Detailed information for compound 451561

Basic information

Technical information
  • TDR Targets ID: 451561
  • Name: (E)-1-(4-iodophenyl)-3-(4-methoxyphenyl)prop- 2-en-1-one
  • MW: 364.178 | Formula: C16H13IO2
  • H donors: 0 H acceptors: 1 LogP: 4.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C/C(=O)c1ccc(cc1)I
  • InChi: 1S/C16H13IO2/c1-19-15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(17)8-6-13/h2-11H,1H3/b11-4+
  • InChiKey: NPPWBGOAHASNSX-NYYWCZLTSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-1-(4-iodophenyl)-3-(4-methoxyphenyl)-2-propen-1-one
  • 1-(4-iodophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
  • T5762492
  • CBMicro_049683
  • ZINC05061579
  • BIM-0049611.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0096 0.2063 0.2063
Echinococcus granulosus dro:myosuppressin receptor 0.0096 0.2063 1
Brugia malayi follicle stimulating hormone receptor 0.0096 0.2063 0.2063
Brugia malayi hypothetical protein 0.0096 0.2063 0.2063
Brugia malayi hypothetical protein 0.0096 0.2063 0.2063
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0096 0.2063 1
Loa Loa (eye worm) CYP4Cod1 0.0221 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Schistosoma mansoni growth hormone secretagogue receptor 0.0096 0.2063 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0096 0.2063 0.2063
Schistosoma mansoni opsin-like receptor 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Echinococcus multilocularis G-protein coupled receptor, putative 0.0096 0.2063 1
Schistosoma mansoni biogenic amine receptor 0.0096 0.2063 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0063 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Brugia malayi hypothetical protein 0.0096 0.2063 0.2063
Echinococcus granulosus alpha 1A adrenergic receptor 0.0096 0.2063 1
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.2063 0.2063
Onchocerca volvulus 0.0096 0.2063 0.5
Echinococcus multilocularis fmrfamide receptor 0.0096 0.2063 1
Echinococcus granulosus G protein coupled receptor 139 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Echinococcus multilocularis orexin receptor type 2 0.0096 0.2063 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0096 0.2063 1
Brugia malayi larval opioid receptor 0.0096 0.2063 0.2063
Mycobacterium leprae putative cytochrome p450 0.0063 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0063 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.2063 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0096 0.2063 1
Echinococcus granulosus serotonin receptor 0.0096 0.2063 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.2063 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2063 1
Echinococcus multilocularis serotonin receptor 0.0096 0.2063 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0096 0.2063 1
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.2063 1
Echinococcus granulosus neuropeptide s receptor 0.0096 0.2063 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0096 0.2063 1
Onchocerca volvulus 0.0096 0.2063 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Schistosoma mansoni neuropeptide f receptor 76f 0.0096 0.2063 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2063 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0096 0.2063 0.2063
Echinococcus multilocularis neuropeptide receptor A26 0.0096 0.2063 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2063 1
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.2063 0.2063
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0096 0.2063 0.5
Schistosoma mansoni biogenic amine receptor 0.0096 0.2063 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.2063 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2063 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.2063 1
Brugia malayi GnHR receptor homolog 0.0096 0.2063 0.2063
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0096 0.2063 1
Schistosoma mansoni hypothetical protein 0.0096 0.2063 1
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Schistosoma mansoni hypothetical protein 0.0096 0.2063 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Schistosoma mansoni opsin-like receptor 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0096 0.2063 1
Schistosoma mansoni hypothetical protein 0.0096 0.2063 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0063 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2063 1
Schistosoma mansoni neuropeptide receptor 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.2063 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2063 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.2063 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0096 0.2063 1
Brugia malayi hypothetical protein 0.0096 0.2063 0.2063
Echinococcus multilocularis somatostatin receptor 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Echinococcus granulosus fmrfamide receptor 0.0096 0.2063 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0096 0.2063 0.2063
Brugia malayi G-protein coupled receptor 0.0096 0.2063 0.2063
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.2063 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.2063 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.5961 0.5961
