Detailed information for compound 451732

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 634.778 | Formula: C33H39NaO7S2
  • H donors: 2 H acceptors: 5 LogP: 6.02 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCOc1ccc(cc1)Sc1ccc(cc1S(=O)(=O)[O-])c1ccccc1C(C#CCOCCCCCCCO)O.[Na+]
  • InChi: 1S/C33H40O7S2.Na/c1-2-3-24-40-27-16-18-28(19-17-27)41-32-20-15-26(25-33(32)42(36,37)38)29-12-7-8-13-30(29)31(35)14-11-23-39-22-10-6-4-5-9-21-34;/h7-8,12-13,15-20,25,31,34-35H,2-6,9-10,21-24H2,1H3,(H,36,37,38);/q;+1/p-1
  • InChiKey: IHSPTYZLTBSZKL-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sphingosine-1-phosphate receptor 2 Starlite/ChEMBL References
Homo sapiens lysophosphatidic acid receptor 2 Starlite/ChEMBL References
Homo sapiens sphingosine-1-phosphate receptor 1 Starlite/ChEMBL References
Homo sapiens sphingosine-1-phosphate receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0026 0.106
Brugia malayi Steroid receptor seven-up type 2 0.0243 0.0743 0.6332
Brugia malayi hypothetical protein 0.0115 0.0309 0.2632
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0004 0.003
Echinococcus multilocularis caspase 2 0.0094 0.0239 0.025
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0061 0.075
Schistosoma mansoni nuclear receptor 0.0115 0.0309 0.0309
Schistosoma mansoni ran 0.0023 0.0000066385 0.0000066385
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0089 0.3651
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0243 0.0743 0.0743
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0033 0.1361
Loa Loa (eye worm) hypothetical protein 0.0094 0.0239 0.2035
Loa Loa (eye worm) hypothetical protein 0.0129 0.0355 0.3028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0243 0.0743 0.6332
Loa Loa (eye worm) hypothetical protein 0.008 0.019 0.1616
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.0225 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0323 0.1013 0.8631
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.0086 0.3498
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0134 0.5492
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0059 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0243 0.0743 0.0743
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0061 0.0064
Onchocerca volvulus Cell death protein 3 homolog 0.0094 0.0239 0.165
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0115 0.0309 0.0309
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0371 0.1174 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0033 0.1361
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0243 0.0743 0.0777
Echinococcus granulosus caspase 8 0.0049 0.0086 0.0086
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0031 0.0033
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.0122 0.1493
Brugia malayi conserved hypotetical protein 0.0115 0.0309 0.2632
Loa Loa (eye worm) nuclear receptor NHR-67 0.0115 0.0309 0.2632
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0243 0.0743 0.6332
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0245 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0452 0.1448 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0061 0.0454
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0134 0.0134
Plasmodium falciparum glutathione reductase 0.0096 0.0245 1
Echinococcus multilocularis FTZ F1 alpha 0.0243 0.0743 0.0777
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Mycobacterium tuberculosis Conserved protein 0.0041 0.0061 0.075
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0225 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0033 0.1479
Schistosoma mansoni tar DNA-binding protein 0.0055 0.0108 0.0108
Onchocerca volvulus Protein ultraspiracle homolog 0.0243 0.0743 0.5135
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0033 0.1361
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0033 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0243 0.0743 0.6332
Onchocerca volvulus 0.0053 0.0101 0.0697
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0121 0.1477
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0243 0.0743 0.0743
Onchocerca volvulus 0.0045 0.0074 0.0514
Entamoeba histolytica hypothetical protein 0.0026 0.0008 0.0427
Entamoeba histolytica acyl-coA synthetase, putative 0.008 0.019 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0059 0.3092
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0028 0.1159
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0101 0.0105
Mycobacterium tuberculosis Conserved protein 0.0041 0.0061 0.075
Brugia malayi nuclear receptor RXR 0.0129 0.0355 0.3028
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0086 0.0636
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0101 0.0101
Schistosoma mansoni thyroid hormone receptor 0.0243 0.0743 0.0743
Schistosoma mansoni tar DNA-binding protein 0.0055 0.0108 0.0108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.0196 0.0196
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.009 0.0225 0.0225
Mycobacterium ulcerans lipase LipD 0.0041 0.0061 0.2716
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0059 0.2396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0243 0.0743 0.6332
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0086 0.0636
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0243 0.0743 0.6332
