Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.284785 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.284785 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0314644 | 0.0386485 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.273543 | 0.957336 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0214262 | 0.000553453 | 0.0143202 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0427065 | 0.0813121 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0314644 | 0.0386485 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | 0 | Cytotoxicity against Vero cells by neutral red assay | ChEMBL. | 17400457 |
IC50 (functional) | = 3.8 ng/ml | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 | ChEMBL. | 17400457 |
IC50 (functional) | = 3.8 ng/ml | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 | ChEMBL. | 17400457 |
IC50 (functional) | = 3.8 ng/ml | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 | ChEMBL. | 20466465 |
IC50 (functional) | = 4 ng/ml | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 | ChEMBL. | 17400457 |
IC50 (functional) | = 4 ng/ml | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 | ChEMBL. | 17400457 |
IC50 (functional) | = 4 ng/ml | Antimalarial activity against chloroquine-resistant Plasmodium falciparum D6 | ChEMBL. | 20466465 |
IC50 (functional) | = 3 ug ml-1 | Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs by Alamar blue assay | ChEMBL. | 17400457 |
IC50 (functional) | = 3 ug ml-1 | Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs by Alamar blue assay | ChEMBL. | 17400457 |
IC90 (functional) | = 6.5 ug ml-1 | Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs by Alamar blue assay | ChEMBL. | 17400457 |
IC90 (functional) | = 6.5 ug ml-1 | Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs by Alamar blue assay | ChEMBL. | 17400457 |
Ratio IC50 (functional) | > 1200 | Selectivity index, ratio of IC50 for Plasmodium falciparum D6 to IC50 for Plasmodium falciparum W2 | ChEMBL. | 20466465 |
Ratio IC50 (functional) | > 1190 | Selectivity index, ratio of IC50 for Vero cells to IC50 for chloroquine-resistant Plasmodium falciparum W2 | ChEMBL. | 17400457 |
Ratio IC50 (functional) | > 1252.3 | Selectivity index, ratio of IC50 for Vero cells to IC50 for chloroquine-sensitive Plasmodium falciparum D6 | ChEMBL. | 17400457 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 17400457 | |
Leishmania donovani | ChEMBL23 | 17400457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.