Echinococcus granulosus neuropeptide receptor 0.0096 0.2063 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0096 0.2063 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.2063 1
Brugia malayi Dopamine receptor protein 1 0.0096 0.2063 0.2063
Loa Loa (eye worm) cytochrome P450 family protein 0.0221 1 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0063 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Echinococcus granulosus orexin receptor type 2 0.0096 0.2063 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0096 0.2063 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.2063 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2063 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0096 0.2063 0.2063
Schistosoma mansoni opsin-like receptor 0.0096 0.2063 1
Brugia malayi Serotonin receptor 0.0096 0.2063 0.2063
Schistosoma mansoni neuropeptide receptor 0.0096 0.2063 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0063 0 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Brugia malayi Melatonin receptor type 1A 0.0096 0.2063 0.2063
Onchocerca volvulus 0.0096 0.2063 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2063 1
Onchocerca volvulus 0.0096 0.2063 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0221 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0096 0.2063 1
Brugia malayi hypothetical protein 0.0096 0.2063 0.2063
Onchocerca volvulus 0.0096 0.2063 0.5
Echinococcus multilocularis neuropeptide receptor 0.0096 0.2063 1
Echinococcus multilocularis g protein coupled receptor 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2063 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.2063 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0221 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Onchocerca volvulus 0.0096 0.2063 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Brugia malayi G protein-coupled receptor F59B2.13 0.0096 0.2063 0.2063
Echinococcus granulosus neuropeptide receptor 0.0096 0.2063 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0096 0.2063 1
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.2063 0.2063
Brugia malayi sulfakinin receptor protein 0.0096 0.2063 0.2063
Brugia malayi G protein-coupled receptor 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0063 0 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0096 0.2063 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.2063 1
Brugia malayi Cytochrome P450 family protein 0.0221 1 1
Onchocerca volvulus 0.0096 0.2063 0.5
Echinococcus granulosus g protein coupled receptor 0.0096 0.2063 1
Echinococcus multilocularis G protein coupled receptor 139 0.0096 0.2063 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2063 1
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.2063 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.2063 1
Schistosoma mansoni amine GPCR 0.0096 0.2063 1
Trypanosoma brucei cytochrome P450, putative 0.0221 1 1
Brugia malayi hypothetical protein 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0096 0.2063 1
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Brugia malayi ORL1-like opioid receptor 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Echinococcus granulosus allatostatin A receptor 0.0096 0.2063 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0096 0.2063 0.2063
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0063 0 0.5
Schistosoma mansoni myosin xvIII 0.0096 0.2063 1
Onchocerca volvulus 0.0096 0.2063 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2063 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0063 0 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Brugia malayi Serotonin receptor 0.0096 0.2063 0.2063
Schistosoma mansoni amine GPCR 0.0096 0.2063 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0063 0 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0096 0.2063 1
Echinococcus multilocularis neuropeptide s receptor 0.0096 0.2063 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Onchocerca volvulus 0.0096 0.2063 0.5
Brugia malayi putative neuropeptide receptor 0.0096 0.2063 0.2063
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0063 0 0.5
Brugia malayi G-protein coupled receptor 0.0096 0.2063 0.2063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2063 1
Onchocerca volvulus 0.0096 0.2063 0.5
Echinococcus granulosus sex peptide receptor 0.0096 0.2063 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0063 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2063 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2063 1
Schistosoma mansoni adenoreceptor 0.0096 0.2063 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.2063 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2063 1
Schistosoma mansoni amine GPCR 0.0096 0.2063 1
Echinococcus multilocularis g protein coupled receptor 0.0096 0.2063 1
Trypanosoma cruzi cytochrome P450, putative 0.0221 1 1
Brugia malayi AKH receptor 0.0096 0.2063 0.2063
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0096 0.2063 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0063 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0063 0 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0096 0.2063 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0063 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0096 0.2063 1