Echinococcus granulosus caspase 3 0.008 0.0192 0.0192
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0243 0.0743 0.0743
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0243 0.0743 0.0777
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.008 0.019 0.8418
Schistosoma mansoni microtubule-associated protein tau 0.2785 0.9325 0.9325
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Schistosoma mansoni survival motor neuron protein 0.0053 0.0101 0.0101
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0033 0.1361
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0033 0.1361
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0115 0.0309 0.0323
Plasmodium falciparum glutathione reductase 0.0033 0.0033 0.1361
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0243 0.0743 0.0777
Brugia malayi beta-lactamase family protein 0.0041 0.0061 0.0521
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0059 0.2396
Toxoplasma gondii hypothetical protein 0.0031 0.0026 0.106
Brugia malayi Nuclear hormone receptor E75 0.0115 0.0309 0.2632
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0059 0.0122 0.4608
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0243 0.0742 0.9093
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0134 0.0141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0243 0.0743 0.6332
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0243 0.0742 0.9093
Brugia malayi Nuclear hormone receptor-like 1 0.0129 0.0355 0.3028
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0061 0.25
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0225 1
Schistosoma mansoni ran 0.0023 0.0000066385 0.0000066385
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0061 0.0825
Brugia malayi ecdysone receptor 0.0115 0.0309 0.2632
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0521
Schistosoma mansoni RAR-like nuclear receptor 0.0243 0.0743 0.0743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0243 0.0743 0.6332
Loa Loa (eye worm) glutathione reductase 0.0096 0.0245 0.2086
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1603 0.5333 0.5576
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0243 0.0743 0.6332
Loa Loa (eye worm) hypothetical protein 0.0107 0.0283 0.2413
Brugia malayi Pre-SET motif family protein 0.0371 0.1174 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0521
Echinococcus multilocularis geminin 0.0382 0.121 0.1265
Echinococcus granulosus FTZ F1 alpha 0.0243 0.0743 0.0743
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Entamoeba histolytica hypothetical protein 0.0033 0.0031 0.1653
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0033 0.1361
Loa Loa (eye worm) hypothetical protein 0.0337 0.1058 0.901
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0115 0.0309 0.2632
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0101 0.0101
Brugia malayi AMP-binding enzyme family protein 0.008 0.019 0.1616
Mycobacterium tuberculosis Conserved protein 0.0041 0.0061 0.075
Loa Loa (eye worm) hypothetical protein 0.0129 0.0355 0.3028
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0245 0.0245
Schistosoma mansoni retinoic acid receptor RXR 0.2985 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0101 0.0101
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0000066385 0.0000066385
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.019 0.2325
Onchocerca volvulus 0.008 0.019 0.131
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0111 0.1359
Echinococcus granulosus Nuclear hormone receptor HR96 0.0115 0.0309 0.0309
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0121 0.1477
Brugia malayi tailless protein 0.0115 0.0309 0.2632
Brugia malayi RNA recognition motif domain containing protein 0.0055 0.0108 0.0923
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0089 0.3651
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.0196 0.0196
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0111 0.1359
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0061 0.0454
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0033 0.1361
Loa Loa (eye worm) hypothetical protein 0.026 0.08 0.6819
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0219 0.066 0.8084
Loa Loa (eye worm) hypothetical protein 0.0129 0.0355 0.3028
Loa Loa (eye worm) hypothetical protein 0.0243 0.0743 0.6332
Brugia malayi beta-lactamase 0.0041 0.0061 0.0521
Echinococcus multilocularis caspase 8 0.0049 0.0086 0.009
Brugia malayi hypothetical protein 0.0115 0.0309 0.2632
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0061 0.0454
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0219 0.066 0.8889
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0115 0.0309 0.0323
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0033 0.1361
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0243 0.0743 0.0743
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0129 0.0356 0.0356
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0008 0.006
Brugia malayi nuclear hormone receptor 0.0323 0.1013 0.8631
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.008 0.019 0.8418
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0061 0.2716
Entamoeba histolytica hypothetical protein 0.0033 0.0031 0.1653
Treponema pallidum NADH oxidase 0.0033 0.0033 0.037
