TDR Targets

Basic information

Technical information

TDR Targets ID: 451769
Name: N-tert-butyl-1-(3-methoxy-4-phenylmethoxyphen yl)methanimine oxide
MW: 313.391 | Formula: C19H23NO3
H donors: 0 H acceptors: 1 LogP: 3.34 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OCc1ccccc1)/C=[N+](\C(C)(C)C)/[O-]
InChi: 1S/C19H23NO3/c1-19(2,3)20(21)13-16-10-11-17(18(12-16)22-4)23-14-15-8-6-5-7-9-15/h5-13H,14H2,1-4H3/b20-13+
InChiKey: XXPBRYXWOHKPJN-DEDYPNTBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(4-benzyloxy-3-methoxy-phenyl)-N-tert-butyl-methanimine oxide
1-(4-benzyloxy-3-methoxyphenyl)-N-tert-butylmethanimine oxide
N-tert-butyl-1-(3-methoxy-4-phenylmethoxy-phenyl)methanimine oxide
1-(4-benzoxy-3-methoxy-phenyl)-N-tert-butyl-methanimine oxide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	steroid hormone receptor	0.0137	0.0569	0.3574
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0132	0.054	0.0556
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0143	0.0601	0.3775
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0085	0.0292	0.1634
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0065	0.0186	0.1601
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0569	0.5816
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0569	0.5816
Mycobacterium tuberculosis	Probable dehydrogenase	0.0085	0.0292	0.1634
Schistosoma mansoni	nuclear hormone receptor	0.0137	0.0569	0.0563
Echinococcus granulosus	peregrin	0.0033	0.0016	0.0016
Onchocerca volvulus	Protein ultraspiracle homolog	0.0137	0.0569	0.5008
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0137	0.0569	0.0586
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0072	0.0227	0.0221
Onchocerca volvulus		0.0137	0.0569	0.5008
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0065	0.0186	0.018
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0137	0.0569	0.3574
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0137	0.0569	0.5816
Brugia malayi	ecdysteroid receptor	0.0137	0.0569	0.3574
Echinococcus granulosus	geminin	0.019	0.0847	0.0847
Echinococcus granulosus	nuclear receptor nhr 48	0.0065	0.0186	0.0186
Onchocerca volvulus	Alhambra homolog	0.0033	0.0016	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0227	0.2283
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0065	0.0186	0.1142
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0107	0.0409	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0569	0.5816
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0328	0.1582	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0328	0.1582	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0065	0.0186	0.1601
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0016	0.0067
Schistosoma mansoni	nuclear receptor nhr-48	0.0065	0.0186	0.018
Schistosoma mansoni	zinc finger protein	0.0065	0.0186	0.018
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0328	0.1582	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0137	0.0569	0.0569
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0137	0.0569	0.0569
Brugia malayi	Nuclear hormone receptor E75	0.0065	0.0186	0.1142
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0137	0.0569	0.0586
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0143	0.0601	0.0601
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0065	0.0186	0.0186
Schistosoma mansoni	hypothetical protein	0.019	0.0847	0.0842
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0085	0.0292	0.1634
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0137	0.0569	0.0586
Echinococcus granulosus	FTZ F1 alpha	0.0137	0.0569	0.0569
Brugia malayi	Nuclear hormone receptor E75	0.0065	0.0186	0.1142
Brugia malayi	nuclear receptor NHR-67	0.0065	0.0186	0.1142
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0137	0.0569	0.5816
Brugia malayi	PHD-finger family protein	0.0033	0.0016	0.0067
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0137	0.0569	0.0569
Brugia malayi	photoreceptor-specific nuclear receptor	0.0137	0.0569	0.3574
Brugia malayi	Nuclear hormone receptor-like 1	0.0072	0.0227	0.1403
Echinococcus multilocularis	nuclear receptor nhr 48	0.0065	0.0186	0.0187
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0137	0.0569	0.0586
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0328	0.1582	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0065	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0056	0.014	0.1382
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0065	0.0186	0.0187
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0137	0.0569	0.5816
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0137	0.0569	0.0586
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0137	0.0569	0.0563
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0065	0.0186	0.0186
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0072	0.0227	0.2283
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0137	0.0569	0.0563
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0065	0.0186	0.0186
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0137	0.0569	0.0563
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0137	0.0569	0.0569
Onchocerca volvulus		0.0243	0.113	1
Brugia malayi	nuclear hormone receptor	0.0137	0.0569	0.3574
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0094	0.0342	0.0388
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0328	0.1582	0.1576
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0143	0.0601	0.0619
Schistosoma mansoni	nuclear receptor	0.0065	0.0186	0.018
