TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.386 | Formula: C19H18N6O
H donors: 3 H acceptors: 3 LogP: 2.81 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)cccc2CNc1cnc2c(c1)c(N)nc(n2)N
InChi: 1S/C19H18N6O/c1-26-14-5-6-15-11(7-14)3-2-4-12(15)9-22-13-8-16-17(20)24-19(21)25-18(16)23-10-13/h2-8,10,22H,9H2,1H3,(H4,20,21,23,24,25)
InChiKey: UNQZLUARHOQAJL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Dihydrofolate reductase	Starlite/ChEMBL	References
Pneumocystis carinii	Dihydrofolate reductase	Starlite/ChEMBL	References
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	Get druggable targets OG5_128410	All targets in OG5_128410
Candida albicans	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus granulosus	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium ulcerans	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium yoelii	thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium knowlesi	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Schistosoma japonicum	ko:K00560 thymidylate synthase [EC2.1.1.45], putative	Get druggable targets OG5_127385	All targets in OG5_127385
Neospora caninum	Bifunctional dihydrofolate reductase-thymidylate synthase, related	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	hypothetical protein	Get druggable targets OG5_128410	All targets in OG5_128410
Babesia bovis	dihydrofolate reductase/thymidilate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Chlamydia trachomatis	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Onchocerca volvulus		Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania donovani	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus granulosus	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania mexicana	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania major	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	Get druggable targets OG5_128410	All targets in OG5_128410
Leishmania braziliensis	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Brugia malayi	dihydrofolate reductase family protein	Get druggable targets OG5_128410	All targets in OG5_128410
Schistosoma japonicum	ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative	Get druggable targets OG5_128410	All targets in OG5_128410
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma mansoni	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Candida albicans	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Plasmodium berghei	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Cryptosporidium parvum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Brugia malayi	Dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410
Cryptosporidium hominis	chain A, crystal structure of Dhfr	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania infantum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium ulcerans	dihydrofolate reductase DfrA	Get druggable targets OG5_128410	All targets in OG5_128410
Brugia malayi	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma brucei gambiense	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	dihydrofolate reductase	Get druggable targets OG5_128410	All targets in OG5_128410