Onchocerca volvulus 0.0115 0.0309 0.2135
Brugia malayi AMP-binding enzyme family protein 0.008 0.019 0.1616
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.009 0.0225 0.3037
Schistosoma mansoni tar DNA-binding protein 0.0055 0.0108 0.0108
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0061 0.075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0243 0.0743 0.6332
Leishmania major trypanothione reductase 0.0096 0.0245 1
Onchocerca volvulus 0.0031 0.0026 0.018
Loa Loa (eye worm) hypothetical protein 0.0129 0.0355 0.3028
Echinococcus multilocularis muscleblind protein 1 0.0337 0.1058 0.1106
Loa Loa (eye worm) RNA binding protein 0.0055 0.0108 0.0923
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0059 0.2396
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0026 0.0222
Schistosoma mansoni peptidase Clp (S14 family) 0.009 0.0225 0.0225
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0059 0.2396
Schistosoma mansoni lamin 0.0031 0.0026 0.0026
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0061 0.075
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0086 0.3498
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0000066385 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0243 0.0743 0.0777
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.0086 0.3498
Echinococcus multilocularis snurportin 1 0.0339 0.1066 0.1114
Trypanosoma brucei Metacaspase-4 0.0049 0.0086 0.3498
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0086 0.0636
Brugia malayi photoreceptor-specific nuclear receptor 0.0243 0.0743 0.6332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0243 0.0743 0.6332
Entamoeba histolytica hypothetical protein 0.0033 0.0031 0.1653
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0245 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0243 0.0743 0.0743
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.2856 0.9566 1
Loa Loa (eye worm) beta-lactamase 0.0041 0.0061 0.0521
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0059 0.0436
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0059 0.05
Echinococcus multilocularis musashi 0.0031 0.0026 0.0027
Schistosoma mansoni lamin 0.0031 0.0026 0.0026
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0033 0.1361
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0086 0.0636
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0115 0.0309 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0243 0.0743 0.6332
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0061 0.0061
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0243 0.0743 0.0777
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0028 0.1159
Loa Loa (eye worm) hypothetical protein 0.0059 0.0122 0.1038
Onchocerca volvulus 0.0031 0.0026 0.018
Brugia malayi Nuclear hormone receptor-like 1 0.0129 0.0355 0.3028
Echinococcus multilocularis thyroid hormone receptor alpha 0.0243 0.0743 0.0777
Loa Loa (eye worm) hypothetical protein 0.0059 0.0122 0.1038
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0061 0.25
Schistosoma mansoni caspase-7 (C14 family) 0.0129 0.0356 0.0356
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0225 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0243 0.0743 0.0743
Echinococcus granulosus caspase 2 0.0094 0.0239 0.0239
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0129 0.0355 0.3028
Onchocerca volvulus Huntingtin homolog 0.0107 0.0283 0.1957
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.0122 0.5405
Plasmodium vivax acyl-CoA synthetase, putative 0.0059 0.0122 0.4975
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0061 0.0061
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0059 0.0059
Brugia malayi Thioredoxin reductase 0.0096 0.0245 0.2086
Schistosoma mansoni hypothetical protein 0.0382 0.121 0.121
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0004 0.003
Mycobacterium ulcerans hypothetical protein 0.0041 0.0061 0.2716
Schistosoma mansoni hypothetical protein 0.0045 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0086 0.0636
Brugia malayi nuclear hormone receptor 0.0243 0.0743 0.6332
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0243 0.0743 0.6332
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.019 0.2557
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Onchocerca volvulus 0.0041 0.0061 0.0423
Schistosoma mansoni coup transcription factor 0.0243 0.0743 0.0743
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0033 0.1361
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Schistosoma mansoni hypothetical protein 0.0339 0.1066 0.1066
Brugia malayi ecdysteroid receptor 0.0243 0.0743 0.6332
Onchocerca volvulus 0.0041 0.0061 0.0423
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0059 0.0059
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0061 0.0061
Trypanosoma cruzi metacaspase, putative 0.0049 0.0086 0.3498
Toxoplasma gondii thioredoxin reductase 0.0096 0.0245 1
Schistosoma mansoni hypothetical protein 0.0382 0.121 0.121
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0008 0.0331
Echinococcus granulosus snurportin 1 0.0339 0.1066 0.1066
Echinococcus multilocularis lamin 0.0031 0.0026 0.0027
Trypanosoma brucei metacaspase MCA3 0.0049 0.0086 0.3498
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0000066385 0.0003
Echinococcus multilocularis caspase 3 0.008 0.0192 0.02
