Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | Starlite/ChEMBL | References |
Giardia intestinalis | Putative fructose-1,6-bisphosphate aldolase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.3835 | 0.3835 |
Echinococcus granulosus | Receptor type tyrosine protein phosphatase O | 0.0707 | 0.3199 | 0.3199 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.1411 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0075 | 0.0006 | 0.0006 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.1411 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0353 | 0.1411 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0158 | 0.0428 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0051 | 0.1071 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0075 | 0.0006 | 0.0006 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0158 | 0.0428 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0158 | 0.0428 | 0.0446 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0075 | 0.0006 | 0.0007 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0172 | 0.05 | 1 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0051 | 0.1071 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0158 | 0.0428 | 0.0428 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0084 | 0.0051 | 0.0054 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0158 | 0.0428 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0158 | 0.0428 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0353 | 0.1411 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0428 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0158 | 0.0428 | 0.0428 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0158 | 0.0428 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0075 | 0.0006 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0428 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0051 | 0.1071 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0158 | 0.0428 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0075 | 0.0006 | 0.0006 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0158 | 0.0428 | 0.0428 |
Schistosoma mansoni | coup transcription factor | 0.0158 | 0.0428 | 0.0428 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0158 | 0.0428 | 0.0446 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.2055 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0075 | 0.0006 | 0.0006 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0158 | 0.0428 | 0.0446 |
Schistosoma mansoni | nuclear hormone receptor | 0.0075 | 0.0006 | 0.0006 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0172 | 0.05 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0158 | 0.0428 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0158 | 0.0428 | 0.0446 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0158 | 0.0428 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1411 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0158 | 0.0428 | 0.0428 |
Brugia malayi | steroid hormone receptor | 0.0158 | 0.0428 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0158 | 0.0428 | 0.0428 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1411 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0075 | 0.0006 | 0.0006 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0084 | 0.0051 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0084 | 0.0051 | 0.1071 |
Brugia malayi | ecdysteroid receptor | 0.0158 | 0.0428 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0075 | 0.0006 | 0.0007 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0075 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0051 | 0.1071 |
Schistosoma mansoni | zinc finger protein | 0.0075 | 0.0006 | 0.0006 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0158 | 0.0428 | 0.0428 |
Brugia malayi | nuclear receptor RXR | 0.0084 | 0.0051 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0051 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0158 | 0.0428 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0158 | 0.0428 | 0.0428 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0158 | 0.0428 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0158 | 0.0428 | 0.0446 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0158 | 0.0428 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0084 | 0.0051 | 0.0051 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1972 | 0.9579 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0428 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0158 | 0.0428 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0051 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0428 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0158 | 0.0428 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.3835 | 0.4004 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0158 | 0.0428 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0075 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0428 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0075 | 0.0006 | 0.0007 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0158 | 0.0428 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0084 | 0.0051 | 0.0051 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1411 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.3835 | 0.3835 |
Schistosoma mansoni | thyroid hormone receptor | 0.0158 | 0.0428 | 0.0428 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0158 | 0.0428 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0428 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0158 | 0.0428 | 0.0428 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0158 | 0.0428 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0051 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0428 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0158 | 0.0428 | 0.0428 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0158 | 0.0428 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0075 | 0.0006 | 0.0007 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0158 | 0.0428 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1411 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1411 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1411 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0158 | 0.0428 | 0.0428 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0158 | 0.0428 | 0.0428 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0075 | 0.0006 | 0.0006 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0075 | 0.0006 | 0.0006 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0158 | 0.0428 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1411 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0075 | 0.0006 | 0.0006 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0158 | 0.0428 | 1 |