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Dihydrofolate reductase	187 aa	209 aa	29.2 %
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	202 aa	29.2 %
Theileria parva	dihydrofolate reductase-thymidylate synthase, putative	Dihydrofolate reductase	187 aa	193 aa	32.1 %
Leishmania mexicana	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	172 aa	33.7 %
Leishmania major	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	172 aa	36.0 %
Plasmodium knowlesi	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Dihydrofolate reductase	187 aa	209 aa	29.2 %
Plasmodium berghei	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Dihydrofolate reductase	187 aa	211 aa	28.4 %
Trypanosoma brucei gambiense	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	210 aa	30.0 %
Plasmodium yoelii	thymidylate synthase, putative	Dihydrofolate reductase	187 aa	212 aa	27.8 %
Leishmania braziliensis	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	172 aa	34.3 %
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	210 aa	30.0 %
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	206 aa	193 aa	29.5 %
Leishmania donovani	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	172 aa	36.0 %
Neospora caninum	Bifunctional dihydrofolate reductase-thymidylate synthase, related	Dihydrofolate reductase	187 aa	187 aa	35.8 %
Cryptosporidium parvum	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	182 aa	33.5 %
Leishmania infantum	dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	172 aa	36.0 %
Babesia bovis	dihydrofolate reductase/thymidilate synthase	Dihydrofolate reductase	187 aa	191 aa	31.9 %
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	Dihydrofolate reductase	187 aa	186 aa	37.1 %
Cryptosporidium hominis	chain A, crystal structure of Dhfr	Dihydrofolate reductase	187 aa	182 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	chromobox protein 1	0.0068	0.0683	0.1133
Trichomonas vaginalis	set domain proteins, putative	0.023	0.2785	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0148	0.0006
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0683	0.2008
Schistosoma mansoni	chromobox protein	0.0068	0.0683	0.1167
Echinococcus granulosus	thymidylate synthase	0.013	0.1485	0.2507
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0336	0.0687
Brugia malayi	dihydrofolate reductase family protein	0.0468	0.5858	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0788	0.1576
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0067	0.0064
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0341	0.4221	1
Echinococcus granulosus	dihydrofolate reductase	0.0468	0.5858	1
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.013	0.1485	0.1914
Onchocerca volvulus		0.004	0.0326	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0788	0.13
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.0558	0.0537
Brugia malayi	Probable ClpP-like protease	0.0076	0.0788	0.1304
Brugia malayi	Dihydrofolate reductase	0.0468	0.5858	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0183	0.0092
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0183	0.0161
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0788	0.1576
Echinococcus granulosus	chromobox protein 1	0.0068	0.0683	0.1133
Echinococcus multilocularis	zinc finger protein	0.0019	0.0054	0.0032
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0183	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0148	0.0202
Schistosoma mansoni	zinc finger protein	0.0019	0.0054	0.0092
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.045	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0697	0.1144
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0299	0.0409
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0169	0.0252
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0468	0.5858	1
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.013	0.1485	0.2345
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0046	0.0397	0.0678
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0148	0.035
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0046	0.0397	0.0678
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0091	0.0118
Brugia malayi	Bromodomain containing protein	0.0037	0.0289	0.0449
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0788	0.1576
Onchocerca volvulus		0.023	0.2785	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0299	0.0545
Chlamydia trachomatis	dihydrofolate reductase	0.0468	0.5858	1
Brugia malayi	hypothetical protein	0.0062	0.0606	0.0992
Schistosoma mansoni	hypothetical protein	0.002	0.0067	0.0114
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0788	1
Brugia malayi	Pre-SET motif family protein	0.0029	0.0183	0.0267
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2424	0.4107
Loa Loa (eye worm)	hypothetical protein	0.003	0.0193	0.0279
Leishmania major	hypothetical protein, conserved	0.0026	0.0148	0.035
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.0558	0.0919
Brugia malayi	thymidylate synthase	0.013	0.1485	0.25
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0259	0.0407
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0788	0.1344
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0091	0.0155
Loa Loa (eye worm)	hypothetical protein	0.004	0.032	0.0498
Echinococcus granulosus	zinc finger protein	0.0019	0.0054	0.0054
Onchocerca volvulus		0.013	0.1485	0.4985
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0091	0.0069
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0148	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0397	0.0631
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0336	0.0553
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0788	0.1124
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0468	0.5858	1
Schistosoma mansoni	bromodomain containing protein	0.0062	0.0603	0.103
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0341	0.4221	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0148	0.035
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0341	0.4221	1
Brugia malayi	Pre-SET motif family protein	0.0202	0.2424	0.411
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.013	0.1485	0.2535
Loa Loa (eye worm)	dihydrofolate reductase	0.0468	0.5858	1
Mycobacterium ulcerans	thymidylate synthase	0.013	0.1485	0.1376
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.045	0.0733
Brugia malayi	Heterochromatin protein 1	0.0068	0.0683	0.1125
Plasmodium vivax	SET domain protein, putative	0.0029	0.0183	0.0092
Echinococcus multilocularis	dihydrofolate reductase	0.0468	0.5858	0.5849
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0788	0.1576
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0683	0.1122
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0341	0.4221	1
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0683	0.2008
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.004	0.0326	0.0557
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0148	0.0006
Schistosoma mansoni	chromobox protein	0.0068	0.0683	0.1167
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0022	0.0038
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0341	0.4221	1
Loa Loa (eye worm)	thymidylate synthase	0.013	0.1485	0.2497
Brugia malayi	Bromodomain containing protein	0.0073	0.075	0.124
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0336	0.0687
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0683	0.0663
Brugia malayi	hypothetical protein	0.0026	0.0148	0.0207
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0046	0.0397	0.0376
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0788	0.5
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0788	0.1312
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0606	0.1713
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0468	0.5858	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0148	0.0006
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.045	0.0533
Schistosoma mansoni	dihydrofolate reductase	0.0468	0.5858	1
Echinococcus multilocularis	thymidylate synthase	0.013	0.1485	0.1466
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0299	0.0545
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0788	0.0767
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0148	0.035
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0259	0.0238
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0062	0.0606	0.1435
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0341	0.4221	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0344	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0299	0.0461
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0683	0.0663
Mycobacterium tuberculosis	Hypothetical protein	0.0062	0.0606	0.0288
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0022	0.0038
Brugia malayi	PHD-finger family protein	0.0024	0.0121	0.016
Loa Loa (eye worm)	hypothetical protein	0.0037	0.029	0.0446
Brugia malayi	chromobox protein homolog 3	0.0038	0.0299	0.0465
Echinococcus granulosus	histone lysine methyltransferase setb	0.0046	0.0397	0.0643

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 370 nM	Inhibitory activity against rat liver dihydrofolate reductase (in 90 microM dihydrofolic acid)	ChEMBL.	8691474
IC50 (binding)	= 370 nM	Inhibitory activity against rat liver dihydrofolate reductase (in 90 microM dihydrofolic acid)	ChEMBL.	8691474
IC50 (binding)	= 710 nM	Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 microM dihydrofolic acid)	ChEMBL.	8691474
IC50 (binding)	= 710 nM	Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 microM dihydrofolic acid)	ChEMBL.	8691474
IC50 (binding)	= 15400 nM	Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 microM dihydrofolic acid)	ChEMBL.	8691474
IC50 (binding)	= 15400 nM	Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 microM dihydrofolic acid)	ChEMBL.	8691474
Selectivity ratio (binding)	= 0.02	Selectivity ratio is defined as IC50 rlDHFR/IC50 pcDHFR	ChEMBL.	8691474
Selectivity ratio (binding)	= 0.5	Selectivity ratio is defined as IC50 rlDHFR/IC50 tgDHFR	ChEMBL.	8691474

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL33357

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 45134