Mycobacterium ulcerans fatty-acid-CoA ligase 0.008 0.019 0.8418
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0243 0.0742 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0061 0.0521
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.008 0.019 0.2325
Echinococcus granulosus tar DNA binding protein 0.0055 0.0108 0.0108
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0086 0.3498
Onchocerca volvulus 0.0053 0.0101 0.0694
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0196 0.0196
Schistosoma mansoni steroid hormone receptor ad4bp 0.0243 0.0743 0.0743
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0033 0.1479
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0086 0.0636
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0086 0.3498
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0107 0.0907
Echinococcus granulosus apoptotic protease activating factor 1 0.0045 0.0074 0.0074
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0089 0.3651
Loa Loa (eye worm) hypothetical protein 0.0129 0.0355 0.3028
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0000066385 0.00000694
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0033 0.1361
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0031 0.0031
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0101 0.0856
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0243 0.0743 0.6332
Brugia malayi orphan nuclear receptor NR2E1 0.0115 0.0309 0.2632
Brugia malayi Probable ClpP-like protease 0.009 0.0225 0.192
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0243 0.0743 0.6332
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0008 0.006
Schistosoma mansoni caspase-7 (C14 family) 0.0094 0.0239 0.0239
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0033 0.1361
Loa Loa (eye worm) hypothetical protein 0.008 0.019 0.1616
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0086 0.0636
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0115 0.0309 0.0309
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0129 0.0355 0.0355
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0245 0.3001
Plasmodium vivax importin-beta 2, putative 0.0032 0.0028 0.1159
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0033 0.0247
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0086 0.3498
Schistosoma mansoni tar DNA-binding protein 0.0055 0.0108 0.0108
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0028 0.1159
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0243 0.0743 0.0777
Loa Loa (eye worm) hypothetical protein 0.0031 0.0026 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0243 0.0743 0.6332
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0089 0.3651
Trichomonas vaginalis set domain proteins, putative 0.0422 0.1347 1
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0061 0.2716
Loa Loa (eye worm) hypothetical protein 0.0243 0.0743 0.6332
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0033 0.0035
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0059 0.0061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.019 0.2557
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0049 0.0086 0.073
Trypanosoma cruzi metacaspase, putative 0.0049 0.0086 0.3498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0243 0.0743 0.6332
Trypanosoma cruzi metacaspase, putative 0.0049 0.0086 0.3498
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0134 0.1145
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0115 0.0309 0.0323
Echinococcus granulosus intermediate filament protein 0.0031 0.0026 0.0026
Schistosoma mansoni intermediate filament proteins 0.0031 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.0242
Echinococcus multilocularis lamin dm0 0.0031 0.0026 0.0027
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0115 0.0309 0.2135
Onchocerca volvulus 0.0041 0.0061 0.0423
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0086 0.0636
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.019 0.7747
Schistosoma mansoni nuclear hormone receptor 0.0115 0.0309 0.0309
Leishmania major hypothetical protein, conserved 0.005 0.0089 0.3651
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0026 0.035
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0059 0.0061
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0033 0.0408
Echinococcus granulosus muscleblind protein 0.0337 0.1058 0.1058
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0033 0.0284
Echinococcus granulosus importin subunit beta 1 0.0032 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0243 0.0743 0.6332
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0000066385 0.0003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0033 0.1361
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0033 0.1361
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.019 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.05
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0033 0.1361
Schistosoma mansoni thyroid hormone receptor 0.0243 0.0743 0.0743
Brugia malayi hypothetical protein 0.005 0.0089 0.0761
Toxoplasma gondii ABC1 family protein 0.0041 0.0061 0.25
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0243 0.0743 0.0743
Plasmodium falciparum metacaspase 1 0.0049 0.0086 0.3498
