Activity (functional)
|
|
Inhibition of LPS-induced plasma TNFalpha level in sc dosed mouse pretreated 1 hr before LPS chalenge by CBA assay
|
ChEMBL.
|
17583517
|
Activity (functional)
|
|
Inhibition of LPS-induced plasma IL6 level in sc dosed mouse pretreated 1 hr before LPS challenge by CBA assay
|
ChEMBL.
|
17583517
|
Activity (binding)
|
|
Inhibition of p38MAPK phosphorylation in TNFalpha-induced human whole blood neutrophils
|
ChEMBL.
|
17583517
|
Activity (binding)
|
|
Inhibition of p38MAPK phosphorylation in LPS-induced human whole blood neutrophils
|
ChEMBL.
|
17583517
|
Activity (ADMET)
|
|
Toxicity in mouse at 40 mg/kg, sc after 5 days
|
ChEMBL.
|
17583517
|
Activity (functional)
|
|
Prevention of LPS-induced lethality in D-galactosamine-primed CF1 mouse model of lethal endotoxic shock at 8 mg/kg, sc administered concurrently to LPS administration
|
ChEMBL.
|
17583517
|
Activity (functional)
|
|
Prevention of LPS-induced lethality in D-galactosamine-primed CF1 mouse model of lethal endotoxic shock
|
ChEMBL.
|
17583517
|
Activity (functional)
|
|
Inhibition of LPS-induced plasma MCP1 level in sc dosed mouse pretreated 1 hr before LPS chalenge by CBA assay
|
ChEMBL.
|
17583517
|
Activity (binding)
|
|
Inhibition of TNFalpha induced p38MAPK phosphorylation in human whole blood netrophils
|
ChEMBL.
|
17583517
|
Activity (functional)
|
|
Prevention of TNFalpha induced lethality in CF1 mouse
|
ChEMBL.
|
17583517
|
Activity (binding)
|
0
|
Inhibition of p38MAPK phosphorylation in LPS-induced human whole blood neutrophils
|
ChEMBL.
|
17583517
|
Activity (binding)
|
0
|
Inhibition of TNFalpha induced p38MAPK phosphorylation in human whole blood netrophils
|
ChEMBL.
|
17583517
|
Activity (functional)
|
0
|
Prevention of LPS-induced lethality in D-galactosamine-primed CF1 mouse model of lethal endotoxic shock at 8 mg/kg, sc administered concurrently to LPS administration
|
ChEMBL.
|
17583517
|
Activity (functional)
|
0
|
Inhibition of LPS-induced plasma IL6 level in sc dosed mouse pretreated 1 hr before LPS challenge by CBA assay
|
ChEMBL.
|
17583517
|
Activity (functional)
|
0
|
Prevention of LPS-induced lethality in D-galactosamine-primed CF1 mouse model of lethal endotoxic shock
|
ChEMBL.
|
17583517
|
Activity (functional)
|
0
|
Inhibition of LPS-induced plasma TNFalpha level in sc dosed mouse pretreated 1 hr before LPS chalenge by CBA assay
|
ChEMBL.
|
17583517
|
Activity (functional)
|
0
|
Inhibition of LPS-induced plasma MCP1 level in sc dosed mouse pretreated 1 hr before LPS chalenge by CBA assay
|
ChEMBL.
|
17583517
|
Activity (functional)
|
0
|
Prevention of TNFalpha induced lethality in CF1 mouse
|
ChEMBL.
|
17583517
|
Activity (ADMET)
|
0
|
Toxicity in mouse at 40 mg/kg, sc after 5 days
|
ChEMBL.
|
17583517
|
Activity (binding)
|
0
|
Inhibition of p38MAPK phosphorylation in TNFalpha-induced human whole blood neutrophils
|
ChEMBL.
|
17583517
|
ED50 (binding)
|
= 3.14 uM
|
Binding affinity to LPS by BODIPY-TR-cadaverine displacement assay
|
ChEMBL.
|
17583517
|
IC50 (functional)
|
= 2.22 uM
|
Inhibition of nitric oxide production in LPS-stimulated mouse J774A.1 cells
|
ChEMBL.
|
17583517
|
IC50 (functional)
|
= 2.22 uM
|
Inhibition of nitric oxide production in LPS-stimulated mouse J774A.1 cells
|
ChEMBL.
|
17583517
|
IC50 (functional)
|
= 2.9 uM
|
Inhibition of LPS-induced NFkappaB induction in HEK293 cells cotransfected with TLR4, CD14 and MD2
|
ChEMBL.
|
17583517
|
IC50 (functional)
|
= 2.9 uM
|
Inhibition of LPS-induced NFkappaB induction in HEK293 cells cotransfected with TLR4, CD14 and MD2
|
ChEMBL.
|
17583517
|
IC50 (functional)
|
= 3.08 uM
|
Inhibition of LPS-induced IL8 production in human whole blood
|
ChEMBL.
|
17583517
|
IC50 (functional)
|
= 3.08 uM
|
Inhibition of LPS-induced IL8 production in human whole blood
|
ChEMBL.
|
17583517
|
IC50 (functional)
|
= 3.85 uM
|
Inhibition of LPS-induced TNFalpha production in human whole blood
|
ChEMBL.
|
17583517
|
IC50 (functional)
|
= 3.85 uM
|
Inhibition of LPS-induced TNFalpha production in human whole blood
|
ChEMBL.
|
17583517
|
IC50 (functional)
|
= 4 uM
|
Inhibition of LPS-induced IL6 production in human whole blood
|
ChEMBL.
|
17583517
|
IC50 (functional)
|
= 4 uM
|
Inhibition of LPS-induced IL6 production in human whole blood
|
ChEMBL.
|
17583517
|