Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | twitchin | 0.017 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0148 | 0.035 | 0.6472 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1989 | 0.9608 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0148 | 0.035 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 0.6472 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0148 | 0.035 | 0.6472 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 0.6472 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0477 | 0.8811 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0148 | 0.035 | 0.6472 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0148 | 0.035 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 0.6472 |
Echinococcus granulosus | Immunoglobulin | 0.0167 | 0.0449 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0449 | 0.8302 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0167 | 0.0449 | 0.0467 |
Echinococcus multilocularis | neuroglian | 0.017 | 0.0461 | 0.048 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0449 | 0.8302 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0148 | 0.035 | 0.6472 |
Echinococcus granulosus | roundabout 2 | 0.0173 | 0.0477 | 0.0477 |
Schistosoma mansoni | vesicular amine transporter | 0.0167 | 0.0449 | 0.0449 |
Brugia malayi | nuclear receptor NHR-88 | 0.0148 | 0.035 | 0.6472 |
Brugia malayi | hypothetical protein | 0.0167 | 0.0449 | 0.8302 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0148 | 0.035 | 0.035 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0148 | 0.035 | 0.6472 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0148 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0148 | 0.035 | 0.6472 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0148 | 0.035 | 0.035 |
Schistosoma mansoni | nephrin | 0.017 | 0.0461 | 0.0461 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0148 | 0.035 | 0.035 |
Schistosoma mansoni | nuclear hormone receptor | 0.0148 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0148 | 0.035 | 0.6472 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0148 | 0.035 | 0.035 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0148 | 0.035 | 0.0364 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0148 | 0.035 | 0.0364 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0148 | 0.035 | 0.0364 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0167 | 0.0449 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0449 | 0.8302 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0148 | 0.035 | 0.0364 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0186 | 0.0541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 0.6472 |
Echinococcus multilocularis | Immunoglobulin | 0.0167 | 0.0449 | 0.0467 |
Schistosoma mansoni | cell adhesion molecule | 0.017 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0449 | 0.8302 |
Echinococcus granulosus | defective proboscis extension response | 0.0167 | 0.0449 | 0.0449 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0148 | 0.035 | 0.6472 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0148 | 0.035 | 0.035 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0148 | 0.035 | 0.6472 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0148 | 0.035 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 0.6472 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0148 | 0.035 | 0.6472 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0148 | 0.035 | 0.6472 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0148 | 0.035 | 0.6472 |
Echinococcus multilocularis | roundabout 2 | 0.0173 | 0.0477 | 0.0496 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0574 | 0.2494 | 0.2494 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0148 | 0.035 | 0.6472 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0148 | 0.035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0449 | 0.8302 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0148 | 0.035 | 0.035 |
Echinococcus granulosus | neuroglian | 0.017 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0464 | 0.8587 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 0.6472 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0148 | 0.035 | 0.035 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.017 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0186 | 0.0541 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0148 | 0.035 | 0.6472 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0148 | 0.035 | 0.6472 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0148 | 0.035 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0148 | 0.035 | 0.6472 |
Schistosoma mansoni | thyroid hormone receptor | 0.0148 | 0.035 | 0.035 |
Schistosoma mansoni | thyroid hormone receptor | 0.0148 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0148 | 0.035 | 0.6472 |
Echinococcus granulosus | FTZ F1 alpha | 0.0148 | 0.035 | 0.035 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0148 | 0.035 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0148 | 0.035 | 0.6472 |
Echinococcus multilocularis | Immunoglobulin | 0.0167 | 0.0449 | 0.0467 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0148 | 0.035 | 0.035 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0148 | 0.035 | 0.035 |
Brugia malayi | ecdysteroid receptor | 0.0148 | 0.035 | 0.6472 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0148 | 0.035 | 0.6472 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0148 | 0.035 | 0.6472 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0167 | 0.0449 | 0.8302 |
Schistosoma mansoni | coup transcription factor | 0.0148 | 0.035 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0477 | 0.8811 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0148 | 0.035 | 0.0364 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0148 | 0.035 | 0.035 |
Brugia malayi | steroid hormone receptor | 0.0148 | 0.035 | 0.6472 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0167 | 0.0449 | 0.8302 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0148 | 0.035 | 0.6472 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0148 | 0.035 | 0.6472 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0148 | 0.035 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0449 | 0.8302 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 0.6472 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0148 | 0.035 | 0.035 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.2067 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0148 | 0.035 | 0.0364 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0148 | 0.035 | 0.6472 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0148 | 0.035 | 0.0364 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0167 | 0.0449 | 0.0449 |
Brugia malayi | nuclear hormone receptor | 0.0148 | 0.035 | 0.6472 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0148 | 0.035 | 0.6472 |
Onchocerca volvulus | 0.0148 | 0.035 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 0.6472 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0148 | 0.035 | 0.035 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Inhibition of BPAO assessed as redox cycling activity by NBT assay | ChEMBL. | 17150363 |
IC50 (binding) | = 0.86 uM | Inhibition of BPAO after 20 mins by benzylamine assay | ChEMBL. | 17150363 |
Ratio (binding) | = 40 /mM/min | Ratio of kinact to Ki for BPAO | ChEMBL. | 17150363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.