Schistosoma mansoni nuclear receptor nhr-48 0.0115 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0243 0.0743 0.6332
Loa Loa (eye worm) hypothetical protein 0.008 0.019 0.1616
Loa Loa (eye worm) DR-78 0.0115 0.0309 0.2632
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0061 0.0521
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0031 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.019 0.8418
Brugia malayi nuclear receptor RXR 0.0115 0.0309 0.2632
Brugia malayi hypothetical protein 0.0045 0.0074 0.0633
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.0031
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0033 0.1361
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0115 0.0309 0.0309
Brugia malayi Nuclear hormone receptor E75 0.0115 0.0309 0.2632
Echinococcus granulosus lamin 0.0031 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0243 0.0743 0.6332
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0033 0.1361
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0121 0.0121
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.08 0.0837
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0061 0.25
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0086 0.0636
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0026 0.106
Echinococcus multilocularis microtubule associated protein 2 0.2785 0.9325 0.9749
Schistosoma mansoni importin beta-1 0.0032 0.0028 0.0028
Echinococcus granulosus caspase 0.0129 0.0356 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0086 0.0636
Brugia malayi nuclear receptor NHR-88 0.0243 0.0743 0.6332
Brugia malayi nuclear hormone receptor family member odr-7 0.0115 0.0309 0.2632
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0059 0.0436
Loa Loa (eye worm) hypothetical protein 0.0038 0.0048 0.0408
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Brugia malayi nuclear receptor NHR-67 0.0115 0.0309 0.2632
Onchocerca volvulus Huntingtin homolog 0.0107 0.0283 0.1957
Schistosoma mansoni caspase-3 (C14 family) 0.0129 0.0356 0.0356
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0129 0.0355 0.0372
Brugia malayi hypothetical protein 0.026 0.08 0.6819
Loa Loa (eye worm) hypothetical protein 0.0055 0.0107 0.0907
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0049 0.0086 0.0086
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0121 0.0126
Plasmodium vivax metacaspase 1, putative 0.0049 0.0086 0.3498
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.012 0.1023
Mycobacterium tuberculosis Probable oxidoreductase 0.0243 0.0742 0.9093
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0089 0.3651
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0082 0.0196 0.1674
Mycobacterium tuberculosis Probable dehydrogenase 0.0219 0.066 0.8084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0243 0.0743 0.0743
Brugia malayi hypothetical protein 0.0129 0.0355 0.3028
Schistosoma mansoni nuclear hormone receptor 0.0243 0.0743 0.0743
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.019 0.7747
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0521
Loa Loa (eye worm) hypothetical protein 0.0059 0.0122 0.1038
Schistosoma mansoni hypothetical protein 0.0038 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0053 0.0101 0.0859
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0219 0.066 0.8084
Onchocerca volvulus Bile acid receptor homolog 0.0243 0.0743 0.5135
Plasmodium vivax glutathione reductase, putative 0.0096 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.009 0.0225 1
Plasmodium vivax SET domain protein, putative 0.0053 0.0101 0.4118
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0061 0.075
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0053 0.0101 0.0101
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.0816 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0245 0.0256
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0059 0.0061
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0059 0.0059
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0225 0.9203
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0339 0.1066 0.9079
Plasmodium falciparum metacaspase-like protein 0.0049 0.0086 0.3498
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.019 0.8418
Entamoeba histolytica Ran family GTPase 0.0023 0.0000066385 0.0003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0521
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0033 0.1361
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0048 0.0408
Brugia malayi hypothetical protein 0.0129 0.0355 0.3028
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0219 0.066 0.8084
Loa Loa (eye worm) hypothetical protein 0.0059 0.0122 0.1038
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.0225 0.9203
Loa Loa (eye worm) hypothetical protein 0.0337 0.1058 0.901
Brugia malayi glutathione reductase 0.0096 0.0245 0.2086
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0033 0.0033
Leishmania major hypothetical protein, conserved 0.0041 0.0061 0.25
Brugia malayi beta-lactamase family protein 0.0041 0.0061 0.0521
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0061 0.25
Echinococcus multilocularis caspase 0.0129 0.0356 0.0372
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0000066385 0.0001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0033 0.1479