Onchocerca volvulus | 0.0158 | 0.0428 | 1 | |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0158 | 0.0428 | 0.0428 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0158 | 0.0428 | 0.0428 |
Brugia malayi | nuclear hormone receptor | 0.0158 | 0.0428 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0158 | 0.0428 | 0.0446 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0158 | 0.0428 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0075 | 0.0006 | 0.0006 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0158 | 0.0428 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0158 | 0.0428 | 0.0446 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0172 | 0.05 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0158 | 0.0428 | 0.0428 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0158 | 0.0428 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0158 | 0.0428 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0158 | 0.0428 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0158 | 0.0428 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0075 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0084 | 0.0051 | 0.1071 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0158 | 0.0428 | 0.0428 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0428 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0158 | 0.0428 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0158 | 0.0428 | 0.0428 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0158 | 0.0428 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0084 | 0.0051 | 0.0051 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0158 | 0.0428 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0158 | 0.0428 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0158 | 0.0428 | 0.0446 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.1411 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of pig pancreatic elastase | ChEMBL. | 17532221 | |
Activity (binding) | 0 | Inhibition of pig pancreatic elastase | ChEMBL. | 17532221 |
Activity (functional) | = 23 % | Antiinflammatory activity in CD1 mouse assessed as inhibition of croton oil-induced ear oedema at 0.3 umol/cm^2 after 6 hrs | ChEMBL. | 17768049 |
Activity (functional) | = 23 % | Antiinflammatory activity in CD1 mouse assessed as inhibition of croton oil-induced ear oedema at 0.3 umol/cm^2 after 6 hrs | ChEMBL. | 17768049 |
IC50 (binding) | uM | Inhibitory activity against papain using HPLC assay; Not tested | ChEMBL. | 11720861 |
IC50 (binding) | = 5.6 uM | Inhibition of LYP (unknown origin) using DiFMUP substrate incubated for 2 hrs | ChEMBL. | 24997687 |
IC50 (binding) | > 100 uM | Inhibitory activity against HIV-1 integrase | ChEMBL. | 8691444 |
IC50 (binding) | > 100 uM | Inhibitory activity against HIV-1 protease | ChEMBL. | 8691444 |
IC50 (functional) | > 100 uM | Growth inhibition of human LoVo cells by MTT assay | ChEMBL. | 24374273 |
IC50 (functional) | > 100 uM | Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay | ChEMBL. | 24913712 |
IC50 (binding) | > 150 uM | Inhibitory activity against HRV 3Cpro using HPLC assay | ChEMBL. | 11720861 |
IC50 (binding) | = 675 uM | Inhibition of purified human recombinant IDO | ChEMBL. | 18318466 |
IC50 (binding) | = 675 uM | Inhibition of purified human recombinant IDO | ChEMBL. | 18318466 |
IC50 (functional) | > 2500 uM | Trypanocidal activity against bloodstream form of Trypanosoma cruzi Y isolated from albino mouse blood after 24 hrs by neubauer chamber analysis | ChEMBL. | 22483633 |
IC50 (functional) | > 2500 uM | Antitrypanosomal activity against Trypanosoma cruzi Y bloodstream trypomastigotes isolated from infected Swiss mouse blood assessed as lysis level after 24 hrs | ChEMBL. | 23279867 |
Inhibition (binding) | Inhibition of LYP (unknown origin) incubated for 30 mins at 25 degC before addition of DiFMUP substrate in presence of 5 uM zinc acetate | ChEMBL. | 24997687 | |
Inhibition (binding) | Inhibition of LYP (unknown origin) incubated for 30 mins at 25 degC before addition of DiFMUP substrate in presence of 5 uM zinc acetate | ChEMBL. | 24997687 | |
Inhibition (binding) | = 69 % | Inhibition of mushroom tyrosinase at 1 mM after 10 mins | ChEMBL. | 21189019 |
Inhibition (binding) | = 82 % | Inhibition of papain at 1.3 mM after 20 mins | ChEMBL. | 17532221 |
Inhibition (binding) | = 82 % | Inhibition of papain at 1.3 mM after 20 mins | ChEMBL. | 17532221 |
Inhibition (binding) | = 84 % | Inhibition of human recombinant MMP3 at 1 mM after 30 mins | ChEMBL. | 21189019 |
Inhibition (binding) | = 84 % | Inhibition of human recombinant MMP2 at 1 mM after 30 mins | ChEMBL. | 21189019 |
Inhibition (binding) | = 85 % | Inhibition of human recombinant MMP9 at 1 mM after 30 mins | ChEMBL. | 21189019 |
Inhibition (binding) | = 86 % | Inhibition of human recombinant MMP8 at 1 mM after 30 mins | ChEMBL. | 21189019 |
Inhibition (binding) | = 86 % | Inhibition of human recombinant MMP1 at 1 mM after 30 mins | ChEMBL. | 21189019 |
Inhibition (ADMET) | = 99.75885467 % | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Inhibition (binding) | = 100 % | Inhibition of human recombinant 5-lipoxygenase at 1 mM after 10 mins by fluorescence assay | ChEMBL. | 21189019 |
Inhibition (binding) | = 100 % | Inhibition of recombinant anthrax lethal factor at 1 mM after 30 mins by fluorescence assay | ChEMBL. | 21189019 |
Inhibition (ADMET) | = 101.6024591 % | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
IZ (functional) | = 14 mm | Antifungal activity against fluconazole-resistant Candida albicans at 100 ug/well after 24 hrs by well diffusion assay | ChEMBL. | 24913712 |
LD50 (ADMET) | = 100 mg kg-1 | Tested for acute toxicity which is the single dose of the compound given intraperitoneally that will kill one-half of the mice within 5 days | ChEMBL. | 6834390 |
Lysis (functional) | = 76 % | Tested for its ability to eliminate the infective trypomastigote form of T. cruzi, Y strain present in blood of infected mice at the dose of 0.29 mM | ChEMBL. | No reference |
Optimal dose (functional) | = 104 % | Maximum survival by an optimum dose at 25 mg/kg in treated to that of untreated mice | ChEMBL. | 6834390 |
Potency (functional) | = 0.0316 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 15.8114 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (binding) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (ADMET) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (ADMET) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
TC50 (ADMET) | > 100000 nM | Neurotoxicity in mouse HT22 cells assessed as cell viability after 24 hrs by MTS assay | ChEMBL. | 23327468 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
6 literature references were collected for this gene.