Onchocerca volvulus 0.0096 0.2063 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0096 0.2063 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Schistosoma mansoni biogenic amine receptor 0.0096 0.2063 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0063 0 0.5
Brugia malayi RE15519p 0.0096 0.2063 0.2063
Echinococcus granulosus hypothetical protein 0.0096 0.2063 1
Brugia malayi putative neuropeptide receptor NPR1 0.0096 0.2063 0.2063
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.2063 1
Mycobacterium leprae Conserved hypothetical protein 0.0063 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Schistosoma mansoni neuropeptide receptor 0.0096 0.2063 1
Leishmania major cytochrome p450-like protein 0.0221 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0096 0.2063 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2063 1
Loa Loa (eye worm) TYRA-2 protein 0.0096 0.2063 0.2063
Onchocerca volvulus 0.0096 0.2063 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Brugia malayi Dopamine receptor protein 2 0.0096 0.2063 0.2063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2063 1
Brugia malayi hypothetical protein 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Onchocerca volvulus 0.0096 0.2063 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0096 0.2063 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0063 0 0.5
Onchocerca volvulus 0.0096 0.2063 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Onchocerca volvulus 0.0096 0.2063 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0063 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0096 0.2063 1
Schistosoma mansoni histamine h1 receptor 0.0096 0.2063 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0096 0.2063 1
Schistosoma mansoni hypothetical protein 0.0096 0.2063 1
Echinococcus multilocularis fmrfamide receptor 0.0096 0.2063 1
Echinococcus multilocularis allatostatin A receptor 0.0096 0.2063 1
Echinococcus granulosus somatostatin receptor 0.0096 0.2063 1
Echinococcus granulosus neuropeptide receptor A26 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Schistosoma mansoni alpha-1 adrenergic receptor 0.0096 0.2063 1
Echinococcus multilocularis neuropeptide receptor 0.0096 0.2063 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.2063 1
Brugia malayi hypothetical protein 0.0096 0.2063 0.2063
Trypanosoma cruzi cytochrome P450, putative 0.0221 1 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0063 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.2063 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0096 0.2063 1
Echinococcus multilocularis serotonin receptor 0.0096 0.2063 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.2063 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.2063 1
Echinococcus multilocularis g protein coupled receptor 0.0096 0.2063 1
Brugia malayi Dopamine receptor 0.0096 0.2063 0.2063
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.2063 1
Echinococcus multilocularis sex peptide receptor 0.0096 0.2063 1
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.2063 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0096 0.2063 0.2063
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0063 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0063 0 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0096 0.2063 0.2063
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0096 0.2063 1
Brugia malayi neuropeptide F receptor 0.0096 0.2063 0.2063
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.2063 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0096 0.2063 0.2063
Schistosoma mansoni amine GPCR 0.0096 0.2063 1
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.2063 1
Echinococcus granulosus g protein coupled receptor 0.0096 0.2063 1
Echinococcus granulosus g protein coupled receptor 0.0096 0.2063 1
Schistosoma mansoni amine GPCR 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0096 0.2063 0.2063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Onchocerca volvulus 0.0096 0.2063 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0096 0.2063 0.2063
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0063 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.2063 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0096 0.2063 1
Brugia malayi hypothetical protein 0.0096 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0096 0.2063 1
Brugia malayi neuropeptide F receptor 0.0096 0.2063 0.2063
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.2063 1
Echinococcus granulosus g-protein coupled receptor 0.0096 0.2063 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2063 0.2063
Onchocerca volvulus 0.0096 0.2063 0.5

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 299 mg/dl Antidiabetic activity in mouse 3T3L1 cells assessed as decrease in glucose consumption from cell culture medium using 450 mg/dL D-glucose at 30 ug/mL after 24 hrs (Rvb = 310 +/- 4 mg/dl) ChEMBL. 22608392
Ki (binding) = 6.3 nM Displacement of [125](E)-3-(4-(Dimethylamino-phenyl)-1-(4-iodophenyl)prop-2-en-1-one from beta amyloid(1-42) aggregates ChEMBL. 17826102

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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