Leishmania major importin beta-1 subunit, putative 0.0026 0.0008 0.0331
Loa Loa (eye worm) hypothetical protein 0.0243 0.0743 0.6332
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0111 0.1359
Brugia malayi intermediate filament protein 0.0031 0.0026 0.0222
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0028 0.003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0107 0.0907
Echinococcus multilocularis nuclear receptor nhr 48 0.0115 0.0309 0.0323
Echinococcus granulosus lamin dm0 0.0031 0.0026 0.0026
Mycobacterium leprae Probable lipase LipE 0.0041 0.0061 0.0825
Mycobacterium ulcerans hypothetical protein 0.008 0.019 0.8418
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0061 0.0454
Onchocerca volvulus 0.0115 0.0309 0.2135
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0521
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0033 0.1361
Brugia malayi RNA binding protein 0.0055 0.0108 0.0923
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0055 0.0108 0.0923
Schistosoma mansoni hypothetical protein 0.0053 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0243 0.0743 0.6332
Brugia malayi hypothetical protein 0.0033 0.0031 0.0267
Echinococcus granulosus thyroid hormone receptor alpha 0.0115 0.0309 0.0309
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0061 0.075
Echinococcus granulosus geminin 0.0382 0.121 0.121
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0219 0.066 0.8084
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0111 0.1359
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0033 0.0031 0.1653
Brugia malayi Cell death protein 3 precursor 0.0094 0.0239 0.2035
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0089 0.3651
Schistosoma mansoni zinc finger protein 0.0115 0.0309 0.0309
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0134 0.0134
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.008 0.019 0.8418
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0033 0.1361
Brugia malayi Muscleblind-like protein 0.0337 0.1058 0.901
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.0196 0.0205
Loa Loa (eye worm) hypothetical protein 0.0045 0.0074 0.0633
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0089 0.3651
Echinococcus multilocularis tar DNA binding protein 0.0055 0.0108 0.0113
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0082 0.0196 0.1674
Schistosoma mansoni nuclear receptor 0.0115 0.0309 0.0309
Plasmodium falciparum thioredoxin reductase 0.0096 0.0245 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0033 0.1361
Brugia malayi nuclear hormone receptor family member nhr-6 0.0115 0.0309 0.2632
Leishmania major GTP-binding protein, putative 0.0023 0.0000066385 0.0003
Mycobacterium ulcerans beta-lactamase 0.0041 0.0061 0.2716
Loa Loa (eye worm) hypothetical protein 0.009 0.0225 0.192
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0243 0.0743 0.6332
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0086 0.0636
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0033 0.0247
Trichomonas vaginalis esterase, putative 0.0041 0.0061 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0243 0.0743 0.6332
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0033 0.0033
Brugia malayi Importin beta-1 subunit 0.0032 0.0028 0.0242
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0026 0.0222
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0061 0.0454
Trypanosoma brucei metacaspase 0.0049 0.0086 0.3498
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0059 0.0436
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.019 0.8418
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0243 0.0743 0.0743
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0101 0.0101
Loa Loa (eye worm) nuclear hormone receptor 0.0115 0.0309 0.2632
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0086 0.0636
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0061 0.075
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0115 0.0309 0.2135
Brugia malayi TAR-binding protein 0.0055 0.0108 0.0923
Plasmodium falciparum thioredoxin reductase 0.0033 0.0033 0.1361
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0053 0.0101 0.0105
Brugia malayi hypothetical protein 0.0032 0.003 0.0254
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0051 0.0094 0.0094
Schistosoma mansoni nuclear hormone receptor 0.0115 0.0309 0.0309
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0115 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0049 0.0086 0.073
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0026 0.0222
Onchocerca volvulus 0.0422 0.1347 0.9305
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0243 0.0743 0.0743
Loa Loa (eye worm) hypothetical protein 0.0243 0.0743 0.6332
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0134 0.1648
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0134 0.5967
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0225 0.9203
Brugia malayi AMP-binding enzyme family protein 0.008 0.019 0.1616
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0086 0.0636
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0243 0.0743 0.6332
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.0225 0.9203
Onchocerca volvulus 0.0243 0.0743 0.5135
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0243 0.0743 0.0743
