462
Echinococcus granulosus	BC026374 protein S09 family	0.0034	0.0292	0.036
Onchocerca volvulus	Peroxidasin homolog	0.0064	0.0945	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Brugia malayi	FAD binding domain containing protein	0.0026	0.0109	0.0279
Trichomonas vaginalis	sulfite reductase, putative	0.0026	0.0109	0.036
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0049	0.0608	0.0752
Onchocerca volvulus		0.0064	0.0945	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0945	0.2416
Brugia malayi	hypothetical protein	0.0026	0.0103	0.0262
Loa Loa (eye worm)	animal heme peroxidase	0.0064	0.0945	0.2416
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0074	0.1162	0.2971
Schistosoma mansoni	nuclear receptor	0.0023	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0108
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0049	0.0608	0.1554
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0049	0.0608	0.0752

Activities

Activity type	Activity value	Assay description	Source	Reference
RBA (binding)	= 1.7	Relative binding affinity for the calf uterine estrogen receptor measured as the ratio of molar concentration of 17-beta-estradiol (E2) and inhibitor required to decrease the amount of bound [3H]-E2 by 50%	ChEMBL.	6492074

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 45117