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Brugia malayi	hypothetical protein	0.0065	0.0186	0.1142
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0137	0.0569	0.5008
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0328	0.1582	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0137	0.0569	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0227	0.2283
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0137	0.0569	0.3574
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.0601	0.0595
Mycobacterium tuberculosis	Probable reductase	0.0085	0.0292	0.1634
Brugia malayi	Thioredoxin reductase	0.0037	0.004	0.0219
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0137	0.0569	0.0569
Onchocerca volvulus		0.0065	0.0186	0.1601
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.0601	0.0595
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0137	0.0569	0.5816
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0132	0.054	0.054
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0143	0.0601	0.6144
Plasmodium falciparum	thioredoxin reductase	0.0037	0.004	0.0153
Brugia malayi	hypothetical protein	0.0072	0.0227	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0016	0.0108
Echinococcus multilocularis	peregrin	0.0033	0.0016	0.0011
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0328	0.1582	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0065	0.0186	0.0187
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0137	0.0569	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0227	0.2283
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0132	0.054	0.0297
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0137	0.0569	0.3574
Brugia malayi	Nuclear hormone receptor-like 1	0.0072	0.0227	0.1403
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0128	0.0522	0.3127
Schistosoma mansoni	coup transcription factor	0.0137	0.0569	0.0563
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0137	0.0569	0.3574
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.0053	0.0047
Loa Loa (eye worm)	glutathione reductase	0.0037	0.004	0.0356
Plasmodium vivax	glutathione reductase, putative	0.0037	0.004	0.0219
Brugia malayi	hypothetical protein	0.0065	0.0186	0.1142
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0065	0.0186	0.0187
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0085	0.0292	0.1634
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0137	0.0569	0.0586
Echinococcus multilocularis	FTZ F1 alpha	0.0137	0.0569	0.0586
Brugia malayi	jmjC domain containing protein	0.0107	0.0409	0.2559
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0065	0.0186	0.1859
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0006	0.0006
Echinococcus multilocularis	lysine specific demethylase 5A	0.0039	0.0053	0.0049
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0328	0.1582	1
Brugia malayi	nuclear receptor RXR	0.0065	0.0186	0.1142
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0085	0.0292	0.1634
Onchocerca volvulus	Bile acid receptor homolog	0.0137	0.0569	0.5008
Schistosoma mansoni	hypothetical protein	0.0033	0.0016	0.001
Mycobacterium tuberculosis	Probable oxidoreductase	0.0094	0.0342	0.1959
Loa Loa (eye worm)	PHD-finger family protein	0.0033	0.0016	0.0108
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0328	0.1582	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0137	0.0569	0.0563
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0016	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0137	0.0569	0.3574
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0137	0.0569	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0569	0.5816
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0227	0.2283
Loa Loa (eye worm)	DR-78	0.0065	0.0186	0.1859
Echinococcus multilocularis	ecdysone induced protein 78C	0.0137	0.0569	0.0586
Onchocerca volvulus		0.0065	0.0186	0.1601
Brugia malayi	nuclear hormone receptor	0.0065	0.0186	0.1142
Echinococcus multilocularis	jumonji domain containing protein	0.0045	0.0084	0.0081
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0016	0.0067
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.0601	0.0595
Brugia malayi	conserved hypotetical protein	0.0065	0.0186	0.1142
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0137	0.0569	0.3574
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0065	0.0186	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0569	0.5816
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0569	0.5816
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Brugia malayi	nuclear hormone receptor family member odr-7	0.0065	0.0186	0.1142
Trichomonas vaginalis	set domain proteins, putative	0.0243	0.113	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0227	0.2283
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0107	0.0409	0.0419
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0137	0.0569	0.5816
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0137	0.0569	0.0569
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0132	0.054	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0569	0.5816
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0137	0.0569	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Schistosoma mansoni	jumonji domain containing protein	0.0085	0.0293	0.0287
Schistosoma mansoni	nuclear hormone receptor	0.0065	0.0186	0.018
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0143	0.0601	0.0619
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0137	0.0569	0.3574
Brugia malayi	Zinc finger, C2H2 type family protein	0.0128	0.0522	0.3278