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0107 0.0907
Trypanosoma brucei metacaspase 5, putative 0.0049 0.0086 0.3498
Brugia malayi Nuclear hormone receptor-like 1 0.0243 0.0743 0.6332
Loa Loa (eye worm) hypothetical protein 0.0059 0.0122 0.1038
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0000066385 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0024 0.0206
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0121 0.1625
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0129 0.0356 0.0372
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0033 0.1361
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.019 0.7747
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0243 0.0743 0.6332
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0225 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0045 0.0074 0.0078
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0000066385 0.0003
Loa Loa (eye worm) TAR-binding protein 0.0055 0.0108 0.0923
Plasmodium falciparum importin beta, putative 0.0032 0.0028 0.1159
Echinococcus multilocularis ecdysone induced protein 78C 0.0243 0.0743 0.0777
Trypanosoma brucei trypanothione reductase 0.0096 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Echinococcus granulosus microtubule associated protein 2 0.2785 0.9325 0.9325
Echinococcus granulosus survival motor neuron protein 1 0.026 0.08 0.08
Brugia malayi hypothetical protein 0.0107 0.0283 0.2413
Loa Loa (eye worm) hypothetical protein 0.0107 0.0283 0.2413
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.019 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0033 0.5676
Brugia malayi nuclear receptor NHR-88 0.0115 0.0309 0.2632
Trypanosoma cruzi metacaspase, putative 0.0049 0.0086 0.3498
Brugia malayi steroid hormone receptor 0.0243 0.0743 0.6332
Onchocerca volvulus 0.0028 0.0014 0.0099
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.009 0.0225 0.0236
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0000066385 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0086 0.0636
Echinococcus granulosus nuclear receptor nhr 48 0.0115 0.0309 0.0309
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0000066385 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0086 0.0636
Mycobacterium tuberculosis Probable reductase 0.0219 0.066 0.8084
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0521
Echinococcus multilocularis muscleblind protein 0.0337 0.1058 0.1106
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0245 0.2086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.0196 0.0205
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0129 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0209 0.0625 0.5327
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0061 0.075
Brugia malayi RNA, U transporter 1 0.009 0.0226 0.1926
Loa Loa (eye worm) steroid hormone receptor 0.0243 0.0743 0.6332
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0134 0.5967
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0008 0.006
Echinococcus granulosus Nuclear hormone receptor HR96 0.0115 0.0309 0.0309
Brugia malayi Pre-SET motif family protein 0.0053 0.0101 0.0859
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0129 0.0355 0.0355
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.2632
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0196 0.0196
Leishmania major metacaspase, putative 0.0049 0.0086 0.3498
Trypanosoma brucei metacaspase MCA2 0.0049 0.0086 0.3498
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0053 0.0101 0.4118
Loa Loa (eye worm) hypothetical protein 0.005 0.0089 0.0761
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.0122 0.4975
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0196 0.0196
Echinococcus granulosus ecdysone induced protein 78C 0.0243 0.0743 0.0743
Schistosoma mansoni tar DNA-binding protein 0.0055 0.0108 0.0108

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.031 uM Antagonist activity at human S1P1 receptor expressed in CHO cell membrane by cAMP assay ChEMBL. 17379528
IC50 (functional) = 0.031 uM Antagonist activity at human S1P1 receptor expressed in CHO cell membrane by cAMP assay ChEMBL. 17379528
IC50 (functional) = 0.5 uM Antagonist activity at human S1P1 receptor expressed in CHO cell membrane by FLIPR assay ChEMBL. 17379528
IC50 (functional) = 0.5 uM Antagonist activity at human S1P1 receptor expressed in CHO cell membrane by FLIPR assay ChEMBL. 17379528
IC50 (functional) = 5 uM Antagonist activity at human S1P3 receptor expressed in CHO cell membrane by FLIPR assay ChEMBL. 17379528
IC50 (functional) = 5 uM Antagonist activity at human S1P3 receptor expressed in CHO cell membrane by FLIPR assay ChEMBL. 17379528
IC50 (functional) = 6 uM Antagonist activity at human S1P4 receptor expressed in CHO cell membrane by FLIPR assay ChEMBL. 17379528
IC50 (functional) = 6 uM Antagonist activity at human S1P4 receptor expressed in CHO cell membrane by FLIPR assay ChEMBL. 17379528
IC50 (functional) = 11 uM Antagonist activity at human S1P2 receptor expressed in CHO cell membrane by FLIPR assay ChEMBL. 17379528
IC50 (functional) = 11 uM Antagonist activity at human S1P2 receptor expressed in CHO cell membrane by FLIPR assay ChEMBL. 17379528

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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