Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.0285 | 0.0399 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0285 | 0.0399 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.2063 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0368 | 0.0846 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.198 | 0.9553 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 21.69 % | Analgesic activity in Albino mouse assessed as number of acetic acid-induced writhing at 50 mg/kg, po after 30 min | ChEMBL. | 17317192 |
Activity (functional) | = 21.69 % | Analgesic activity in Albino mouse assessed as number of acetic acid-induced writhing at 50 mg/kg, po after 30 min | ChEMBL. | 17317192 |
Activity (functional) | = 23.29 % | Antiinflammatory activity against carrageenan-induced hind paw oedema in Charles foster rat assessed as inhibition of paw oedema at 50 mg/kg, po after 1 hr | ChEMBL. | 17317192 |
ALD50 (ADMET) | > 1000 mg kg-1 | Acute toxicity in albino mouse assessed as percent mortatality after 24 hrs | ChEMBL. | 17317192 |
ALD50 (ADMET) | > 1000 mg kg-1 | Acute toxicity in albino mouse assessed as percent mortatality after 24 hrs | ChEMBL. | 17317192 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.