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0569	0.5816
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.0043	0.0043
Brugia malayi	tailless protein	0.0065	0.0186	0.1142
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0137	0.0569	0.5816
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0328	0.1582	1
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0328	0.1582	0.5
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.004	0.0219
Giardia lamblia	PHD finger protein 15	0.0033	0.0016	0.5
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.0043	0.0039
Brugia malayi	glutathione reductase	0.0037	0.004	0.0219
Loa Loa (eye worm)	jmjC domain-containing protein	0.0039	0.0053	0.0483
Loa Loa (eye worm)	steroid hormone receptor	0.0137	0.0569	0.5816
Toxoplasma gondii	thioredoxin reductase	0.0037	0.004	0.0219
Loa Loa (eye worm)	nuclear hormone receptor	0.0065	0.0186	0.1859
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0033	0.0016	0.001
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Schistosoma mansoni	hypothetical protein	0.019	0.0847	0.0842
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0143	0.0601	0.0601
Brugia malayi	jmjC domain containing protein	0.0039	0.0053	0.0297
Leishmania major	dihydroorotate dehydrogenase	0.0328	0.1582	1
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0132	0.054	0.054
Echinococcus granulosus	lysine specific demethylase 5A	0.0039	0.0053	0.0053
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0065	0.0186	0.1859
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0137	0.0569	0.0563
Brugia malayi	ecdysone receptor	0.0065	0.0186	0.1142
Echinococcus multilocularis	geminin	0.019	0.0847	0.0875
Echinococcus granulosus	thyroid hormone receptor alpha	0.0065	0.0186	0.0186
Schistosoma mansoni	nuclear receptor	0.0065	0.0186	0.018
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0137	0.0569	0.3574
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0137	0.0569	0.0586
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1847	0.9617	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0132	0.054	0.0297
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0065	0.0186	0.018
Brugia malayi	Nuclear hormone receptor-like 1	0.0137	0.0569	0.3574
Brugia malayi	nuclear receptor NHR-88	0.0065	0.0186	0.1142
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0137	0.0569	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Plasmodium falciparum	glutathione reductase	0.0037	0.004	0.0153
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0033	0.0016	0.0011
Loa Loa (eye worm)	jmjC domain-containing protein	0.0067	0.02	0.2007
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0137	0.0569	0.3574
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0072	0.0227	0.0227
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.004	0.0356
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0214	0.0974	1
Schistosoma mansoni	nuclear hormone receptor	0.0065	0.0186	0.018
Schistosoma mansoni	retinoic acid receptor RXR	0.1919	1	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0094	0.0342	0.1959
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0137	0.0569	0.3574
Echinococcus granulosus	jumonji domain containing protein	0.0045	0.0084	0.0084
Brugia malayi	nuclear receptor NHR-88	0.0137	0.0569	0.3574
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0094	0.0342	0.1959
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0328	0.1582	1
Schistosoma mansoni	thyroid hormone receptor	0.0137	0.0569	0.0563
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0072	0.0227	0.0221
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0072	0.0227	0.023
Echinococcus granulosus	PHD finger protein rhinoceros	0.0033	0.0016	0.0016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0137	0.0569	0.5816
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0065	0.0186	0.0187
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0137	0.0569	0.3574
Brugia malayi	hypothetical protein	0.0072	0.0227	0.1403
Brugia malayi	orphan nuclear receptor NR2E1	0.0065	0.0186	0.1142
Brugia malayi	Bromodomain containing protein	0.0033	0.0016	0.0067
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0328	0.1582	1
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0328	0.1582	1
Brugia malayi	Steroid receptor seven-up type 2	0.0137	0.0569	0.3574
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0137	0.0569	0.0563
Brugia malayi	Pre-SET motif family protein	0.0214	0.0974	0.6144
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0132	0.054	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0137	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Brugia malayi	nuclear receptor RXR	0.0072	0.0227	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0186	0.1859
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.0053	0.0047

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 35 cm2	Protective effect against ischemia/reperfusion-induced microvascular damages in golden hamster assessed as number of leakage site per cm^2 at 3 mg/kg, po after 15 mins by cheek pouch assay	ChEMBL.	17379527
Activity (functional)	= 40 cm2	Protective effect against ischemia/reperfusion-induced microvascular damages in golden hamster assessed as number of leakage site per cm^2 at 3 mg/kg, po after 10 mins by cheek pouch assay	ChEMBL.	17379527
LogP	= 2.68	Partition coefficient, log P of the compound	ChEMBL.	17379527

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL397881
PubChem: 18433740

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 451769